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    • 9. 发明申请
    • GABAalpha receptor epsilon subunits
    • GABAalpha受体ε亚基
    • US20060148036A1
    • 2006-07-06
    • US11346326
    • 2006-02-03
    • Michael HannaEwen Kirkness
    • Michael HannaEwen Kirkness
    • C07K14/705C07H21/04C12P21/06
    • C07K14/70571A61K38/00
    • The present invention relates to a novel GABAA receptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.
    • 本发明涉及一种新的GABA A受体ε亚基(GABRE)及其替代转录物(ET2)。 更具体地,提供编码人GABRE和ET2受体亚单位的分离的核酸分子。 还提供了ET2和GABRE多肽,载体,宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定ET2和GABRE活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测异常GABRE和ET2表达的诊断方法,以及用于治疗涉及ET2和GABRE的疾病的治疗方法。