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1. 发明申请

US20100331236A1 CYCLIC PEPTIDES AS G-PROTEIN COUPLED RECEPTOR ANTAGONISTS 审中-公开
标题翻译：循环肽作为G蛋白偶联受体拮抗剂
公开(公告)号：US20100331236A1
公开(公告)日：2010-12-30
申请号：US12502937
申请日：2009-07-14
申请人： Stephen Maxwell Taylor , Ian Alexander Shiels , David Fairlie , Darren March , Michael Whitehouse
发明人： Stephen Maxwell Taylor , Ian Alexander Shiels , David Fairlie , Darren March , Michael Whitehouse
IPC分类号： A61K38/12 , C07K7/64 , A61P9/10 , A61P25/28 , A61P29/00 , A61P19/02 , A61P11/00 , A61P11/06 , A61P25/00
CPC分类号： A61K38/12 , C07K7/56 , C07K14/472
摘要： The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
摘要翻译：本发明涉及具有调节G蛋白偶联受体活性的能力的新型环状化合物。化合物优选用作拮抗剂。在优选的实施方案中，本发明提供C5a受体的环状肽和拟肽拮抗剂，其对多形核白细胞和巨噬细胞上的C5a受体具有活性。本发明的化合物既有效又有选择性，可用于治疗各种炎性病症。

2. 发明授权

US07579432B2 Cyclic peptides as G-protein-coupled receptor antagonists 失效
标题翻译：循环肽作为G蛋白偶联受体拮抗剂
公开(公告)号：US07579432B2
公开(公告)日：2009-08-25
申请号：US10493117
申请日：2002-10-17
申请人： Stephen Maxwell Taylor , Ian Alexander Shiels , David Fairlie , Darren March , Michael Whitehouse
发明人： Stephen Maxwell Taylor , Ian Alexander Shiels , David Fairlie , Darren March , Michael Whitehouse
IPC分类号： C07K5/12 , A61K38/12
CPC分类号： A61K38/12 , C07K7/56 , C07K14/472
摘要： The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
摘要翻译：本发明涉及具有调节G蛋白偶联受体活性的能力的新型环状化合物。化合物优选用作拮抗剂。在优选的实施方案中，本发明提供C5a受体的环状肽和拟肽拮抗剂，其对多形核白细胞和巨噬细胞上的C5a受体具有活性。本发明的化合物既有效又有选择性，可用于治疗各种炎性病症。

3. 发明申请

US20080058252A1 Use of C5A receptor antagonist in the treatment of fibrosis 失效
标题翻译：使用C5A受体拮抗剂治疗纤维化
公开(公告)号：US20080058252A1
公开(公告)日：2008-03-06
申请号：US11807651
申请日：2007-05-30
申请人： Stephen Taylor , Ian Shiels , Lindsay Brown , Michael Whitehouse
发明人： Stephen Taylor , Ian Shiels , Lindsay Brown , Michael Whitehouse
IPC分类号： A61K38/12 , A61K38/02 , A61P17/02 , A61P3/10 , A61P43/00 , A61P9/12
CPC分类号： A61K38/12
摘要： This invention relates to the use of an antagonist of a G protein-coupled receptor in the prevention and/or treatment of fibrosis, such as the treatment of fibrosis associated with myocardial infarction or diabetes or certain pulmonary conditions. In a preferred embodiment, the antagonist is a C5a receptor antagonist, more preferably a cyclic peptide antagonist of the C5a receptor. In particular, the invention provides a method of prevention, treatment or alleviation of a fibrotic condition, comprising the step of administering an effective amount of an antagonist of a G protein-coupled receptor to a subject in need of such treatment.
摘要翻译：本发明涉及G蛋白偶联受体的拮抗剂在预防和/或治疗纤维化中的用途，例如治疗与心肌梗塞或糖尿病或某些肺部病症相关的纤维化。在优选的实施方案中，拮抗剂是C5a受体拮抗剂，更优选C5a受体的环肽拮抗剂。特别地，本发明提供了预防，治疗或缓解纤维化病症的方法，其包括向需要这种治疗的受试者施用有效量的G蛋白偶联受体拮抗剂的步骤。

4. 发明申请

US20060217530A1 Cyclic peptides as g-protein-coupled receptor antagonists 失效
标题翻译：循环肽作为g-蛋白偶联受体拮抗剂
公开(公告)号：US20060217530A1
公开(公告)日：2006-09-28
申请号：US10493117
申请日：2002-10-17
申请人： Stephen Maxwell , Ian Alexander , David Fairlie , Darren March , Michael Whitehouse
发明人： Stephen Maxwell , Ian Alexander , David Fairlie , Darren March , Michael Whitehouse
IPC分类号： C07K5/12 , A61K38/12
CPC分类号： A61K38/12 , C07K7/56 , C07K14/472
摘要： The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
摘要翻译：本发明涉及具有调节G蛋白偶联受体活性的能力的新型环状化合物。化合物优选用作拮抗剂。在优选的实施方案中，本发明提供C5a受体的环状肽和拟肽拮抗剂，其对多形核白细胞和巨噬细胞上的C5a受体具有活性。本发明的化合物既有效又有选择性，可用于治疗各种炎性病症。

5. 发明授权

US5431924A Anti-inflammatory composition derived from emu oil 失效
标题翻译：来自em油的抗炎组合物
公开(公告)号：US5431924A
公开(公告)日：1995-07-11
申请号：US50423
申请日：1993-07-16
申请人： Peter Ghosh , Michael Whitehouse , Michael Dawson , Athol G. Turner
发明人： Peter Ghosh , Michael Whitehouse , Michael Dawson , Athol G. Turner
IPC分类号： A61K35/57 , A61P29/00 , C07G99/00 , C11B3/10 , C11B7/00 , A61K47/00
CPC分类号： A61K35/57 , B01D15/00 , Y10S514/825
摘要： A biologically active component of emu oil is disclosed which is useful in pharmaceutical composition for the treatment of inflammation of environmental and systemic origins. Pharmaceutical composition including emu oil and dermal transport enhancing compounds are also disclosed as useful topical anti-inflammatory treatments.
摘要翻译： PCT No.PCT / AU91 / 00517 Sec。 371日期：1993年7月16日 102（e）日期1993年7月16日PCT 1991年11月14日PCT PCT。出版物WO92 / 08470 日期：1992年5月29日。公开了em u油的生物活性成分，其可用于治疗环境和系统性起源炎症的药物组合物。还公开了包含em油和皮肤转运增强化合物的药物组合物作为有用的局部抗炎治疗。

6. 发明申请

US20100299956A1 Apparatus and Method for Drying Wallboard 审中-公开
标题翻译：干燥墙板的设备和方法
公开(公告)号：US20100299956A1
公开(公告)日：2010-12-02
申请号：US12765274
申请日：2010-04-22
申请人： Thomas O'Brien , John Michael Whitehouse
发明人： Thomas O'Brien , John Michael Whitehouse
IPC分类号： F26B3/00 , F26B25/00 , F26B19/00
CPC分类号： F26B15/12 , F26B21/002 , F26B21/04 , F26B23/10
摘要： A process and apparatus used for heating and drying a material. The process uses supplemental radiant heat supplied by circulating thermal oil that is heated using fuels, as well as exhaust heat from other sources. The supplemental heat replaces a portion of the heat provided by the direct-firing. The supplemental heating is achieved by retrofitting existing direct-fired or radiant heat gypsum dryers with thermal oil-to-air heat exchangers in the combustion air lines and the air recirculation lines. Heated thermal oil is circulated through the exchangers, providing supplemental heat to both the combustion air and the re-circulated dryer air. The existing natural gas burners are fired to achieve the desired exit temperature. A Organic Rankine Cycle (ORC) system is coupled to the dryer exhaust vent to recapture heat energy produced by the thermal oil and produce electricity.
摘要翻译：用于加热和干燥材料的方法和装置。该过程使用通过使用燃料加热的循环热油提供的补充辐射热，以及来自其他来源的排气热。补充热量代替直接燃烧提供的一部分热量。补充加热通过在燃烧空气管线和空气再循环管线中用热油对空热交换器改装现有的直接燃烧或辐射热石膏干燥器来实现。加热的热油循环通过交换器，为燃烧空气和再循环的干燥器空气提供补充热量。燃烧现有的天然气燃烧器达到理想的出口温度。有机朗肯循环（ORC）系统耦合到干燥器排气口以重新获得由热油产生的热能并产生电力。

7. 外观设计

USD513497S1 Electronic controller housing 失效
标题翻译：电子控制器外壳
公开(公告)号：USD513497S1
公开(公告)日：2006-01-10
申请号：US29198420
申请日：2004-01-29
申请人： Michael Whitehouse
设计人： Michael Whitehouse

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