专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06566066B1 Aquaporin-8 variant 失效
标题翻译：水通道蛋白-8变体
公开(公告)号：US06566066B1
公开(公告)日：2003-05-20
申请号：US09610906
申请日：2000-07-06
申请人： Michael G. Walker , Wayne Volkmuth , Tod M. Klinger
发明人： Michael G. Walker , Wayne Volkmuth , Tod M. Klinger
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
摘要翻译：本发明提供编码哺乳动物AQP8V的哺乳动物cDNA。它还提供使用cDNA，其片段，补体和变体，以及编码的蛋白质，其部分及其抗体用于诊断和治疗胰腺疾病，特别是I型糖尿病。本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统。

2. 发明授权

US06546340B2 Computer-aided probability base calling for arrays of nucleic acid probes on chips 有权
公开(公告)号：US06546340B2
公开(公告)日：2003-04-08
申请号：US09814144
申请日：2001-03-20
申请人： Robert J. Lipshutz , Michael G. Walker
发明人： Robert J. Lipshutz , Michael G. Walker
IPC分类号： G06F1900
CPC分类号： C12Q1/6837 , C12Q1/68 , G06F19/20 , Y10S435/973
摘要： A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, information from multiple experiments is utilized to improve the accuracy of calling unknown bases.

3. 发明授权

US06602667B1 Inflammation-associated polynucleotides 失效
公开(公告)号：US06602667B1
公开(公告)日：2003-08-05
申请号：US09855323
申请日：2001-05-14
申请人： Michael G. Walker , Wayne Volkmuth , Tod M. Klingler
发明人： Michael G. Walker , Wayne Volkmuth , Tod M. Klingler
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.

4. 发明授权

US06389428B1 System and method for a precompiled database for biomolecular sequence information 失效
标题翻译：用于生物分子序列信息的预编译数据库的系统和方法
公开(公告)号：US06389428B1
公开(公告)日：2002-05-14
申请号：US09797653
申请日：2001-04-11
申请人： Philippe E. Rigault , Anne L. Curtis , Richard D. Goold , David A. Hadley , Harold H. Hibbert , Tod M. Klingler , Robert E. Lagace , Laura L. Stuve , Michael G. Walker , Michael P. Wood
发明人： Philippe E. Rigault , Anne L. Curtis , Richard D. Goold , David A. Hadley , Harold H. Hibbert , Tod M. Klingler , Robert E. Lagace , Laura L. Stuve , Michael G. Walker , Michael P. Wood
IPC分类号： G06F1730
CPC分类号： G06F19/28 , Y10S707/99936 , Y10S707/99945 , Y10S707/99948
摘要： A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
摘要翻译：计算机系统将生物分子数据存储在存储器中的数据库中。生物分子数据库有一套实体。每个实体存储多个条目的属性。至少有一个属性存储在数组中。与条目关联的数据存储在数组中的某个位置。实体偏移量指定数组中数据的位置。相同的实体偏移值用于访问与实体内的所有属性的特定条目相关联的数据。

5. 发明授权

US06277574B1 Genes associated with diseases of the kidney 失效
标题翻译：与肾脏疾病相关的基因
公开(公告)号：US06277574B1
公开(公告)日：2001-08-21
申请号：US09289349
申请日：1999-04-09
申请人： Michael G. Walker , Wayne Volkmuth , Tod M. Klingler , Yalda Azimzai , Henry Yue
发明人： Michael G. Walker , Wayne Volkmuth , Tod M. Klingler , Yalda Azimzai , Henry Yue
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The invention provides novel kidney disease-associated genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for diagnosing, treating or preventing diseases of the kidney.
摘要翻译：本发明提供了由这些基因编码的新型肾病相关基因和多肽。本发明还提供表达载体，宿主细胞和抗体。本发明还提供了用于诊断，治疗或预防肾脏疾病的方法。

6. 发明授权

US06524799B1 DNA encoding sparc-related proteins 失效
标题翻译：编码sparc相关蛋白的DNA
公开(公告)号：US06524799B1
公开(公告)日：2003-02-25
申请号：US09642703
申请日：2000-08-16
申请人： Michael G. Walker , Randi E. Krasnow
发明人： Michael G. Walker , Randi E. Krasnow
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides mammalian cDNAs which encode mammalian SPARC-related proteins. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides expression vectors and host cells for the production of the proteins and transgenic model systems.
摘要翻译：本发明提供编码哺乳动物SPARC相关蛋白的哺乳动物cDNA。它还提供使用cDNA，其片段，补体和变体，以及编码的蛋白质，其部分及其抗体用于诊断和治疗动脉粥样硬化和细胞增殖性疾病。本发明另外提供用于产生蛋白质和转基因模型系统的表达载体和宿主细胞。

7. 发明授权

US06223186B1 System and method for a precompiled database for biomolecular sequence information 失效
标题翻译：用于生物分子序列信息的预编译数据库的系统和方法
公开(公告)号：US06223186B1
公开(公告)日：2001-04-24
申请号：US09175738
申请日：1998-10-20
申请人： Philippe E. Rigault , Anne L. Curtis , Richard D. Goold , David A. Hadley , Harold H. Hibbert , Tod M. Klingler , Robert E. Lagace , Laura L. Stuve , Michael G. Walker , Michael P. Wood
发明人： Philippe E. Rigault , Anne L. Curtis , Richard D. Goold , David A. Hadley , Harold H. Hibbert , Tod M. Klingler , Robert E. Lagace , Laura L. Stuve , Michael G. Walker , Michael P. Wood
IPC分类号： G06F1730
CPC分类号： G06F19/28 , Y10S707/99936 , Y10S707/99945 , Y10S707/99948
摘要： A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
摘要翻译：计算机系统将生物分子数据存储在存储器中的数据库中。生物分子数据库有一套实体。每个实体存储多个条目的属性。至少有一个属性存储在数组中。与条目关联的数据存储在数组中的某个位置。实体偏移量指定数组中数据的位置。相同的实体偏移值用于访问与实体内的所有属性的特定条目相关联的数据。

8. 发明授权

US06957149B2 Computer-aided probability base calling for arrays of nucleic acid probes on chips 失效
标题翻译：计算机辅助概率库，要求芯片上的核酸探针阵列
公开(公告)号：US06957149B2
公开(公告)日：2005-10-18
申请号：US10405962
申请日：2003-04-01
申请人： Robert J. Lipshutz , Michael G. Walker
发明人： Robert J. Lipshutz , Michael G. Walker
IPC分类号： C12Q1/68 , G06F19/20 , G06F19/00 , G11C17/00
CPC分类号： C12Q1/6837 , C12Q1/68 , G06F19/20 , Y10S435/973
摘要： A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, information from multiple experiments is utilized to improve the accuracy of calling unknown bases.
摘要翻译：提供了用于分析核酸序列的计算机系统。计算机系统用于通过分析生物芯片上杂交的核酸探针的荧光强度来计算用于确定未知碱基的概率。另外，利用来自多个实验的信息来提高呼叫未知基数的准确性。

9. 发明授权

US06633817B1 Sequence database search with sequence search trees 失效
标题翻译：序列数据库搜索与序列搜索树
公开(公告)号：US06633817B1
公开(公告)日：2003-10-14
申请号：US09474929
申请日：1999-12-29
申请人： Michael G. Walker , James Z. Wang , Eldar Y. Giladi
发明人： Michael G. Walker , James Z. Wang , Eldar Y. Giladi
IPC分类号： G01N3348
CPC分类号： G06F19/22 , G06F19/24
摘要： A method and system for generating and searching a tree-structured index of window vectors that represent database sequences comprise a window vector generation module, a tree-structured index generation module, a query sequence partitioning module, and a retrieval component. The window vector generation module partitions a database sequence into a plurality of overlapping windows. Each window has a fixed length W comprising a fixed number of nucleotides, and the offset among windows is determined by a parameter &Dgr;. The window vector generation module then maps each database sequence window into a window vector. The database sequence window vector indicates the frequency of appearance of each k-tuple in the corresponding database sequence window. The tree-structured index generation module then generates a tree-structured index using the database sequence window vectors. The query sequence partitioning module partitions a query sequence into a plurality of windows and maps each query sequence window into a query sequence window vector. Each query sequence window vector is then compared against the tree-structured index to locate the database sequences that are similar to the query sequence. The list of database sequences that are similar to the query sequence is then returned as the result of the search.
摘要翻译：用于生成和搜索表示数据库序列的窗口向量的树结构索引的方法和系统包括窗口向量生成模块，树结构索引生成模块，查询序列分区模块和检索组件。窗口向量生成模块将数据库序列分割成多个重叠窗口。每个窗口具有包含固定数目的核苷酸的固定长度W，并且窗口之间的偏移由参数Delta确定。然后，窗口向量生成模块将每个数据库序列窗口映射到窗口向量中。数据库序列窗口向量表示相应数据库序列窗口中每个k元组的出现频率。然后，树结构索引生成模块使用数据库序列窗口向量生成树结构索引。查询序列分区模块将查询序列分割成多个窗口，并将每个查询序列窗口映射到查询序列窗口向量中。然后将每个查询序列窗口向量与树结构索引进行比较，以定位与查询序列相似的数据库序列。作为搜索结果，返回与查询序列相似的数据库序列列表。

10. 发明授权

US6066454A Computer-aided probability base calling for arrays of nucleic acid probes on chips 失效
公开(公告)号：US6066454A
公开(公告)日：2000-05-23
申请号：US948896
申请日：1997-10-10
申请人： Robert J. Lipshutz , Michael G. Walker
发明人： Robert J. Lipshutz , Michael G. Walker
IPC分类号： C12Q1/68 , G06F19/20 , C07H21/04 , G06K9/18
CPC分类号： C12Q1/6837 , C12Q1/68 , G06F19/20 , Y10S435/973
摘要： A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, information from multiple experiments is utilized to improve the accuracy of calling unknown bases.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式