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1. 发明申请

WO2012121682A3 ANTI-FOLATE ANTIMALARIALS WITH DUAL-BINDING MODES AND THEIR PREPARATION 审中-公开
标题翻译：抗双胞胎抗体与双重结合模式及其制备
公开(公告)号：WO2012121682A3
公开(公告)日：2012-12-27
申请号：PCT/TH2012000006
申请日：2012-02-09
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY , TARNCHOMPOO BONGKOCH , CHITNUMSUB PENCHIT , KAMCHONWONGPAISAN SUMALEE , SHAW PHILIP JAMES , RATTANAJAK ROONGLAWAN , POEN SINOTHAI , ANUKUNWITHAYA TOSAPOL , WONGSOMBAT CHAYAPHAT , YUTHAVONG YONGYUTH
发明人： TARNCHOMPOO BONGKOCH , CHITNUMSUB PENCHIT , KAMCHONWONGPAISAN SUMALEE , SHAW PHILIP JAMES , RATTANAJAK ROONGLAWAN , POEN SINOTHAI , ANUKUNWITHAYA TOSAPOL , WONGSOMBAT CHAYAPHAT , YUTHAVONG YONGYUTH
IPC分类号： A61K31/496
CPC分类号： C07D239/48 , C07D403/02
摘要： The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are independently selected from methyl or ethyl or alkylphenyl, R3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is X(CH2)nY wherein X and Y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an intege from 1 to 2-6, or pharmaceutically acceptable salts therefore. The anti-folate antimalarials with dual-binding modes act as novel inhibitors with good inhibition constants against wild-type, double (C59R+SIOSN), triple (N51+C59R+SIOSN, C59R+S 1 OSN+I164L), and quadruple (N51+C59R+S108N+I164L) mutant enzymes. The compounds are also effective against wild type (Tm4/S.2) and mutants (K1CB1, W2, Csl-2 and V1/S) malaria parasites.
摘要翻译：本发明是具有通式（I）的双重结合模式的抗叶酸抗疟药物[参考以下结构]，其中可以相同或不同的R 1和R 2独立地选自甲基或乙基或烷基苯基，R 3 独立地是氢，卤化物，被酯，羧酸，酰胺和醚取代的低级烷基。接头是X（CH 2）n Y，其中可以相同或不同的X和Y独立地选自氧，碳，氮，取代的苯基，其中n是1至2-6的整数，或其药学上可接受的盐。具有双重结合模式的抗叶酸抗疟药作为具有对野生型，双重（C59R + SIOSN），三重（N51 + C59R + SIOSN，C59R + S 1 OSN + I164L）和四重（ N51 + C59R + S108N + I164L）突变酶。该化合物对野生型（Tm4 / S.2）和突变体（K1CB1，W2，CsI-2和V1 / S）疟疾寄生虫也有效。

2. 发明申请

WO2015047199A3 A BACTERIAL SURROGATE FOR TESTING OF ANTIMALARIALS: KNOCKOUT BACTERIA FOR TESTING OF INHIBITION OF ANTIFOLATE PATHWAY 审中-公开
标题翻译：用于测试抗生素途径的细菌筛选：用于测试抗病毒途径的阻塞细菌
公开(公告)号：WO2015047199A3
公开(公告)日：2016-05-26
申请号：PCT/TH2014000045
申请日：2014-09-18
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY
发明人： SUWANAKITTI NATTIDA , TALAWANICH YUWADEE , YUTHAVONG YONGYUTH , KAMCHONWONGPAISAN SUMALEE
IPC分类号： C12N1/21
CPC分类号： C12N15/70 , C12N9/003 , C12N9/1007 , C12N9/1085 , C12N9/1235 , C12N9/93 , C12Q1/48 , G01N2333/91017 , G01N2333/91165 , G01N2333/91171
摘要： In this invention, cell lines are created for enzyme inhibitory testing of inhibitors against Plasmodium falciparum DHFR-TS and HPPK-DHPS. Provided the complementing DHFR-TS and HPPK-DHPS have sufficient activities to support growth of the surrogates in un-supplemented medium, the same surrogates could be used for screening inhibitors of targets against other parasite and pathogen species e.g. Plasmodium vivax, Trypanosoma brucei, Trypanosoma cruzi, Toxoplasma gondii or Mycobacterium tuberculosis. The cell lines in this invention are Escherichia coli strain whose thyA, folA, folK, and folP genes were disrupted using genetic knockout coupled with elimination of antibiotic resistance markers. The thyA KO, folP KO, folK KO, thyAfolA KO, folKfolP KO, thyAfolAfolP KO, thyAfolAfolK KO and thyAfolAfolKfolP KO E. coli cell lines are easy and convenient for testing single and combination drugs as plasmids bearing complementing parasite genes can be introduced simply by transformation using standard antibiotic selection.
摘要翻译：在本发明中，产生了针对恶性疟原虫DHFR-TS和HPPK-DHPS的抑制剂的酶抑制测试的细胞系。如果补充DHFR-TS和HPPK-DHPS具有足够的活性来支持未补充培养基中替代物的生长，则相同的替代物可用于筛选针对其他寄生虫和病原体物种的靶标的抑制剂，例如间日疟原虫，布鲁斯锥虫，克氏锥虫，弓形虫或结核分枝杆菌。本发明中的细胞系是大肠杆菌菌株，其thyA，folA，folk和folP基因使用遗传敲除与消除抗生素抗性标记相结合而被破坏。 thy A O，K K，，，，，by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by by 使用标准抗生素选择进行转化。

3. 发明申请

WO2011133119A3 SYSTEM WITH ZERO POWER STANDBY MODE FOR CONTROLLING ELECTRIC APPARATUS 审中-公开
标题翻译：用于控制电气设备的具有零功率待机模式的系统
公开(公告)号：WO2011133119A3
公开(公告)日：2011-12-15
申请号：PCT/TH2011000009
申请日：2011-04-21
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY , KOANANTAKOOL THAWEESAK
发明人： KOANANTAKOOL THAWEESAK , SIWAMOGSATHAM SIWARUK , RATTANAWAN PATHARAKORN , KITJAROEN MATANEE , PONGPAIBOOL PORNANONG
IPC分类号： H02J9/00
CPC分类号： H02J9/005 , Y10T307/977
摘要： A zero power standby system for controlling electric appliances is able to wait for switch on instructions without any power consumption. This is done by a remote controller (1) transmitting power in form of either electromagnetic field, light, or audio signal to a power receiving section (2) of a control signal receiving device (13). The power receiving section will then use the received power to force a multi-switch section (7) to connect between a power supply and a control signal receiving section (9) and a control signal processing section (3) and put the appliance into its usual running mode. When a user desires to turn off the electric appliance, the system stop supplying power to the control signal receiving section (9) and the control signal processing section (3) by turning off multi-switch section (7) and put the electric appliance back to its zero power standby mode (i.e. consuming no power). Therefore, wasting of electrical energy in standby mode is thus reduced to zero.
摘要翻译：用于控制电器的零功率待机系统能够等待接通指令而没有任何功耗。这通过遥控器（1）以电磁场，光或音频信号的形式向控制信号接收装置（13）的电力接收部分（2）发送电力来完成。然后电力接收部分将使用所接收的电力来迫使多开关部分（7）连接在电源和控制信号接收部分（9）和控制信号处理部分（3）之间并将电器置于其中通常的运行模式。当用户想要关闭电器时，系统通过关闭多开关部分（7）并将电器放回来而停止向控制信号接收部分（9）和控制信号处理部分（3）供电到其零功耗待机模式（即不消耗功率）。因此，待机模式下的电能浪费因此减少到零。

4. 发明专利

PH22013000303Y1 WATER-BAG 未知
公开(公告)号：PH22013000303Y1
公开(公告)日：2015-03-13
申请号：PH22013000303
申请日：2013-07-03
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY
发明人： SOMSAK SURIYAKOON , WIYONG KANGWANSUPAMONKON , WORAPROT WONGSIYA , KANITTHA BOONPAVANITCHAKUL
IPC分类号： E02B3/00 , E02B3/10 , E02B3/12
摘要： The water-bag in this utility model is a cotton bag with double-stitched seams on all sides to form a rectangular shape which has been designed for easy stacking on top of one another. Pockets are sewn to the inside of the bag. The water-bag has three main structural components wherein the middle section is for the placement of water-absorbing polymer material. Pockets are sewn to the left and right sides of the bottom section inside the bag for the placement of counterweights.

5. 发明专利

GB201218311D0 System with zero power standby mode for controlling electric apparatus 未知
公开(公告)号：GB201218311D0
公开(公告)日：2012-11-28
申请号：GB201218311
申请日：2011-04-21
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY

6. 发明专利

AT555652T 未知
公开(公告)号：AT555652T
公开(公告)日：2012-05-15
申请号：AT06075179
申请日：2006-01-25
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY , KASETSART UNIVERSITY
发明人： VANAVICHIT APICHART , WACHANA SAMART , TRAGOONRUNG SOMVONG , TOOJINDA THEERAYUT , KAMOLSUKYUNYONG WINTAI
IPC分类号： A01H5/00

7. 发明专利

DK1981668T3 Fremgangsmåde til fremstilling af en metalkonstruktion, der er egnet til bearbejdning af halvfast metal 未知
公开(公告)号：DK1981668T3
公开(公告)日：2013-04-15
申请号：DK07763446
申请日：2007-01-31
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY
发明人： WANNASIN JESSADA , MARTINEZ RAUL A , FLEMMINGS MERTON C
IPC分类号： B22D23/00

8. 发明专利

GB2492024A System with zero power standby mode for controlling electric apparatus 未知
公开(公告)号：GB2492024A
公开(公告)日：2012-12-19
申请号：GB201218311
申请日：2011-04-21
申请人： NAT SCIENCE AND TECHNOLOGY DEV AGENCY
发明人： SIWAMOGSATHAM SIWARUK , RATTANAWAN PATHARAKORN , KITJAROEN MATANEE , PONGPAIBOOL PORNANONG , KOANANTAKOOL THAWEESAK
IPC分类号： H02J9/00
摘要： A zero power standby system for controlling electric appliances is able to wait for switch on instructions without any power consumption. This is done by a remote controller (1) transmitting power in form of either electromagnetic field, light, or audio signal to a power receiving section (2) of a control signal receiving device (13). The power receiving section will then use the received power to force a multi-switch section (7) to connect between a power supply and a control signal receiving section (9) and a control signal processing section (3) and put the appliance into its usual running mode. When a user desires to turn off the electric appliance, the system stop supplying power to the control signal receiving section (9) and the control signal processing section (3) by turning off multi-switch section (7) and put the electric appliance back to its zero power standby mode (i.e. consuming no power). Therefore, wasting of electrical energy in standby mode is thus reduced to zero.

10. 发明专利

AU2012200075A1 Nucleic acids that enhance the synthesis of 2-acetyl-1-pyrroline in plants and fungi 未知
公开(公告)号：AU2012200075A1
公开(公告)日：2012-02-02
申请号：AU2012200075
申请日：2012-01-06
申请人： KASETSART UNIVERSITY , NAT SCIENCE AND TECHNOLOGY DEV AGENCY
发明人： VANAVICHIT APICHART , TRAGOONRUNG SOMVONG , TOOJINDA THEERAYUT , WANCHANA SAMART , KAMOLSUKYUNYONG WINTAI
IPC分类号： A01H5/00 , A01H1/00 , A01H3/00 , C12N15/52 , C12Q1/68
摘要： The aromatic compound 2-acetyl-1-pyrroline (2AP) is the major potent flavor component of all aromatic rice. This present invention provides non-naturally occurring plants in which 2-acetyl 1 -pyrroline is synthesized at a level greater than in naturally occurring non-aromatic varieties. Also provided are nucleic acids that can be used as molecular markers for selecting plants and fungi which synthesize a greater level of 2-acetyl-1-pyrroline.

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