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1. 发明授权

US07711493B2 Micropressors, devices and methods for use in analyte monitoring systems 有权
标题翻译：用于分析物监测系统的微压机，装置和方法
公开(公告)号：US07711493B2
公开(公告)日：2010-05-04
申请号：US11270856
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
发明人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
IPC分类号： G06F19/00 , G01N33/66
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于通过利用预测的较慢时间常数（1 / k2）来改善受试者的葡萄糖水平的预测来提高分析物监测装置的性能的方法。在本发明的另一方面，预指数项（1 / c2）可以用于提供信号衰减的校正（例如增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

2. 发明申请

US20070019502A1 Combination vertical and lateral flow immunoassay device 审中-公开
标题翻译：组合垂直和横向流量免疫测定装置
公开(公告)号：US20070019502A1
公开(公告)日：2007-01-25
申请号：US11391981
申请日：2006-03-28
申请人： Timothy Foley , P. Beaty , Michael Walters , Alexander Clark , Dwight Livingston , A. Lentz , Miroslaw Bartkowiak , Daniel Schwartz , Nicholas Bachur
发明人： Timothy Foley , P. Beaty , Michael Walters , Alexander Clark , Dwight Livingston , A. Lentz , Miroslaw Bartkowiak , Daniel Schwartz , Nicholas Bachur
IPC分类号： B01F13/08
CPC分类号： B01F9/0016 , B01F13/0818 , B01F2009/0063 , G01N35/00 , G01N35/028 , G01N2035/00465
摘要： A system comprising one or more sample vessels is provided, the sample vessels comprising a liquid growth medium and a stirrer element, the stirrer element capable of being influenced by a magnetic force, and an incubation and measurement module comprising one or more openings for holding the one or more sample vessels. The incubation and measurement module further comprises at least two drive magnets associated with each of the sample vessels, and a magnet driver adapted to repeatedly move each of the at least two drive magnets toward and away from the surface of the associated sample vessel.
摘要翻译：提供了包括一个或多个样品容器的系统，所述样品容器包括液体生长培养基和搅拌器元件，所述搅拌器元件能够受到磁力的影响，以及培养和测量模块，包括一个或多个开口，用于保持一个或多个样品容器。孵化和测量模块还包括与每个样品容器相关联的至少两个驱动磁体，以及磁体驱动器，其适于将至少两个驱动磁体中的每一个朝向和远离相关联的样品容器的表面移动。

3. 发明申请

US20060074564A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
标题翻译：用于分析物监测系统的微压机，装置和方法
公开(公告)号：US20060074564A1
公开(公告)日：2006-04-06
申请号：US11270856
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于改进分析物监测装置的性能的方法，包括通过利用预测的较慢时间常数（1 / k 2）来预测受试者中的葡萄糖水平，。在本发明的另一方面，可以使用前指数项（1 / c2）来提供信号衰减的校正（例如，增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

4. 发明授权

US5854586A Rare earth doped zinc oxide varistors 失效
标题翻译：稀土掺杂氧化锌压敏电阻
公开(公告)号：US5854586A
公开(公告)日：1998-12-29
申请号：US932948
申请日：1997-09-17
申请人： April D. McMillan , Frank A. Modine , Robert J. Lauf , Mohammad A. Alim , Gerald D. Mahan , Miroslaw Bartkowiak
发明人： April D. McMillan , Frank A. Modine , Robert J. Lauf , Mohammad A. Alim , Gerald D. Mahan , Miroslaw Bartkowiak
IPC分类号： H01C7/112 , H01C7/10
CPC分类号： H01C7/112
摘要： A varistor includes a Bi-free, essentially homogeneous sintered body of a ceramic composition including, expressed as nominal weight %, 0.2-4.0% oxide of at least one rare earth element, 0.5-4.0% Co.sub.3 O.sub.4, 0.05-0.4% K.sub.2 O, 0.05-0.2% Cr.sub.2 O.sub.3, 0-0.2% CaO, 0.00005-0.01% Al.sub.2 O.sub.3, 0-2% MnO, 0-0.05% MgO, 0-0.5% TiO.sub.3, 0-0.2% SnO.sub.2, 0-0.02% B.sub.2 O.sub.3, balance ZnO.
摘要翻译：一种变阻器包括一种陶瓷组合物的Bi-free基本上均匀的烧结体，其包括以标称重量％表示的至少一种稀土元素的氧化物为0.2-4.0％，Co3O4为0.5-4.0％，Co3O4为0.05-0.4％，K2O为0.05 -0.2％Cr 2 O 3，0-0.2％CaO，0.00005-0.01％Al 2 O 3，0-2％MnO，0-0.05％MgO，0-0.5％TiO 3，0-0.2％SnO 2，0-0.02％B 2 O 3，余量ZnO。

5. 发明授权

US08386184B2 Systems and methods for determining an amount of starting reagent using the polymerase chain reaction 有权
标题翻译：使用聚合酶链式反应测定起始试剂的量的系统和方法
公开(公告)号：US08386184B2
公开(公告)日：2013-02-26
申请号：US12196339
申请日：2008-08-22
申请人： Miroslaw Bartkowiak , Richard L. Moore
发明人： Miroslaw Bartkowiak , Richard L. Moore
IPC分类号： G06F19/00 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , G06F19/20
摘要： Systems and methods for calculating an initial amount of target nucleic acid N0 in a sample are provided. A plurality of fluorescent measurements is received. Each respective fluorescent measurement FSn is taken in a different cycle n in a PCR amplification experiment of the sample. Then, a model for the PCR amplification experiment is computed. For each respective fluorescent measurement, the model comprises a respective equation for Nn, where (i) Nn is the calculated amount of the target nucleic acid in cycle n of the corresponding PCR amplification experiment, and (ii) the equation for Nn is expressed in terms of K and N0, where K is the Michaelis-Menton constant. The model can be refined by adjusting K and N0 until differences between model values Nn and corresponding fluorescent measurements are minimized, thereby calculating the initial amount of a target nucleic acid N0 as the minimized value for N0 for the model.
摘要翻译：提供了用于计算样品中目标核酸N0的初始量的系统和方法。接收多个荧光测量。在样品的PCR扩增实验中，各自的荧光测量FSn以不同的周期n进行。然后，计算PCR扩增实验的模型。对于每个相应的荧光测量，该模型包括Nn的相应等式，其中（i）Nn是相应PCR扩增实验的周期n中靶核酸的计算量，（ii）Nn的方程式 K和N0的项，其中K是Michaelis-Menton常数。可以通过调整K和N0来改进模型，直到模型值Nn和相应的荧光测量之间的差异被最小化，从而计算目标核酸N0的初始量作为模型的N0的最小值。

6. 发明授权

US07523004B2 Micropressors, devices and methods for use in analyte monitoring systems 有权
标题翻译：用于分析物监测系统的微压机，装置和方法
公开(公告)号：US07523004B2
公开(公告)日：2009-04-21
申请号：US11270857
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
发明人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于通过利用预测的较慢时间常数（1 / k2）来改善受试者的葡萄糖水平的预测来提高分析物监测装置的性能的方法。在本发明的另一方面，预指数项（1 / c2）可以用于提供信号衰减的校正（例如增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

7. 发明申请

US20060085137A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
公开(公告)号：US20060085137A1
公开(公告)日：2006-04-20
申请号：US11270857
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

8. 发明申请

US20060063218A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
公开(公告)号：US20060063218A1
公开(公告)日：2006-03-23
申请号：US11270063
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00 , C12Q1/54
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

9. 发明授权

US07519478B2 Microprocessors, devices and methods for use in analyte monitoring systems 有权
标题翻译：用于分析物监测系统的微处理器，设备和方法
公开(公告)号：US07519478B2
公开(公告)日：2009-04-14
申请号：US11270063
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
发明人： Miroslaw Bartkowiak , Wesley S. Harper , Eray Kulcu , Matthew J. Lesho , Janet A. Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于通过利用预测的较慢时间常数（1 / k2）来改善受试者的葡萄糖水平的预测来提高分析物监测装置的性能的方法。在本发明的另一方面，预指数项（1 / c2）可以用于提供信号衰减的校正（例如增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

10. 发明申请

US20090068666A1 Systems and Methods for Determining an Amount of Starting Reagent using the Polymerase Chain Reaction 有权
标题翻译：使用聚合酶链反应测定起始试剂量的系统和方法
公开(公告)号：US20090068666A1
公开(公告)日：2009-03-12
申请号：US12196339
申请日：2008-08-22
申请人： Miroslaw Bartkowiak , Richard L. Moore
发明人： Miroslaw Bartkowiak , Richard L. Moore
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , G06F19/20
摘要： Systems and methods for calculating an initial amount of target nucleic acid N0 in a sample are provided. A plurality of fluorescent measurements is received. Each respective fluorescent measurement FSn is taken in a different cycle n in a PCR amplification experiment of the sample. Then, a model for the PCR amplification experiment is computed. For each respective fluorescent measurement, the model comprises a respective equation for Nn, where (i) Nn is the calculated amount of the target nucleic acid in cycle n of the corresponding PCR amplification experiment, and (ii) the equation for Nn is expressed in terms of K and N0, where K is the Michaelis-Menton constant. The model can be refined by adjusting K and N0 until differences between model values Nn and corresponding fluorescent measurements are minimized, thereby calculating the initial amount of a target nucleic acid N0 as the minimized value for N0 for the model.
摘要翻译：提供了用于计算样品中目标核酸N0的初始量的系统和方法。接收多个荧光测量。在样品的PCR扩增实验中，各自的荧光测量FSn以不同的周期n进行。然后，计算PCR扩增实验的模型。对于每个相应的荧光测量，该模型包括Nn的相应等式，其中（i）Nn是相应PCR扩增实验的周期n中靶核酸的计算量，（ii）Nn的方程式 K和N0的项，其中K是Michaelis-Menton常数。可以通过调整K和N0来改进模型，直到模型值Nn和相应的荧光测量值之间的差异最小化，从而计算目标核酸N0的初始量作为模型的N0的最小值。

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