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    • 2. 发明授权
    • Method for production of pyrrolidinone derivatives
    • 吡咯烷酮衍生物的制备方法
    • US06207825B1
    • 2001-03-27
    • US09190297
    • 1998-11-13
    • Hajime IizukaHiroshi NagaseNaruyoshi Mita
    • Hajime IizukaHiroshi NagaseNaruyoshi Mita
    • C07D40106
    • C07D207/277
    • A compound represented by the following formula (12) useful as an intermediate for production of drug or agricultural chemical: (wherein R21 to R25 are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms, a perfluoroalkyl group of 1 to 4 carbon atoms, a cyano group, a nitro group, an amino group, a carboxyl group, a thiol group, an alkylthio group of 1 to 4 carbon atoms or a carbamoyl group) can be produced by reacting a compound represented by the formula (13): (wherein R21 to R25 have the same definitions as given above) with 1,1-cyclopropanedicarboxylic acid. The compound of the formula (12) is useful as a raw material for production of a pyrrolidinone compound useful as an active ingredient of drug.
    • 由下式(12)表示的化合物可用作药物或农药的生产中间体:(其中R21至R25各自独立地为氢原子,羟基,卤素原子,1-4个碳原子的烷基 1〜4个碳原子的烷氧基,1〜4个碳原子的全氟烷基,氰基,硝基,氨基,羧基,硫醇基,1〜4个碳的烷硫基 原子或氨基甲酰基)可以通过使式(13)表示的化合物(其中R21至R25具有与上述相同的定义)与1,1-环丙烷二羧酸反应来制备。 式(12)的化合物可用作生产用作药物活性成分的吡咯烷酮化合物的原料。
    • 4. 发明授权
    • Method for production of pyrrolidinone derivatives
    • 吡咯烷酮衍生物的制备方法
    • US06555694B1
    • 2003-04-29
    • US09694340
    • 2000-10-24
    • Hajime IizukaHiroshi NagaseNaruyoshi Mita
    • Hajime IizukaHiroshi NagaseNaruyoshi Mita
    • C07D20726
    • C07D207/277
    • A compound represented by the following formula (12) useful as an intermediate for production of drug or agricultural chemical: (wherein R21 to R25 are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms, a perfluoroalkyl group of 1 to 4 carbon atoms, a cyano group, a nitro group, an amino group, a carboxyl group, a thiol group, an alkylthio group of 1 to 4 carbon atoms or a carbamoyl group) can be produced by reacting a compound represented by the formula (13): (wherein R21 to R25 have the same definitions as given above) with 1,1-cyclopropanedicarboxylic acid. The compound of the formula (12) is useful as a raw material for production of a pyrrolidinone compound useful as an active ingredient of drug.
    • 由下式(12)表示的化合物可用作药物或农药的生产中间体:(其中R21至R25各自独立地为氢原子,羟基,卤素原子,1-4个碳原子的烷基 1〜4个碳原子的烷氧基,1〜4个碳原子的全氟烷基,氰基,硝基,氨基,羧基,硫醇基,1〜4个碳的烷硫基 原子或氨基甲酰基)可以通过使式(13)表示的化合物(其中R21至R25具有与上述相同的定义)与1,1-环丙烷二羧酸反应来制备。 式(12)的化合物可用作生产用作药物活性成分的吡咯烷酮化合物的原料。