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    • 1. 发明授权
    • Method and apparatus for two-step surface-enhanced raman spectroscopy
    • 两步表面增强拉曼光谱法的方法和装置
    • US09134247B2
    • 2015-09-15
    • US13374225
    • 2011-12-16
    • Atanu SenguptaFrank E. InscoreChetan ShendeMichael J. DonahueStuart Farquharson
    • Atanu SenguptaFrank E. InscoreChetan ShendeMichael J. DonahueStuart Farquharson
    • G01N21/65G01N33/58
    • G01N21/658G01N33/54373G01N33/58G01N33/587
    • A SERS method and apparatus employ a sample device having support structure including a first material containing a SER-active metal functionalized with a binding agent having specific capability for binding a designated target analyte. An analyte sample is introduced upon the functionalized SER-active metal; conditions to effect binding of the target analyte to the binding agent are maintained; unbound chemicals, biochemicals, or biologicals are removed; a second SER-active material is introduced to cause it to attach to the bound target analyte; the support structure is irradiated to generate a SER spectrum, with the first and second SER-active materials acting in concert; and the SER spectrum is detected and analyzed to determine the presence and quantity of the target analyte. Alternatively, the second SER-active material may be functionalized with a binding agent, with the procedure being modified accordingly.
    • SERS方法和装置使用具有支撑结构的样品装置,该样品装置包括含有用具有特异性结合指定靶标分析物能力的结合剂官能化的SER-活性金属的第一材料。 将分析物样品引入功能化的SER-活性金属上; 维持目标分析物与结合剂结合的条件; 未结合的化学物质,生物化学物质或生物制品被去除; 引入第二SER活性材料以使其附着于结合的靶分析物; 照射支撑结构以产生SER光谱,其中第一和第二SER活性材料一致; 并检测和分析SER光谱,以确定目标分析物的存在和数量。 或者,第二SER活性材料可以用粘合剂进行官能化,其过程被相应地改变。
    • 2. 发明授权
    • Sourceless orientation sensor
    • 无源定向传感器
    • US5526022A
    • 1996-06-11
    • US000992
    • 1993-01-06
    • Michael J. DonahueMark D. PesceMarc de GrootMichael A. PerryDonald E. Drumm
    • Michael J. DonahueMark D. PesceMarc de GrootMichael A. PerryDonald E. Drumm
    • G01C9/06G01C9/20G06F3/00G06F3/01G06F3/0346G06F3/042G09G5/00
    • G06F3/011G01C9/20G06F3/0312G06F3/0346G01C2009/066
    • A sourceless orientation sensor having an azimuthal sensor which determines the azimuthal orientation relative to a planetary magnetic field, and a tilt sensor which determines the direction and magnitude of the displacement from vertical using the planetary gravitational field. The tilt sensor includes a transparent gas and a transparent viscous fluid in a spherical shell, a light emitting diode (LED) mounted at the top of the shell, and four photodetectors mounted at the bottom of the shell. As the tilt sensor is rotated the path of the light cone emanating from the LED and refracting at the gas/fluid interface is altered, thereby altering the intensity of light incident on the photodetectors. The magnitude of the light incident on the photodetectors is processed to provide the tilt angles. A thin transparent disk floats at the gas/fluid interface to damp surface waves caused by reorientation of the device. A time sequence of orientations of the sensor may be interpreted to provided a gesture sensing device.
    • 具有确定相对于行星磁场的方位角取向的方位传感器的无源定向传感器以及使用行星重力场确定垂直位移的方向和大小的倾斜传感器。 倾斜传感器包括透明气体和球形壳体中的透明粘性流体,安装在壳体顶部的发光二极管(LED)和安装在壳体底部的四个光电检测器。 当倾斜传感器旋转时,从LED发出的光锥的路径和在气体/流体界面处的折射改变,从而改变入射在光电检测器上的光的强度。 对入射到光电检测器上的光的大小进行处理以提供倾斜角度。 薄的透明盘浮在气体/流体界面以阻止由装置的重新取向引起的表面波。 可以将传感器的取向的时间序列解释为提供手势感测装置。