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1. 发明授权

US08962256B2 Surface-assisted hemagglutination and hemagglutination inhibition assays 有权
标题翻译：表面辅助血细胞凝集和血细胞凝集抑制试验
公开(公告)号：US08962256B2
公开(公告)日：2015-02-24
申请号：US12908211
申请日：2010-10-20
申请人： Anatoly Kachurin , Vaughan Wittman , Mike N. Nguyen , Olga Kachurina , Tenekua Tapia , Vipra Dhir , Alexander Karol
发明人： Anatoly Kachurin , Vaughan Wittman , Mike N. Nguyen , Olga Kachurina , Tenekua Tapia , Vipra Dhir , Alexander Karol
IPC分类号： G01N33/53 , G01N33/555 , G01N33/569 , G01N33/543
CPC分类号： G01N33/56983 , G01N33/54353 , G01N33/54393 , G01N33/555
摘要： Hemagglutination (HA) and hemagglutination inhibition (HAI) functional assays remain important instruments of analysis of virus-cell interaction and protecting efficacy of virus-specific antibodies and sera. However, they demonstrate limited sensitivity towards many viruses, and require significant volumes of viruses, erythrocytes, sera, and antibodies. The present invention comprises new and significantly more sensitive versions of the HA and HAI assays based on observing agglutination on activated surfaces of specifically opsonized plates and ELISA plates rather than in solution. A version of the new assay that uses ELISA plates additionally allows characterizing the affinity of functional antibodies in the tested sera and fluids, which is not possible in the classical HAI assay. The methods of the present invention can also be used to improve the sensitivity of agglutination methods based on latex beads and to develop agglutination methods using target cells other than erythrocytes.
摘要翻译：血细胞凝集（HA）和血细胞凝集抑制（HAI）功能测定仍然是分析病毒 - 细胞相互作用和保护病毒特异性抗体和血清功效的重要手段。然而，它们对许多病毒的敏感性有限，并且需要大量的病毒，红细胞，血清和抗体。本发明包括基于观察特异性调理板和ELISA板的活化表面上的凝集而不是在溶液中的HA和HAI测定的新的和显着更敏感的版本。使用ELISA板的新测定版本另外允许表征所测试的血清和液体中功能性抗体的亲和力，这在经典的HAI测定中是不可能的。本发明的方法也可用于提高基于乳胶珠的凝集方法的灵敏度，并且使用除了红细胞以外的靶细胞产生凝集方法。

2. 发明授权

US08547739B2 Methods, devices, and systems relating to a memory cell having a floating body 有权
标题翻译：与具有浮体的存储单元相关的方法，装置和系统
公开(公告)号：US08547739B2
公开(公告)日：2013-10-01
申请号：US13403596
申请日：2012-02-23
申请人： Sanh D. Tang , Mike N. Nguyen
发明人： Sanh D. Tang , Mike N. Nguyen
IPC分类号： G11C11/34
CPC分类号： H01L27/10802 , H01L27/1203 , H01L29/66833 , H01L29/7841
摘要： Methods, devices, and systems are disclosed for a memory cell having a floating body. A memory cell may include a transistor over an insulation layer, the transistor including a source, and a drain. The memory cell may also include a floating body including a first region positioned between the source and the drain, a second region positioned remote from each of the source and drain, and a passage extending through the insulation layer and coupling the first region to the second region. Additionally, the memory cell may include a bias gate at least partially surrounding the second region and configured for operably coupling to a bias voltage. Furthermore, the memory cell may include a plurality of dielectric layers, wherein each outer vertical surface of the second region has a dielectric layer of the plurality adjacent thereto.
摘要翻译：公开了具有浮体的存储单元的方法，装置和系统。存储单元可以包括绝缘层上的晶体管，晶体管包括源极和漏极。存储单元还可以包括浮动体，其包括位于源极和漏极之间的第一区域，远离源极和漏极中的每一个定位的第二区域，以及延伸穿过绝缘层并且将第一区域耦合到第二区域的第二区域地区。另外，存储单元可以包括至少部分地围绕第二区域并被配置为可操作地耦合到偏置电压的偏置栅极。此外，存储单元可以包括多个电介质层，其中第二区域的每个外部垂直表面具有与其相邻的多个电介质层。

3. 发明授权

US08148780B2 Devices and systems relating to a memory cell having a floating body 有权
标题翻译：与具有浮体的存储单元有关的装置和系统
公开(公告)号：US08148780B2
公开(公告)日：2012-04-03
申请号：US12410207
申请日：2009-03-24
申请人： Sanh D. Tang , Mike N. Nguyen
发明人： Sanh D. Tang , Mike N. Nguyen
IPC分类号： H01L27/12
CPC分类号： H01L27/10802 , H01L27/1203 , H01L29/66833 , H01L29/7841
摘要： Methods, devices, and systems are disclosed for a memory cell having a floating body. A memory cell may include a transistor over an insulation layer, the transistor including a source, and a drain. The memory cell may also include a floating body including a first region positioned between the source and the drain, a second region positioned remote from each of the source and drain, and a passage extending through the insulation layer and coupling the first region to the second region. Additionally, the memory cell may include a bias gate at least partially surrounding the second region and configured for operably coupling to a bias voltage. Furthermore, the memory cell may include a plurality of dielectric layers, wherein each outer vertical surface of the second region has a dielectric layer of the plurality adjacent thereto.
摘要翻译：公开了具有浮体的存储单元的方法，装置和系统。存储单元可以包括绝缘层上的晶体管，晶体管包括源极和漏极。存储单元还可以包括浮动体，其包括位于源极和漏极之间的第一区域，远离源极和漏极中的每一个定位的第二区域，以及延伸穿过绝缘层并且将第一区域耦合到第二区域的第二区域地区。另外，存储单元可以包括至少部分地围绕第二区域并被配置为可操作地耦合到偏置电压的偏置栅极。此外，存储单元可以包括多个电介质层，其中第二区域的每个外部垂直表面具有与其相邻的多个电介质层。

4. 发明申请

US20120147681A1 METHODS, DEVICES, AND SYSTEMS RELATING TO A MEMORY CELL HAVING A FLOATING BODY 有权
标题翻译：与具有浮动体的记忆体相关的方法，装置和系统
公开(公告)号：US20120147681A1
公开(公告)日：2012-06-14
申请号：US13403596
申请日：2012-02-23
申请人： Sanh D. Tang , Mike N. Nguyen
发明人： Sanh D. Tang , Mike N. Nguyen
IPC分类号： G11C7/00 , H01L21/336
CPC分类号： H01L27/10802 , H01L27/1203 , H01L29/66833 , H01L29/7841
摘要： Methods, devices, and systems are disclosed for a memory cell having a floating body. A memory cell may include a transistor over an insulation layer, the transistor including a source, and a drain. The memory cell may also include a floating body including a first region positioned between the source and the drain, a second region positioned remote from each of the source and drain, and a passage extending through the insulation layer and coupling the first region to the second region. Additionally, the memory cell may include a bias gate at least partially surrounding the second region and configured for operably coupling to a bias voltage. Furthermore, the memory cell may include a plurality of dielectric layers, wherein each outer vertical surface of the second region has a dielectric layer of the plurality adjacent thereto.
摘要翻译：公开了具有浮体的存储单元的方法，装置和系统。存储单元可以包括绝缘层上的晶体管，晶体管包括源极和漏极。存储单元还可以包括浮动体，其包括位于源极和漏极之间的第一区域，远离源极和漏极中的每一个定位的第二区域，以及延伸穿过绝缘层并且将第一区域耦合到第二区域的第二区域地区。另外，存储单元可以包括至少部分地围绕第二区域并被配置为可操作地耦合到偏置电压的偏置栅极。此外，存储单元可以包括多个电介质层，其中第二区域的每个外部垂直表面具有与其相邻的多个电介质层。

5. 发明申请

US20100246285A1 METHODS, DEVICES, AND SYSTEMS RELATING TO A MEMORY CELL HAVING A FLOATING BODY 有权
标题翻译：与具有浮动体的记忆体相关的方法，装置和系统
公开(公告)号：US20100246285A1
公开(公告)日：2010-09-30
申请号：US12410207
申请日：2009-03-24
申请人： Sanh D. Tang , Mike N. Nguyen
发明人： Sanh D. Tang , Mike N. Nguyen
IPC分类号： G11C7/00 , H01L27/12 , H01L21/84
CPC分类号： H01L27/10802 , H01L27/1203 , H01L29/66833 , H01L29/7841
摘要： Methods, devices, and systems are disclosed for a memory cell having a floating body. A memory cell may include a transistor over an insulation layer and including a source, and a drain. The memory cell may also include a floating body including a first region positioned between the source and the drain, a second region positioned remote from each of the source and drain, and a passage and extending through the insulation layer and coupling the first region to the second region. Additionally, the memory cell includes a bias gate at least partially surrounding the second region and configured for operably coupling to a bias voltage. Furthermore, the memory cell may include a plurality of dielectric layers, wherein each outer vertical surface of the second region has a dielectric layer of the plurality adjacent thereto.
摘要翻译：公开了具有浮体的存储单元的方法，装置和系统。存储单元可以包括绝缘层上的晶体管，并且包括源极和漏极。存储单元还可以包括浮动体，其包括位于源极和漏极之间的第一区域，远离源极和漏极中的每一个定位的第二区域，以及通过并延伸穿过绝缘层的第二区域，并将第一区域耦合到第二区。另外，存储器单元包括偏置栅极，至少部分地围绕第二区域并被配置为可操作地耦合到偏置电压。此外，存储单元可以包括多个电介质层，其中第二区域的每个外部垂直表面具有与其相邻的多个电介质层。

6. 发明申请

US20110097705A1 Surface-assisted hemagglutination and hemagglutination inhibition assays 有权
标题翻译：表面辅助血细胞凝集和血细胞凝集抑制试验
公开(公告)号：US20110097705A1
公开(公告)日：2011-04-28
申请号：US12908211
申请日：2010-10-20
申请人： Anatoly Kachurin , Vaughan Wittman , Mike N. Nguyen , Olga Kachurina , Tenekua Tapia , Vipra Dhir , Alexander Karol
发明人： Anatoly Kachurin , Vaughan Wittman , Mike N. Nguyen , Olga Kachurina , Tenekua Tapia , Vipra Dhir , Alexander Karol
IPC分类号： C12Q1/70 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/54353 , G01N33/54393 , G01N33/555
摘要： Hemagglutination (HA) and hemagglutination inhibition (HAI) functional assays remain important instruments of analysis of virus-cell interaction and protecting efficacy of virus-specific antibodies and sera. However, they demonstrate limited sensitivity towards many viruses, and require significant volumes of viruses, erythrocytes, sera, and antibodies. The present invention comprises new and significantly more sensitive versions of the HA and HAI assays based on observing agglutination on activated surfaces of specifically opsonized plates and ELISA plates rather than in solution. A version of the new assay that uses ELISA plates additionally allows characterizing the affinity of functional antibodies in the tested sera and fluids, which is not possible in the classical HAI assay. The methods of the present invention can also be used to improve the sensitivity of agglutination methods based on latex beads and to develop agglutination methods using target cells other than erythrocytes.
摘要翻译：血细胞凝集（HA）和血细胞凝集抑制（HAI）功能测定仍然是分析病毒 - 细胞相互作用和保护病毒特异性抗体和血清功效的重要手段。然而，它们对许多病毒的敏感性有限，并且需要大量的病毒，红细胞，血清和抗体。本发明包括基于观察特异性调理板和ELISA板的活化表面上的凝集而不是在溶液中的HA和HAI测定的新的和显着更敏感的版本。使用ELISA板的新测定版本另外允许表征所测试的血清和液体中功能性抗体的亲和力，这在经典的HAI测定中是不可能的。本发明的方法也可用于提高基于乳胶珠的凝集方法的灵敏度，并且使用除了红细胞以外的靶细胞产生凝集方法。

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