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1. 发明授权

US07064823B2 Consumable tube for use with a flow cytometry-based hematology system 有权
公开(公告)号：US07064823B2
公开(公告)日：2006-06-20
申请号：US10159944
申请日：2002-05-31
申请人： John W. Roche , W. Peter Hansen , Michelle L. Coleman , Harold R. Crews
发明人： John W. Roche , W. Peter Hansen , Michelle L. Coleman , Harold R. Crews
IPC分类号： G01N1/10 , G01N21/00
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.

2. 再颁专利

USRE42143E1 Consumable tube for use with a flow cytometry-based hematology system 有权
标题翻译：用于流式细胞仪的血液系统的消耗管
公开(公告)号：USRE42143E1
公开(公告)日：2011-02-15
申请号：US11714721
申请日：2007-03-06
申请人： John W. Roche , Peter W. Hansen , Michelle L. Coleman , Harold R. Crews
发明人： John W. Roche , Peter W. Hansen , Michelle L. Coleman , Harold R. Crews
IPC分类号： G01N1/10 , G01N21/00
CPC分类号： H04L25/063 , G01N1/38 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N35/1095 , G01N2015/0069 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493
摘要： The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.
摘要翻译：本发明是用于分析生物样品，特别是全血或血液衍生样品的基于流式细胞术的血液学系统。该系统能够从全血样品中确定至少一个完整的血细胞计数（CBC），五部分白细胞差异和网织红细胞计数。该系统优选使用发射细束以照射流动池中的细胞的激光二极管和无透镜光学检测系统，以测量轴向光损失，低角度前向散射光，高角度前向散射光，右角散射光和由细胞产生的飞行时间测量。透镜式光学检测系统不包含除光反应元件之外的光学部件，并且不包括任何移动部件。最后，该系统使用独特的消耗性试剂管系统作为反应室，混合室和废液室进行血液样品分析。消耗品管包含参考颗粒，其作为内部标准，以确保样品处理过程中进行的稀释度已经正确进行，并确保仪器正常工作。本发明还涉及使用该系统的方法。

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