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1. 发明申请

US20130046128A1 Radiotherapy Delivery Cannula With Visual Confirmation Window 审中-公开
标题翻译：放射治疗交付插管与视觉确认窗口
公开(公告)号：US20130046128A1
公开(公告)日：2013-02-21
申请号：US13653519
申请日：2012-10-17
申请人： NeoVista, Inc.
发明人： David Gyorke , Benjamin Woodward , John N. Hendrick , John P. Dunbar , Michael D. Tocci , Jay Daulton , William Metzger
IPC分类号： A61M36/12 , A61F9/00
CPC分类号： A61N5/1017
摘要： A radiotherapy delivery device is provided comprising an elongated applicator having a proximal end and a distal end having a tip. The distal end is adapted to be introduced into a body including a treatment zone to be located adjacent a target tissue. A radiotherapy emitter is provided that is moveable between the proximal end of the applicator and the treatment zone of the applicator. The applicator includes a window to permit visual confirmation of the location of the radiation emitter and the treatment zone.
摘要翻译：提供了放射治疗递送装置，其包括具有近端和具有尖端的远端的细长施用器。远端适于被引入到包括待定位在邻近靶组织的处理区的主体中。提供放射治疗发射器，其可以在施用器的近端和施用器的处理区之间移动。涂抹器包括允许视觉确认辐射发射器和处理区的位置的窗口。

2. 发明申请

WO2007040825A3 METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY 审中-公开
标题翻译：方法和装置用于室内BRACHYTHERAPY
公开(公告)号：WO2007040825A3
公开(公告)日：2009-04-30
申请号：PCT/US2006031004
申请日：2006-08-09
申请人： NEOVISTA INC , LARSEN CHARLES E , HILLSTEAD RICHARD , TRIP ROELOF , DE JUAN EUGENE , HUMAYUN MARK , FRITZ EBERHARD , PINTASKE RAINER
发明人： LARSEN CHARLES E , HILLSTEAD RICHARD , TRIP ROELOF , DE JUAN EUGENE , HUMAYUN MARK , FRITZ EBERHARD , PINTASKE RAINER
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1017 , A61N5/1049 , A61N2005/1058
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.
摘要翻译：公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。辐射源安装到具有柔性远端和较硬的近端的导线上。

3. 发明申请

WO2007059208A2 METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY 审中-公开
标题翻译：方法和装置用于室内BRACHYTHERAPY
公开(公告)号：WO2007059208A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/044335
申请日：2006-11-15
申请人： NEOVISTA INC. , HILLSTEAD, Richard, A. , LARSEN, Charles, A. , TRIP, Roelof , ANDERSON, Cory, S. , FRITZ, Eberhard , PINTASKE, Rainer , HENDRICK, John, N. , WOODWARD, Benjamin, W.
发明人： HILLSTEAD, Richard, A. , LARSEN, Charles, A. , TRIP, Roelof , ANDERSON, Cory, S. , FRITZ, Eberhard , PINTASKE, Rainer , HENDRICK, John, N. , WOODWARD, Benjamin, W.
IPC分类号： A61N5/00 , A61B5/05 , A61B8/00
CPC分类号： A61N5/1017 , A61N5/1007 , A61N5/1049 , A61N2005/1058
摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.
摘要翻译：公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗法。

4. 发明专利

CA2724327A1 HANDHELD RADIATION DELIVERY SYSTEM FOR ADVANCING A RADIATION SOURCE WIRE 未知
公开(公告)号：CA2724327A1
公开(公告)日：2009-12-10
申请号：CA2724327
申请日：2009-06-03
申请人： NEOVISTA INC
发明人： VERMEERE BILL , METZGER WILLIAM , DAULTON JAY , WOODWARD BENJAMIN , DIEL MARK , BEAULIEU DAVID , KONAWALIK KRISTOPHER , KELLY CHRISTOPHER , CHEN GUANG QUN MAX
IPC分类号： A61N5/10 , A61M36/04
摘要： A handheld radiation delivery system is disclosed that includes a two-part delivery module comprising a reusable portion that contains a radioactive source wire and a disposable portion that includes a drive assembly for moving the radioactive source wire between storage and treatment positions. A disposable applicator tip is provided that includes a cannula for receiving the radioactive source wire when in the treatment position and a mechanism for limiting the number of uses of the device. A handheld cable actuator is operatively connected to the disposable portion of the handpiece to impart motion to the source wire.

5. 发明专利

CA2554961A1 METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY 未知
公开(公告)号：CA2554961A1
公开(公告)日：2005-09-01
申请号：CA2554961
申请日：2005-02-11
申请人： NEOVISTA INC
发明人： LARSEN CHARLES , TRIP ROELOF , HUMAYUN MARK , PINTASKE RAINER , DE JUAN EUGENE , BEHRMANN SABINE , PHILLIPPS GERD T , FRITZ EBERHARD , HILLSTEAD RICHARD
IPC分类号： A61M36/12 , A61N5/00 , A61N5/10
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand- held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiec e provides for shielded storage of the radiation source when retracted from th e cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

6. 发明专利

BRPI0618677A2 未知
公开(公告)号：BRPI0618677A2
公开(公告)日：2011-09-06
申请号：BRPI0618677
申请日：2006-11-15
申请人： NEOVISTA INC
发明人： HILLSTEAD RICHARD A , LARSEN CHARLES A , TRIP ROELOF , ANDERSON CORY S , FRITZ EBERHARD , PINTASKE RAINER , HENDRICK JOHN N , WOODWARD BENJAMIN W
IPC分类号： A61N5/00 , A61N5/10
摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

7. 发明专利

AU2006315425A1 Methods and apparatus for intraocular brachytherapy 未知
公开(公告)号：AU2006315425A1
公开(公告)日：2007-05-24
申请号：AU2006315425
申请日：2006-11-15
申请人： NEOVISTA INC
发明人： ANDERSON CORY S , HILLSTEAD RICHARD A , WOODWARD BENJAMIN W , LARSEN CHARLES A , HENDRICK JOHN N , FRITZ EBERHARD , PINTASKE RAINER , TRIP ROELOF
IPC分类号： A61N5/00 , A61B5/05 , A61B8/00 , A61N5/10
摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

8. 发明专利

AT334717T 未知
公开(公告)号：AT334717T
公开(公告)日：2006-08-15
申请号：AT03025416
申请日：2003-11-05
申请人： NEOVISTA INC
发明人： BEHRMANN SABINE , FRITZ EBERHARD DR
IPC分类号： A61N5/10

9. 发明申请

WO2007040825A2 METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY 审中-公开
标题翻译：方法和装置用于室内BRACHYTHERAPY
公开(公告)号：WO2007040825A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/031004
申请日：2006-08-09
申请人： NEOVISTA, INC. , LARSEN, Charles, E. , HILLSTEAD, Richard , TRIP, Roelof , DE JUAN, Eugene , HUMAYUN, Mark , FRITZ, Eberhard , PINTASKE, Rainer
发明人： LARSEN, Charles, E. , HILLSTEAD, Richard , TRIP, Roelof , DE JUAN, Eugene , HUMAYUN, Mark , FRITZ, Eberhard , PINTASKE, Rainer
IPC分类号： A61N5/00
CPC分类号： A61N5/1017 , A61N5/1049 , A61N2005/1058
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.
摘要翻译：公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。辐射源安装到具有柔性远端和较硬的近端的导线上。

10. 发明申请

WO2005049139A1 RADIOACTIVE RADIATION SOURCE FOR OPHTHALMIC BRACHYTHERAPY 审中-公开
标题翻译：放射性放射源用于透视BRACHYTHERAPY
公开(公告)号：WO2005049139A1
公开(公告)日：2005-06-02
申请号：PCT/EP2004/012415
申请日：2004-11-03
申请人： NEOVISTA, INC. , BEHRMANN, Sabine , EBERHARD, Fritz
发明人： BEHRMANN, Sabine , EBERHARD, Fritz
IPC分类号： A61N5/10
CPC分类号： A61N5/1017 , A61N2005/1005 , A61N2005/1019 , A61N2005/1094
摘要： The radioactive radiation source of the invention is suitable for brachytherapy and especially for ocular or ophthalmic brachytherapy such as in the treatment of macula degeneration, preferably age related macula degeneration (AMD). The radiation source of the invention comprises a radiation source for brachytherapy having an elongated radiation emitting element (1) within an elongated means for containment (2) preferably arranged such that the longitudinal axis of the radiation emitting element and the longitudinal axis of said means for containment are aligned. Said means for containment comprises a shielding section (3) and a radiation transition section (4). Said shielding section (3) covers said radiation emitting element at least partially to substantially attenuate any radiation emitted in the direction of said shielding section. Preferably the shielding section covers the element to about 30-90 %, preferably 40-70 % and more preferably 50-60 %.
摘要翻译：本发明的放射性辐射源适用于近距离放射治疗，特别适用于眼部或眼睛近距离放射疗法，例如治疗黄斑变性，优选年龄相关性黄斑变性（AMD）。本发明的辐射源包括用于近距离放射治疗的辐射源，其具有在用于容纳的细长装置（2）内的细长辐射发射元件（1），优选地布置成使得辐射发射元件的纵向轴线和所述用于遏制对齐。所述用于容纳的装置包括屏蔽部分（3）和辐射过渡部分（4）。所述屏蔽部分（3）至少部分地覆盖所述辐射发射元件，以基本上衰减在所述屏蔽部分的方向上发射的任何辐射。优选地，屏蔽部分将元件覆盖至约30-90％，优选为40-70％，更优选为50-60％。

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