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1. 发明申请

WO2003068230A1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE 审中-公开
标题翻译：作为P38 MAP激酶的调节剂的替代吡啶酮
公开(公告)号：WO2003068230A1
公开(公告)日：2003-08-21
申请号：PCT/US2003/004634
申请日：2003-02-14
申请人： PHARMACIA CORPORATION , DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , SAMBANDAM, Aruna , LIU, Shuang , SCOTT, Ian, L. , MCGEE, Kevin, F.
发明人： DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , SAMBANDAM, Aruna , LIU, Shuang , SCOTT, Ian, L. , MCGEE, Kevin, F.
IPC分类号： A61K31/4412
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

2. 发明申请

WO2004087074A2 PROCESS FOR MAKING SUBSTITUTED PYRAZOLES 审中-公开
标题翻译：制备取代的吡唑的方法
公开(公告)号：WO2004087074A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009659
申请日：2004-03-30
申请人： PHARMACIA CORPORATION , ALLEN, Kimberley, C. , ANDERSON, Dennis, K. , BALDUS, John, E. , BOEHLOW, Todd , CLARK, Jerry, D. , DUKESHERER, Daniel, R. , EDNEY, Albert, D. , FEVIG, Tom , KUNDA, Sastry , LAWSON, Jon, P. , LAU, Patrick, H. , MCDERMOTT, Lisa, L. , MAO, Michael, K. , MOE, Jodi, L. , MUDIPALLI, Partha , NAING, Win , SELNESS, Shaun, R. , SEYMOUR, Christine, B. , SCHILKE, Tobin, C. , VISWANATH, Shekhar , WALKER, John, K. , YALAMANCHILI, Gopichand
发明人： ALLEN, Kimberley, C. , ANDERSON, Dennis, K. , BALDUS, John, E. , BOEHLOW, Todd , CLARK, Jerry, D. , DUKESHERER, Daniel, R. , EDNEY, Albert, D. , FEVIG, Tom , KUNDA, Sastry , LAWSON, Jon, P. , LAU, Patrick, H. , MCDERMOTT, Lisa, L. , MAO, Michael, K. , MOE, Jodi, L. , MUDIPALLI, Partha , NAING, Win , SELNESS, Shaun, R. , SEYMOUR, Christine, B. , SCHILKE, Tobin, C. , VISWANATH, Shekhar , WALKER, John, K. , YALAMANCHILI, Gopichand
IPC分类号： A61K
CPC分类号： C07D401/06 , C07D401/14
摘要： This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I) wherein R 3A R 3B R 3C , Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are as defined in the specification.
摘要翻译：本发明一般涉及制备取代的吡唑，取代的吡唑的互变异构体和取代的吡唑和互变异构体的盐的方法。取代的吡唑在结构上对应于其中R 3A，R 3B，Y 1，Y 2，Y 3，Y 4和Y 5中的式（I）如说明书中所定义。

3. 发明申请

WO2003026663A1 PROCESS FOR MAKING SUBSTITUTED PYRAZOLES 审中-公开
标题翻译：制备取代的吡唑的方法
公开(公告)号：WO2003026663A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/030409
申请日：2002-09-25
申请人： PHARMACIA CORPORATION , ALLEN, Kimberly, K. , ANDERSON, Dennis, K. , BALDUS, John, E. , CLARK, Jerry, D. , EDENY, Albert, D. , LAU, Patrick, H. , MCDERMOTT, Lisa, L. , MOE, Jodi, L. , MUDIPALLI, Partha, S. , NAING, Win , SELNESS, Shaun, R. , SEYMOUR, Christine, B. , VISWANATH, Shekhar , WALKER, John, K.
发明人： ALLEN, Kimberly, K. , ANDERSON, Dennis, K. , BALDUS, John, E. , CLARK, Jerry, D. , EDENY, Albert, D. , LAU, Patrick, H. , MCDERMOTT, Lisa, L. , MOE, Jodi, L. , MUDIPALLI, Partha, S. , NAING, Win , SELNESS, Shaun, R. , SEYMOUR, Christine, B. , VISWANATH, Shekhar , WALKER, John, K.
IPC分类号： A61K31/506
CPC分类号： C07D401/14
摘要： This invention is directed to a process for making substituted pyrazoles, (I) tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers, wherein R 3A , R 3B , R 3C , Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are as defined in the specification. The process comprises: forming a mixture by a process comprising introducing a hydrazone (II) and an optionally-substituted benzoyl halide (III) into a reactor, and heating the mixture to a temparature of greater than 50 °C (II); and (III).
摘要翻译：本发明涉及制备取代的吡唑，（I）取代的吡唑的互变异构体和取代的吡唑和互变异构体的盐的方法，其中R 3A，R 3B，R 3C，Y 1， Y 2，Y 3，Y 4和Y 5如说明书中所定义。该方法包括：通过包括将腙（II）和任选取代的苯甲酰卤（III）引入反应器中并将混合物加热至大于50℃（II）的温度的方法形成混合物; 和（III）。

4. 发明申请

WO2005018557A2 SUBSTITUTED PYRIDINONES 审中-公开
标题翻译：取代的吡啶酮
公开(公告)号：WO2005018557A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/026193
申请日：2004-08-13
申请人： PHARMACIA CORPORATION , DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , SAMBANDAM, Aruna , LIU, Shuang , SCOTT, Ian, L. , MCGEE, Kevin, F.
发明人： DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , SAMBANDAM, Aruna , LIU, Shuang , SCOTT, Ian, L. , MCGEE, Kevin, F.
IPC分类号： A61K
CPC分类号： C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，本文定义了R 4，R 5和R 5。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加剧的疾病和病症。还公开了含有该化合物的药物组合物，制备该化合物的方法和使用该化合物的治疗方法。

5. 发明申请

WO2003104223A1 PYRAZOLE-DERIVATIVES AS P38 KINASE INHIBITORS 审中-公开
标题翻译：吡唑衍生物作为P38激酶抑制剂
公开(公告)号：WO2003104223A1
公开(公告)日：2003-12-18
申请号：PCT/US2003/017906
申请日：2003-06-05
申请人： PHARMACIA CORPORATION , BENSON, Alan, G. , FRAHER, Thomas, Phillip , HEPPERLE, Michael, E. , JEROME, Kevin, D. , NAING, Win , SELNESS, Shaun, Raj , WALKER, John, K.
发明人： BENSON, Alan, G. , FRAHER, Thomas, Phillip , HEPPERLE, Michael, E. , JEROME, Kevin, D. , NAING, Win , SELNESS, Shaun, Raj , WALKER, John, K.
IPC分类号： C07D403/04
CPC分类号： C07F9/591 , C07D401/14 , C07D403/04 , C07D405/14 , C07F9/65583
摘要： This invention is directed generally to pyrazoles that, inter alia, inhibit p38 kinase, TNF, and/or cyclooxygenase-2 activity. Such pyrazoles include compounds generally corresponding in structure to the following formula (I), wherein L 1 , L 2 ,X l , X 2 , X 3 , X 4 , X 5 , X 6 , R l , R 3A , R 3b , R 3C , R 4 , and R 5 are as defined in this specification. The pyrazoles further include tautomers of such compounds, as well as salts of such compounds and tautomers. This invention also is directed to compositions of such pyrazoles, intermediates for the syntheses of such pyrazoles, methods for making such pyrazoles, and methods for treating (including preventing) conditions (particularly pathological conditions) associated with p38 kinase, TNF, and/or cyclooxygenase-2 activity.
摘要翻译：本发明一般涉及特别是抑制p38激酶，TNF和/或环氧合酶-2活性的吡唑。这种吡唑类包括通式相应于下式（I）的化合物，其中L 1，L 2，X 1，X 2，X 3，X 4，X 5 >，X 6，R 1，R 3A，R 3b，R 3C，R 4和R 5如本说明书中所定义。吡唑还包括这种化合物的互变异构体，以及这些化合物和互变异构体的盐。本发明还涉及这种吡唑的组合物，用于合成这种吡唑的中间体，制备这种吡唑的方法，以及用于治疗（包括预防）与p38激酶，TNF和/或环氧合酶相关的病症（特别是病理状态）的方法 -2活动。

6. 发明申请

WO2005018557A3 SUBSTITUTED PYRIDINONES 审中-公开
标题翻译：取代的吡啶酮
公开(公告)号：WO2005018557A3
公开(公告)日：2005-08-04
申请号：PCT/US2004026193
申请日：2004-08-13
申请人： PHARMACIA CORP , DEVADAS BALEKUDRU , WALKER JOHN , SELNESS SHAUN R , BOEHM TERRI L , DURLEY RICHARD C , DEVRAJ RAJESH , HICKORY BRIAN S , RUCKER PAUL V , JEROME KEVIN D , MADSEN HEATHER M , ALVIRA EDGARDO , PROMO MICHELE A , BLEVIS-BAL RADHIKA M , MARRUFO LAURA D , HITCHCOCK JEFF , OWEN THOMAS , NAING WIN , XING LI , SHIEH HUEY S , SAMBANDAM ARUNA , LIU SHUANG , SCOTT IAN L , MCGEE KEVIN F
发明人： DEVADAS BALEKUDRU , WALKER JOHN , SELNESS SHAUN R , BOEHM TERRI L , DURLEY RICHARD C , DEVRAJ RAJESH , HICKORY BRIAN S , RUCKER PAUL V , JEROME KEVIN D , MADSEN HEATHER M , ALVIRA EDGARDO , PROMO MICHELE A , BLEVIS-BAL RADHIKA M , MARRUFO LAURA D , HITCHCOCK JEFF , OWEN THOMAS , NAING WIN , XING LI , SHIEH HUEY S , SAMBANDAM ARUNA , LIU SHUANG , SCOTT IAN L , MCGEE KEVIN F
IPC分类号： A61K20060101 , A61K31/4412 , A61K31/4415 , A61K31/4439 , A61P29/00 , C07D211/86 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/84 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
CPC分类号： C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

7. 发明申请

WO2005061485A1 PROCESS FOR MAKING SUBSTITUTED PYRAZOLES 审中-公开
标题翻译：制备取代的吡唑的方法
公开(公告)号：WO2005061485A1
公开(公告)日：2005-07-07
申请号：PCT/IB2004/004071
申请日：2004-12-08
申请人： PHARMACIA CORPORATION , CHEKAL, Brian, P. , DUKESHERER, Daniel, R. , MAO, Michael, K. , NAING, Win , SELNESS, Shuan, R. , WALKER, John, K. , WETTACH, Richard, H. , YALAMANCHILI, Gopichand
发明人： CHEKAL, Brian, P. , DUKESHERER, Daniel, R. , MAO, Michael, K. , NAING, Win , SELNESS, Shuan, R. , WALKER, John, K. , WETTACH, Richard, H. , YALAMANCHILI, Gopichand
IPC分类号： C07D401/14
CPC分类号： A61K31/565 , C07D401/14 , Y02A50/411 , Y02P20/55
摘要： This invention is directed generally to a process for making substituted pyrazoles, The substituted pyrazole corresponds in structure to formula 9 : wherein Q, R 4 ,R 3A , R 3B , R 3C , R 3D , and R 3E are as defined in the specification.
摘要翻译：本发明一般涉及制备取代的吡唑的方法。取代的吡唑在结构上对应于式9：其中Q，R 4，R 3A，R 3B，R 3C，R 3，，且R 3E如说明书中所定义。

8. 发明申请

WO2004087074A3 PROCESS FOR MAKING SUBSTITUTED PYRAZOLES 审中-公开
标题翻译：制备取代的吡唑的方法
公开(公告)号：WO2004087074A3
公开(公告)日：2005-03-24
申请号：PCT/US2004009659
申请日：2004-03-30
申请人： PHARMACIA CORP , ALLEN KIMBERLEY C , ANDERSON DENNIS K , BALDUS JOHN E , BOEHLOW TODD , CLARK JERRY D , DUKESHERER DANIEL R , EDNEY ALBERT D , FEVIG TOM , KUNDA SASTRY , LAWSON JON P , LAU PATRICK H , MCDERMOTT LISA L , MAO MICHAEL K , MOE JODI L , MUDIPALLI PARTHA , NAING WIN , SELNESS SHAUN R , SEYMOUR CHRISTINE B , SCHILKE TOBIN C , VISWANATH SHEKHAR , WALKER JOHN K , YALAMANCHILI GOPICHAND
发明人： ALLEN KIMBERLEY C , ANDERSON DENNIS K , BALDUS JOHN E , BOEHLOW TODD , CLARK JERRY D , DUKESHERER DANIEL R , EDNEY ALBERT D , FEVIG TOM , KUNDA SASTRY , LAWSON JON P , LAU PATRICK H , MCDERMOTT LISA L , MAO MICHAEL K , MOE JODI L , MUDIPALLI PARTHA , NAING WIN , SELNESS SHAUN R , SEYMOUR CHRISTINE B , SCHILKE TOBIN C , VISWANATH SHEKHAR , WALKER JOHN K , YALAMANCHILI GOPICHAND
IPC分类号： A61K20060101 , A61P29/00 , C07D211/36 , C07D401/04 , C07D401/06 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14
摘要： This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I) wherein R R R , Y , Y , Y , Y , and Y are as defined in the specification.
摘要翻译：本发明一般涉及制备取代的吡唑，取代的吡唑的互变异构体和取代的吡唑和互变异构体的盐的方法。取代的吡唑在结构上对应于其中R 3A，R 3B，Y 1，Y 2，Y 3，Y 4和Y 5中的式（I）如说明书中所定义。

9. 发明申请

US20070085843A1 Audio information display in a multimode display device 审中-公开
标题翻译：音频信息显示在多模显示设备中
公开(公告)号：US20070085843A1
公开(公告)日：2007-04-19
申请号：US10579310
申请日：2004-11-16
申请人： Weng Lam , Chunrui Zhang , Naing Win , Jun Cai
发明人： Weng Lam , Chunrui Zhang , Naing Win , Jun Cai
IPC分类号： G09G5/00
CPC分类号： H04N5/46 , H04N5/44513 , H04N5/60 , H04N21/4122 , H04N21/4312 , H04N21/488
摘要： The present invention relates to a multimode display device (101) comprising a display area, where said display device is, in a first mode, adapted for displaying displayfocused applications on the display area, where said display device is, in a second mode, adapted for displaying audio-specific information on the display area describing audio being played back and where the display device is, in a third mode, adapted for simultaneously displaying independent display-focused applications and audio-specific information on the display area, the device comprises: receiving means (307) adapted for receiving audio data comprising said audio-specific information; processing means (309) adapted for displaying said audio-specific information on said display area. Thereby the user can choose to view the audio-specific information on the display device, while listening to the audio. Because of the separate processing means for adding the audio-specific information on the display area, the information can be added without obstructing the view of the display-focused application. This can advantageously be used e.g. for the FM Radio feature in an LCD TV Monitor product, where the user can view the FM Radio channel frequency when selecting different radio broadcasting stations.
摘要翻译：本发明涉及一种包括显示区域的多模显示设备（101），其中所述显示设备处于第一模式，适于在显示区域上显示显示聚焦应用，其中所述显示设备处于第二模式，适配用于在描述正在播放的音频的显示区域上显示音频专用信息，并且在第三模式中适用于在显示区域上同时显示独立的以显示为中心的应用程序和音频专用信息的显示设备，该设备包括：适于接收包括所述音频专用信息的音频数据的接收装置（307）; 适于在所述显示区域上显示所述音频专用信息的处理装置（309）。从而用户可以在收听音频的同时选择在显示设备上查看音频专用信息。由于用于在显示区域上添加音频专用信息的单独处理装置，可以添加该信息，而不会妨碍以显示为重点的应用的视图。这可以有利地例如使用。对于液晶电视监视器产品中的FM收音机功能，用户可以在选择不同的无线电广播电台时查看FM无线电频道频率。

10. 发明申请

US20050146954A1 Product and method for preventing incorrect storage of data 审中-公开
标题翻译：防止数据不正确存储的产品和方法
公开(公告)号：US20050146954A1
公开(公告)日：2005-07-07
申请号：US10506274
申请日：2003-02-17
申请人： Naing Win , Jun Cai , Joseph Jimson , Weng Lam
发明人： Naing Win , Jun Cai , Joseph Jimson , Weng Lam
IPC分类号： G06F1/26 , G06F1/30 , G06F12/16 , G11C5/14 , G11C16/20 , G11C16/22 , G11C7/00
CPC分类号： G06F1/30 , G11C5/143 , G11C16/20 , G11C16/225
摘要： The product has a power supply (P2) and a processor (P). The processor (P) has an input (PDD) for receiving a power-down signal indicating a status of the power supply (P2) and another input (Q) connected to another supply. The product also has a non-volatile memory (M) for storing data supplied by the processor (P). The processor (P) has an algorithm to detect a power-down status of the power supply (P2) by repeatedly checking the power-down signal and, upon detection that the power-down signal has a value (S0) corresponding to the power-down status, to complete an ongoing writing operation and stop the storage of data. The method prevents incorrect storage of data in a non-volatile memory by using the mentioned algorithm.
摘要翻译：该产品具有电源（P 2）和一个处理器（P）。处理器（P）具有用于接收指示电源状态（P 2）的断电信号和与另一电源连接的另一输入（Q）的输入（PDD）。该产品还具有用于存储由处理器（P）提供的数据的非易失性存储器（M）。处理器（P）具有通过重复检查掉电信号来检测电源（P 2）的掉电状态的算法，并且在检测到掉电信号具有对应于停电状态，完成持续写入操作并停止数据存储。该方法通过使用上述算法防止数据在非易失性存储器中的不正确存储。

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