专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20160060344A1 COMBINATION THERAPY FOR PD-L1 NEGATIVE TUMORS 审中-公开
标题翻译： PD-L1阴性肿瘤的组合治疗
公开(公告)号：US20160060344A1
公开(公告)日：2016-03-03
申请号：US14838650
申请日：2015-08-28
申请人： Rajesh Narwal , Marlon C. Rebelatto , Keith Steele , Paul Robbins , Ross Anthony Stewart , John A. Blake-Haskins , Joyson J. Karakunnel , Ramy Ibrahim , Aiman Shalabi , Alessandra Di Pietro , Li Shi , Shengyan Hong , Paul Stockman , Marc Ballas , Mohammed M. Dar
发明人： Rajesh Narwal , Marlon C. Rebelatto , Keith Steele , Paul Robbins , Ross Anthony Stewart , John A. Blake-Haskins , Joyson J. Karakunnel , Ramy Ibrahim , Aiman Shalabi , Alessandra Di Pietro , Li Shi , Shengyan Hong , Paul Stockman , Marc Ballas , Mohammed M. Dar
IPC分类号： C07K16/28
CPC分类号： C07K16/2827 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2818 , C07K2317/21 , C07K2317/76
摘要： The present invention features methods of treating lung cancer (e.g., NSCLC) with an anti-PD-L1 antibody and tremelimumab in a subject identified as having a PD-L1 negative tumor.
摘要翻译：本发明的特征在于鉴定为具有PD-L1阴性肿瘤的受试者中具有抗PD-L1抗体和tremeimumab治疗肺癌（例如NSCLC）的方法。

2. 发明授权

US09192604B2 Method of administration and treatment 有权
标题翻译：给药和治疗方法
公开(公告)号：US09192604B2
公开(公告)日：2015-11-24
申请号：US14128007
申请日：2012-06-28
申请人： Kurt R. Auger , Mohammed M. Dar , Ronald A. Fleming
发明人： Kurt R. Auger , Mohammed M. Dar , Ronald A. Fleming
IPC分类号： A61K31/4439 , A61K31/535 , G01N33/574
CPC分类号： A61K31/4439 , A61K31/535 , G01N33/57407
摘要： This invention relates to a method of treating cancer in a human in need thereof by determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected.
摘要翻译：本发明涉及通过测定来自人的样品中可检测量的神经纤维瘤蛋白-2（NF2）基因的基因产物的存在或不存在来治疗有需要的人中的癌症的方法，并且向人施用如果没有检测到基因产物或没有同种型1基因产物，则有效量的粘着斑激酶（FAK）抑制剂或其药学上可接受的盐。本发明还涉及在有需要的人中治疗癌症的方法，其包括在来自人的样品中测定可检测量的NF2基因或其功能片段的功能异构体1蛋白质的存在或不存在，如果没有检测到基因产物或没有同种型1基因产物，则向人施用有效量的粘着斑激酶（FAK）抑制剂或其药学上可接受的盐。

3. 发明申请

US20140128434A1 METHOD OF ADMINISTRATION AND TREATMENT 有权
标题翻译：管理和治疗方法
公开(公告)号：US20140128434A1
公开(公告)日：2014-05-08
申请号：US14128007
申请日：2012-06-28
申请人： Kurt R. Auger , Mohammed M. Dar , Ronald A. Fleming
发明人： Kurt R. Auger , Mohammed M. Dar , Ronald A. Fleming
IPC分类号： A61K31/4439
CPC分类号： A61K31/4439 , A61K31/535 , G01N33/57407
摘要： This invention relates to a method of treating cancer in a human in need thereof by determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected.
摘要翻译：本发明涉及通过测定来自人的样品中可检测量的神经纤维瘤蛋白-2（NF2）基因的基因产物的存在或不存在来治疗有需要的人中的癌症的方法，并且向人施用如果没有检测到基因产物或没有同种型1基因产物，则有效量的粘着斑激酶（FAK）抑制剂或其药学上可接受的盐。本发明还涉及在有需要的人中治疗癌症的方法，其包括在来自人的样品中测定可检测量的NF2基因或其功能片段的功能异构体1蛋白质的存在或不存在，如果没有检测到基因产物或没有同种型1基因产物，则向人施用有效量的粘着斑激酶（FAK）抑制剂或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式