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1. 发明申请

US20150056305A1 DITHIOL MUCOLYTIC AGENTS 有权
公开(公告)号：US20150056305A1
公开(公告)日：2015-02-26
申请号：US14458898
申请日：2014-08-13
申请人： Michael R. Johnson , William R. Thelin , Ronald A. Aungst, JR.
发明人： Michael R. Johnson , William R. Thelin , Ronald A. Aungst, JR.
IPC分类号： C07C323/16 , A61K31/4965 , A61K33/14 , A61K31/165 , A61K31/27 , A61K31/145 , A61K45/06 , C07D241/32
CPC分类号： C07C323/16 , A61K9/0043 , A61K9/0073 , A61K9/0082 , A61K31/047 , A61K31/138 , A61K31/145 , A61K31/155 , A61K31/165 , A61K31/27 , A61K31/382 , A61K31/4965 , A61K31/7004 , A61K33/14 , A61K45/06 , C07D241/32 , C07D339/08 , Y02A50/406 , A61K2300/00
摘要： Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
摘要翻译：提供二硫醇粘液溶解剂。这些药剂增加粘液或粘液过多时患者粘液液化，增加粘弹性，内聚性或粘合性。还提供了使用这些本发明的粘液分解剂的各种治疗方法。

2. 发明授权

US08676606B1 Systems and methods for providing comprehensive pharmaceutical consultations 有权
标题翻译：提供全面药物咨询的制度和方法
公开(公告)号：US08676606B1
公开(公告)日：2014-03-18
申请号：US12917061
申请日：2010-11-01
申请人： Gyula J. Nadas , Michael R. Johnson , Anthony James Fields
发明人： Gyula J. Nadas , Michael R. Johnson , Anthony James Fields
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G06F19/00 , G06F19/3456 , G06Q10/10 , G16H40/20
摘要： Systems and methods of providing comprehensive pharmaceutical consultations are disclosed, including generating a consultation recording block corresponding to a filling of a prescription order for a patient. The consultation recording block may include multiple consultation entries, where each consultation entry corresponds to a particular pharmaceutical consultation that is desired or required to occur in conjunction with the prescription fill. Input corresponding to various fields of various consultation entries may be received and stored. Different fields of different consultation entries corresponding to a particular patient and to a particular prescription order may be displayed, populated, viewed, resolved and authorized by different pharmaceutical personnel at different work flow stages of the filling, and in some cases, one or more consultation entries may be automatically generated and at least partially automatically populated. The techniques described herein allow for more comprehensive pharmaceutical consultations as compared to presently known techniques.
摘要翻译：公开了提供综合性药物咨询的系统和方法，包括生成与填充患者的处方顺序相对应的咨询记录块。咨询记录块可以包括多个咨询条目，其中每个咨询条目对应于期望或需要与处方填充一起发生的特定药物咨询。可以接收并存储与各种咨询条目的各个领域相对应的输入。在不同的工作流程阶段，不同的药剂人员在不同的工作流程阶段可以显示，填充，查看，解决和授权与特定患者和特定处方顺序相对应的不同咨询条目的不同领域，并且在一些情况下，一个或多个咨询条目可能会自动生成，至少部分自动填充。与目前已知的技术相比，本文描述的技术允许更全面的药物咨询。

3. 发明授权

US08386489B2 Applying formal concept analysis to validate expanded concept types 有权
标题翻译：应用正式的概念分析来验证扩展的概念类型
公开(公告)号：US08386489B2
公开(公告)日：2013-02-26
申请号：US12266724
申请日：2008-11-07
申请人： Bruce E. Peoples , Michael R. Johnson , Jonathon P. Smith
发明人： Bruce E. Peoples , Michael R. Johnson , Jonathon P. Smith
IPC分类号： G06F17/30
CPC分类号： G06F17/30684
摘要： According to one embodiment, attributes associated with a concept type of a query conceptual graph are received. A potentially conceptually similar term is received from an onomasticon. The potentially conceptually similar term is validated according to the attributes. According to another embodiment, attributes associated with a concept type of a document conceptual graph are received. A potentially conceptually similar term is received from an onomasticon. The potentially conceptually similar term is validated according to the attributes.
摘要翻译：根据一个实施例，接收与查询概念图的概念类型相关联的属性。从onomasticon接收到潜在的概念上类似的术语。潜在的概念上类似的术语根据属性进行验证。根据另一实施例，接收与文档概念图的概念类型相关联的属性。从onomasticon接收到潜在的概念上类似的术语。潜在的概念上类似的术语根据属性进行验证。

4. 发明申请

US20120165342A1 Methods of Reducing Risk of Infection from Pathogens 审中-公开
标题翻译：降低病原体感染风险的方法
公开(公告)号：US20120165342A1
公开(公告)日：2012-06-28
申请号：US12784550
申请日：2010-05-21
申请人： Michael R. JOHNSON , Samuel E. HOPKINS
发明人： Michael R. JOHNSON , Samuel E. HOPKINS
IPC分类号： A61K31/497 , A61P31/04 , A61P31/00
CPC分类号： C07D241/30 , A61K31/00 , A61K31/4965 , C07D253/07 , Y02A50/402 , Y02A50/406 , Y02A50/463
摘要： Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
摘要翻译：提供预防性治疗方法以保护个体和/或群体免受空气传播病原体的感染。特别地，提供了预防性治疗方法，其包括将钠通道阻断剂或其药学上可接受的盐给予暴露于或已经暴露于一种或多种空气传播病原体的风险的群体的一个或多个成员，所述病原体来自天然来源或有意释放的病原体进入环境。

5. 发明授权

US08143256B2 Cyclic amide and ester pyrazinoylguanidine sodium channel blockers 有权
标题翻译：环酰胺和酯吡嗪基胍钠通道阻断剂
公开(公告)号：US08143256B2
公开(公告)日：2012-03-27
申请号：US11573693
申请日：2005-08-18
申请人： Michael R. Johnson
发明人： Michael R. Johnson
IPC分类号： A61K31/497
CPC分类号： C07D239/48 , C07D241/32 , C07D401/12
摘要： The present invention provides compounds represented by formula (I): where the structural variables are defined herein. The compound of the present invention are useful as sodium channel blockers.
摘要翻译：本发明提供由式（I）表示的化合物：其中结构变量在本文中定义。本发明的化合物可用作钠通道阻断剂。

6. 发明申请

US20110003832A1 NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS 有权
标题翻译：新CAPPED吡嗪酰胍胍SODIUM通道阻断剂
公开(公告)号：US20110003832A1
公开(公告)日：2011-01-06
申请号：US12876615
申请日：2010-09-07
申请人： Michael R. JOHNSON , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
发明人： Michael R. JOHNSON , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
IPC分类号： A61K31/4965 , C07D241/30 , A61P11/00 , A61P1/02 , A61P9/12 , A61P15/02
CPC分类号： C07D241/26 , A61K31/495 , A61K31/50 , A61K45/06
摘要： The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
摘要翻译：本发明涉及钠通道阻断剂。本发明还包括使用这些本发明的钠通道阻断剂的各种治疗方法。

7. 发明授权

US07853555B2 Enhancing multilingual data querying 有权
标题翻译：加强多语言数据查询
公开(公告)号：US07853555B2
公开(公告)日：2010-12-14
申请号：US11468856
申请日：2006-08-31
申请人： Bruce E. Peoples , Michael R. Johnson
发明人： Bruce E. Peoples , Michael R. Johnson
IPC分类号： G06F7/00
CPC分类号： G06F17/30669
摘要： In one aspect, a method for multilingual data querying includes receiving a request for a query. The query includes a base word in a source language used for a search of a database in a target language. The method further includes applying the request to factors, selecting components based on the factors and performing the query based on the selecting.
摘要翻译：一方面，一种用于多语言数据查询的方法包括接收对查询的请求。该查询包括用于以目标语言搜索数据库的源语言中的基本词。所述方法还包括将所述请求应用于因素，基于所述因素选择组件并基于所述选择执行所述查询。

8. 发明授权

US07820678B2 Sodium channel blockers 失效
标题翻译：钠通道阻滞剂
公开(公告)号：US07820678B2
公开(公告)日：2010-10-26
申请号：US11950674
申请日：2007-12-05
申请人： Michael R. Johnson
发明人： Michael R. Johnson
IPC分类号： A61K31/4965
CPC分类号： A61K31/4965 , A61K31/497 , C07D241/26 , C07D405/12 , C07D405/14
摘要： Provided are methods of increasing hydration of mucosal surfaces by topically administering sodium channel blocking pyrazinoylguanidine compounds.
摘要翻译：提供了通过局部施用钠通道阻断吡嗪基胍化合物来增加粘膜表面水合的方法。

9. 发明申请

US20100139062A1 LOWERING AND RAISING A SINGLE WIND TURBINE ROTOR BLADE FROM SIX-O'CLOCK POSITION 审中-公开
标题翻译：降低和提升六点钟位置的单风轮转子叶片
公开(公告)号：US20100139062A1
公开(公告)日：2010-06-10
申请号：US12392353
申请日：2009-02-25
申请人： Bryan P. Reed , Thomas O. Converse , Steven H. Olson , Michael R. Johnson
发明人： Bryan P. Reed , Thomas O. Converse , Steven H. Olson , Michael R. Johnson
IPC分类号： B23P15/04 , B23P6/00
CPC分类号： F03D13/10 , Y02E10/721 , Y10T29/37 , Y10T29/49318
摘要： A method and lifting arrangement for lowering and raising a single rotor blade of a wind turbine from a six-o'clock position is provided. Lifting fixtures are symmetrically installed on a hub surface about the rotor blade being replaced. Lifting lines from coordinated ground winches pass over the lifting fixtures to support the blade and attach to a blade harness. The blade harness attaches over a substantial length of the rotor blade, distributing the blade weight broadly. A tail pick crane facilitates transfer of the rotor blade between a vertical and a horizontal position stored position.
摘要翻译：提供了用于从六点钟位置降低和升高风力涡轮机的单个转子叶片的方法和提升装置。提升夹具对称地安装在围绕要更换的转子叶片的轮毂表面上。来自协调的地面绞车的起重线路通过提升装置，以支撑叶片并附接到叶片线束。叶片线束附接在转子叶片的相当长度上，大体分布叶片重量。尾部起重机有助于转子叶片在垂直位置和水平位置存储位置之间的传送。

10. 发明申请

US20090253714A1 Methods of reducing risk of infection from pathogens 审中-公开
标题翻译：降低病原体感染风险的方法
公开(公告)号：US20090253714A1
公开(公告)日：2009-10-08
申请号：US10920527
申请日：2004-08-18
申请人： Michael R. Johnson , Samuel E. Hopkins
发明人： Michael R. Johnson , Samuel E. Hopkins
IPC分类号： A61K31/4965 , A61L9/04
CPC分类号： A61K31/495 , Y02A50/402 , Y02A50/406
摘要： Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering amiloride, benzamil, phenamil or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
摘要翻译：提供预防性治疗方法以保护个体和/或群体免受空气传播病原体的感染。特别地，提供了预防性治疗方法，其包括向暴露于或已经暴露于一种或多种空气传播病原体的风险的群体的一个或多个成员施用阿米洛利，苯甲酰胺或其药学上可接受的盐，无论是从天然来源或故意的将病原体释放到环境中。

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