专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

FR2037134A7 未知
公开(公告)号：FR2037134A7
公开(公告)日：1970-12-31
申请号：FR7003344
申请日：1970-01-30
申请人： NEITZEL MARTIN
IPC分类号： B22D41/26 , B22D41/00

2. 发明专利

FR2037134B3 未知
公开(公告)号：FR2037134B3
公开(公告)日：1973-06-08
申请号：FR7003344
申请日：1970-01-30
申请人： NEITZEL MARTIN
IPC分类号： B22D41/26 , B22D41/00

3. 发明专利

GB1276625A IMPROVEMENTS IN OR RELATING TO ROTARY POURING VALVES FOR VESSELS CONTAINING MOLTEN METAL 未知
公开(公告)号：GB1276625A
公开(公告)日：1972-06-07
申请号：GB670170
申请日：1970-02-11
申请人： NEITZEL MARTIN
发明人： NEITZEL MARTIN
IPC分类号： B22D41/26
摘要： 1276625 Valves M NEITZEL 11 Feb 1970 [28 Feb 1969] 6701/70 Heading F2V A valve for a vessel holding molten metal comprises a stationary disc-shaped member 6 having at least one flow opening therein, one face of the disc being in rotary sliding engagement with an adjacent face of a rotatable valve member 9 through which extends at least one passage capable of being moved into and out of register with the or each opening in the disc, the disc 6 being thin in relation to the rotary valve member 9 and having a higher thermal conductivity. The sliding surfaces are lubricated by tar exuding from pores in the members 6 and 9 and they are held together by a thrust ring 14 bearing on an actuator ring 10. The actuator ring 10 is formed as a gear-ring and is driven by two parallel racks 11. The disc member 6 makes direct contact with the high temperature region of the melt so that, together with the thickness of section of the disc 6 relative to the member 9, the temperature of the sliding face V is 80% of that of the metal when pouring. In order to prevent the melt entering the initially cold vessel from solidifying in the region of the fixed disc 6, a powder mass which reacts exothermically to a minimum temperature is filled into the passages of the disc 6. The passages of the valve are lined with metal-ceramic or liquid cast materials having a high grade surface quality to prevent wetting.

4. 发明申请

WO2009023179A2 CERTAIN NITROGEN CONTAINING BICYCLIC CHEMICAL ENTITIES FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：含有用于治疗病毒感染的双相化学实验室的含氮
公开(公告)号：WO2009023179A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/009606
申请日：2008-08-08
申请人： GENELABS TECHNOLOGIES, INC. , SCHMITZ, Franz Ulrich , TAI, Vincent W-F , RAI, Roopa , ROBERTS, Christopher Don , ABADI, Ali Dehghani Mohammad , BASKARAN, Subramanian , SLOBODOV, Irina , MAUNG, Jack , NEITZEL, Martin Leon
发明人： SCHMITZ, Franz Ulrich , TAI, Vincent W-F , RAI, Roopa , ROBERTS, Christopher Don , ABADI, Ali Dehghani Mohammad , BASKARAN, Subramanian , SLOBODOV, Irina , MAUNG, Jack , NEITZEL, Martin Leon
IPC分类号： A61K31/437 , A61P31/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
摘要翻译：提供某些化学实体，药物组合物和治疗黄病毒属病毒家族（例如肝炎病毒（丙型肝炎或HCV））的方法。

5. 发明申请

WO2007143523A3 FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE 审中-公开
标题翻译：融合三酰甘氨酸抑制剂GAMMA分泌酶的研究
公开(公告)号：WO2007143523A3
公开(公告)日：2008-06-12
申请号：PCT/US2007070176
申请日：2007-06-01
申请人： ELAN PHARM INC , KONRADI ANDREI W , PROBST GARY , AUBELE DANNIELLE L , GAROFALO ALBERT W , HOM ROY , NEITZEL MARTIN L , SEMKO CHRISTOPHER M , TRUONG ANH P
发明人： KONRADI ANDREI W , PROBST GARY , AUBELE DANNIELLE L , GAROFALO ALBERT W , HOM ROY , NEITZEL MARTIN L , SEMKO CHRISTOPHER M , TRUONG ANH P
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61K31/519 , A61P25/00 , C07D471/14 , C07D513/14
CPC分类号： C07D471/04 , C07D471/14 , C07D487/14 , C07D495/14 , C07D513/14
摘要： The invention provides compounds of formula (I): or pharmaceutically salts thereof, where R 1 , R 2 and the A, B, and C-rings are as defined herein. Compounds of formula (I) are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula (I), methods of preparing the desired compunds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of Formula (I).
摘要翻译：本发明提供了式（I）的化合物：或其药学上可接受的盐，其中R 1，R 2和A，B和C环如本文所定义。式（I）化合物可用于治疗或预防认知障碍，例如阿尔茨海默氏病。本发明还包括包含式（I）化合物或其盐的药物组合物，制备所需化合物的方法以及使用式（I）化合物或盐治疗认知障碍如阿尔茨海默病的方法。

6. 发明申请

WO2006078753A1 N-SUBSTITUTED HETEROCYCLIC SULFONAMIDES 审中-公开
标题翻译： N-取代的杂环磺酰胺
公开(公告)号：WO2006078753A1
公开(公告)日：2006-07-27
申请号：PCT/US2006001792
申请日：2006-01-18
申请人： ELAN PHARM INC , NEITZEL MARTIN
发明人： NEITZEL MARTIN
IPC分类号： C07D403/12 , A61K31/55 , A61P25/28 , C07D223/12 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D413/12 , C07D223/12 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R 1 , R 2 , Z and n are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
摘要翻译：本发明提供了用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代的杂环磺酰胺。特别感兴趣的化合物由式（I）定义，其中R 1，R 2，Z和n如说明书中所述。本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍的方法。

7. 发明申请

WO2004098589A1 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 4-溴 - 5-（2-氯代苯甲酰氨基） - 1H-吡唑-3-羧酸酰胺衍生物及相关化合物作为治疗炎症性疾病的BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004098589A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/013219
申请日：2004-04-30
申请人： ELAN PHARMACEUTICALS, INC. , TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , NEITZ, R., Jeffrey , MARUGG, Jennifer , NEITZEL, Martin
发明人： TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , NEITZ, R., Jeffrey , MARUGG, Jennifer , NEITZEL, Martin
IPC分类号： A61K31/415
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了作为缓激肽B1受体拮抗剂的式I和II化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

8. 发明申请

WO2009023179A3 NITROGEN CONTAINING BICYCLIC CHEMICAL ENTITIES FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：含有治疗病毒感染的双相化学实验的硝酸
公开(公告)号：WO2009023179A3
公开(公告)日：2009-08-06
申请号：PCT/US2008009606
申请日：2008-08-08
申请人： GENELABS TECH INC , SCHMITZ FRANZ ULRICH , TAI VINCENT W-F , RAI ROOPA , ROBERTS CHRISTOPHER DON , ABADI ALI DEHGHANI MOHAMMAD , BASKARAN SUBRAMANIAN , SLOBODOV IRINA , MAUNG JACK , NEITZEL MARTIN LEON
发明人： SCHMITZ FRANZ ULRICH , TAI VINCENT W-F , RAI ROOPA , ROBERTS CHRISTOPHER DON , ABADI ALI DEHGHANI MOHAMMAD , BASKARAN SUBRAMANIAN , SLOBODOV IRINA , MAUNG JACK , NEITZEL MARTIN LEON
IPC分类号： A61K31/437 , A61P31/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Provided are certain chemical entities selected from compounds of Formula (1) pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
摘要翻译：提供了选自式（1）化合物药物组合物的某些化学实体，以及治疗黄病毒属病毒家族成员如肝炎病毒（丙型肝炎或HCV）的方法。

9. 发明申请

WO2004098589A8 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 4-溴 - 5-（2-氯代苯甲酰氨基） - 1H-吡唑-3-羧酸酰胺衍生物及相关化合物作为治疗炎症性疾病的BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004098589A8
公开(公告)日：2005-12-08
申请号：PCT/US2004013219
申请日：2004-04-30
申请人： ELAN PHARM INC , TUNG JAY S , GAROFALO ALBERT W , PLEISS MICHAEL A , WU JING , WONE DAVID W G , GUINN ASHLEY C , DRESSEN DARREN B , NEITZ R JEFFREY , MARUGG JENNIFER , NEITZEL MARTIN
发明人： TUNG JAY S , GAROFALO ALBERT W , PLEISS MICHAEL A , WU JING , WONE DAVID W G , GUINN ASHLEY C , DRESSEN DARREN B , NEITZ R JEFFREY , MARUGG JENNIFER , NEITZEL MARTIN
IPC分类号： A61P29/00 , C07D231/16 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08 , A61K31/415 , A61K31/4155
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了作为缓激肽B1受体拮抗剂的式I和II化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

10. 发明申请

WO2010091411A1 PIPERIDINYL CYCLIC AMIDO ANTIVIRAL AGENTS 审中-公开
标题翻译：哌啶类循环型AMIDO抗病毒剂
公开(公告)号：WO2010091411A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023642
申请日：2010-02-09
申请人： GLAXOSMITHKLINE LLC , BANKA, Anna , BASKARAN, Subramanian , CATALANO, John , CHONG, Pek , DICKSON, Hamilton , FANG, Jing , MAUNG, Jack , NEITZEL, Martin, Leon , PEAT, Andy , PRICE, Daniel , RAI, Roopa , ROBERTS, Christopher, Don , SHOTWELL, Brad , TAI, Vincent , ZHANG, Huichang
发明人： BANKA, Anna , BASKARAN, Subramanian , CATALANO, John , CHONG, Pek , DICKSON, Hamilton , FANG, Jing , MAUNG, Jack , NEITZEL, Martin, Leon , PEAT, Andy , PRICE, Daniel , RAI, Roopa , ROBERTS, Christopher, Don , SHOTWELL, Brad , TAI, Vincent , ZHANG, Huichang
IPC分类号： C07D405/00
CPC分类号： C07D471/04
摘要： Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
摘要翻译：提供式（I）的化合物及其药学上可接受的盐，其药物组合物，其制备方法及其用于治疗由病毒如丙型肝炎病毒（HCV）的黄病毒科家族介导的病毒感染的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式