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1. 发明授权

US07201890B2 Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy 失效
标题翻译：术中，血管内和内镜下肿瘤和病变检测，活检及治疗
公开(公告)号：US07201890B2
公开(公告)日：2007-04-10
申请号：US10086637
申请日：2002-03-04
申请人： Milton D. Goldenberg
发明人： Milton D. Goldenberg
IPC分类号： A61K51/00 , A61K39/00
CPC分类号： A61K49/0058 , A61K47/6898 , A61K49/0036 , A61K51/1048 , A61K51/1072 , A61K51/1093 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions with photodynamic agents and methods of treating lesions with a protein conjugated to an agent capable of being activated to emit Auger electron or other ionizing radiation. Compositions and kits useful in the above methods are also provided.
摘要翻译：提供方法用于近距离术中，内窥镜和血管内检测和治疗病变，包括肿瘤和非恶性病变。该方法使用用同位素和非同位素标记的抗体片段或亚片段。还提供了用光动力学试剂检测和治疗病变的方法以及用能够被活化以发射俄歇电子或其他电离辐射的药物缀合的蛋白质处理病变的方法。还提供了在上述方法中有用的组合物和试剂盒。

2. 发明授权

US5439665A Detection and treatment of infectious and inflammatory lesions 失效
标题翻译：检测和治疗感染性和炎症性病变
公开(公告)号：US5439665A
公开(公告)日：1995-08-08
申请号：US777499
申请日：1991-10-17
申请人： Hans J. Hansen , Milton D. Goldenberg
发明人： Hans J. Hansen , Milton D. Goldenberg
IPC分类号： A61K47/48 , A61K51/10 , A61K51/00 , A61K39/44
CPC分类号： A61K47/48546 , A61K51/1018 , A61K2123/00
摘要： A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types.A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate.A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent and/or radionuclide.A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.
摘要翻译：用于靶向白细胞增生灶的多特异性抗白细胞抗体缀合物包含与至少一种成像剂缀合的至少两种不同的基本单特异性抗体或抗体片段的免疫反应性多特异性复合物，其中至少两种所述抗体或抗体片段特异性结合到不同的白细胞类型。用于将成像剂靶向炎性或感染性病变的方法包括以有效量肠胃外注射哺乳动物以靶向上述抗白细胞成像缀合物。用于靶向白细胞吸积灶的治疗性抗白细胞抗体 - 试剂缀合物包含与至少一种治疗性抗微生物剂和/或放射性核素缀合的至少一种特异性结合至少一种白细胞类型的免疫反应性基本上单特异性抗体或抗体片段。治疗感染性病变的方法包括用有效量的胃肠外注射哺乳动物治疗上述抗白细胞治疗缀合物。

3. 发明授权

US5057313A Diagnostic and therapeutic antibody conjugates 失效
标题翻译：诊断和治疗性抗体缀合物
公开(公告)号：US5057313A
公开(公告)日：1991-10-15
申请号：US309204
申请日：1988-08-23
申请人： Lisa B. Shih , Frederick J. Primus , Milton D. Goldenberg
发明人： Lisa B. Shih , Frederick J. Primus , Milton D. Goldenberg
IPC分类号： A61K47/48 , A61K49/08 , A61K51/10
CPC分类号： A61K49/128 , A61K47/48692 , A61K49/085 , A61K49/16 , A61K51/1093 , A61K2123/00
摘要： The present invention relates to conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as an aminodextran or a polypeptide of at least 50 amino acids in length, and this intermediate is in turn site-specifically conjugated to a targeting antibody such as an antitumor antibody. The resultant conjugate substantially retains the immunoreactivity of the antibody, and targets the diagnostic or therapeutic principle to a target tissue or organ where the diagnostic or therapeutic effect is realized.
摘要翻译： PCT No.PCT / US87 / 00406 Sec。 371日期1988年8月23日 102（e）1988年8月23日PCT 1987年2月25日PCT。本发明涉及诊断或治疗原理如药物，毒素，螯合剂，硼化合物和可检测标记物与抗体的缀合物，其中首先将诊断或治疗原理加载到聚合物载体上，例如长度为至少50个氨基酸的氨基葡聚糖或多肽，并且该中间体又与靶向抗体如抗肿瘤抗体位点特异性缀合。所得到的缀合物基本上保留抗体的免疫反应性，并将诊断或治疗原理靶向实现诊断或治疗效果的靶组织或器官。

4. 发明授权

US4818709A CEA-family antigens, Anti-CEA antibodies and CEA immunoassay 失效
标题翻译： CEA家族抗原，抗CEA抗体和CEA免疫测定
公开(公告)号：US4818709A
公开(公告)日：1989-04-04
申请号：US65355
申请日：1987-01-12
申请人： Frederick J. Primus , Milton D. Goldenberg
发明人： Frederick J. Primus , Milton D. Goldenberg
IPC分类号： C07K16/30 , G01N33/574 , G01N33/543 , C07K15/04 , G01N33/577
CPC分类号： G01N33/57473 , C07K16/30
摘要： Antibodies specific to specific CEA epitopes and epitopes of CEA-cross-reactive antigens are provided. Methods of use of these antibodies and purified CEA antigens and cross-reactive antigens are also provided.
摘要翻译：提供了对CEA交叉反应性抗原的特异性CEA表位和表位特异的抗体。还提供了使用这些抗体和纯化的CEA抗原和交叉反应性抗原的方法。

5. 发明授权

US4699784A Tumoricidal methotrexate-antibody conjugate 失效
标题翻译：抗肿瘤甲氨蝶呤 - 抗体缀合物
公开(公告)号：US4699784A
公开(公告)日：1987-10-13
申请号：US833204
申请日：1986-02-25
申请人： Lisa B. Shih , Frederick J. Primus , Milton D. Goldenberg
发明人： Lisa B. Shih , Frederick J. Primus , Milton D. Goldenberg
IPC分类号： G01N33/531 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K49/00 , A61K49/08 , A61K51/00 , A61K51/10 , C07K1/113 , C07K14/00 , C07K14/415 , C07K16/00 , C07K17/08 , C07K17/10 , C07K19/00 , G01N33/532 , G01N33/543 , G01N33/548 , G01N33/574 , A61K31/705 , C07K15/00
CPC分类号： A61K49/16 , A61K47/48692 , A61K49/085 , A61K49/128 , A61K51/1093 , A61K2123/00 , Y10S530/809
摘要： A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.
摘要翻译：通过将甲氨蝶呤加载到氨基葡聚糖上，然后使用还原的席夫碱连接将聚合物载体特异性地缀合到抗肿瘤抗体的碳水化合物部分来制备甲氨蝶呤与抗体的缀合物。该缀合物可用于肿瘤靶向治疗。

6. 发明授权

US4444744A Tumor localization and therapy with labeled antibodies to cell surface antigens 失效
标题翻译：用细胞表面抗原标记的抗体进行肿瘤定位和治疗
公开(公告)号：US4444744A
公开(公告)日：1984-04-24
申请号：US414729
申请日：1982-09-03
申请人： Milton D. Goldenberg
发明人： Milton D. Goldenberg
IPC分类号： A61K38/00 , A61K51/10 , C07K16/30 , A61K43/00 , A61K49/00
CPC分类号： C07K16/3007 , A61K51/1048 , A61K2121/00 , A61K2123/00 , A61K38/00 , Y10S436/804 , Y10S436/813
摘要： Improved methods are provided for using radiolabeled antibodies to tumor cell surface antigens to locate, diagnose and stage tumors having such antigens on their cell surfaces by external photoscanning, whereby significantly increased resolution, convenience and/or efficiency of operation may be achieved. A method is provided for using highly specific radiolabeled antibodies to cell surface antigens for tumor therapy. Radiolabeled antibodies and injectable compositions containing them are provided for use in the method of the invention.
摘要翻译：提供了改进的方法来使用放射性标记的抗体对肿瘤细胞表面抗原定位，诊断和分期在其细胞表面上具有这种抗原的肿瘤通过外部照相扫描，由此可以实现明显增加的分辨率，方便性和/或操作效率。提供了一种使用高度特异性的放射性标记的抗体作为肿瘤治疗的细胞表面抗原的方法。提供放射性标记的抗体和含有它们的可注射组合物用于本发明的方法。

7. 发明授权

US4361544A Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers 失效
标题翻译：肿瘤定位和用细胞内肿瘤相关标志物特异标记的抗体治疗
公开(公告)号：US4361544A
公开(公告)日：1982-11-30
申请号：US126261
申请日：1980-03-03
申请人： Milton D. Goldenberg
发明人： Milton D. Goldenberg
IPC分类号： A61K38/00 , A61K51/10 , C07K16/30 , A61K49/00 , A61K43/00
CPC分类号： C07K16/3007 , A61K51/1048 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Methods are provided for using radiolabeled antibodies specific to intracellular tumor-associated markers for detection, locatization and therapy of tumors. Antibodies and injectable compositions for use in the methods of the invention are also provided.
摘要翻译：提供了使用放射性标记的细胞内肿瘤相关标志物特异性检测，定位和治疗肿瘤的方法。还提供了用于本发明方法的抗体和可注射组合物。

8. 发明授权

US4331647A Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers 失效
标题翻译：用肿瘤相关标志物特异性标记的抗体片段进行肿瘤定位和治疗
公开(公告)号：US4331647A
公开(公告)日：1982-05-25
申请号：US126263
申请日：1980-03-03
申请人： Milton D. Goldenberg
发明人： Milton D. Goldenberg
IPC分类号： A61K38/00 , A61K51/10 , C07K16/30 , A61K49/00 , A61K43/00
CPC分类号： C07K16/3007 , A61K51/1048 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Methods are provided for using radiolabeled antibody fragments specific to tumor-associated markers for detection, localization and therapy of tumors. Mixtures of labeled fragments with varied specificity or multivalent hybrid fragments permit detection and localization of more than one tumor or tumor cell type. Antibodies and injectable compositions for use in the methods of the invention are also provided.
摘要翻译：提供了使用肿瘤相关标志物特异性的放射性标记抗体片段进行肿瘤检测，定位和治疗的方法。具有不同特异性或多价杂交片段的标记片段的混合物允许检测和定位多于一种肿瘤或肿瘤细胞类型。还提供了用于本发明方法的抗体和可注射组合物。

9. 发明授权

US4925648A Detection and treatment of infectious and inflammatory lesions 失效
标题翻译：检测和治疗感染性和炎症性病变
公开(公告)号：US4925648A
公开(公告)日：1990-05-15
申请号：US226180
申请日：1988-07-29
申请人： Hans J. Hansen , Milton D. Goldenberg
发明人： Hans J. Hansen , Milton D. Goldenberg
IPC分类号： A61K9/08 , A61K39/395 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P43/00 , C12P21/08
CPC分类号： A61K47/48546 , A61K51/1018 , A61K2123/00 , Y10S530/866
摘要： A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types.A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate.A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent.A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.

10. 发明授权

US4348376A Tumor localization and therapy with labeled anti-CEA antibody 失效
标题翻译：肿瘤定位和标记抗CEA抗体治疗
公开(公告)号：US4348376A
公开(公告)日：1982-09-07
申请号：US126262
申请日：1980-03-03
申请人： Milton D. Goldenberg
发明人： Milton D. Goldenberg
IPC分类号： A61K38/00 , A61K51/10 , C07K16/30 , A61K49/00
CPC分类号： C07K16/3007 , A61K51/1048 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Improved methods are provided for using radiolabeled antibodies to carcinoembronic antigen (CEA) to locate, diagnose and stage CEA-containing tumors by external photoscanning, whereby significantly increased resolution, convenience and/or efficiency of operation may be achieved. A method is provided for using highly specific radiolabeled anti-CEA antibodies for tumor therapy. An injectable composition and radiolabeled antibodies are provided for use in the method of the invention.
摘要翻译：提供了改进的方法来使用放射性标记抗癌抗原（CEA）的抗体来定位，诊断和通过外部照片扫描来定位含CEA的肿瘤，由此可以实现显着增加的分辨率，方便性和/或操作效率。提供了一种使用高度特异性放射性标记的抗CEA抗体进行肿瘤治疗的方法。提供可注射组合物和放射性标记的抗体用于本发明的方法。

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