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1. 发明授权

US08580307B2 High glass transition temperature absorbable microspheres 有权
标题翻译：高玻璃化转变温度可吸收微球
公开(公告)号：US08580307B2
公开(公告)日：2013-11-12
申请号：US11472830
申请日：2006-06-22
申请人： Dennis D. Jamiolkowski , Modesto Erneta , Robert DiLuccio
发明人： Dennis D. Jamiolkowski , Modesto Erneta , Robert DiLuccio
IPC分类号： A61K9/14
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译：可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。本文还描述了包含这种可吸收微球体的制剂。

2. 发明授权

US07964211B2 Semi-crystalline absorbable microspheres 有权
标题翻译：半结晶可吸收微球
公开(公告)号：US07964211B2
公开(公告)日：2011-06-21
申请号：US12793217
申请日：2010-06-03
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
IPC分类号： A61F2/00 , C08G63/82
CPC分类号： A61L27/58 , A61L27/18 , C08L67/04
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译：本发明涉及可吸收微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自下组的不同的第二单体：乙交酯，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。

3. 发明授权

US07868127B2 Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide 有权
标题翻译：聚（乙氧基乙二醇二乙酸酯）和乙交酯的可吸收共聚酯
公开(公告)号：US07868127B2
公开(公告)日：2011-01-11
申请号：US11693118
申请日：2007-03-29
申请人： Sasa Andjelic , Modesto Erneta , Michel Gensini
发明人： Sasa Andjelic , Modesto Erneta , Michel Gensini
IPC分类号： C08G63/66 , C08G63/02
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.
摘要翻译：包含缩聚聚酯和至少一种内酯的反应产物的半结晶可吸收的共聚酯组合物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。

4. 发明申请

US20090092648A1 ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF 有权
标题翻译：抗微生物聚合物组合物及其用途
公开(公告)号：US20090092648A1
公开(公告)日：2009-04-09
申请号：US11869397
申请日：2007-10-09
申请人： Modesto ERNETA , Joerg PRIEWE
发明人： Modesto ERNETA , Joerg PRIEWE
IPC分类号： A01N25/34 , A61B17/04 , A61B17/064 , A61B17/58 , A61F2/82 , A61K9/14 , C08G69/26 , A01P1/00 , A61K31/765 , C08G63/00 , A61P31/04 , C08G69/44 , C08G63/91 , C08L67/04
CPC分类号： A61L31/06 , A61L31/10 , C08L67/04
摘要： An antimicrobial composition. The antimicrobial composition includes a complex of an anionic polyester with a monomeric amidoamine a complex of an anionic polyester with a monomeric amidoamine or an organic cation, wherein the monomeric amidoamine comprises: (R1,2)N—R3—NH—CO—R4 wherein: R1═H, Alkyl, Aryl, HO—(CH2CH2—O—)n—, MeO—(CH2CH2—O—)n—, HO—(CH2)n—; R2═H, Alkyl, Aryl, HO—(CH2CH2—O—)n—, MeO—(CH2CH2—O—)n—, HO—(CH2)n—; R3=Alkyl, Aryl, —(CH2CH2—O—)—(CH2—)n; R4=Alkyl, Aryl, —(CH2CH2—O—)—(CH2—)n—CH3, —O—CH3, —O—C2H5, —O—C3H7; and n=1-30; and wherein the organic cation comprises: wherein: R1═H, Alkyl, Aryl, HO—(CH2CH2-O—)n-, MeO—(CH2CH2-O—)n-, HO—(CH2)n-; R2═H, Alkyl, Aryl, HO—(CH2CH2-O—)n-, MeO—(CH2CH2-O—)n, HO—(CH2)n-; R3═H, Alkyl, Aryl, —(CH2CH2—O—)—(CH2—)n; R4,5═H, Alkyl, Aryl, —(CH2CH2—O—)—(CH2-)n-CH3, —O—CH3, —O—C2H5, —O—C3H7; and n=1-30; and the anionic polyester is selected from the group consisting of an anionic polyester having at least one carboxylic group, a sulfonic acid polymer, and a phosphoric acid polymer. A medical device having an antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group is also provided.
摘要翻译：抗微生物组合物。抗微生物组合物包括阴离子聚酯与单体酰胺胺的复合物，阴离子聚酯与单体酰氨基胺或有机阳离子的络合物，其中单体酰氨基胺包括：<？在线公式描述=“在线式” （R1,2）N-R3-NH-CO-R4 <β-in-line-formula description =“In-line formula”end =“tail”？>其中：R1-H，烷基，芳基，HO-（CH 2 CH 2 -O-）n-，MeO-（CH 2 CH 2 -O-）n-，HO-（CH 2）n - （CH 2 CH 2 -O-）n-，MeO-（CH 2 CH 2 -O-）n-，HO-（CH 2）n - R3 =烷基，芳基， - （CH2CH2-O - ） - （CH2-）n; R4 =烷基，芳基， - （CH2CH2-O - ） - （CH2-）n-CH3，-O-CH3，-O-C2H5，-O-C3H7; n = 1-30; 并且其中所述有机阳离子包括：其中：R 1 -H，烷基，芳基，HO-（CH 2 CH 2 -O-）n-，MeO-（CH 2 CH 2 -O-）n-，HO-（CH 2） R2-H，烷基，芳基，HO-（CH2CH2-O-）n-，MeO-（CH2CH2-O-）n，HO-（CH2）n-; R3-H，烷基，芳基， - （CH2CH2-O - ） - （CH2-）n; （CH 2 CH 2 -O - ） - （CH 2）n -CH 3，-O-CH 3，-O-C 2 H 5，-O-C 3 H 7， n = 1-30; 阴离子聚酯选自具有至少一个羧基的阴离子聚酯，磺酸聚合物和磷酸聚合物。一种具有抗微生物组合物的医疗装置，其包含阴离子聚酯与具有至少一个酰胺基团和至少一个胺基团的单体酰氨基胺的络合物，其中所述胺基团为伯胺或仲胺，或叔胺胺或季胺或其组合，并且阴离子聚酯还具有至少一个羧基。

5. 发明授权

US07148315B2 Monomer addition techniques to control manufacturing of bioabsorbable copolymers 有权
标题翻译：用于控制生物可吸收性共聚物制造的单体添加技术
公开(公告)号：US07148315B2
公开(公告)日：2006-12-12
申请号：US10278494
申请日：2002-10-23
申请人： Modesto Erneta , Terry E. Lawler
发明人： Modesto Erneta , Terry E. Lawler
IPC分类号： C08G63/06
CPC分类号： C08G63/08 , C08G63/64
摘要： Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.
摘要翻译：提供单体添加方法以调节单体加入聚合反应器的速率。本发明的优点包括生物可吸收共聚物结构的控制，单体转化率的提高，反应温度的控制以及反应时间的缩短。总体结果是改进的过程和增强的产品性能。该技术在具有不同反应性比例的单体如乙交酯/丙交酯共聚物和乙交酯/己内酯共聚物的共聚中是特别有用的。单体反应活性比和反应动力学被用于调节单体添加速率。

6. 发明授权

US4085198A Hydrochlorination of spray dried magnesium chloride 失效
标题翻译：喷雾干燥氯化镁的氢氯化
公开(公告)号：US4085198A
公开(公告)日：1978-04-18
申请号：US641428
申请日：1975-12-17
申请人： Modesto Erneta
发明人： Modesto Erneta
IPC分类号： C01F5/34
CPC分类号： C01F5/34
摘要： Hydrous magnesium chloride in the form of spray dried particulate material of relatively high density is predried, initially using a dry gas at elevated temperature and for a period of time sufficient to partially hydrolyze the magnesium chloride and reduce the chemically combined water to at least as low as about 3.0%, and thereafter hydrochlorinated to reduce the oxides of Mg to at least as low as about 0.6% as MgO.
摘要翻译：预先干燥具有较高密度的喷雾干燥颗粒材料的氯化镁水溶液，最初在高温下使用干燥气体并在足以部分水解氯化镁的时间内将化学结合的水降至至少一样约3.0％，然后氢氯化以将Mg的氧化物还原为至少低至约0.6％作为MgO。

7. 发明申请

US20140134220A1 High-Glass Transition Temperature Absorbable Microspheres 有权
标题翻译：高玻璃化转变温度可吸收微球
公开(公告)号：US20140134220A1
公开(公告)日：2014-05-15
申请号：US14062229
申请日：2013-10-24
申请人： Dennis D. Jamiolkowski , Modesto Erneta , Robert Diluccio
发明人： Dennis D. Jamiolkowski , Modesto Erneta , Robert Diluccio
IPC分类号： A61K8/02 , A61K8/85
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译：可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。本文还描述了包含这种可吸收微球体的制剂。

8. 发明授权

US08691899B2 Antimicrobial polymer compositions and the use thereof 有权
标题翻译：抗微生物聚合物组合物及其用途
公开(公告)号：US08691899B2
公开(公告)日：2014-04-08
申请号：US11869397
申请日：2007-10-09
申请人： Modesto Erneta , Joerg Priewe
发明人： Modesto Erneta , Joerg Priewe
IPC分类号： A61L31/06 , A61K31/16 , C08G63/91 , C08G63/08
CPC分类号： A61L31/06 , A61L31/10 , C08L67/04
摘要： An antimicrobial composition and a medical device having that antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group.
摘要翻译：一种抗微生物组合物和具有该抗微生物组合物的医疗装置，其包含阴离子聚酯与具有至少一个酰胺基团和至少一个胺基团的单体酰氨基胺的络合物，其中所述胺基团为伯胺或仲胺，或叔胺，季胺或其组合，阴离子聚酯具有至少一个羧基。

9. 发明申请

US20130005829A1 Segmented, epsilon-Caprolactone-Rich, Poly(epsilon-Caprolactone-co-p-Dioxanone) Copolymers for Medical Applications and Devices Therefrom 审中-公开
标题翻译：用于医疗应用和器件的分段，ε-己内酯丰富的聚（ε-己内酯 - 共对二恶烷酮）共聚物
公开(公告)号：US20130005829A1
公开(公告)日：2013-01-03
申请号：US13249730
申请日：2011-10-14
申请人： Dennis D. Jamiolkowski , Sasa Andjelic , Modesto Erneta
发明人： Dennis D. Jamiolkowski , Sasa Andjelic , Modesto Erneta
IPC分类号： A61K31/09 , A61P31/04 , C08G63/66 , A61K47/34
CPC分类号： A61L27/18 , A61K31/09 , A61L17/005 , A61L17/105 , A61L17/12 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/56 , A61L31/06 , A61L31/16 , A61L2300/202 , A61L2300/404 , C08G63/08 , C08G63/664 , C08L67/04
摘要： Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.
摘要翻译：公开了用于长期吸收医疗应用的ε-己内酯和对二恶烷酮的新型半结晶，ε-己内酯的嵌段共聚物。新型聚合物组合物可用于长期可吸收外科缝合线和其它医疗器械。还公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。

10. 发明申请

US20080103285A1 ABSORBABLE COPOLYESTERS OF POLY(ETHOXYETHYLENE DIGLYCOLATE) AND GLYCOLIDE 有权
标题翻译：聚（乙氧基乙烯酯）和甘油三酯的可吸收共聚物
公开(公告)号：US20080103285A1
公开(公告)日：2008-05-01
申请号：US11693118
申请日：2007-03-29
申请人： Sasa Andjelic , Modesto Erneta , Michel Gensini
发明人： Sasa Andjelic , Modesto Erneta , Michel Gensini
IPC分类号： C08G63/66
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.
摘要翻译：包含缩聚聚酯和至少一种内酯的反应产物的半结晶可吸收的共聚酯组合物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。

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