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1. 发明申请

US20060068016A1 Paticulate product comprising pantethine 有权
标题翻译：含Pantethine的Paticulate产品
公开(公告)号：US20060068016A1
公开(公告)日：2006-03-30
申请号：US10529207
申请日：2003-09-29
申请人： Motonori Kidokoro , Yasuhiro Tsutsumi , Mitsumasa Nada
发明人： Motonori Kidokoro , Yasuhiro Tsutsumi , Mitsumasa Nada
IPC分类号： A61K9/14
CPC分类号： A61K31/145 , A61K9/1611 , A61K9/1652 , A61K9/2009 , A61K9/2054 , A61K31/16
摘要： A particulate containing a pantethine, a light anhydrous silicic acid and a microcrystalline cellulose, in which the total content of the light anhydrous silicic acid the microcrystalline cellulose amounts to a quantity that yields a 0.6 or higher adsorptivity. The present pantethine-containing particulate has a good flowability and an adequate particle size providing excellent handling properties. It is free from impediments such as blocking, and has a good storage stability.
摘要翻译：含有泛胺，轻质无水硅酸和微晶纤维素的微粒，其中微晶纤维素的轻质无水硅酸的总含量达到0.6或更高的吸附性的量。本发明的含有甜胺的颗粒具有良好的流动性和足够的颗粒尺寸，提供优异的操作性能。它没有障碍物，如堵塞，并具有良好的储存稳定性。

2. 发明授权

US07709028B2 Particulate product comprising pantethine 有权
标题翻译：包含泛液碱的颗粒产品
公开(公告)号：US07709028B2
公开(公告)日：2010-05-04
申请号：US10529207
申请日：2003-09-29
申请人： Motonori Kidokoro , Yasuhiro Tsutsumi , Mitsumasa Nada
发明人： Motonori Kidokoro , Yasuhiro Tsutsumi , Mitsumasa Nada
IPC分类号： A61K9/14
CPC分类号： A61K31/145 , A61K9/1611 , A61K9/1652 , A61K9/2009 , A61K9/2054 , A61K31/16
摘要： A particulate containing a pantethine, a light anhydrous silicic acid and a microcrystalline cellulose, in which the total content of the light anhydrous silicic acid the microcrystalline cellulose amounts to a quantity that yields a 0.6 or higher adsorptivity. The present pantethine-containing particulate has a good flowability and an adequate particle size providing excellent handling properties. It is free from impediments such as blocking, and has a good storage stability.
摘要翻译：含有泛胺，轻质无水硅酸和微晶纤维素的微粒，其中微晶纤维素的轻质无水硅酸的总含量达到0.6或更高的吸附性的量。本发明的含有甜胺的颗粒具有良好的流动性和足够的颗粒尺寸，提供优异的操作性能。它没有障碍物，如堵塞，并具有良好的储存稳定性。

3. 发明授权

US08449896B2 Pharmaceutical composition having improved solubility 有权
标题翻译：药物组合物具有改善的溶解度
公开(公告)号：US08449896B2
公开(公告)日：2013-05-28
申请号：US13328847
申请日：2011-12-16
申请人： Makoto Kamada , Motonori Kidokoro , Gaku Sekiguchi
发明人： Makoto Kamada , Motonori Kidokoro , Gaku Sekiguchi
IPC分类号： A61K9/14 , A61K9/20
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/2059 , A61K31/444 , C07D513/04
摘要： It is desired to provide a pharmaceutical composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof, or a solvate thereof, which exhibits an inhibitory effect on activated blood coagulation factor X (FXa), and is useful as an agent for preventing and/or treating thrombosis, wherein the pharmaceutical composition exhibits favorable dissolution properties. The present invention relates to a solid pharmaceutical composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof, or a solvate thereof, wherein the content of the compound represented by formula (I) is 0.5% by weight or more and less than 15% by weight with respect to the total weight of the pharmaceutical composition.
摘要翻译：期望提供含有对活化凝血因子X（FXa）具有抑制作用的由式（I）表示的化合物或其药理学上可接受的盐或其溶剂化物的药物组合物，并且可用作试剂用于预防和/或治疗血栓形成，其中药物组合物表现出有利的溶解性质。本发明涉及含有式（I）表示的化合物或其药理学可接受的盐或其溶剂化物的固体药物组合物，其中由式（I）表示的化合物的含量为0.5重量％以上，相对于药物组合物的总重量小于15重量％。

4. 发明申请

US20120114711A1 PHARMACEUTICAL COMPOSITION HAVING IMPROVED SOLUBILITY 有权
标题翻译：具有改善溶解性的药物组合物
公开(公告)号：US20120114711A1
公开(公告)日：2012-05-10
申请号：US13328847
申请日：2011-12-16
申请人： Makoto Kamada , Motonori Kidokoro , Gaku Sekiguchi
发明人： Makoto Kamada , Motonori Kidokoro , Gaku Sekiguchi
IPC分类号： A61K9/00 , A61P7/02 , A61K31/437
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/2059 , A61K31/444 , C07D513/04
摘要： It is desired to provide a pharmaceutical composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof, or a solvate thereof, which exhibits an inhibitory effect on activated blood coagulation factor X (FXa), and is useful as an agent for preventing and/or treating thrombosis, wherein the pharmaceutical composition exhibits favorable dissolution properties. The present invention relates to a solid pharmaceutical composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof, or a solvate thereof, wherein the content of the compound represented by formula (I) is 0.5% by weight or more and less than 15% by weight with respect to the total weight of the pharmaceutical composition.
摘要翻译：期望提供含有对活化凝血因子X（FXa）具有抑制作用的由式（I）表示的化合物或其药理学上可接受的盐或其溶剂化物的药物组合物，并且可用作试剂用于预防和/或治疗血栓形成，其中药物组合物表现出有利的溶解性质。本发明涉及含有式（I）表示的化合物或其药理学可接受的盐或其溶剂化物的固体药物组合物，其中由式（I）表示的化合物的含量为0.5重量％以上，相对于药物组合物的总重量小于15重量％。

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