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    • 9. 发明申请
    • FUNCTIONALIZED FLUORESCENT NANOCRYSTALS, AND METHODS FOR THEIR PREPARATION AND USE
    • 功能化的荧光纳米晶及其制备和使用方法
    • WO2007001438A3
    • 2007-03-08
    • PCT/US2005039434
    • 2005-10-28
    • MOLECULAR PROBES INCNAASANI IMAD
    • NAASANI IMAD
    • C09K11/54G01N33/58
    • B82Y15/00C09K11/025C09K11/883G01N33/588Y10S977/773Y10S977/792Y10S977/793Y10S977/795Y10S977/811Y10S977/827Y10S977/83Y10T428/2991Y10T428/2993
    • Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
    • 公开了官能化荧光纳米晶体组合物以及制备和使用这些组合物的方法。 该组合物是用至少一种材料涂覆的荧光纳米晶体。 涂层材料具有化学化合物或具有带有共轭电子和部分的官能团或部分的配体,用于赋予水溶液中涂覆的荧光纳米晶体溶解性。 涂层材料提供了官能化的荧光纳米晶体组合物,其是水溶性的,化学稳定的,并且在用光激发时以高量子产率和/或发光效率发光。 涂层材料还可以具有化学化合物或具有用于与目标分子和细胞结合的部分的配体以及用于交联涂层的部分。 在适于反应以形成覆盖层的试剂存在下,覆盖层中的化合物可以在荧光纳米晶体上形成覆盖层,其中覆盖层可操作地结合到覆盖层。
    • 10. 发明申请
    • FUNCTIONALIZED FLUORESCENT NANOCRYSTALS, AND METHODS FOR THEIR PREPARATION AND USE
    • 功能化荧光纳米晶及其制备和使用方法
    • WO2007001438A2
    • 2007-01-04
    • PCT/US2005/039434
    • 2005-10-28
    • MOLECULAR PROBES, INC.NAASANI, Imad
    • NAASANI, Imad
    • B82Y15/00C09K11/025C09K11/883G01N33/588Y10S977/773Y10S977/792Y10S977/793Y10S977/795Y10S977/811Y10S977/827Y10S977/83Y10T428/2991Y10T428/2993
    • Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
    • 公开了功能化荧光纳米晶体组合物和制备和使用这些组合物的方法。 组合物是涂覆有至少一种材料的荧光纳米晶体。 涂层材料具有具有带有共轭电子和部分的官能团或部分的化学化合物或配体,以在水溶液中赋予包被的荧光纳米晶体的溶解性。 涂层材料提供了在用光激发时具有水溶性,化学稳定性和发射具有高量子产率和/或发光效率的光的官能化荧光纳米晶体组合物。 涂层材料还可以具有化学化合物或具有用于键合到靶分子和细胞的部分的配体以及用于交联涂层的部分。 在适于反应形成封盖层的试剂存在下,涂层中的化合物可以在荧光纳米晶体上形成覆盖层,其中涂层化合物可操作地结合到覆盖层。