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1. 发明申请

WO2005123121A3 USE OF DNA MOLECULE AS VACCINE ADJUVANT 审中-公开
标题翻译：使用DNA分子作为疫苗补充剂
公开(公告)号：WO2005123121A3
公开(公告)日：2006-06-15
申请号：PCT/GB2005002472
申请日：2005-06-22
申请人： FORINNOVA AS , OWEN DEBORAH JANE , NERLAND AUDUN HELGE , LORENZEN NIELS , SOMMERSET INGUNN
发明人： NERLAND AUDUN HELGE , LORENZEN NIELS , SOMMERSET INGUNN
IPC分类号： A61K39/00 , A61K39/12 , A61K39/205 , A61K39/39 , A61K48/00 , C07K14/08
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/552 , A61K2039/55561 , C12N2760/20022 , C12N2770/30034
摘要： The present invention provides the use of a DNA molecule encoding an antigen (and in particular encoding a bacteria or virus glycoprotein, preferably a rhabdovirus glycoprotein) which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a medicament for use as a vaccine adjuvant or to enhance the immune stimulating properties or vaccination properties of a vaccine molecule, or to enhance the immune response to a vaccine molecule. A composition comprising said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, and a vaccine molecule, is also provided. A further aspect of the present invention provides the use of said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a composition which can improve or increase the elimination of other foreign DNA molecules from an organism.
摘要翻译：本发明提供编码抗原（特别是编码细菌或病毒糖蛋白，优选弹状病毒糖蛋白）的DNA分子在宿主细胞表面或其变体或片段上的表达的用途，制造用作疫苗佐剂或增强疫苗分子的免疫刺激性质或疫苗接种性质或增强对疫苗分子的免疫应答的药物。还提供了包含编码在宿主细胞或其变体或其片段表面上表达的抗原的DNA分子和疫苗分子的组合物。本发明的另一方面提供了编码在宿主细胞或其变体或片段的表面上表达的抗原的所述DNA分子在制备可以改善或增加来自生物体的其他外来DNA分子。

2. 发明申请

WO2005123121A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2005123121A2
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002472
申请日：2005-06-22
申请人： FORINNOVA AS , OWEN, Deborah, Jane , NERLAND, Audun, Helge , LORENZEN, Niels , SOMMERSET, Ingunn
发明人： NERLAND, Audun, Helge , LORENZEN, Niels , SOMMERSET, Ingunn
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/552 , A61K2039/55561 , C12N2760/20022 , C12N2770/30034
摘要： The present invention provides the use of a DNA molecule encoding an antigen (and in particular encoding a bacteria or virus glycoprotein, preferably a rhabdovirus glycoprotein) which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a medicament for use as a vaccine adjuvant or to enhance the immune stimulating properties or vaccination properties of a vaccine molecule, or to enhance the immune response to a vaccine molecule. A composition comprising said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, and a vaccine molecule, is also provided. A further aspect of the present invention provides the use of said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a composition which can improve or increase the elimination of other foreign DNA molecules from an organism.
摘要翻译：本发明提供编码抗原（特别是编码细菌或病毒糖蛋白，优选弹状病毒糖蛋白）的DNA分子在宿主细胞表面或其变体或片段上的表达的用途，制造用作疫苗佐剂或增强疫苗分子的免疫刺激性质或疫苗接种性质或增强对疫苗分子的免疫应答的药物。还提供了包含编码在宿主细胞或其变体或其片段表面上表达的抗原的DNA分子和疫苗分子的组合物。本发明的另一方面提供了编码在宿主细胞或其变体或片段的表面上表达的抗原的所述DNA分子在制备可以改善或增加来自生物体的其他外来DNA分子。

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