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1. 发明授权

US07812032B2 Crystalline forms of rapamycin analogs 有权
标题翻译：雷帕霉素类似物的结晶形式
公开(公告)号：US07812032B2
公开(公告)日：2010-10-12
申请号：US11781804
申请日：2007-07-23
申请人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
发明人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
IPC分类号： C07D498/18 , A61K31/395
CPC分类号： A61K31/33
摘要： A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, or combination thereof:
摘要翻译：雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。该晶体可以是水合物，脱水剂，溶剂化物或去溶剂化物。雷帕霉素类似物可以具有式1的结构，其可任选地是前药，盐，衍生物或其组合：

2. 发明授权

US07180590B2 Transmission spectrometer with improved spectral and temperature characteristics 有权
标题翻译：透射光谱仪具有改进的光谱和温度特性
公开(公告)号：US07180590B2
公开(公告)日：2007-02-20
申请号：US10616398
申请日：2003-07-09
申请人： Jens Bastue , Nicolai Herholdt-Rasmussen , Michael Rasmussen , Ole Jespersen
发明人： Jens Bastue , Nicolai Herholdt-Rasmussen , Michael Rasmussen , Ole Jespersen
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/0286 , G01J3/18
摘要： Transmission spectrometers require low levels of background light so that the signal to noise ratio is increased, and also require stable performance over wide temperature ranges. Light reflected by the transmission grating can result in increased background levels. One approach to reducing the background level is to orient the transmissive diffraction grating so that light reflected by the grating is reflected out of the diffraction plane. The temperature-induced wavelength drift of a transmission spectrometer can be due to the frame upon which the transmission grating is mounted. The wavelength drift is reduced by allowing the thermal expansion of the grating to be independent of the frame.
摘要翻译：透射光谱仪需要低水平的背景光，从而增加信噪比，并且在宽温度范围内也需要稳定的性能。由透射光栅反射的光可导致背景增加。降低背景水平的一种方法是使透射衍射光栅定向，使得由光栅反射的光被反射出衍射平面。透射光谱仪的温度感应波长漂移可能是由于安装透射光栅的框架。通过允许光栅的热膨胀独立于框架来减小波长漂移。

3. 发明申请

US20060257083A1 Fiber bundles and methods of making fiber bundles 有权
标题翻译：纤维束和纤维束的制造方法
公开(公告)号：US20060257083A1
公开(公告)日：2006-11-16
申请号：US11126778
申请日：2005-05-10
申请人： Michael Rasmussen
发明人： Michael Rasmussen
IPC分类号： G02B6/04
CPC分类号： C03B23/207 , G02B6/06 , G02B6/2821 , H01S3/094007 , H01S3/094053
摘要： The present invention relates to fiber bundles and methods for making fiber bundles. According to one embodiment of the invention, a fused fiber bundle has a terminal section ending with an endface, and includes a plurality of optical fibers, each of the optical fibers having a terminal segment ending with a proximal end, and a distal end; and a cellular holding structure, the cellular holding structure including a cellular web portion having a plurality of longitudinal cells arranged substantially in parallel and surrounded by a web material; and a tube portion surrounding the cellular web portion. The terminal segments of the optical fibers are arranged substantially in parallel, and the terminal segment of each optical fiber is disposed in a longitudinal cell of the cellular holding structure and substantially fused to the web material, thereby forming the terminal section of the fused fiber bundle.
摘要翻译：本发明涉及纤维束和纤维束的制造方法。根据本发明的一个实施例，熔融纤维束具有以端面结束的端子部分，并且包括多根光纤，每条光纤具有终端段，其末端为近端，远端; 以及细胞保持结构，所述细胞保持结构包括具有多个纵向细胞的多孔腹板部分，所述多个纵向细胞基本上平行布置并被网状材料包围; 以及围绕所述蜂窝状网部分的管部分。光纤的端子段基本上平行地布置，并且每个光纤的端子段设置在蜂窝保持结构的纵向电池中，并且基本上熔合到幅材材料上，从而形成熔融纤维束的端部。

4. 发明授权

US06878844B2 Synthesis of acyclic nucleoside derivatives 失效
标题翻译：无环核苷衍生物的合成
公开(公告)号：US06878844B2
公开(公告)日：2005-04-12
申请号：US10315580
申请日：2002-12-09
申请人： M. Robert Leanna , Michael Rasmussen , Howard Morton , Zhenping Tian , Daniel Plata , Bradley D. Gates , Bikshandarkoil A. Narayanan
发明人： M. Robert Leanna , Michael Rasmussen , Howard Morton , Zhenping Tian , Daniel Plata , Bradley D. Gates , Bikshandarkoil A. Narayanan
IPC分类号： C07D473/18 , A61K31/522 , C07B53/00 , C07B61/00 , C07C303/30 , C07C309/45 , C07C309/73 , C07D473/00 , C07D473/12 , C07D473/32 , C07D473/40 , C07C69/00
CPC分类号： C07D473/00 , C07C309/73 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
摘要翻译：用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或单不饱和，任选取代的烷基和R 3是OH或H; 或其药学上可接受的盐。

5. 发明申请

US20050007586A1 Transmission spectrometer with improved spectral and temperature characteristics 有权
标题翻译：透射光谱仪具有改进的光谱和温度特性
公开(公告)号：US20050007586A1
公开(公告)日：2005-01-13
申请号：US10616398
申请日：2003-07-09
申请人： Jens Bastue , Nicolai Herholdt-Rasmussen , Michael Rasmussen , Ole Jespersen
发明人： Jens Bastue , Nicolai Herholdt-Rasmussen , Michael Rasmussen , Ole Jespersen
IPC分类号： G01J3/02 , G01J3/18 , G01J3/28
CPC分类号： G01J3/02 , G01J3/0286 , G01J3/18
摘要： Transmission spectrometers require low levels of background light so that the signal to noise ratio is increased, and also require stable performance over wide temperature ranges. Light reflected by the transmission grating can result in increased background levels. One approach to reducing the background level is to orient the transmissive diffraction grating so that light reflected by the grating is reflected out of the diffraction plane. The temperature-induced wavelength drift of a transmission spectrometer can be due to the frame upon which the transmission grating is mounted. The wavelength drift is reduced by allowing the thermal expansion of the grating to be independent of the frame.
摘要翻译：透射光谱仪需要低水平的背景光，从而增加信噪比，并且在宽温度范围内也需要稳定的性能。由透射光栅反射的光可导致背景增加。降低背景水平的一种方法是使透射衍射光栅定向，使得由光栅反射的光被反射出衍射平面。透射光谱仪的温度感应波长漂移可能是由于安装透射光栅的框架。通过允许光栅的热膨胀独立于框架来减小波长漂移。

6. 发明授权

US06613936B1 Synthesis of acyclic nucleoside derivatives 失效
标题翻译：无环核苷衍生物的合成
公开(公告)号：US06613936B1
公开(公告)日：2003-09-02
申请号：US09692599
申请日：2000-10-18
申请人： M. Robert Leanna , Steven M. Hannick , Michael Rasmussen , Howard Morton , Daniel Plata
发明人： M. Robert Leanna , Steven M. Hannick , Michael Rasmussen , Howard Morton , Daniel Plata
IPC分类号： C07C6900
CPC分类号： C07D473/00 , C07C309/73 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
摘要翻译：用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或单不饱和，任选取代的烷基和R 3是OH或H; 或其药学上可接受的盐。

7. 发明授权

US09141415B2 Method for dynamically transforming the bytecode of Java virtual machine bootstrap classes 有权
标题翻译：用于动态转换Java虚拟机引导类的字节码的方法
公开(公告)号：US09141415B2
公开(公告)日：2015-09-22
申请号：US13885915
申请日：2011-11-02
申请人： Michael Rasmussen , Allan Raundahl Gregersen , Bo Norregaard Jorgensen
发明人： Michael Rasmussen , Allan Raundahl Gregersen , Bo Norregaard Jorgensen
IPC分类号： G06F9/45 , G06F9/455 , G06F9/445
CPC分类号： G06F9/45516 , G06F8/656
摘要： A method for dynamically transforming bytecode of Java Virtual Machine (JVM) bootstrap classes during program startup uses a JVM agent to intercept startup of a JVM compliant computer program to transform the bytecode of already loaded JVM bootstrap classes and store the resulting set of modified bootstrap classes. Subsequently, the JVM Agent intercepts all class loading events to transform the bytecode of classes declaring special program startup method “ ”, by inserting bytecode at the beginning of the method to invoke a callback method declared within the JVM Agent and passing the arguments passed to the JVM upon program startup as callback method parameters. Subsequently, when the callback method intercepts the execution flow of the computer program, the callback method starts a second JVM instance, passing parameters including the obtained input parameters, the main method arguments, and a JVM input argument for accessing the stored set of modified bootstrap classes.
摘要翻译：在程序启动期间动态转换Java虚拟机（JVM）引导类的字节码的方法使用JVM代理拦截启动符合JVM的计算机程序来转换已加载的JVM引导类的字节码，并存储经过修改的引导类的结果集。随后，JVM代理拦截所有类加载事件，以转换声明特殊程序启动方法“”的类的字节码，方法是在方法开头插入字节码以调用在JVM代理中声明的回调方法并传递参数在程序启动时传递给JVM作为回调方法参数。随后，当回调方法拦截计算机程序的执行流程时，回调方法启动第二个JVM实例，传递参数，包括获取的输入参数，主方法参数和JVM输入参数，用于访问存储的修改引导集课程

8. 发明申请

US20140075422A1 METHOD FOR DYNAMICALLY TRANSFORMING THE BYTECODE OF JAVA VIRTUAL MACHINE BOOTSTRAP CLASSES 有权
标题翻译：动态变换JAVA虚拟机BOOTSTRAP类别的保护方法
公开(公告)号：US20140075422A1
公开(公告)日：2014-03-13
申请号：US13885915
申请日：2011-11-02
申请人： Michael Rasmussen , Allan Raundahl Gregersen , Bo Norregaard Jorgensen
发明人： Michael Rasmussen , Allan Raundahl Gregersen , Bo Norregaard Jorgensen
IPC分类号： G06F9/455
CPC分类号： G06F9/45516 , G06F8/656
摘要： Under the present invention, a method for dynamically transforming the bytecode of Java Virtual Machine (JVM) bootstrap classes during program startup is provided. A JVM agent is used to intercept the execution flow before the execution of the special program startup-method of a JVM compliant computer program. The said JVM Agent executes code to transform the bytecode of the already loaded JVM bootstrap classes, storing the new set of modified bootstrap classes onto data storage. Subsequently, the JVM Agent intercepts all class loading events transforming the bytecode of classes declaring a special program statrup-method. In those classes the bytecode within the method body of the special class-initialize method, as defined in the present JVM class file format as “ ”, is removed to avoid any side-effects in the program. The special program startup-method in the said classes is transformed to insert bytecode at the beginning of the method to invoke a special callback method, as declared within the said JVM Agent, passing as parameters to the callback method the main arguments as passed to the JVM upon program startup. Subsequently, when the said callback method intercepts the execution flow it starts a second JVM instance passing to it the obtained input parameters, the main method arguments as well as a JVM input argument to use the stored set of modified bootstrap classes.
摘要翻译：本发明提供了一种在程序启动期间动态变换Java虚拟机（JVM）引导类的字节码的方法。在执行符合JVM的计算机程序的特殊程序startup-method之前，使用JVM代理拦截执行流程。所述JVM代理执行代码来转换已加载的JVM引导类的字节码，将新的修改的引导类集合存储到数据存储上。随后，JVM Agent拦截所有类加载事件，转换声明特殊程序statrup方法的类的字节码。在这些类中，特殊类初始化方法的方法体中的字节码（如当前JVM类文件格式定义为“”）被删除，以避免程序中的任何副作用。所述类中的特殊程序启动方法被转换为在方法开始处插入字节码，以调用在所述JVM代理中声明的特殊回调方法，将参数传递给回调方法，将传递给程序启动时的JVM 随后，当所述回调方法拦截执行流时，它启动第二个JVM实例传递获取的输入参数，主方法参数以及JVM输入参数，以使用存储的修改引导类的集合。

9. 发明授权

US08034926B2 Methods of manufacturing crystalline forms of rapamycin analogs 有权
标题翻译：制备雷帕霉素类似物结晶形式的方法
公开(公告)号：US08034926B2
公开(公告)日：2011-10-11
申请号：US12886398
申请日：2010-09-20
申请人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
发明人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
IPC分类号： C07D498/18
CPC分类号： C07D498/18
摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.
摘要翻译：制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

10. 发明申请

US20070154988A1 Bacillus Host Cell 审中-公开
标题翻译：芽孢杆菌宿主细胞
公开(公告)号：US20070154988A1
公开(公告)日：2007-07-05
申请号：US11611621
申请日：2006-12-15
申请人： Jens Andersen , Steen Jorgensen , Michael Rasmussen , Peter Olsen , Ib Clausen
发明人： Jens Andersen , Steen Jorgensen , Michael Rasmussen , Peter Olsen , Ib Clausen
IPC分类号： C12P21/06 , C12N9/02 , C12N9/08 , C12N9/10 , C12N9/16 , C12N9/22 , C12N9/24 , C12N9/32 , C12N1/21
CPC分类号： C12P21/02 , C07K14/32 , C12N15/75
摘要： A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more polypeptide(s) involved in sporulation which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 to 191, wherein the mutant host cell expresses at least 5% less of the one or more polypeptide(s) involved in sporulation than the parent host cell, when they are cultivated under comparable conditions.
摘要翻译：衍生自地衣芽孢杆菌宿主细胞的地衣芽孢杆菌突变宿主细胞，所述突变宿主细胞在编码参与孢子形成的一种或多种多肽的一个或多个基因中突变，所述多个基因与一个或多个与一个或更多的SEQ ID NO：2至191所示的多肽，其中当它们在可比较的条件下培养时，突变宿主细胞表达与母体宿主细胞相关的至少5％以上参与孢子形成的一种或多种多肽条件。

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