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1. 发明授权

US07785580B2 Modified IL-4 mutein receptor antagonists 失效
标题翻译：修饰的IL-4突变蛋白受体拮抗剂
公开(公告)号：US07785580B2
公开(公告)日：2010-08-31
申请号：US11940217
申请日：2007-11-14
申请人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson , David Boisvert , Elise Burmeister-Getz , Kathy Delaria
发明人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson , David Boisvert , Elise Burmeister-Getz , Kathy Delaria
IPC分类号： A61K38/20 , A61K38/00 , C07K14/47 , C12P21/06
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/7155
摘要： This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.
摘要翻译：本发明涉及包含与聚乙二醇偶联的IL-4突变蛋白受体拮抗剂的经修饰的IL-4突变蛋白受体拮抗剂。还提供了用于治疗目的的相关制剂和剂量及其施用方法。这些修饰的IL-4突变蛋白受体拮抗剂，组合物和方法通过抑制IL-4和IL-13介导的气道高反应性和嗜酸性粒细胞增多为患有呼吸系统疾病如哮喘的个体提供治疗选择。更具体地，这些拮抗剂由于更大的血浆半衰期而对未改性的IL-4RA具有增加的作用持续时间。

2. 发明申请

US20050232402A1 Voice messaging system with e-mail reply 审中-公开
标题翻译：具有电子邮件回复的语音留言系统
公开(公告)号：US20050232402A1
公开(公告)日：2005-10-20
申请号：US11092048
申请日：2005-03-29
申请人： Michael Greve
发明人： Michael Greve
IPC分类号： H04M1/64 , H04M3/537 , H04M11/00
CPC分类号： H04M3/537 , H04M2203/4536
摘要： A method for enabling a direct reply to a sent message sent by a sender includes receiving the sent message using a messaging system. The identification data of the sender is matched to an address of the message sender using a database, and the address is retrieved. Using the message system, the sent message is forwarded in an electronic form to a recipient so as to enable the recipient to send back a reply message to the sender using the retrieved address.
摘要翻译：用于使得能够直接回复由发送方发送的消息的方法包括使用消息系统接收所发送的消息。使用数据库将发送方的标识数据与消息发送方的地址进行匹配，并检索该地址。使用消息系统，将发送的消息以电子形式转发给接收者，以使接收者能够使用检索到的地址向发送者发送回复消息。

3. 发明申请

US20050154728A1 Notification of access for a sender of an electronic message 审中-公开
标题翻译：通知电子邮件的发件人的访问
公开(公告)号：US20050154728A1
公开(公告)日：2005-07-14
申请号：US10508076
申请日：2003-10-14
申请人： Michael Greve
发明人： Michael Greve
IPC分类号： H04L12/58 , G06F17/30
CPC分类号： H04L51/30
摘要： A method for notifying a sender of an electronic message to a recipient that the recipient has accessed the electronic message includes integrating data into the electronic message so as to associate message identification data with the electronic message before the electronic message is accessed. An access to the electronic message is detected by detecting an access to the integrated data. An access notification is provided to the sender indicating the access to the electronic message.
摘要翻译：一种用于向接收方通知电子消息的发送方接收者已经访问电子消息的方法包括将数据集成到电子消息中，以便在电子消息被访问之前将消息标识数据与电子消息相关联。通过检测对集成数据的访问来检测对电子消息的访问。向发送者提供指示对电子消息的访问的访问通知。

4. 发明申请

US20070280465A1 METHOD AND DEVICE FOR PROVIDING A SELECTION OPTION FOR ESTABLISHING A COMMUNICATION BETWEEN AT LEAST TWO TERMINALS 审中-公开
标题翻译：提供选择选项的方法和装置，用于建立至少两个端子之间的通信
公开(公告)号：US20070280465A1
公开(公告)日：2007-12-06
申请号：US11755896
申请日：2007-05-31
申请人： Michael Greve
发明人： Michael Greve
IPC分类号： H04M3/42
CPC分类号： H04L67/18 , H04L51/04 , H04L51/38 , H04L67/306 , H04M1/72577 , H04M3/42008 , H04M2242/14 , H04W8/20 , H04W76/10
摘要： A method and device for providing a selection option for establishing a communication between at least two terminals is provided. The communication is established on a first terminal of at least two terminals in a network. Each terminal has a public mode and a private mode. The public mode indicates that a user of a respective terminal is available as a communication partner to the other terminals. The private mode indicates that spontaneously establishing contacts via a selection of the selection option is not permitted. The other terminals operating in the public mode are detected when the first terminal is set in public mode and made available as a communication partner to the first terminal. At least one piece of identification information pertaining to the other terminals is displayed for selection on the first terminal.
摘要翻译：提供了一种用于提供用于在至少两个终端之间建立通信的选择选项的方法和装置。通信在网络中的至少两个终端的第一终端上建立。每个终端都有公共模式和私有模式。公共模式指示相应终端的用户作为与其他终端的通信伙伴可用。私人模式表示不允许通过选择选项自发建立联系人。当第一终端被设置为公共模式并且作为第一终端的通信伙伴可用时，检测在公共模式下工作的其他终端。显示与其他终端有关的至少一条识别信息，用于在第一终端上进行选择。

5. 发明申请

US20070083637A1 Protection from undesirable messages 审中-公开
标题翻译：防止不需要的信息
公开(公告)号：US20070083637A1
公开(公告)日：2007-04-12
申请号：US10576860
申请日：2004-10-21
申请人： Michael Greve
发明人： Michael Greve
IPC分类号： G06F15/173
CPC分类号： H04L51/12 , G06Q10/107 , H04L51/063
摘要： A method and system for monitoring messages addressed to a first receiver (E1), comprising a first receiver (E1) which contains a first undesirable receiver device (UNE) and which prevents a user of the first receiver (E1) from accessing the undesirable receiver (UNE), wherein a message category is defined as undesirable, and messages which are to be prevented from being made available to a user of the first receiver (E1) a re indicated. Verification occurs as to whether a message (M) addressed to the first receiver (E1) falls into the undesirable category. If the message (M) falls into the undesirable category, it is assigned to the undesirable receiver device (UNE). The first receiver (E1) is configured in such a way that the undesirable receiver (UNE) can only be accessed by a second receiver (E2). The first receiver (E1) is, f or example, an e-mail account of a child and the second receiver E2) is the e-mail account of an adult who can prevent the child from accessing undesirable messages, particularly Spam.
摘要翻译：一种用于监视寻址到第一接收机（E 1）的消息的方法和系统，包括：第一接收机（E 1），其包含第一不期望的接收机设备（UNE），并且防止第一接收机（E 1）的用户接入不期望的接收器（UNE），其中消息类别被定义为不期望的，并且将要防止对第一接收器（E 1）的用户可用的消息进行再次指示。关于寻址到第一接收机（E 1）的消息（M）是否落入不期望的类别中的验证。如果消息（M）落入不期望的类别，则将其分配给不期望的接收机设备（UNE）。第一接收机（E 1）被配置为使得不期望的接收机（UNE）只能被第二接收机（E 2）访问。第一接收者（E 1）是f或示例，儿童的电子邮件帐户，第二接收者E 2）是成年人的电子邮件帐户，可以防止孩子访问不期望的消息，特别是垃圾邮件。

6. 发明申请

US20090010874A1 MODIFIED IL-4 MUTEIN RECEPTOR ANTAGONISTS 失效
标题翻译：修饰的IL-4 MUTEIN受体拮抗剂
公开(公告)号：US20090010874A1
公开(公告)日：2009-01-08
申请号：US11940217
申请日：2007-11-14
申请人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson
发明人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson
IPC分类号： C07K14/54 , A61K38/20
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/7155
摘要： This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.
摘要翻译：本发明涉及包含与聚乙二醇偶联的IL-4突变蛋白受体拮抗剂的经修饰的IL-4突变蛋白受体拮抗剂。还提供了用于治疗目的的相关制剂和剂量及其施用方法。这些修饰的IL-4突变蛋白受体拮抗剂，组合物和方法通过抑制IL-4和IL-13介导的气道高反应性和嗜酸性粒细胞增多为患有呼吸系统疾病如哮喘的个体提供治疗选择。更具体地，这些拮抗剂由于更大的血浆半衰期而对未改性的IL-4RA具有增加的作用持续时间。

7. 发明申请

US20080214214A1 Method and System for Telecommunication with the Aid of Virtual Control Representatives 审中-公开
标题翻译：虚拟控制代表援助电信方法与系统
公开(公告)号：US20080214214A1
公开(公告)日：2008-09-04
申请号：US10597557
申请日：2005-01-31
申请人： Christian Reissmueller , Frank Schueler , Markus Knaup , Pierre-Alain Cotte , Michael Greve , Matthias Greve
发明人： Christian Reissmueller , Frank Schueler , Markus Knaup , Pierre-Alain Cotte , Michael Greve , Matthias Greve
IPC分类号： H04Q7/20
CPC分类号： H04L67/36 , G06F3/0486 , H04L12/1822 , H04L51/10 , H04L67/38 , H04M1/72544
摘要： Method and system of telecommunication between at least two users over a telecommunications network, wherein the first user is connected to the telecommunications network via a first terminal and the second user via a second terminal, and wherein a virtual representative is allocated to each user. A first virtual representative is allocated to the first user and a second virtual representative to the second user. The first and second virtual representatives are presented on the first terminal and on the second terminal. Information is transferred from the first user to the second user and vice versa by an animation of at least one of the first and second representatives and by an interaction between the first and second representatives, wherein at least one of the animation and the interaction takes place in response to a drag & drop command of a user, and wherein an animation of the first virtual representative takes place in response to a command of the first user and an animation of the second virtual representative takes place in response to a command of the second user.
摘要翻译：通过电信网络的至少两个用户之间的电信方法和系统，其中所述第一用户经由第一终端连接到所述电信网络，并且所述第二用户经由第二终端连接，并且其中虚拟代表被分配给每个用户。第一虚拟代表被分配给第一用户，第二虚拟代表被分配给第二用户。第一和第二虚拟代表呈现在第一终端和第二终端上。信息通过第一和第二代表中的至少一个的动画以及第一和第二代表之间的交互作用从第一用户传送到第二用户，反之亦然，其中动画和交互中的至少一个发生响应于用户的拖放命令，并且其中响应于第一用户的命令而发生第一虚拟代表的动画，并且响应于第二虚拟代表的命令发生第二虚拟代表的动画用户。

8. 发明授权

US07404957B2 Modified IL-4 mutein receptor antagonists 失效
标题翻译：修饰的IL-4突变蛋白受体拮抗剂
公开(公告)号：US07404957B2
公开(公告)日：2008-07-29
申请号：US10820559
申请日：2004-04-08
申请人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-fun Wong , Adrian Tomkinson
发明人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-fun Wong , Adrian Tomkinson
IPC分类号： A61K38/20 , A61K38/00 , C12P21/06 , C07K14/47
CPC分类号： A61K38/1709 , C07K14/5406 , C07K14/7155
摘要： This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.
摘要翻译：本发明涉及包含与聚乙二醇偶联的IL-4突变蛋白受体拮抗剂的经修饰的IL-4突变蛋白受体拮抗剂。还提供了用于治疗目的的相关制剂和剂量及其施用方法。这些修饰的IL-4突变蛋白受体拮抗剂，组合物和方法通过抑制IL-4和IL-13介导的气道高反应性和嗜酸性粒细胞增多为患有呼吸系统疾病如哮喘的个体提供治疗选择。更具体地，这些拮抗剂由于更大的血浆半衰期而对未改性的IL-4RA具有增加的作用持续时间。

9. 发明申请

US20060218233A1 Method and system for an e-mail service with processing of information e-mails of another internet service 审中-公开
标题翻译：用于处理另一互联网服务的信息电子邮件的电子邮件服务的方法和系统
公开(公告)号：US20060218233A1
公开(公告)日：2006-09-28
申请号：US11371132
申请日：2006-03-08
申请人： Michael Greve , Tino Anic
发明人： Michael Greve , Tino Anic
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , H04L51/24
摘要： A method of providing and operating an e-mail service (FM), wherein a user account (NK) with multiple folders (PE, PE1, PE2, . . . ) is assigned in each case to Internet users, wherein for the case that the user uses another Internet service (EB), particularly an auction service, which sends information e-mails to the user account (UK) of the e-mail service (FM), a services folder (AA) is provided, and wherein at least the incoming information e-mails from the Internet service (EB) are automatically tested depending on at least one specifiable criterion (ADR, IPA), particularly by testing the header data of the incoming e-mail, and, if the at least one criterion is fulfilled, are assigned to this services folder (AA). Preferably, and irrespective of the assignment of the e-mails to existing logical folders (PE1, PE2, PE3 . . . ), all e-mails which are recognized as auction e-mails are displayed in a common view (MA) and in the form of threads (A1, A2, A3 and A4). Additionally, a search function which is integrated into the e-mail system (FM), and can search by article designation and/or article number of the auction article, is offered to the user.
摘要翻译：一种提供和操作电子邮件服务（FM）的方法，其中具有多个文件夹（PE，PE 1，PE 2，...）的用户帐户（NK）在每种情况下被分配给互联网用户，其中对于用户使用将电子邮件发送到电子邮件服务（FM）的用户帐户（UK）的另一个互联网服务（EB），特别是拍卖服务，提供服务文件夹（AA），以及其中至少根据至少一个可指定标准（ADR，IPA）来自互联网服务（EB）的传入信息电子邮件被自动测试，特别是通过测试传入电子邮件的标题数据，以及如果在至少满足一个条件，分配给此服务文件夹（AA）。优选地，不管将电子邮件分配给现有的逻辑文件夹（PE 1，PE 2，PE 3 ...），被识别为拍卖电子邮件的所有电子邮件都以公共视图（MA ）和螺纹（A 1，A 2，A 3和A 4）的形式。此外，向用户提供集成到电子邮件系统（FM）中并且可以通过文章指定和/或拍卖品的商品号搜索的搜索功能。

10. 发明申请

US20050281206A1 Communications robot 审中-公开
标题翻译：通讯机器人
公开(公告)号：US20050281206A1
公开(公告)日：2005-12-22
申请号：US11189642
申请日：2005-07-26
申请人： Michael Greve , Pierre-Alain Cotte
发明人： Michael Greve , Pierre-Alain Cotte
IPC分类号： H04L12/26 , H04L12/58 , H04L29/06 , H04L29/08 , H04M1/2745 , H04M1/725 , H04M3/42 , H04M3/432 , H04M3/487 , H04M7/00
CPC分类号： H04L67/02 , H04L51/00 , H04L63/14 , H04L69/329 , H04M3/42 , H04M3/432 , H04M3/4878 , H04M7/003 , H04M7/0048 , H04M7/0054 , H04M7/123 , H04M7/128
摘要： A method for providing communications includes defining a communications parameter under control of a communications offering entity; implementing the communications parameter in a communications offering element; assigning the communications offering element to a target entity; providing at least a part of the communications offering element to the target entity; and providing, using the communications offering element, a communications offer to the target entity to communicate according to the communications parameter.
摘要翻译：一种用于提供通信的方法包括在通信提供实体的控制下定义通信参数; 在通信提供元素中实现通信参数; 将通信提供元素分配给目标实体; 向目标实体提供至少一部分通信提供元素; 以及使用所述通信提供元件向所述目标实体提供通信报价以根据所述通信参数进行通信。

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