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1. 发明申请

WO2009031861A3 TEMPERATURE AND PH-SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT SAFETY IN VIVO AND HYDROGEL AND DRUG DELIVERY SYSTEM USING THEREOF 审中-公开
标题翻译：使用它的温度和敏感性嵌段共聚物在血液和水和药物输送系统中具有优异的安全性
公开(公告)号：WO2009031861A3
公开(公告)日：2009-05-07
申请号：PCT/KR2008005270
申请日：2008-09-05
申请人： UNIV SUNGKYUNKWAN FOUND , NGUYEN MINH KHANH , LEE DOO SUNG , KIM BONG SUP
发明人： NGUYEN MINH KHANH , LEE DOO SUNG , KIM BONG SUP
IPC分类号： C08G65/32
CPC分类号： C08G65/30 , A61K9/0024 , A61K47/34 , C08G65/3322 , C08G65/33317 , C08G65/33324 , C08L2203/02 , C08L2205/05
摘要： Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH-and temperature- sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (ß-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (ß-amino ester)-based oligomer and then coupling them.
摘要翻译：本文公开了具有优异安全性的pH和温度敏感性嵌段共聚物及其制备方法以及使用该嵌段共聚物的水凝胶和药物载体。根据本发明，pH和温度敏感性嵌段共聚物包括：（a）聚乙二醇基化合物（A）的共聚获得的; 和（b）聚（β-氨基酯）的低聚物（B）或聚（酰氨基胺）的低聚物（C）或其混合物（D）的偶联。为了控制生物降解速率，将嵌段共聚物与基于聚（酰氨基胺）的低聚物代替聚（β-氨基酯）的低聚物混合，然后将其偶联。

2. 发明申请

WO2006109945A1 TEMPERATURE AND PH SENSITIVE BLOCK COPOLYMER AND POLYMERIC HYDROGLES USING THE SAME 审中-公开
标题翻译：使用温度和敏感性嵌段共聚物和聚合氢化物
公开(公告)号：WO2006109945A1
公开(公告)日：2006-10-19
申请号：PCT/KR2006/001185
申请日：2006-03-31
申请人： SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION , LEE, Doo-Sung , KIM, Min-Sang , YOU, Je-Sun , PHU, Huynh Dai , KIM, Bong-Sup , NGUYEN, Minh Khanh
发明人： LEE, Doo-Sung , KIM, Min-Sang , YOU, Je-Sun , PHU, Huynh Dai , KIM, Bong-Sup , NGUYEN, Minh Khanh
IPC分类号： C08G65/48
CPC分类号： C08G81/00 , C08L7/02 , C08L67/00 , C08L71/02 , C08L77/00 , C08L2205/05 , C08L2666/18 , C08L2666/20
摘要： Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly (β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly (β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body.
摘要翻译：公开了通过将以下组分彼此偶联而形成的嵌段共聚物：（a）聚乙二醇（PEG）型化合物与可生物降解聚合物的共聚物（A）和（b）选自聚（β-氨基酯）和聚（酰氨基胺）中的至少一种低聚物（B）。还公开了制备相同嵌段共聚物的方法和包含温度和pH敏感性嵌段共聚物的聚合物水凝胶型药物组合物和可以用嵌段共聚物包封的生理活性物质。多嵌段共聚物通过pH敏感的聚（β-氨基酯）和/或聚（酰氨基胺）型低聚物，亲水和温度敏感的聚乙二醇型化合物和疏水和可生物降解的聚合物的共聚获得。因此，嵌段共聚物由于其在共聚物中的亲水基团和疏水基团的组合引起的两亲性而形成聚合物水凝胶结构，并且根据pH变化而具有电离特性，因此可以用作靶向的药物载体，定向药物递送取决于体内的pH变化。

3. 发明申请

WO2009031861A2 TEMPERATURE AND PH-SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT SAFETY IN VIVO AND HYDROGEL AND DRUG DELIVERY SYSTEM USING THEREOF 审中-公开
标题翻译：在体内具有优异安全性的温度和PH敏感的嵌段共聚物以及使用它的水凝胶和药物递送系统
公开(公告)号：WO2009031861A2
公开(公告)日：2009-03-12
申请号：PCT/KR2008/005270
申请日：2008-09-05
申请人： SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION , NGUYEN, Minh Khanh , LEE, Doo Sung , KIM, Bong Sup
发明人： NGUYEN, Minh Khanh , LEE, Doo Sung , KIM, Bong Sup
IPC分类号： C08G65/32
CPC分类号： C08G65/30 , A61K9/0024 , A61K47/34 , C08G65/3322 , C08G65/33317 , C08G65/33324 , C08L2203/02 , C08L2205/05
摘要： Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH-and temperature- sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (β-amino ester)-based oligomer and then coupling them.
摘要翻译：本文公开了具有优异安全性的pH和温度敏感性嵌段共聚物及其制备方法，以及使用该嵌段共聚物的水凝胶和药物载体。根据本发明，所述pH和温度敏感性嵌段共聚物包含：通过以下物质的共聚获得：（a）基于聚乙二醇的化合物（A）; 和（b）基于聚（β-氨基酯）的低聚物（B）或聚（酰氨基胺）基低聚物（C）或其混合物（D）的偶联。为了控制生物降解速率，将嵌段共聚物与基于聚（酰氨基胺）的低聚物代替基于聚（β-氨基酯）的低聚物混合，然后偶联它们。

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