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    • 6. 发明授权
    • Dipyrano-quinolinones useful as anti viral agents and a process for preparing the same
    • 可用作抗病毒剂的二亚氨基 - 喹啉酮及其制备方法
    • US06191279B1
    • 2001-02-20
    • US09321851
    • 1999-05-28
    • Mukund Keshao GurjarGangavaram Vasantha Madhava SharmaAindivelu IlangovanVen Narayanan
    • Mukund Keshao GurjarGangavaram Vasantha Madhava SharmaAindivelu IlangovanVen Narayanan
    • C07D49112
    • C07D491/14A61K31/436Y10S436/815
    • The invention relates to novel dipyrano-quinolinone class of compounds having the general formula: Wherein R is hydrogen, alkyl optionally substituted about C-1 to C-10 alkenyl optionally substituted about C-1 to C-10 with one or more double bounds, alkynyl optionally substituted about C-1 to C-10 with one or more triple bonds, aryl, hetero aryl, carbocyclic aryl, alkyl aryl, alcyclic compounds, C-1 to C-6 alkyl with terminal dialkyl amino group, thio alkyl, hydroxyl alkyl groups; R1 is H, lower dialkyl amino alkyls such as methyl, ethyl, propyl, and other alkyl groups or b-amino acid moieties, hydroxy alkyl groups having optionally substituted about C-1 to C-10 carbons, acid amides such as aliphatic acids, aromatic acids, sulphonic acids trihalo acids. x—x is either a carbon-carbon single bond or a carbon-carbon double bond; R2 and R3, R4 and R5 are each independently hydrogen and methyl there by resulting the cis and trans diastereomers as well as enantiomers; R4 and R5 are each independently hydrogen and methyl while R6 and R7 are each independently hydrogen and hydroxyl/—OR8, where R8 is independently alkyl, aryl alkyl, amino alkyl, hydroxy alkyl with C-1 to C-10 carbons, sugars which include mono saccharides both in the furanose form as well as pyranose form, amino sugars, disaccharides, amino acids, small peptides through lower alkyl spacer groups, thereby resulting the cis and trans diastereomers as well as enantiomers; and a process for producing the above novel dipyrano-quinolinone class of compounds.
    • 本发明涉及具有以下通式的新颖的二吡喹烷 - 喹啉酮类化合物:其中R是氢,任选取代有C1-至C-10烯基的烷基,该C 1至C 10链烯基具有一个或多个双重界限的C-1至C-10, 芳基,杂芳基,碳环芳基,烷基芳基,异环化合物,具有末端二烷基氨基的C 1至C 6烷基,硫代烷基,羟基,C 1 -C 6烷基, 烷基; R 1为H,低级二烷基氨基烷基如甲基,乙基,丙基和其它烷基或b-氨基酸部分,具有任选取代为C-1至C-10碳原子的羟基烷基,酰胺如 脂肪酸,芳香酸,磺酸三卤酸.xx是碳 - 碳单键或碳 - 碳双键; R2和R3,R4和R5各自独立地为氢和甲基,得到顺式和反式非对映异构体 以及对映体; R4和R5各自独立 氢和甲基,而R6和R7各自独立地为氢和羟基-OR8,其中R8独立地是烷基,芳基烷基,氨基烷基,具有C-1至C-10碳的羟基烷基,包括单糖的糖, 呋喃糖形式以及吡喃糖形式,氨基糖,二糖,氨基酸,通过低级烷基间隔基团的小肽,从而得到顺式和反式非对映体以及对映异构体; 以及制备上述新型双吡喃 - 喹啉酮类化合物的方法。