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1. 发明授权

US11497818B2 Ultrafine nanoparticles comprising a functionalized polyorganosiloxane matrix and including metal complexes; method for obtaining same and uses thereof in medical imaging and/or therapy 有权
公开(公告)号：US11497818B2
公开(公告)日：2022-11-15
申请号：US15987500
申请日：2018-05-23
申请人： NANOH , UNIVERSITE LYON 1 CLAUDE BERNARD , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
发明人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
IPC分类号： A61K49/18 , A61K9/14 , A61K41/00 , A61K49/00 , B82Y5/00 , B82Y15/00 , A61K9/00
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.
The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.
Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).
The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

2. 发明申请

US20180008729A1 ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY 审中-公开
公开(公告)号：US20180008729A1
公开(公告)日：2018-01-11
申请号：US15677167
申请日：2017-08-15
申请人： NANOH , UNIVERSITE LYON 1 CLAUDE BERNARD , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
发明人： François LUX , Olivier TILLEMENT , Maxime SAINT JEAN , Pierre MOWAT , Pascal PERRIAT , Stéphane ROUX , Anna MIGNOT
IPC分类号： A61K49/18 , A61K9/14 , A61K49/00 , A61K41/00 , B82Y15/00 , A61K9/00 , B82Y5/00
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

3. 发明申请

WO2022023676A1 DISPOSITIF MEDICAL IMAGEABLE ET RESORBABLE ET SES UTILISATIONS 审中-公开
公开(公告)号：WO2022023676A1
公开(公告)日：2022-02-03
申请号：PCT/FR2021/051418
申请日：2021-07-29
申请人： NANOH , UNIVERSITE CLAUDE BERNARD LYON 1 , HOSPICES CIVILS DE LYON , VETAGRO-SUP INSTITUT D'ENSEIGNEMENT SUPÉRIEUR ET DE RECHERCHE , UNIVERSITE JEAN MONNET SAINT ETIENNE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
发明人： DAVID, Laurent , MONTEMBAULT, Alexandra , SUDRE, Guillaume , NUNES DE OLIVEIRA, Paula , CAROZZO, Claude , LUX, François , TILLEMENT, Olivier , UDRESCU, Corina , CHAPET, Olivier , LOUIS, Cédric
IPC分类号： A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14
摘要： L’invention concerne un dispositif médical imageable et résorbable, comprenant au moins une partie tubulaire (1) formée d’un hydrogel physique de polysaccharides, apte à être inséré dans l’urètre d’un sujet, pour différentes applications médicales et/ou chirurgicales.

4. 发明申请

WO2009053644A2 UTILISATION DE NANOPARTICULES A BASE DE LANTHANIDES COMME AGENTS RADIOSENSIBILISANTS 审中-公开
标题翻译：使用作为放射增敏剂的基于兰氢化合物的纳米粒子
公开(公告)号：WO2009053644A2
公开(公告)日：2009-04-30
申请号：PCT/FR2008/051860
申请日：2008-10-14
申请人： UNIVERSITE CLAUDE BERNARD LYON I , HOSPICES CIVILS DE LYON , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , NANOH , EUROPEAN SYNCHROTRON RADIATION FACILITY (INSTALLATION EUROPEENNE DE RAYONNEMENT SYNCHROTRON) , TILLEMENT, Olivier , ROUX, Stéphane , PERRIAT, Pascal , LEDUC, Géraldine , MANDON, Céline , MUTELET, Brice , ALRIC, Christophe , BILLOTEY, Claire , JANIER, Marc , LOUIS, Cédric
发明人： TILLEMENT, Olivier , ROUX, Stéphane , PERRIAT, Pascal , LEDUC, Géraldine , MANDON, Céline , MUTELET, Brice , ALRIC, Christophe , BILLOTEY, Claire , JANIER, Marc , LOUIS, Cédric
IPC分类号： A61K51/12 , A61P35/00 , A61K9/51 , A61K103/34 , A61K103/36
CPC分类号： A61K41/0038 , A61K9/0019
摘要： L'invention concerne l'utilisation de nanoparticules de dimensions comprises entre 1 et 50 nm, dont une partie au moins est constituée d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide, lesdites nanoparticules étant : soit constituées d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide, soit sous forme de nanoparticules comprenant un cœur oxohydroxyde d'au moins un lanthanide, et un enrobage constitué d'un polysiloxane, avec éventuellement des molécules organiques greffées en surface ou comprises en son sein, en tant qu'agent radio-sensibilisant dans la fabrication d'une composition injectable destinée à améliorer l'efficacité du traitement d'une tumeur par irradiations X ou gamma. Elle concerne également des nanoparticules particulièrement adaptées pour l'utilisation ci-dessus, constituées d'un cœur constitué d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide et d'un enrobage en polysiloxane comprenant 1 à 5 silicium par lanthanide et dont au moins 10% des atomes de silicium sont liés à des molécules organiques hydrophiles de masses molaires inférieures à 450 g/mol.
摘要翻译：本发明涉及使用尺寸为1至50nm的纳米颗粒，其至少一部分由至少一种氧化物和/或至少镧系元素的一种羟基氧化物构成，所述纳米颗粒是： - 由至少一个至少一种镧系元素的氧化物和/或一种羟基氧化物，或以包含至少一种镧系元素的羟基氧化物核心的纳米颗粒的形式，以及由聚硅氧烷，任选地接枝到表面上或包含在其中的有机分子构成的涂层，作为用于通过X射线或γ照射改善肿瘤治疗有效性的可注射组合物的制造中的放射增敏剂。它还涉及特别适用于上述用途的纳米颗粒，由由至少一种镧系元素的至少一种氧化物和/或一种羟基氧化物构成的核心和每镧系元素包含1至5个硅的聚硅氧烷涂层组成，至少10％的硅原子与摩尔质量小于450g / mol的亲水性有机分子连接。

5. 发明授权

US10987435B2 Ultrafine nanoparticles comprising a functionalized polyorganosiloxane matrix and including metal complexes; method for obtaining same and uses thereof in medical imaging and/or therapy 有权
公开(公告)号：US10987435B2
公开(公告)日：2021-04-27
申请号：US15677167
申请日：2017-08-15
申请人： NANOH , UNIVERSITE LYON 1 CLAUDE BERNARD , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
发明人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
IPC分类号： A61K49/18 , A61K9/14 , A61K41/00 , A61K49/00 , B82Y5/00 , B82Y15/00 , A61K9/00
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.
The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

6. 发明申请

US20180264145A1 ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY 审中-公开
公开(公告)号：US20180264145A1
公开(公告)日：2018-09-20
申请号：US15987500
申请日：2018-05-23
申请人： NANOH , UNIVERSITE LYON 1 CLAUDE BERNARD , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
发明人： François LUX , Olivier TILLEMENT , Maxime SAINT JEAN , Pierre MOWAT , Pascal PERRIAT , Stéphane ROUX , Anna MIGNOT
IPC分类号： A61K49/18 , A61K9/14 , A61K41/00 , A61K49/00
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

7. 发明申请

WO2011135101A3 ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY 审中-公开
标题翻译：包含官能化聚硅氧烷基质并包括金属络合物的超纳米纳米粒子; 用于获得其的方法及其在医学成像和/或治疗中的用途
公开(公告)号：WO2011135101A3
公开(公告)日：2012-05-31
申请号：PCT/EP2011056972
申请日：2011-05-02
申请人： NANOH , UNIV LYON 1 CLAUDE BERNARD , INST NAT SCIENCES APPLIQ , LUX FRANCOIS , TILLEMENT OLIVIER , SAINT JEAN MAXIME , MOWAT PIERRE , PERRIAT PASCAL , ROUX STEPHANE , MIGNOT ANNA
发明人： LUX FRANCOIS , TILLEMENT OLIVIER , SAINT JEAN MAXIME , MOWAT PIERRE , PERRIAT PASCAL , ROUX STEPHANE , MIGNOT ANNA
IPC分类号： A61K49/18 , B82Y5/00 , B82Y15/00
CPC分类号： A61K49/1824 , A61K9/0019 , A61K9/14 , A61K41/0038 , A61K49/0002 , A61K49/0093 , A61K49/1857 , A61K49/1881 , B82Y5/00 , B82Y15/00 , Y10T428/2982
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size that are of use in particular for diagnosis and/or therapy. The objective of the invention is to provide novel nanoparticles which are of use in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which are more effective than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high metal (e.g. rare earth) loading rate, in particular so as to have, in imaging (e.g. MRI), a strong enhancement and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, of diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations, optionally associated with doping cations; a DTPABA (diethylenetriaminepentaacetic acid bisanhydride) chelating C1 graft bonded to the POS matrix via -Si-C- covalent bonding, and present in sufficient amount to be able to complex all the gadolinium cations; and optionally an other functionalization graft Gf* bonded to the POS matrix via -Si-C- covalent bonding (it being possible for Gf* to result from a hydrophilic compound (PEG); from a compound comprising an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein)). The method for obtaining these nanoparticles and the uses thereof in imaging and in therapy are also part of the invention.
摘要翻译：本发明涉及特别用于诊断和/或治疗的非常小尺寸的新型生物相容性杂合纳米颗粒。本发明的目的是提供新颖的纳米颗粒，其特别用作成像（例如MRI）和/或其它诊断技术和/或作为治疗剂的造影剂，其比其相同的已知纳米颗粒更有效类型，并且其结合了小尺寸（例如小于20nm）和高金属（例如稀土）加载速率，特别是在成像（例如MRI）中具有强增强和正确响应（增加弛豫力）。因此，根据本发明的直径为d1至1nm的纳米颗粒各自包含任选与掺杂阳离子相关的包含钆阳离子的聚有机硅氧烷（POS）基质; 通过-Si-C-共价键合键合到POS基质上的DTPABA（二亚乙基三胺五乙酸双酐）螯合C1，并且存在足以使所有钆阳离子复合的量; 和任选的通过-Si-C-共价结合到POS基质上的其它官能化移植物Gf *（Gf *可以由亲水性化合物（PEG）产生）;来自包含活性成分PA1的化合物;来自靶向化合物;由发光化合物（荧光素））。获得这些纳米颗粒的方法及其在成像和治疗中的用途也是本发明的一部分。

8. 发明申请

WO2009053644A8 USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS 审中-公开
标题翻译：基于镧系元素的纳米粒子作为放射增敏剂
公开(公告)号：WO2009053644A8
公开(公告)日：2009-12-17
申请号：PCT/FR2008051860
申请日：2008-10-14
申请人： UNIV CLAUDE BERNARD LYON , HOSPICES CIVILS LYON , CENTRE NAT RECH SCIENT , NANOH , EUROP SYNCHROTRON RADIATION FA , TILLEMENT OLIVIER , ROUX STEPHANE , PERRIAT PASCAL , LEDUC GERALDINE , MANDON CELINE , MUTELET BRICE , ALRIC CHRISTOPHE , BILLOTEY CLAIRE , JANIER MARC , LOUIS CEDRIC
发明人： TILLEMENT OLIVIER , ROUX STEPHANE , PERRIAT PASCAL , LEDUC GERALDINE , MANDON CELINE , MUTELET BRICE , ALRIC CHRISTOPHE , BILLOTEY CLAIRE , JANIER MARC , LOUIS CEDRIC
IPC分类号： A61K51/12 , A61P35/00
CPC分类号： A61K41/0038 , A61K9/0019
摘要： The invention relates to the use of nanoparticles having dimensions between 1 and 50 nm, at least one part of which is constituted of at least one oxide and/or one oxyhydroxide of at least lanthanide, said nanoparticles being: - either constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide, - or in the form of nanoparticles comprising an oxyhydroxide core of at least one lanthanide, and a coating constituted of a polysiloxane, optionally with organic molecules grafted to the surface or included within it, as a radiosensitizing agent in the manufacture of an injectable composition intended for improving the effectiveness of the treatment of a tumour by X-ray or gamma irradiation. It also relates to nanoparticles that are particularly suitable for the above use, constituted of a core constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide and of a polysiloxane coating comprising 1 to 5 silicons per lanthanide and of which at least 10% of the silicon atoms are linked to hydrophilic organic molecules having molar masses of less than 450 g/mol.
摘要翻译：本发明涉及尺寸在1和50nm之间的纳米颗粒的用途，其至少一部分由至少一种镧系元素的氧化物和/或一种羟基氧化物构成，所述纳米颗粒是： - 由至少一种至少一种镧系元素的氧化物和/或一种羟基氧化物，或者以包含至少一种镧系元素的羟基氧化物核的纳米颗粒的形式，以及由聚硅氧烷构成的涂层，任选地将有机分子接枝到表面上或包含在其中，作为放射增敏剂用于制备旨在改善通过X射线或γ射线治疗肿瘤的有效性的可注射组合物。本发明还涉及特别适用于上述用途的纳米颗粒，其由至少一种镧系元素的至少一种氧化物和/或一种羟基氧化物和每个镧系元素含有1至5个硅的聚硅氧烷涂层构成的核构成，并且其中在至少10％的硅原子与摩尔质量小于450g / mol的亲水性有机分子连接。

9. 发明申请

WO2011135101A2 NANOPARTICULES ULTRAFINES A MATRICE POLYORGANOSILOXANE FONCTIONNALISEE ET INCLUANT DES COMPLEXES METALLIQUES; LEUR PROCEDE D'OBTENTION ET LEURS APPLICATIONS EN IMAGERIE MEDICALE ET/OU THERAPIE 审中-公开
标题翻译：包含官能化聚硅氧烷基质并包括金属络合物的超纳米纳米粒子; 用于获得其的方法及其在医学成像和/或治疗中的用途
公开(公告)号：WO2011135101A2
公开(公告)日：2011-11-03
申请号：PCT/EP2011/056972
申请日：2011-05-02
申请人： NANOH , UNIVERSITE LYON 1 CLAUDE BERNARD , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON , LUX, François , TILLEMENT, Olivier , SAINT JEAN, Maxime , MOWAT, Pierre , PERRIAT, Pascal , ROUX, Stéphane , MIGNOT, Anna
发明人： LUX, François , TILLEMENT, Olivier , SAINT JEAN, Maxime , MOWAT, Pierre , PERRIAT, Pascal , ROUX, Stéphane , MIGNOT, Anna
IPC分类号： A61K49/18 , B82Y5/00 , B82Y15/00 , B82B1/00 , C01F17/00 , C08L83/04 , A61K51/12
CPC分类号： A61K49/1824 , A61K9/0019 , A61K9/14 , A61K41/0038 , A61K49/0002 , A61K49/0093 , A61K49/1857 , A61K49/1881 , B82Y5/00 , B82Y15/00 , Y10T428/2982
摘要： L'invention concerne de nouvelles nanoparticules hybrides biocompatibles de très faible taille, utiles notamment pour le diagnostic et/ou la thérapie. Le but de l'invention est de proposer de nouvelles nanoparticules qui soient utiles notamment comme agents de contraste en imagerie (e.g. IRM) et/ou dans d'autres techniques de diagnostic et/ou comme agents de thérapie, qui soient plus performantes que les nanoparticules de même type connues et qui combinent à la fois une petite taille (par exemple inférieure à 20 nm) et un fort taux de charge en métaux (e.g. terres rares), en particulier pour avoir en imagerie (e.g. IRM) un fort rehaussement et une réponse correcte (relaxivité accrue) aux hautes fréquences. Ainsi, les nanoparticules selon l'invention, de diamètre d 1 entre 1 et 20 nm, comprennent chacune une matrice polyorganosiloxane (POS) incluant des cations gadolinium éventuellement associé à des cations dopants; un greffon C 1 chélatant DTPABA (dianydride d'acide diéthylènetriaminepentaacétique) lié à la matrice POS par liaison covalente -Si-C-, et présent en quantité suffisante pour pouvoir complexer tous les cations gadolinium; et éventuellement un autre greffon de fonctionnalisation Gf* lié à la matrice POS par liaison covalente -Si-C- (Gf* pouvant être issu d'un composé hydrophile (PEG); d'un composé comportant un principe actif PA1;d'un composé ciblant; d'un composé luminescent (fluorescéine). Le procédé d'obtention de ces nanoparticules et leurs applications en imagerie et en thérapie font également partie de l'invention.
摘要翻译：本发明涉及非常小尺寸的新型生物相容性杂交纳米颗粒，其特别用于诊断和/或治疗。本发明的目的是提供新颖的纳米颗粒，其特别用作成像（例如MRI）和/或其它诊断技术和/或作为治疗剂的造影剂，其比其相同的已知纳米颗粒更有效类型，并且其结合了小尺寸（例如小于20nm）和高金属（例如稀土）加载速率，特别是在成像（例如MRI）中具有强增强和正确响应（增加弛豫力）。因此，根据本发明的直径为d1至1nm的纳米颗粒各自包含任选与掺杂阳离子相关的包含钆阳离子的聚有机硅氧烷（POS）基质; 通过-Si-C-共价键合键合到POS基质上的DTPABA（二亚乙基三胺五乙酸双酐）螯合C1，并且存在足以使所有钆阳离子复合的量; 和任选的通过-Si-C-共价结合到POS基质上的其它官能化移植物Gf *（可以由亲水性化合物（PEG）产生Gf *）;来自包含活性成分AI1的化合物;来自靶向化合物;由发光化合物（荧光素））。获得这些纳米颗粒的方法及其在成像和治疗中的用途也是本发明的一部分。

10. 发明申请

WO2009053644A3 USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS 审中-公开
公开(公告)号：WO2009053644A3
公开(公告)日：2009-06-25
申请号：PCT/FR2008051860
申请日：2008-10-14
申请人： UNIV CLAUDE BERNARD LYON , HOSPICES CIVILS LYON , CENTRE NAT RECH SCIENT , NANOH , EUROP SYNCHROTRON RADIATION FA , TILLEMENT OLIVIER , ROUX STEPHANE , PERRIAT PASCAL , LEDUC GERALDINE , MANDON CELINE , MUTELET BRICE , ALRIC CHRISTOPHE , BILLOTEY CLAIRE , JANIER MARC , LOUIS CEDRIC
发明人： TILLEMENT OLIVIER , ROUX STEPHANE , PERRIAT PASCAL , LEDUC GERALDINE , MANDON CELINE , MUTELET BRICE , ALRIC CHRISTOPHE , BILLOTEY CLAIRE , JANIER MARC , LOUIS CEDRIC
IPC分类号： A61K51/12 , A61P35/00
CPC分类号： A61K41/0038 , A61K9/0019
摘要： The invention relates to the use of nanoparticles having dimensions between 1 and 50 nm, at least one part of which is constituted of at least one oxide and/or one oxyhydroxide of at least lanthanide, said nanoparticles being: - either constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide, - or in the form of nanoparticles comprising an oxyhydroxide core of at least one lanthanide, and a coating constituted of a polysiloxane, optionally with organic molecules grafted to the surface or included within it, as a radiosensitizing agent in the manufacture of an injectable composition intended for improving the effectiveness of the treatment of a tumour by X-ray or gamma irradiation. It also relates to nanoparticles that are particularly suitable for the above use, constituted of a core constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide and of a polysiloxane coating comprising 1 to 5 silicons per lanthanide and of which at least 10% of the silicon atoms are linked to hydrophilic organic molecules having molar masses of less than 450 g/mol.

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