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1. 发明授权

US4940734A Process for the preparation of porous polymer beads 失效
标题翻译：制备多孔聚合物珠粒的方法
公开(公告)号：US4940734A
公开(公告)日：1990-07-10
申请号：US275170
申请日：1988-11-23
申请人： David A. Ley , Laura J. Hiscock , Michael T. Cooke
发明人： David A. Ley , Laura J. Hiscock , Michael T. Cooke
IPC分类号： C08J9/16 , B01J20/26 , C08J3/12 , C08J9/28
CPC分类号： C08J3/12 , B01J20/26 , C08J9/28 , C08J2333/20
摘要： Isotropic porous polymer beads having controllable surface porosity and large pore diameters from about 0.002 to about 5 microns are produced from solutions of an acrylonitrile polymer or a copolymer by a thermally-induced phase separation process including intensively shearing the polymer solution into small droplets. The use of mixed solvent non-solvent combinations as solvents for the polymers, and preferably reducing the polymer content in solution to below 10 percent produces high pore content, substantially spherical beads having a morphology ideally suited to the chromatography of large molecules, such as proteins, and for enzyme-binding.

2. 发明授权

US5314923A Porous polymer beads and process 失效
标题翻译：多孔聚合物珠粒和工艺
公开(公告)号：US5314923A
公开(公告)日：1994-05-24
申请号：US752915
申请日：1991-08-29
申请人： Michael T. Cooke , Laura J. Hiscock
发明人： Michael T. Cooke , Laura J. Hiscock
IPC分类号： C08J9/16 , B01J20/26 , C08J3/12 , C08J9/28
CPC分类号： B01J20/26 , C08J3/12 , C08J9/28 , C08J2201/052 , Y10T428/2982 , Y10T428/31
摘要： Isotropic porous polymer beads having a high surface porosity and large pore diameters from about 0.002 to about 5 microns are produced from solutions of a polymer or a copolymer by a thermally-induced phase separation process. The use of mixed solvent-non-solvent combinations as solvents for the polymers, produces high pore content, substantially spherical beads having a morphology ideally suited to the chromatography of large molecules, such as proteins, and for enzyme-binding.
摘要翻译：通过热诱导相分离方法由聚合物或共聚物的溶液制备具有高表面孔隙率和大孔直径约0.002至约5微米的各向同性多孔聚合物珠粒。使用混合溶剂 - 非溶剂组合作为聚合物的溶剂，产生高孔含量，基本上为球形的珠，其具有理想地适合于大分子如蛋白质和酶结合的色谱分析的形态。

3. 发明授权

US5047437A Porous polyacrylonitrile beads and process for their production 失效
标题翻译：多孔聚丙烯腈珠及其生产工艺
公开(公告)号：US5047437A
公开(公告)日：1991-09-10
申请号：US275317
申请日：1988-11-23
申请人： Michael T. Cooke , Laura J. Hiscock
发明人： Michael T. Cooke , Laura J. Hiscock
IPC分类号： B01J20/26 , C08J3/14 , C08J9/28
CPC分类号： C08J3/14 , B01J20/26 , C08J9/28 , C08J2333/20
摘要： Isotropic porous polymer beads having a high surface porosity and large pore diameters from about 0.002 to about 5 microns are produced from solutions of an acrylonitrile polymer or a copolymer by a thermally-induced phase separation process. The use of mixed solvent-non-solvent combinations as solvents for the polymers, produces high pore content, substantially spherical beads having a morphology ideally suited to the chromatography of large molecules, such as proteins, and for enzyme-binding.
摘要翻译：通过热诱导相分离方法由丙烯腈聚合物或共聚物的溶液制备具有约0.002至约5微米的高表面孔率和大孔径的各向同性多孔聚合物珠粒。使用混合溶剂 - 非溶剂组合作为聚合物的溶剂，产生高孔含量，基本上为球形的珠，其具有理想地适合于大分子如蛋白质和酶结合的色谱分析的形态。

4. 发明授权

US5306632A Porous acrylonitrile polymer substrate for bonding ligands and separating biologically active substances 失效
标题翻译：用于结合配体和分离生物活性物质的多孔丙烯腈聚合物底物
公开(公告)号：US5306632A
公开(公告)日：1994-04-26
申请号：US22223
申请日：1993-02-25
申请人： Larry S. Anderson , Michael T. Cooke , David A. Ley
发明人： Larry S. Anderson , Michael T. Cooke , David A. Ley
IPC分类号： B01J20/285 , B01D15/08 , B01D71/42 , B01J20/281 , C08F8/00 , C08J9/22 , D01D5/24 , D01F6/18 , G01N30/88 , C12N11/08 , C12N11/06 , G01N33/546 , G01N33/549
CPC分类号： C08F8/00 , Y10S435/915 , Y10S436/824
摘要： A porous shaped substrate such as a porous bead is formed from polyacrylonitrile or a copolymer thereof containing nitrile groups. The substrate has a hydrophilic surface containing amide groups constituting about 1.8 mole percent to less than about 15 mole percent of the total nitrile groups, and containing no amide or carboxyl groups. The substrate is substantially non-swellable in water and is able to resist pressures in a columnar bed of up to about 3000 psi without collapsing. In forming the amide groups, polyacrylonitrile or copolymer thereof containing nitrile groups, an alkaline catalyst such as sodium hydroxide and a nonsolvent for the substrate such as methanol are combined to form a suspension. A peroxide is added to the suspension and the suspension is heated to hydrolyze nitrile groups to amide groups. Succinylated aminoethyl groups or activated carboxyl groups can be formed on the substrate and a bioactive ligand such as p-aminobenzamidine covalently bonded to the substrate. The bound ligand can then be used to complex a biologically active substance such as an enzyme to separate the substance from solution.
摘要翻译：由聚丙烯腈或其含有腈基的共聚物形成多孔形状的基材如多孔珠粒。底物具有含有酰胺基团的亲水性表面，其构成总腈基团的约1.8摩尔％至小于约15摩尔％，并且不含酰胺基或羧基。基材在水中基本上不溶胀，并且能够抵抗高达约3000psi的柱状床中的压力而不会塌陷。在形成酰胺基团时，将含有腈基的聚丙烯腈或其共聚物，氢氧化钠等碱性催化剂和甲醇等底物的非溶剂合并形成悬浮液。向悬浮液中加入过氧化物，加热悬浮液将腈基水解成酰胺基。可以在底物上形成琥珀酰氨基乙基或活化的羧基，以及与基底共价结合的生物活性配体如对氨基苯甲脒。然后可以将结合的配体用于复合生物活性物质如酶，以将物质与溶液分离。

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