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1. 发明申请

US20090136482A1 DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD 审中-公开
标题翻译：药物靶标蛋白和目标基因，筛选方法
公开(公告)号：US20090136482A1
公开(公告)日：2009-05-28
申请号：US12065303
申请日：2006-09-01
申请人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
发明人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
IPC分类号： A61K39/395 , G01N33/00 , C12Q1/68 , G01N33/566 , A61K38/02 , A61K31/7088 , A61K31/7105
CPC分类号： G01N33/68 , A61K45/06 , C07K14/47 , G01N33/5008 , G01N33/502 , G01N33/6845 , G01N33/94 , G01N2500/00 , Y10T436/143333
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

2. 发明授权

US08153385B2 Target protein and target gene in drug designing and screening method 失效
标题翻译：靶蛋白和靶基因在药物设计筛选中的应用
公开(公告)号：US08153385B2
公开(公告)日：2012-04-10
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： G01N33/53
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

3. 发明授权

US07729892B2 Simulation parameter determination method 有权
标题翻译：模拟参数确定方法
公开(公告)号：US07729892B2
公开(公告)日：2010-06-01
申请号：US11806195
申请日：2007-05-30
申请人： Motoi Tobita , Shirun Ho
发明人： Motoi Tobita , Shirun Ho
IPC分类号： G06F17/10
CPC分类号： G06F17/5009 , G06F2217/16
摘要： Provided is a method for reducing the amount of calculation time required for parameter determination, and for reducing the amount of calculation time required for parameter determination in satisfaction with a desired accuracy. The method includes preferentially selecting analysis objects, which are capable of providing parameter determination within a high degree of certainty, and controlling a calculation order of the selected analysis objects using a calculation order list.
摘要翻译：提供了一种减少参数确定所需的计算时间量的方法，并且用于减少满足期望精度的参数确定所需的计算时间量。该方法包括优先选择能够高度确定地提供参数确定的分析对象，以及使用计算顺序列表来控制所选择的分析对象的计算顺序。

4. 发明申请

US20070288175A1 Simulation parameter determination method 有权
标题翻译：模拟参数确定方法
公开(公告)号：US20070288175A1
公开(公告)日：2007-12-13
申请号：US11806195
申请日：2007-05-30
申请人： Motoi Tobita , Shirun Ho
发明人： Motoi Tobita , Shirun Ho
IPC分类号： G06F19/00 , G06F17/18
CPC分类号： G06F17/5009 , G06F2217/16
摘要： Provided is a method for reduction of calculation amount required for parameter determination, and for reduction of calculation amount required for parameter determination satisfying desired accuracy. It is a method for preferentially selecting analysis objects, which are capable of providing parameter determination in high degree of certainty, and for controlling calculation order of the selected analysis objects using a calculation order list.
摘要翻译：提供了一种减少参数确定所需的计算量并减少满足期望精度的参数确定所需的计算量的方法。优先选择分析对象的方法，该分析对象能够高度确定地提供参数确定，并且使用计算顺序列表来控制所选择的分析对象的计算顺序。

5. 发明申请

US20100136524A1 TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD 失效
标题翻译：药物设计和筛选方法中的目标蛋白质和目标基因
公开(公告)号：US20100136524A1
公开(公告)日：2010-06-03
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： C12Q1/68 , C07D403/12 , C07D401/12 , C07K14/00 , C12N15/63
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

6. 发明申请

US20090180914A1 Interconnect material and interconnect formation method 审中-公开
标题翻译：互连材料和互连形成方法
公开(公告)号：US20090180914A1
公开(公告)日：2009-07-16
申请号：US12292937
申请日：2008-12-01
申请人： Motoi Tobita , Yusuke Yasuda
发明人： Motoi Tobita , Yusuke Yasuda
IPC分类号： B22F7/00 , B32B15/02
CPC分类号： B22F1/0062 , B22F7/04 , Y10T428/2991
摘要： A metal particle having an organic substance coated thereon, dispersibility that is the same as that of a known metal particle having an organic substance coated thereon, and an improved low temperature connectability. A method for forming interconnect between materials by using the interconnect materials that include a metal particle on which an organic substance is coated, which includes the steps of coating the interconnect materials on subject interconnect materials, and heating the materials at a temperature in the range of 50 to 400° C. for 1 sec to 10 min to form a sintered body made of metal between the subject interconnect materials. The organic substance is a secondary amine having a molecular weight of 250 or less, and the metal particle is made of a unit of silver, copper, or gold, which has a mean diameter of 100 nm or less, or a mixture thereof.
摘要翻译：具有涂布有机物的金属颗粒，其分散性与其上涂覆有有机物质的已知金属颗粒的分散性和改善的低温连接性相同。一种用于通过使用包括其上涂覆有机物质的金属颗粒的互连材料形成材料之间的互连的方法，其包括以下步骤：在物体互连材料上涂布互连材料，并在 50〜400℃，保持1〜10分钟，形成由金属构成的烧结体。有机物质是分子量为250以下的仲胺，金属颗粒由平均直径为100nm以下的银，铜或金的单位或其混合物构成。

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