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1. 发明申请

WO02089973A3 AFFINITY REACTION PROBE DETECTION/ANALYSIS CHIPS AND DETECTION SYSTEM AND APPARATUS USING THE SAME 审中-公开
标题翻译： AFFINITY反应检测/分析检测和检测系统及其设备
公开(公告)号：WO02089973A3
公开(公告)日：2003-09-04
申请号：PCT/JP0204531
申请日：2002-05-09
申请人： EBARA CORP , NAGASAWA HIROSHI
发明人： NAGASAWA HIROSHI
IPC分类号： B01J19/00 , C07B61/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/552 , G01N33/566
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00286 , B01J2219/00322 , B01J2219/00423 , B01J2219/00461 , B01J2219/00497 , B01J2219/005 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00549 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00707 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B60/14 , C40B70/00
摘要： Affinity reaction probe detection/analysis chips each comprising a retainer ring that is marked with individual identifying signals and which has a through-hole filled with or retaining a carrier having probe molecules fixed thereto. The carrier having probe molecules fixed thereto is preferably a porous membrane or nonwoven fabric stretched across the carrier to close the hole. The individual identifying signals may be written according to either a barcode system or an electronic recognition system. To establish a more convenient detection system in a chip-based affinity reaction probe assay, reaction detection/analysis chips are provided that can be used to detect DNA polymorph and diagnose various physiological functions. A detection system using such chips is also provided.
摘要翻译：亲和力反应探针检测/分析芯片，其各自包括保持环，其被标记有单独的识别信号，并且具有填充或保持固定有探针分子的载体的通孔。固定有探针分子的载体优选是穿过载体拉伸以闭合孔的多孔膜或非织造织物。个体识别信号可以根据条形码系统或电子识别系统来写入。为了在基于芯片的亲和力反应探针测定中建立更方便的检测系统，提供了可用于检测DNA多态性并诊断各种生理功能的反应检测/分析芯片。还提供了使用这种芯片的检测系统。

2. 发明申请

WO1995011879A1 PROCESS FOR PRODUCING ACID-ADDITION SALT OF Z-ISOMER OF TRIPHENYLETHYLENE COMPOUND 审中-公开
标题翻译：生产三苯乙烯化合物的Z-异构体酸的添加剂的方法
公开(公告)号：WO1995011879A1
公开(公告)日：1995-05-04
申请号：PCT/JP1994001782
申请日：1994-10-25
申请人： TAIHO PHARMACEUTICAL CO., LTD. , SHINOZAKI, Fumihiko , NAGASAWA, Hiroshi , MARUHASHI, Kazuo
发明人： TAIHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07C217/18
CPC分类号： C07C217/18 , C07C213/08
摘要： A process for producing an acid-addition salt of a Z-isomer of a compound represented by general formula (I) (wherein R and R represent each lower alkyl, or are combined together with the nitrogen atom to which they are bonded to thereby form a nitrogenous heterocyclic group which may bear other heteroatom(s); R and R represent each hydrogen, lower alkyl, hydroxy, lower alkoxy, lower alkylcarbonyloxy, arylcarbonyloxy wherein the benzene ring may be substituted by one or two groups selected from among lower alkyl, lower alkoxy, halogen and cyano, benzylcarbonyloxy, mono- or di(lower alkyl)aminocarbonyloxy, or mono- or di(aryl)aminocarbonyloxy; R represents lower alkyl or halogen; and n represents 1 to 6), which process comprises heating an E-isomer of a compound represented by general formula (I) or an acid-addition salt thereof, either alone or as a mixture thereof with a Z-isomer of a comound represented by general formula (I) or an acid-addition salt thereof, in an organic solvent containing hydrobromic acid.
摘要翻译：一种制备通式（I）表示的化合物的Z-异构体的酸加成盐的方法（其中R 1和R 2代表每个低级烷基，或与氮原子相结合它们被键合从而形成可含有其它杂原子的含氮杂环基; R 3和R 4代表各自的氢，低级烷基，羟基，低级烷氧基，低级烷基羰基氧基，芳基羰基氧基，其中苯环可以是被一个或两个选自低级烷基，低级烷氧基，卤素和氰基的基团取代，苄基羰基氧基，一或二（低级烷基）氨基羰基氧基或一或二（芳基）氨基羰基氧基; R 5表示低级烷基或卤素 ; n表示1至6），该方法包括将通式（I）表示的化合物的E-异构体或其酸加成盐单独或作为其与组合的Z-异构体的混合物由通式（I）表示的化合物或其酸加成盐含有氢溴酸的厌氧溶剂。

3. 发明申请

WO02070597A8 ANTI-CLOUDING AGENT COMPOSITION 审中-公开
标题翻译：防滑剂组合物
公开(公告)号：WO02070597A8
公开(公告)日：2003-03-06
申请号：PCT/JP0201485
申请日：2002-02-20
申请人： CLARIANT INT LTD , NAGASAWA HIROSHI , NAKAMURA MASAKI , ISHIDA MASAKI , OHSAWA HIROSHI , HOGA TAKUYA
发明人： NAGASAWA HIROSHI , NAKAMURA MASAKI , ISHIDA MASAKI , OHSAWA HIROSHI , HOGA TAKUYA
IPC分类号： A01G13/02 , A01G9/14 , C08K5/103 , C08L101/00 , C09K3/00 , C09K3/18 , C08J5/18
CPC分类号： C09K3/18 , C08K5/103 , C08L23/08
摘要： An antifogging agent composition which comprises (a) at least one of polyhydric alcohol esters of C>10-20
摘要翻译：一种防雾剂组合物，其包含（a）C 10-20％以上高级脂肪酸的多元醇酯中的至少一种，例如甘油单硬脂酸酯和（b）至少一种选自环氧烷烃的褐煤酸蜡衍生物褐煤酸多元醇酯的加成物，由褐煤酸蜡的烯化氧加成物和褐煤酸蜡的环氧乙烷加合物与脱水山梨糖醇和褐煤酸多元醇酯组成。将防雾剂组合物通过捏合加入到形成膜的合成树脂中。因此，可以获得在低温防雾性，初始防雾性和持久防雾性全部令人满意的农业用合成树脂膜，透明性优异。

4. 发明申请

WO1998026889A1 ULTRAFINE PARTICLES AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：超细颗粒及其生产方法
公开(公告)号：WO1998026889A1
公开(公告)日：1998-06-25
申请号：PCT/JP1997004648
申请日：1997-12-17
申请人： TOMOE WORKS CO., LTD. , DAIKEN CHEMICAL CO. , OSAKA MUNICIPAL GOVERNMENT , NAGASAWA, Hiroshi , NAKAMOTO, Masami
发明人： TOMOE WORKS CO., LTD. , DAIKEN CHEMICAL CO. , OSAKA MUNICIPAL GOVERNMENT
IPC分类号： B22F09/30
CPC分类号： B82Y30/00 , B22F1/0018 , B22F1/0059 , B22F1/025 , B22F9/30 , B22F2998/00 , B82Y25/00 , H01F1/0054 , Y10T428/12181 , Y10T428/2991
摘要： Ultrafine particles excellent in dispersion stability, characterized by being mainly composed of an organometallic compound and a metal component resulting from the organometallic compound, the core of each particle being made substantially of the metal component and the organometallic compound surrounding the core, and by having a mean particle diameter of 1 to 100 nm; and a process for producing them on an industrial scale.
摘要翻译：分散稳定性优异的超细颗粒，其特征在于主要由有机金属化合物和由有机金属化合物得到的金属成分组成，每个颗粒的核心基本上由金属组分制成，并且包围核心的有机金属化合物，平均粒径为1〜100nm; 以及在工业规模生产这些工艺的过程。

5. 发明申请

WO2004026526A1 BONDING MATERIAL AND BONDING METHOD 审中-公开
标题翻译：粘接材料与粘接方法
公开(公告)号：WO2004026526A1
公开(公告)日：2004-04-01
申请号：PCT/JP2003/011797
申请日：2003-09-17
申请人： EBARA CORPORATION , NAGASAWA, Hiroshi , KAGOSHIMA, Kaori , OGURE, Naoaki , HIROSE, Masayoshi , CHIKAMORI, Yusuke
发明人： NAGASAWA, Hiroshi , KAGOSHIMA, Kaori , OGURE, Naoaki , HIROSE, Masayoshi , CHIKAMORI, Yusuke
IPC分类号： B23K35/02
CPC分类号： B22F1/0022 , B22F1/0059 , B22F1/0062 , B22F7/064 , B22F2998/00 , B22F2999/00 , B23K35/0244 , B23K35/025 , B23K35/3006 , B23K35/3612 , B23K2201/36 , B82Y30/00 , C09J5/06 , C09J11/04 , C09J2400/163 , H01L23/4828 , H01L24/81 , H01L2224/11332 , H01L2224/16225 , H01L2224/16237 , H01L2224/29339 , H01L2224/2949 , H01L2224/81192 , H01L2224/81193 , H01L2224/8121 , H01L2224/81815 , H01L2224/8184 , H01L2924/01006 , H01L2924/01012 , H01L2924/01013 , H01L2924/01019 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/0105 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01322 , H01L2924/01327 , H01L2924/014 , H01L2924/09701 , H01L2924/12042 , H01L2924/12044 , H01L2924/351 , H05K3/321 , H05K2201/0224 , H05K2201/0257 , H05K2203/1572 , B22F1/0018 , H01L2924/00
摘要： There is provided a bonding material and a bonding method which enable lead-free bonding that can replace high-temperature soldering. The bonding material of the present invention comprises a dispersion in an organic solvent of composite metallic nano-particles having such a structure that a metal core of a metal particle having an average particle diameter of not more than 100 nm. The bonding material can be advantageously used in a stepwise bonding process containing at least two bonding steps.
摘要翻译：提供了能够代替高温焊接的无铅接合的接合材料和接合方法。本发明的接合材料包括具有这样的结构的复合金属纳米粒子的有机溶剂中的分散体，即具有平均粒径不大于100nm的金属颗粒的金属芯。接合材料可以有利地用于包含至少两个键合步骤的逐步粘结工艺中。

6. 发明申请

WO2002089973A2 AFFINITY REACTION PROBE DETECTION/ANALYSIS CHIPS AND DETECTION SYSTEM AND APPARATUS USING THE SAME 审中-公开
标题翻译： AFFINITY反应检测/分析检测和检测系统及其设备
公开(公告)号：WO2002089973A2
公开(公告)日：2002-11-14
申请号：PCT/JP2002/004531
申请日：2002-05-09
申请人： EBARA CORPORATION , NAGASAWA, Hiroshi
发明人： NAGASAWA, Hiroshi
IPC分类号： B01J19/00
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00286 , B01J2219/00322 , B01J2219/00423 , B01J2219/00461 , B01J2219/00497 , B01J2219/005 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00549 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00707 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B60/14 , C40B70/00
摘要： Affinity reaction probe detection/analysis chips each comprising a retainer ring that is marked with individual identifying signals and which has a through-hole filled with or retaining a carrier having probe molecules fixed thereto. The carrier having probe molecules fixed thereto is preferably a porous membrane or nonwoven fabric stretched across the carrier to close the hole. The individual identifying signals may be written according to either a barcode system or an electronic recognition system. To establish a more convenient detection system in a chip-based affinity reaction probe assay, reaction detection/analysis chips are provided that can be used to detect DNA polymorph and diagnose various physiological functions. A detection system using such chips is also provided.
摘要翻译：亲和力反应探针检测/分析芯片，其各自包括保持环，其被标记有单独的识别信号，并且具有填充或保持固定有探针分子的载体的通孔。固定有探针分子的载体优选是穿过载体拉伸以闭合孔的多孔膜或非织造织物。个体识别信号可以根据条形码系统或电子识别系统来写入。为了在基于芯片的亲和力反应探针测定中建立更方便的检测系统，提供了可用于检测DNA多态性并诊断各种生理功能的反应检测/分析芯片。还提供了使用这种芯片的检测系统。

7. 发明专利

JP2642316B2 失效
公开(公告)号：JP2642316B2
公开(公告)日：1997-08-20
申请号：JP25524394
申请日：1994-10-20
申请人： NAGASAWA HIROSHI
发明人： NAGASAWA HIROSHI
IPC分类号： A61K36/00 , A61K36/18 , A61P3/00 , A61P35/00 , C07G99/00 , A61K35/78 , C07G17/00

8. 发明专利

JPH08119871A ANTICANCER AGENT 失效
公开(公告)号：JPH08119871A
公开(公告)日：1996-05-14
申请号：JP25524394
申请日：1994-10-20
申请人： NAGASAWA HIROSHI
发明人： NAGASAWA HIROSHI
IPC分类号： A61K36/00 , A61K36/18 , A61P3/00 , A61P35/00 , C07G99/00 , A61K35/78
摘要： PURPOSE: To obtain a new and safe anticancer agent and a whole-body metabolism promotor. CONSTITUTION: This anticancer agent contains an extract obtained by extracting flesh part and/or pericarp of coffee fruit, preferably a dried material thereof with water heated to 20-80 deg.C, preferably 40-50 deg.C as an active ingredient. This whole-body metabolism promotor contains the extract as an active ingredient.

9. 发明授权

US5565611A Process for preparing acid addition salt of Z-isomer of triphenylethylene compound 失效
标题翻译：制备三苯乙烯化合物Z-异构体的酸加成盐的方法
公开(公告)号：US5565611A
公开(公告)日：1996-10-15
申请号：US446736
申请日：1995-06-06
申请人： Shinozaki Fumihiko , Nagasawa Hiroshi , Maruhashi Kazuo
发明人： Shinozaki Fumihiko , Nagasawa Hiroshi , Maruhashi Kazuo
IPC分类号： C07C213/08 , C07C217/18 , C07C213/10
CPC分类号： C07C217/18 , C07C213/08
摘要： The present invention provides a process for preparing an acid addition salt of the Z-isomer of a compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 represent a lower alkyl group, or taken together with the nitrogen atom to which they are attached, form a nitrogen-containing heterocyclic group optionally containing other hetero atom or atoms; R.sup.3 and R.sup.4 represent H, a lower alkyl group, OH, a lower alkoxy group, a lower alkylcarbonyloxy group, an arylcarbonyloxy group optionally substituted with 1-2 substituents selected from lower alkyl, lower alkoxy, halo and CN on the benzene ring, a benzylcarbonyloxy group, a mono- or di(lower alkyl)aminocarbonyloxy group or a mono- or di(aryl)aminocarbonyloxy group; R.sup.5 represents a lower alkyl group or halo; and n represents 1-6, characterized in that the E-isomer of the compound of the formula (I) or its acid addition salt, singly or in admixture with the Z-isomer or its acid addition salt, is heated in an organic solvent containing hydrobromic acid.
摘要翻译：本发明提供了制备式（I）化合物的Z-异构体的酸加成盐的方法，其中R 1和R 2表示低级烷基，或与它们所在的氮原子一起形成任选含有其它杂原子或原子的含氮杂环基; R3和R4表示H，低级烷基，OH，低级烷氧基，低级烷基羰氧基，任选被选自苯环上的选自低级烷基，低级烷氧基，卤素和CN的1-2个取代基取代的芳羰基氧基，一或二（低级烷基）氨基羰基氧基或一或二（芳基）氨基羰基氧基; R5表示低级烷基或卤素; 并且n表示1-6，其特征在于式（I）化合物的E-异构体或其酸加成盐单独或与Z-异构体或其酸加成盐混合，在有机溶剂中加热含氢溴酸。

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