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1. 发明申请

WO2012030988A1 INLINE SPECTROSCOPIC READER AND METHODS 审中-公开
标题翻译：在线光谱读取器和方法
公开(公告)号：WO2012030988A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050008
申请日：2011-08-31
申请人： CABOT SECURITY MATERIALS INC. , WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
发明人： WALTON, Ian D. , DOERING, William E. , NATAN, Michael J.
IPC分类号： G01J3/44
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译：具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光学阅读器。光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。通常，目标在光谱询问期间相对于光学头移动。因此，光谱阅读器是一个在线阅读器，非常适合随着目标沿着生产线或分析线移动，实时提供基于频谱的生产或分析决策。还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。

2. 发明申请

WO2010138914A1 SERS-ACTIVE PARTICLES OR SUBSTANCES AND USES THEREOF 审中-公开
标题翻译： SERS活性颗粒或物质及其用途
公开(公告)号：WO2010138914A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036728
申请日：2010-05-28
申请人： OXONICA MATERIALS INC. , NATAN, Michael, J. , WALTON, Ian, D. , FREEMAN, Richard, Griffith , DOERING, William, E. , PIOTTI, Marcelo, Eduardo
发明人： NATAN, Michael, J. , WALTON, Ian, D. , FREEMAN, Richard, Griffith , DOERING, William, E. , PIOTTI, Marcelo, Eduardo
IPC分类号： G01N33/00
CPC分类号： G01N21/658 , G01N21/554 , G01N21/648
摘要： A particle comprising a surface enhanced spectroscopy (SES)-enhancing antenna, a SES-active reporter molecule and an encapsulant surrounding the SES-active reporter and antenna combination. The particle also includes a security feature in addition to the SES activity provided by the reporter and antenna. Also disclosed are methods of fabricating, using and monitoring the quality of SES-active particles.
摘要翻译：包括表面增强光谱（SES）增强天线，SES活性报道分子和围绕SES活性报道分子和天线组合的密封剂的颗粒。该颗粒还包括除报告人和天线提供的SES活动之外的安全特征。还公开了制造，使用和监测SES活性粒子的质量的方法。

3. 发明申请

WO2009009198A3 SERS NANOTAG ASSAYS 审中-公开
标题翻译： SERS纳米测试
公开(公告)号：WO2009009198A3
公开(公告)日：2009-02-19
申请号：PCT/US2008060871
申请日：2008-04-18
申请人： BECTON DICKINSON CO , NATAN MICHAEL J
发明人： NATAN MICHAEL J
IPC分类号： G01J3/00
CPC分类号： C40B70/00 , B01J2219/00572 , B01J2219/00576 , B01J2219/00722 , B01J2219/00725 , B82Y20/00 , B82Y30/00 , G01N21/658 , G01N2201/06193 , Y10S977/773
摘要： A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.
摘要翻译：产生表面增强拉曼散射光谱的方法，其可用于某些类型的测定，特别是邻近测定。该方法包括提供两种SERS活性纳米颗粒。第一SERS活性纳米颗粒将吸收第一波长的光子并发射第二波长的拉曼偏移光子。第二SERS活性纳米颗粒将吸收第二波长的光子并发射第三波长的拉曼偏移光子。因此，当第一和第二SERS活性纳米粒子彼此接近并且第一SERS活性纳米粒子在第一波长处被照射时，可以发射第二波长的拉曼位移光子。该光子可被第二SERS活性纳米颗粒吸收，引起第三波长处的第二拉曼位移光子的可检测发射。基于上述可以设计各种分析。使用两种SERS活性纳米粒子的接近测定法将具有有利的背景信号特征。

4. 发明申请

WO2008063711A2 CATALYTIC NANOTEMPLATES 审中-公开
标题翻译：催化纳米微粒
公开(公告)号：WO2008063711A2
公开(公告)日：2008-05-29
申请号：PCT/US2007071631
申请日：2007-06-20
申请人： OXONICA INC , NATAN MICHAEL J
发明人： NATAN MICHAEL J
IPC分类号： B28B1/14 , B32B9/00
CPC分类号： B82Y30/00 , Y10S977/89 , Y10T428/2991
摘要： A catalytic nanotemplate including a freestanding template particle and a director associated with the surface of the freestanding template particle. The free standing template particle may have multiple segments and the director may be associated with one or more of the segments. In instances where multiple segments are present, the segments may be made of different materials or be of the same material in different forms. More than one type of director or no director may be associated with any particular segment.
摘要翻译：催化纳米模板，包括独立模板颗粒和与独立模板颗粒的表面相关联的导向体。自由站立模板粒子可以具有多个片段，并且该引导器可以与一个或多个片段相关联。在存在多个片段的情况下，片段可以由不同的材料制成，或由不同形式的相同材料制成。不止一种类型的董事或任何董事可能与任何特定细分相关联。

5. 发明申请

WO2007092941A2 SERS NANOTAG ASSAYS 审中-公开
标题翻译： SERS NANOTAG测试
公开(公告)号：WO2007092941A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061878
申请日：2007-02-08
申请人： OXONICA, INC. , NATAN, Michael , PENN, Sharron Gaynor , CROMER, Remy , SHA, Michael , XU, Hongxia , DOERING, William E.
发明人： NATAN, Michael , PENN, Sharron Gaynor , CROMER, Remy , SHA, Michael , XU, Hongxia , DOERING, William E.
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6816 , G01N33/54373 , Y10T436/143333 , C12Q2537/125 , C12Q2563/131 , C12Q2563/143 , C12Q2565/632
摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
摘要翻译：使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。还公开了多重测定平台。在某些实施方案中，该测定可用于临床蛋白质组学。还公开了适用于生物基质，例如全血或血清中的测定平台。本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。

6. 发明申请

WO2007090058A3 LATERAL FLOW IMMUNOASSAY WITH ENCAPSULATED DETECTION MODALITY 审中-公开
公开(公告)号：WO2007090058A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/061136
申请日：2007-01-26
申请人： OXONICA, INC. , NATAN, Michael , CROMER, Remy , DOERING, William , CORISH, Peter
发明人： NATAN, Michael , CROMER, Remy , DOERING, William , CORISH, Peter
IPC分类号： G01N33/53
摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.

7. 发明申请

WO2001026038A1 METHODS OF IMAGING COLLOIDAL ROD PARTICLES AS NANOBAR CODES 审中-公开
标题翻译：将胶体颗粒作为纳豆代谢物的成像方法
公开(公告)号：WO2001026038A1
公开(公告)日：2001-04-12
申请号：PCT/US2000/027121
申请日：2000-10-02
申请人： THE PENN STATE RESEARCH FOUNDATION , SURROMED, INC. , NATAN, Michael, J. , WALTON, Ian , DIETZ, Louis, J. , NORTON, Scott , KEATING, Christine, D.
发明人： NATAN, Michael, J. , WALTON, Ian , DIETZ, Louis, J. , NORTON, Scott , KEATING, Christine, D.
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N33/54346 , H01F1/0081 , B22F2207/01
摘要： Methods for imaging colloidal rod particles as nanobar codes is described in which imaging or reading free-standing particles comprising a plurality of segments of length from 10 nm to 50 μm and width from 5 nm to 50 μm is performed. The segments of particles may be comprised of any material including metal, allow, a metal allow, a metal nitride, a metal chalcogenide, a metal oxide, a metal sulfide, a metal selenide, a metal telluride, polymeric materials, crystalline or non-crystalline materials.
摘要翻译：描述了将胶体棒粒子作为纳米棒代码成像的方法，其中进行包括长度为10nm至50μm，宽度为5nm至50μm的多个片段的成像或读取独立粒子。颗粒的段可以由包括金属，允许金属允许金属氮化物，金属硫族化物，金属氧化物，金属硫化物，金属硒化物，金属碲化物，聚合物材料，结晶或非金属，结晶材料。

8. 发明申请

WO2001025002A1 COLLOIDAL ROD PARTICLES AS NANOBAR CODES 审中-公开
标题翻译：作为纳豆糖代谢的胶体颗粒
公开(公告)号：WO2001025002A1
公开(公告)日：2001-04-12
申请号：PCT/US2000/027093
申请日：2000-10-02
申请人： SurroMed,Inc. , NATAN, Michael, J. , MALLOUK, Thomas, E.
发明人： NATAN, Michael, J. , MALLOUK, Thomas, E.
IPC分类号： B32B5/16
CPC分类号： G06K9/3233 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N33/54346 , H01F1/0081 , B22F2207/01
摘要： Freestanding particles comprising a plurality of segments, wherein the particle length is from 10 nm to 50 μm and the particle width is from 5 nm to 50 μm.
摘要翻译：包含多个片段的独立粒子，其中粒子长度为10nm至50μm，粒子宽度为5nm至50μm。

9. 发明申请

WO2011119589A1 WAVELENGTH SELECTIVE SERS NANOTAGS 审中-公开
标题翻译：波长选择性纳豆糖
公开(公告)号：WO2011119589A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029395
申请日：2011-03-22
申请人： CABOT SECURITY MATERIALS INC. , NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
发明人： NATAN, Michael J. , FREEMAN, Richard Griffith , DOERING, William E. , PIOTTI, Marcelo Eduardo
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y20/00 , B82Y30/00 , G01N2201/06113 , H01S3/30 , Y10S977/81 , Y10S977/834
摘要： Wavelength selective particles such as SERS nanotags modified for wavelength selectivity. As used herein, a wavelength selective particle is one which cannot be effectively excited or interrogated at one or more wavelengths where a reporter molecule associated with the particle would normally produce a spectrum. Also disclosed are methods of manufacturing wavelength selective particles and methods of tagging materials or objects with wavelength selective particles.
摘要翻译：波长选择性颗粒，如SERS纳米复合材料修饰波长选择性。如本文所用，波长选择性颗粒是在与颗粒相关的报告分子通常产生光谱的一个或多个波长处不能有效激发或询问的粒子。还公开了制造波长选择性颗粒的方法和用波长选择性颗粒标记材料或物体的方法。

10. 发明申请

WO2008063711A3 CATALYTIC NANOTEMPLATES 审中-公开
公开(公告)号：WO2008063711A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/071631
申请日：2007-06-20
申请人： OXONICA, INC. , NATAN, Michael J.
发明人： NATAN, Michael J.
IPC分类号： B32B1/00 , B32B3/00
摘要： A catalytic nanotemplate including a freestanding template particle and a director associated with the surface of the freestanding template particle. The free standing template particle may have multiple segments and the director may be associated with one or more of the segments. In instances where multiple segments are present, the segments may be made of different materials or be of the same material in different forms. More than one type of director or no director may be associated with any particular segment.

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