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1. 发明授权

US08209032B2 Implantable medical device conductor insulation and process for forming 有权
标题翻译：可植入医疗器械导体绝缘和成型工艺
公开(公告)号：US08209032B2
公开(公告)日：2012-06-26
申请号：US12683561
申请日：2010-01-07
申请人： Michael J Ebert , John L Sommer , Richard D Ries , Jordan D Honeck , Pedro A Meregotte , Kenneth R Brennen
发明人： Michael J Ebert , John L Sommer , Richard D Ries , Jordan D Honeck , Pedro A Meregotte , Kenneth R Brennen
IPC分类号： A61N1/00
CPC分类号： H01B3/306 , A61L31/10 , A61N1/056 , C08L79/08
摘要： An elongate medical electrical lead conductor includes a layer of hydrolytically stable polyimide formed thereover.
摘要翻译：细长的医用电引线导体包括一层形成在其上的水解稳定的聚酰亚胺。

2. 发明授权

US6101973A Apparatus for reducing friction on polymeric surfaces 有权
标题翻译：减少聚合物表面摩擦的装置
公开(公告)号：US6101973A
公开(公告)日：2000-08-15
申请号：US262632
申请日：1999-03-04
申请人： Mark T. Stewart , Kenneth E. Cobian , Michael J. Ebert
发明人： Mark T. Stewart , Kenneth E. Cobian , Michael J. Ebert
IPC分类号： A61L29/14 , A61L33/00 , B05D3/14 , B05D7/24 , B29C59/10 , B29C59/14 , C23C16/02 , C23C16/04 , C23C16/30 , C23C16/505 , C23C16/00 , C23F1/02
CPC分类号： B05D1/62 , A61L29/141 , A61L33/0088 , B05D3/144 , B29C59/103 , B29C59/142 , C23C16/0245 , C23C16/045 , C23C16/30 , C23C16/505 , H01J37/32082 , B29L2023/00 , B29L2031/7542
摘要： This invention relates to an apparatus and a method for improving slip characteristics on the surface of a polymeric material, such as an outer surface, inner surface, or both of polymeric tubing.
摘要翻译：本发明涉及用于改善聚合物材料（例如聚合物管的外表面，内表面或两者）的表面上的滑动特性的装置和方法。

3. 发明授权

US5419921A Pacing lead insulator 失效
标题翻译：起搏绝缘子
公开(公告)号：US5419921A
公开(公告)日：1995-05-30
申请号：US312256
申请日：1994-09-26
申请人： Richard L. Molacek , Kenneth E. Cobian , Michael J. Ebert , Allan H. Jevne , James R. Keogh , Paul C. Slaikeu
发明人： Richard L. Molacek , Kenneth E. Cobian , Michael J. Ebert , Allan H. Jevne , James R. Keogh , Paul C. Slaikeu
IPC分类号： A61N1/02 , A61N1/04 , B05D5/12
CPC分类号： A61N1/02 , A61N1/05
摘要： The present invention provides resistance to degradation from environmental stress cracking (ESC) and metal ion induced oxidation (MIO) for implantable, flexible pacing lead insulators having a body of polyether polyurethane elastomer material. A thin layer of a second polyurethane elastomer is applied as an overcoat to the lead insulator body. The second polyurethane is more resistant to ESC and MIO than the elastomer comprising the body of the insulator. Because ESC and MIO are surface phenomina, only a thin layer of the second material is required and the mechanical properties of the base material will determine the overall mechanical properties of the lead insulator.
摘要翻译：本发明提供对具有聚醚聚氨酯弹性体材料体的可植入，柔性起搏引线绝缘子的环境应力开裂（ESC）和金属离子诱导氧化（MIO）的降解性。将第二聚氨酯弹性体的薄层作为外涂层施加到引线绝缘体主体。第二聚氨酯比包含绝缘体主体的弹性体更耐ESC和MIO。因为ESC和MIO是表面的，所以仅需要第二材料的薄层，并且基材的机械性能将决定铅绝缘体的整体机械性能。

4. 发明申请

US20120136422A1 IMPLANTABLE MEDICAL DEVICE CONDUCTOR INSULATION AND PROCESS FOR FORMING 审中-公开
标题翻译：可植入医疗器械导体绝缘及其成型工艺
公开(公告)号：US20120136422A1
公开(公告)日：2012-05-31
申请号：US13367044
申请日：2012-02-06
申请人： Michael J. Ebert , John L. Sommer , Jordan D. Honeck , Richard D. Ries , Pedro A. Meregotte , Kenneth R. Brennen
发明人： Michael J. Ebert , John L. Sommer , Jordan D. Honeck , Richard D. Ries , Pedro A. Meregotte , Kenneth R. Brennen
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable medical device that includes a lead body extending from a proximal end to a distal end, a plurality of conductors extending between the proximal end and the distal end of the lead body, and an insulative layer formed of a hydrolytically stable polyimide material surrounding the plurality of conductors. In one embodiment, the hydrolytically stable polyimide material is an SI polyimide material.
摘要翻译：一种可植入医疗装置，其包括从近端延伸到远端的引线体，在所述引线体的近端和远端之间延伸的多根导体，以及由水解稳定的聚酰亚胺材料形成的绝缘层，多个导体。在一个实施方案中，水解稳定的聚酰亚胺材料是SI聚酰亚胺材料。

5. 发明申请

US20100130963A1 MEDICAL DEVICES WITH DUAL MODALITY VISIBLE SEGMENTS 审中-公开
标题翻译：具有双重模糊可见部分的医疗器械
公开(公告)号：US20100130963A1
公开(公告)日：2010-05-27
申请号：US12609628
申请日：2009-10-30
申请人： Michael J. Ebert , Steven L. Waldhauser , Mark D. Schneider
发明人： Michael J. Ebert , Steven L. Waldhauser , Mark D. Schneider
IPC分类号： A61M25/098 , B29C47/06 , B32B27/34
CPC分类号： A61L29/18 , A61L29/085 , A61L29/14 , Y10T428/31725
摘要： The preparation and use of medical devices having an outer layer over a visibility material-loaded inner layer is disclosed herein.
摘要翻译：本文公开了在可见度材料加载的内层上具有外层的医疗装置的制备和使用。

6. 发明申请

US20090306752A1 IMPLANTABLE MEDICAL DEVICE ELECTRICAL LEAD CONDUCTOR INSULATION AND PROCESS FOR FORMING 审中-公开
标题翻译：可植入医疗器械电导体导体绝缘和成型工艺
公开(公告)号：US20090306752A1
公开(公告)日：2009-12-10
申请号：US12541551
申请日：2009-08-14
申请人： Michael J. Ebert , John L. Sommer , Jordan D. Honeck , Richard D. Ries , Pedro A. Meregotte , Kenneth R. Brennen
发明人： Michael J. Ebert , John L. Sommer , Jordan D. Honeck , Richard D. Ries , Pedro A. Meregotte , Kenneth R. Brennen
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable medical device that includes a lead body extending from a proximal end to a distal end, a plurality of conductors extending between the proximal end and the distal end of the lead body, and an insulative layer formed of a hydrolytically stable polyimide material surrounding the plurality of conductors. In one embodiment, the hydrolytically stable polyimide material is an Si polyimide material.
摘要翻译：一种可植入医疗装置，其包括从近端延伸到远端的引线体，在所述引线体的近端和远端之间延伸的多根导体，以及由水解稳定的聚酰亚胺材料形成的绝缘层，多个导体。在一个实施方案中，水解稳定的聚酰亚胺材料是Si聚酰亚胺材料。

7. 发明授权

US06966322B2 Enhanced chronic lead removal 失效
标题翻译：增强慢性铅清除
公开(公告)号：US06966322B2
公开(公告)日：2005-11-22
申请号：US10126747
申请日：2002-04-19
申请人： Rick D. McVenes , Kenneth B. Stokes , Michael J. Ebert , James M. Anderson
发明人： Rick D. McVenes , Kenneth B. Stokes , Michael J. Ebert , James M. Anderson
IPC分类号： A61L31/10 , A61N1/05 , A61N1/375 , A61B17/88
CPC分类号： A61N1/375 , A61L31/10 , A61L2400/18 , A61N1/056 , C08L33/26
摘要： An implantable medical device, perhaps a pacemaker lead, has a medical unit and a casing at least partially enclosing the medical unit. The casing is formed of a base polymer having surface modifying pendant groups formed of an acrylamide polymer or an acrylamide copolymer, perhaps polyisopropyl acrylamide. The base polymer may be a polyurethane, polyimide, fluoropolymer or polyolefin, for example.
摘要翻译：可植入医疗装置（也许起搏器引线）具有至少部分地包围医疗单元的医疗单元和外壳。壳体由具有由丙烯酰胺聚合物或丙烯酰胺共聚物，或许是聚丙烯丙烯酰胺形成的表面改性侧基的基础聚合物形成。基础聚合物可以是例如聚氨酯，聚酰亚胺，含氟聚合物或聚烯烃。

8. 发明授权

US06961610B2 Branched polyethylene oxide terminated biomedical polymers and their use in biomedical devices 失效
标题翻译：支化聚环氧乙烷封端的生物医学聚合物及其在生物医学装置中的应用
公开(公告)号：US06961610B2
公开(公告)日：2005-11-01
申请号：US10131440
申请日：2002-04-25
申请人： Zhongping Yang , Michael J. Ebert , James M. Anderson
发明人： Zhongping Yang , Michael J. Ebert , James M. Anderson
IPC分类号： A61L31/00 , A61L27/34 , A61L27/54 , A61N1/02 , A61N1/375
CPC分类号： A61L27/34 , A61L27/54 , A61L2300/112 , A61L2300/204 , A61L2300/22 , A61L2300/25 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： A biomedical polymer has a substantially linear base polymer; and branched polyethylene oxide covalently bonded to the base polymer as surface active end groups. The branched polyethylene oxide has at least two, more particularly at least four, and still more particularly at least six branches. Suitable base polymers include epoxies, polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins and silicone rubbers. Biologically active agents may be attached to the branched polyethylene oxide. Suitable biologically active agents include microbial peptide agents, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids, fatty acid salts, heparin and glucocorticosteroids. The biological polymer may be used as a casing for a medical unit of an implantable medical device, such as a pacemaker. In this case, the casing at least partially encloses the medical unit.
摘要翻译：生物医学聚合物具有基本线性的基础聚合物; 和作为表面活性端基共价结合到基础聚合物的支化聚环氧乙烷。支化聚环氧乙烷具有至少两个，更特别是至少四个，更特别是至少六个分支。合适的基础聚合物包括环氧树脂，聚氨酯，聚氨酯共聚物，含氟聚合物，聚烯烃和硅橡胶。生物活性剂可以连接到支化聚环氧乙烷上。合适的生物活性剂包括微生物肽剂，洗涤剂，非甾体抗炎药，阳离子，含胺有机硅氧烷，二膦酸盐，脂肪酸，脂肪酸盐，肝素和糖皮质激素。生物聚合物可以用作可植入医疗装置（例如起搏器）的医疗单元的壳体。在这种情况下，壳体至少部分地包围医疗单元。

9. 发明授权

US06439084B1 Laminated blade assembly for cutting insulation 有权
标题翻译：用于切割绝缘的层压刀片组件
公开(公告)号：US06439084B1
公开(公告)日：2002-08-27
申请号：US09850617
申请日：2001-05-07
申请人： Michael J. Ebert
发明人： Michael J. Ebert
IPC分类号： H02G112
CPC分类号： H02G1/1212
摘要： A laminated blade assembly including a stationary blade and a pair of insulation supports and a movable blade and a pair of insulation supports with each blade sandwiched between a pair of supports. Semi-circular grooves formed in the insulation supports and smaller semi-circular grooves formed in blades in alignment with the insulation support grooves creating circular grooves to support and cut the insulation when the stationary and movable blades come together. The support semi-circular grooves of one of the stationary and movable insulation supports are located with their peripheries tangent to a straight line which is not parallel to the center lines of the blade semi-circular grooves.
摘要翻译：一种层压叶片组件，包括固定叶片和一对绝缘支撑件和可动叶片以及一对绝缘支撑件，每个叶片夹在一对支撑件之间。形成在绝缘支撑件中的半圆形凹槽和形成在叶片中的较小的半圆形凹槽与绝缘支撑槽对准，当固定和可动叶片汇合在一起时，产生圆形凹槽以支撑和切割绝缘体。固定和可移动绝缘支撑件之一的支撑半圆形槽的位置与其外周切线不平行于叶片半圆形槽的中心线的直线。

10. 发明授权

US06438425B1 Textured silicone tubing for electrical pacing leads 有权
标题翻译：用于电起搏导线的纹理硅胶管
公开(公告)号：US06438425B1
公开(公告)日：2002-08-20
申请号：US09416971
申请日：1999-10-12
申请人： Jennifer P. Miller , Michael J. Ebert , Joseph J. Klein , Richard D. Ries
发明人： Jennifer P. Miller , Michael J. Ebert , Joseph J. Klein , Richard D. Ries
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： An implantable lead having a silicone rubber lead body which has a reduced coefficient of friction on an internal or external surface. The reduction in coefficient of friction is accomplished by extruding a tubular lead body to define a plurality of small parallel longitudinally extending grooves on the inner or outer surface of the lead body. The grooves may be formed by means of a die having inwardly or outwardly directed projections that form the grooves during the extrusion process. The formation of the grooves during extrusion provides a lead body having a lower coefficient of friction without the necessity of additional manufacturing process steps and without additional manufacturing costs.
摘要翻译：具有硅橡胶引线体的可植入引线，其在内表面或外表面上具有减小的摩擦系数。摩擦系数的降低通过挤压管状引线体来在引线体的内表面或外表面上限定多个小的平行的纵向延伸的凹槽来实现。凹槽可以通过具有在挤出过程中形成凹槽的向内或向外指向的突起的模具形成。在挤出期间形成凹槽提供具有较低摩擦系数的引线体，而不需要额外的制造工艺步骤，而不需要额外的制造成本。

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