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1. 发明专利

AU2003216506A1 A RAPID IMMUNOCHEMICAL PROCESS FOR MEASURING THIOPURINE METHYLTRANSFERASE REACTION PRODUCTS 未知
公开(公告)号：AU2003216506A1
公开(公告)日：2003-09-22
申请号：AU2003216506
申请日：2003-03-04
申请人： BIOLOG DIAGNOSTICS LLC , PADHYE NISHA V , QUINTANAR ANDRE , NELSON MICHAEL R
发明人： PADHYE NISHA V , QUINTANAR ANDRE , NELSON MICHAEL R
IPC分类号： G01N33/566
摘要： The present invention relates to non-isotopic immunoassays for thiopurine methyltransferase (TPMT). The immunoassays of this invention may be homogenous or heterogenous, in which detection of the TPMT-catalyzed reaction product relies upon specific binding of antibody to 6-MMP or other TPMT-catalyzed reaction products. Preferred embodiments of this invention include a Rapid Immunomigration Cassette and an assay carried out in ELISA assay format.

2. 发明专利

AU2003216506A8 A rapid immunochemical process for measuring thiopurine methyltransferase reaction products 未知
公开(公告)号：AU2003216506A8
公开(公告)日：2003-09-22
申请号：AU2003216506
申请日：2003-03-04
申请人： BIOLOG DIAGNOSTICS LLC , PADHYE NISHA V , NELSON MICHAEL R , QUINTANAR ANDRE
发明人： PADHYE NISHA V , QUINTANAR ANDRE , NELSON MICHAEL R
IPC分类号： G01N33/566 , C12Q1/68 , G01N33/543
摘要： The present invention relates to non-isotopic immunoassays for thiopurine methyltransferase (TPMT). The immunoassays of this invention may be homogenous or heterogenous, in which detection of the TPMT-catalyzed reaction product relies upon specific binding of antibody to 6-MMP or other TPMT-catalyzed reaction products. Preferred embodiments of this invention include a Rapid Immunomigration Cassette and an assay carried out in ELISA assay format.

3. 发明申请

WO2010085770A1 LARGE AREA, HOMOGENEOUS ARRAY FABRICATION INCLUDING SUBSTRATE TEMPERATURE CONTROL 审中-公开
标题翻译：大面积，均匀的阵列制造，包括基板温度控制
公开(公告)号：WO2010085770A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/022016
申请日：2010-01-25
申请人： NANOINK, INC. , AMRO, Nabil, A. , SANEDRIN, Raymond , RENDLEN, Jeffrey, R. , NELSON, Michael, R.
发明人： AMRO, Nabil, A. , SANEDRIN, Raymond , RENDLEN, Jeffrey, R. , NELSON, Michael, R.
IPC分类号： G03F7/00
CPC分类号： G03F7/0002
摘要： Improved patterning at small scale including nanoscale. A method comprising: providing at least one cantilever comprising at least one tip thereon, and a material deposited on the tip, contacting the cantilever with a substrate so that the material is deposited from the tip onto the substrate to form a material deposit, wherein the temperature of the substrate is adapted to control a size of the material deposit. A device comprising: at least one heat sink, at least one heating or cooling stage, at least one vacuum system, wherein the device is adapted to function with a substrate to be subjected to a material deposition and to keep the substrate temperature substantially constant during deposition.
摘要翻译：改进了小尺寸的图案，包括纳米级。一种方法，包括：提供包括至少一个尖端的至少一个悬臂和沉积在所述尖端上的材料，使所述悬臂与基底接触，使得所述材料从所述尖端沉积到所述基底上以形成材料沉积物，其中衬底的温度适于控制材料沉积物的尺寸。一种装置，包括：至少一个散热器，至少一个加热或冷却台，至少一个真空系统，其中所述装置适于与要进行材料沉积的基板起作用，并且使基板温度在沉积。

4. 发明申请

WO2003076894A3 A RAPID IMMUNOCHEMICAL PROCESS FOR MEASURING THIOPURINE METHYLTRANSFERASE REACTION PRODUCTS 审中-公开
公开(公告)号：WO2003076894A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006531
申请日：2003-03-04
申请人： BIOLOGIX DIAGNOSTICS, LLC , PADHYE, Nisha, V. , QUINTANAR, Andre , NELSON, Michael, R.
发明人： PADHYE, Nisha, V. , QUINTANAR, Andre , NELSON, Michael, R.
IPC分类号： C12Q1/68
摘要： The present invention relates to non-isotopic immunoassays for thiopurine methyltransferase (TPMT). The immunoassays of this invention may be homogenous or heterogenous, in which detection of the TPMT-catalyzed reaction product relies upon specific binding of antibody to 6-MMP or other TPMT-catalyzed reaction products. Preferred embodiments of this invention include a Rapid Immunomigration Cassette and an assay carried out in ELISA assay format.

5. 发明申请

WO2012058565A3 INJECTION MOLDING OF MICRON AND NANO SCALE FEATURES FOR PHARMACEUTICAL BRAND PROTECTION 审中-公开
标题翻译：用于制药品牌保护的微米和纳米尺寸注射成型
公开(公告)号：WO2012058565A3
公开(公告)日：2012-07-19
申请号：PCT/US2011058331
申请日：2011-10-28
申请人： NANOINK INC , DISAWAL SANDEEP , ROSNER BJOERN , EISWERTH PATRICK , NELSON MICHAEL R , JANOSKY ROBERT , HE BO
发明人： DISAWAL SANDEEP , ROSNER BJOERN , EISWERTH PATRICK , NELSON MICHAEL R , JANOSKY ROBERT , HE BO
IPC分类号： B29C45/37 , A61J1/00
CPC分类号： A61J1/00 , A61J2205/10 , A61J2205/50 , B29C45/372 , B29L2031/712
摘要： A method for forming a pharmaceutical container portion comprises providing a pharmaceutical container portion mold comprising a surface with at least one identification region, the at least one identification region comprising at least one identification feature that has a lateral dimension of 100 microns or less; and molding a pharmaceutical container portion from a moldable material using the mold, such that the at least one identification region is transferred to a surface of the pharmaceutical container portion. Applications include anti-counterfeiting.
摘要翻译：一种用于形成药物容器部分的方法包括：提供包括具有至少一个识别区域的表面的药物容器部分模具，所述至少一个识别区域包括具有100微米或更小的横向尺寸的至少一个识别特征; 以及使用所述模具由可模制材料模制药物容器部分，使得所述至少一个识别区域被转移到所述药物容器部分的表面。应用程序包括防伪。

6. 发明申请

WO2012061314A1 HIGH-THROUGHPUT SLIDE PROCESSING APPARATUS 审中-公开
标题翻译：高强度滑块加工设备
公开(公告)号：WO2012061314A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058642
申请日：2011-10-31
申请人： NANOINK, INC. , BUSSAN, John E. , NELSON, Michael R. , MORGAN, Pat N. , ROZHOK, Sergey V. , RENDLIN, Jeff
发明人： BUSSAN, John E. , NELSON, Michael R. , MORGAN, Pat N. , ROZHOK, Sergey V. , RENDLIN, Jeff
IPC分类号： G01N35/00 , G01N35/02 , G01N1/31
CPC分类号： G01N35/028 , G01N35/00029 , G01N2035/00138 , Y10T436/112499
摘要： An assay device and method of use thereof includes a sample tray comprising a plurality of sample wells having a first volume, and a slide tray comprising a slide, and a liquid dispenser. The slide comprises a plurality of reaction sites on a bottom surface of the slide. The liquid dispenser is configured to dispense a plurality of liquid samples into the sample wells. The sample wells are configured to hold the liquid samples. Each of the liquid samples has a second volume such that the second volume exceeds the first volume and each of the liquid sample sits within and above one of the sample wells. The slide tray and the sample tray are configured such that the slide tray can be placed onto the sample tray, at least one of the reaction sites can be positioned directly above at least one of the sample wells containing a liquid sample, and the liquid sample can be drawn onto the reaction site upon the liquid sample contacting the bottom surface of the slide.
摘要翻译：测定装置及其使用方法包括包含多个具有第一容积的样品孔的样品盘和包括载玻片的滑动盘和液体分配器。滑块包括滑块底表面上的多个反应位点。液体分配器配置成将多个液体样品分配到样品孔中。样品孔配置成保持液体样品。每个液体样品具有第二体积，使得第二体积超过第一体积，并且每个液体样品位于一个样品孔内和上面。滑动托盘和样品托盘被构造成使得滑动托盘可以放置在样品托盘上，至少一个反应位点可以直接位于至少一个含有液体样品的样品孔的上方，液体样品可以在液体样品接触载玻片的底表面时被吸引到反应部位上。

7. 发明申请

WO2012058565A2 INJECTION MOLDING OF MICRON AND NANO SCALE FEATURES FOR PHARMACEUTICAL BRAND PROTECTION 审中-公开
标题翻译：用于药品品牌保护的麦克风和纳米尺寸特征的注射成型
公开(公告)号：WO2012058565A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/058331
申请日：2011-10-28
申请人： NANOINK, INC. , DISAWAL, Sandeep , ROSNER, Bjoern , EISWERTH, Patrick , NELSON, Michael R. , JANOSKY, Robert , HE, Bo
发明人： DISAWAL, Sandeep , ROSNER, Bjoern , EISWERTH, Patrick , NELSON, Michael R. , JANOSKY, Robert , HE, Bo
IPC分类号： B29C45/37 , A61J1/00
CPC分类号： A61J1/00 , A61J2205/10 , A61J2205/50 , B29C45/372 , B29L2031/712
摘要： A method for forming a pharmaceutical container portion comprises providing a pharmaceutical container portion mold comprising a surface with at least one identification region, the at least one identification region comprising at least one identification feature that has a lateral dimension of 100 microns or less; and molding a pharmaceutical container portion from a moldable material using the mold, such that the at least one identification region is transferred to a surface of the pharmaceutical container portion. Applications include anti-counterfeiting.
摘要翻译：用于形成药物容器部分的方法包括提供药物容器部分模具，其包括具有至少一个识别区域的表面，所述至少一个识别区域包括具有100微米或更小的横向尺寸的至少一个识别特征; 以及使用所述模具从可模制材料模制药物容器部分，使得所述至少一个识别区域被转移到所述药物容器部分的表面。应用包括防伪。

8. 发明申请

WO2011139337A9 BALL-SPACER METHOD FOR PLANAR OBJECT LEVELING 审中-公开
标题翻译：用于平面目标校正的球形间隔法
公开(公告)号：WO2011139337A9
公开(公告)日：2012-01-05
申请号：PCT/US2011000727
申请日：2011-04-26
申请人： NANOINK INC , BUSSAN JOHN EDWARD , HAAHEIM JASON R , MOSKAL JOHN , SOLHEIM EDWARD R , VAL-KHVALABOV VADIM , NELSON MICHAEL R , AMRO NABIL A , VAKIL JAVAD M
发明人： BUSSAN JOHN EDWARD , HAAHEIM JASON R , MOSKAL JOHN , SOLHEIM EDWARD R , VAL-KHVALABOV VADIM , NELSON MICHAEL R , AMRO NABIL A , VAKIL JAVAD M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： An apparatus for leveling an array of microscopic pens with respect to a substrate surface is provided. The apparatus includes an array of microscopic pens; a substrate having a substrate surface; a controllable arm comprising a spherical ball on an end thereof; a force sensor configured to measure a force exerted on the array or the substrate surface at each of the plurality of positions; one or more actuators configured to drive the array and/or the substrate to vary a relative distance and a relative tilting between the array and the substrate surface; and a controller configured to determine a planar offset of the array with respect to the substrate and initiate a leveling of the array with respect to the substrate based on the planar offset. Methods are also provided.
摘要翻译：提供了一种用于使微观笔阵列相对于衬底表面平整的设备。该设备包括一列微型笔; 具有衬底表面的衬底; 在其一端包括球形球的可控制臂; 力传感器，其被配置为测量在所述多个位置中的每个位置处施加在所述阵列或所述衬底表面上的力; 一个或多个致动器，其被配置为驱动所述阵列和/或所述衬底以改变所述阵列和所述衬底表面之间的相对距离和相对倾斜; 以及控制器，被配置为确定阵列相对于衬底的平面偏移，并且基于平面偏移开始阵列相对于衬底的调平。还提供了方法。

9. 发明申请

WO2011139337A2 BALL-SPACER METHOD FOR PLANAR OBJECT LEVELING 审中-公开
标题翻译：用于平面对象平衡的球间距方法
公开(公告)号：WO2011139337A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/000727
申请日：2011-04-26
申请人： NANOINK, INC. , BUSSAN, John, Edward , HAAHEIM, Jason, R. , MOSKAL, John , SOLHEIM, Edward, R. , VAL-KHVALABOV, Vadim , NELSON, Michael, R. , AMRO, Nabil, A. , VAKIL, Javad, M.
发明人： BUSSAN, John, Edward , HAAHEIM, Jason, R. , MOSKAL, John , SOLHEIM, Edward, R. , VAL-KHVALABOV, Vadim , NELSON, Michael, R. , AMRO, Nabil, A. , VAKIL, Javad, M.
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： An apparatus for leveling an array of microscopic pens with respect to a substrate surface is provided. The apparatus includes an array of microscopic pens; a substrate having a substrate surface; a controllable arm comprising a spherical ball on an end thereof; a force sensor configured to measure a force exerted on the array or the substrate surface at each of the plurality of positions; one or more actuators configured to drive the array and/or the substrate to vary a relative distance and a relative tilting between the array and the substrate surface; and a controller configured to determine a planar offset of the array with respect to the substrate and initiate a leveling of the array with respect to the substrate based on the planar offset. Methods are also provided.
摘要翻译：提供了一种用于使微阵列阵列相对于衬底表面调平的装置。该装置包括微阵列阵列; 具有基板表面的基板; 一个可控臂，其一端包括一个球形球; 力传感器，其构造成测量在所述多个位置中的每一个处施加在所述阵列或所述基板表面上的力; 一个或多个致动器被配置为驱动阵列和/或基板以改变阵列和基板表面之间的相对距离和相对倾斜; 以及控制器，被配置为确定阵列相对于衬底的平面偏移，并基于平面偏移启动相对于衬底的阵列的调平。还提供了方法。

10. 发明申请

WO2011139337A3 BALL-SPACER METHOD FOR PLANAR OBJECT LEVELING 审中-公开
标题翻译：用于平面对象平衡的球间距方法
公开(公告)号：WO2011139337A3
公开(公告)日：2012-03-08
申请号：PCT/US2011000727
申请日：2011-04-26
申请人： NANOINK INC , BUSSAN JOHN EDWARD , HAAHEIM JASON R , MOSKAL JOHN , SOLHEIM EDWARD R , VAL-KHVALABOV VADIM , NELSON MICHAEL R , AMRO NABIL A , VAKIL JAVAD M
发明人： BUSSAN JOHN EDWARD , HAAHEIM JASON R , MOSKAL JOHN , SOLHEIM EDWARD R , VAL-KHVALABOV VADIM , NELSON MICHAEL R , AMRO NABIL A , VAKIL JAVAD M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： An apparatus for leveling an array of microscopic pens with respect to a substrate surface is provided. The apparatus includes an array of microscopic pens; a substrate having a substrate surface; a controllable arm comprising a spherical ball on an end thereof; a force sensor configured to measure a force exerted on the array or the substrate surface at each of the plurality of positions; one or more actuators configured to drive the array and/or the substrate to vary a relative distance and a relative tilting between the array and the substrate surface; and a controller configured to determine a planar offset of the array with respect to the substrate and initiate a leveling of the array with respect to the substrate based on the planar offset. Methods are also provided.
摘要翻译：提供了一种用于使微阵列阵列相对于衬底表面调平的装置。该装置包括微阵列阵列; 具有基板表面的基板; 一个可控臂，其一端包括一个球形球; 力传感器，其构造成测量在所述多个位置中的每一个处施加在所述阵列或所述基板表面上的力; 一个或多个致动器被配置为驱动阵列和/或基板以改变阵列和基板表面之间的相对距离和相对倾斜; 以及控制器，被配置为确定阵列相对于衬底的平面偏移，并基于平面偏移启动相对于衬底的阵列的调平。还提供了方法。

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