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1. 发明授权

US5879316A Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method 失效
公开(公告)号：US5879316A
公开(公告)日：1999-03-09
申请号：US835662
申请日：1997-04-10
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M37/00
CPC分类号： A61M25/1011 , A61M1/3621 , A61M1/3647 , A61M1/101 , A61M1/1698 , A61M1/3666 , A61M2025/1015 , A61M2025/1052 , A61M25/0067 , A61M25/0069 , A61M25/04
摘要： The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. An aortic balloon catheter is also provided.

2. 发明授权

US5820593A Portable and modular cardiopulmonar bypass apparatus and associated aortic balloon catheter and associated method 失效
标题翻译：便携式和模块化心肺旁路装置及相关的主动脉球囊导管及相关方法
公开(公告)号：US5820593A
公开(公告)日：1998-10-13
申请号：US637861
申请日：1996-04-25
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M29/00
CPC分类号： A61M25/1011 , A61M1/3621 , A61M1/3647 , A61M1/101 , A61M1/1698 , A61M1/3666 , A61M2025/1015 , A61M2025/1052 , A61M25/0067 , A61M25/0069 , A61M25/04
摘要： An aortic balloon catheter including an elongated tube device formed with a first lumen sized to communicate blood between an aortic lumen of an adult human patient and a location external to the aortic lumen. Mounted on the tube device is an inflatable balloon which is sized to resist or block blood flow through the aortic lumen. The associated method of using the aortic balloon catheter includes introducing the catheter into the aortic lumen of an adult human, positioning the first lumen and the balloon, inflating the balloon and withdrawing and perfusing fluids through the first lumen.
摘要翻译：主动脉球囊导管，其包括细长管装置，其形成有第一腔，其尺寸设计成在成人患者的主动脉腔和主动脉腔外部的位置之间传送血液。安装在管装置上的是可膨胀的气囊，其尺寸适于抵抗或阻断通过主动脉腔的血液流动。使用主动脉球囊导管的相关方法包括将导管引入成人的主动脉腔内，定位第一腔和球囊，使气囊膨胀并且通过第一腔排出和灌注流体。

3. 发明授权

US06475186B1 Cardiopulmonary bypass system 失效
标题翻译：心肺分流系统
公开(公告)号：US06475186B1
公开(公告)日：2002-11-05
申请号：US09749987
申请日：2000-12-26
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61M2900
CPC分类号： A61M25/1011 , A61M1/1006 , A61M1/101 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1074 , A61M1/1086 , A61M1/125 , A61M1/1698 , A61M1/3621 , A61M1/3647 , A61M1/3666 , A61M25/0067 , A61M25/0069 , A61M25/04 , A61M2025/1015 , A61M2025/1052 , A61M2205/3334
摘要： A cardiopulmonary bypass system includes an aortic balloon cannula and a fluid flow cannula configured for connection to a cardiopulmonary bypass pump. The aortic balloon cannula includes an elongated tube device with first and second inflatable balloons mounted on the tube device and first and second lumen sized to communicate blood from the cardiopulmonary bypass pump to the patient's aorta. The cardiopulmonary bypass pump is configured to selectively deliver blood to the patient through the aortic balloon cannula and/or the fluid flow cannula at first, second and third temperatures.
摘要翻译：体外循环系统包括主动脉球囊插管和构造成连接到心肺旁路泵的流体流动套管。主动脉球囊插管包括细长管装置，其具有安装在管装置上的第一和第二可膨胀囊，并且第一和第二管腔的尺寸适于将来自心肺旁路泵的血液传送到患者主动脉。心肺旁路泵构造成在第一，第二和第三温度下通过主动脉球囊套管和/或流体流动套管选择性地将血液输送给患者。

4. 发明授权

US5308320A Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method 失效
标题翻译：便携式和模块化的心肺旁路装置及相关的主动脉球囊导管及相关方法
公开(公告)号：US5308320A
公开(公告)日：1994-05-03
申请号：US637565
申请日：1990-12-28
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M1/14
CPC分类号： A61M25/1011 , A61M1/3621 , A61M1/3647 , A61M1/101 , A61M1/1698 , A61M1/3666 , A61M2025/1015 , A61M2025/1052 , A61M25/0067 , A61M25/0069 , A61M25/04
摘要： The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. An aortic balloon catheter is also provided.
摘要翻译：便携式和模块化的心肺旁路装置已经满足上述需要。该装置包括：（i）用于从患者抽出血液的第一套管组合装置，（ii）连接到第一插管组件装置的泵装置，用于接收抽出的血液并使血液移动通过装置;以及（iii）连接到泵装置的第一管道装置，以将患者的血液从泵装置输送。该设备还包括（iv）用于从第一管道装置接收血液并使血液充氧的氧合器装置和（v）连接到氧合器装置以将含氧血液返回给患者的第二插管组件装置。该装置是便携式的，使得它可以由医务人员在任何地方使用。此外，该装置适于包括用于调节血液的一个或多个模块，例如包括热交换器，血液净化器，血浆和血细胞单采装置等的模块。还提供主动脉球囊导管。

5. 发明授权

US6165162A Method of using aortic balloon catheter 失效
标题翻译：使用主动脉球囊导管的方法
公开(公告)号：US6165162A
公开(公告)日：2000-12-26
申请号：US152589
申请日：1998-09-14
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M31/00
CPC分类号： A61M25/1011 , A61M1/1006 , A61M1/101 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1074 , A61M1/1086 , A61M1/125 , A61M1/1698 , A61M1/3621 , A61M1/3647 , A61M1/3666 , A61M25/0067 , A61M25/0069 , A61M25/04 , A61M2025/1015 , A61M2025/1052 , A61M2205/3334
摘要： What is disclosed is a portable and modular cardiopulmonary bypass apparatus and method. The apparatus includes (i) a first cannula assembly for withdrawing blood from a patient, (ii) a pump connected to the first cannula assembly for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing connected to the pump to transport the patient's blood away from the pump. The apparatus also includes (iv) an oxygenator for receiving blood from the first tubing and for oxygenating the blood and (v) a second cannula assembly connected to the oxygenator for returning the oxygenated blood to the patient. The apparatus may be portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to included one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. An aortic balloon catheter is also provided.
摘要翻译：所公开的是便携式和模块化的心肺旁路装置和方法。该装置包括（i）用于从患者抽出血液的第一插管组件，（ii）连接到第一插管组件的泵，用于接收所抽取的血液并使血液移动通过装置，以及（iii）连接第一管到泵上运送患者的血液远离泵。所述装置还包括（ⅳ）用于从第一管接收血液并使血液充氧的an oxygen and and and））。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。该装置可以是便携式的，使得其可以由医务人员在任何地方使用。此外，该装置适于包括用于调节血液的一个或多个模块，例如包括热交换器，血液净化器，血浆和血细胞单采装置等的模块。还提供主动脉球囊导管。

6. 发明授权

US5906588A Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon and associated method 失效
标题翻译：便携式和模块化的心肺旁路装置及相关主动脉球囊及相关方法
公开(公告)号：US5906588A
公开(公告)日：1999-05-25
申请号：US909380
申请日：1997-08-11
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M31/00
CPC分类号： A61M25/1011 , A61M1/3621 , A61M1/3647 , A61M1/101 , A61M1/1698 , A61M1/3666 , A61M2025/1015 , A61M2025/1052 , A61M25/0067 , A61M25/0069 , A61M25/04
摘要： The selective and differential perfusion method includes withdrawing blood through a cannula introduced into a patient's blood vessel. The temperature of such blood is controlled and flowed through an arterial cannula introduced into a selected arterial vessel of the patient for a sufficient time and at a sufficient flow rate to change the temperature of at least a portion of the patient's body. An aortic balloon catheter is introduced into the aorta of the patient to establish fluid communication through the catheter lumen between an external location and an aortic location which is disposed in a preferential flow relationship with a selected branch artery of the aorta leading to a selected region of the patient's body. A balloon mounted on the exterior of said aortic catheter is positioned at a balloon location spaced longitudinally from the aortic location and inflated to resist blood flow while a fluid is communicated through the catheter lumen between the external location and the aortic location. The aortic balloon catheter may further include a second lumen introduced into the aorta to establish a preferential flow relationship with a second branch artery leading to a second region of the patient's body and wherein the balloon location is disposed between the selected branch artery and the second branch artery.
摘要翻译：选择性和差异性灌注方法包括通过引入患者血管的套管取出血液。这种血液的温度被控制并通过引入患者的选定动脉血管的动脉插管充足的时间和足够的流速来改变患者身体的至少一部分的温度。主动脉球囊导管被引入患者的主动脉以在外部位置和主动脉位置之间通过导管腔建立流体连通，所述外部位置和主动脉位置以与主动脉的选定分支动脉优先流动关系设置，病人的身体。安装在所述主动脉导管的外部的球囊定位在与主动脉位置纵向间隔开的气囊位置处，并且在流体在外部位置和主动脉位置之间通过导管腔连通时充气以抵抗血液流动。主动脉球囊导管还可包括引入主动脉的第二腔，以与通向患者身体的第二区域的第二分支动脉建立优先流动关系，并且其中球囊位置设置在所选择的分支动脉和第二分支动脉。

7. 发明授权

US5383854A Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method 失效
标题翻译：便携式和模块化的心肺旁路装置及相关的主动脉球囊导管及相关方法
公开(公告)号：US5383854A
公开(公告)日：1995-01-24
申请号：US932212
申请日：1992-08-19
申请人： Peter Safar , S. William Stezoski , Miroslav Klain
发明人： Peter Safar , S. William Stezoski , Miroslav Klain
IPC分类号： A61F2/958 , A61M1/10 , A61M1/16 , A61M1/36 , A61M25/00 , A61M25/04 , A61M29/00
CPC分类号： A61M25/1011 , A61M1/3621 , A61M1/3647 , A61M1/101 , A61M1/1698 , A61M1/3666 , A61M2025/1015 , A61M2025/1052 , A61M25/0067 , A61M25/0069 , A61M25/04
摘要： The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. An aortic balloon catheter is also provided.
摘要翻译：便携式和模块化的心肺旁路装置已经满足上述需要。该装置包括：（i）用于从患者抽出血液的第一套管组合装置，（ii）连接到第一插管组件装置的泵装置，用于接收抽出的血液并使血液移动通过装置;以及（iii）连接到泵装置的第一管道装置，以将患者的血液从泵装置输送。该设备还包括（iv）用于从第一管道装置接收血液并使血液充氧的氧合器装置和（v）连接到氧合器装置以将含氧血液返回给患者的第二插管组件装置。该装置是便携式的，使得它可以由医务人员在任何地方使用。此外，该装置适于包括用于调节血液的一个或多个模块，例如包括热交换器，血液净化器，血浆和血细胞单采装置等的模块。还提供主动脉球囊导管。

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