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1. 发明授权

US06406860B1 Method of detecting transmissible spongiform encephalopathies 失效
标题翻译：检测传染性海绵状脑病的方法
公开(公告)号：US06406860B1
公开(公告)日：2002-06-18
申请号：US09326976
申请日：1999-06-07
申请人： Gary Hsich , Kimbra Kenney , Clarence J. Gibbs, Jr. , Michael G. Harrington
发明人： Gary Hsich , Kimbra Kenney , Clarence J. Gibbs, Jr. , Michael G. Harrington
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S436/811
摘要： This invention provides an improved assays for the detection of transmissable spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissable spongiform encephalopathies, in particular Cretzfeldt-Jacob disease in humans or mad cow disease in bovines).
摘要翻译：本发明提供了用于检测人和非人哺乳动物中的透射性海绵状脑病（TSEs）的改进的测定方法。该方法涉及检测来自被测生物体的脑脊液中14-3-3蛋白的存在或不存在。升高的水平14-3-3指示透射性海绵状脑病，特别是人类中的克雷兹费尔特雅各布病或牛的疯牛病。

2. 发明授权

US5637202A Porous electrophoresis sponges 失效
标题翻译：多孔电泳海绵
公开(公告)号：US5637202A
公开(公告)日：1997-06-10
申请号：US400666
申请日：1995-03-08
申请人： Michael G. Harrington , Kelvin H. Lee
发明人： Michael G. Harrington , Kelvin H. Lee
IPC分类号： G01N27/447 , C25B9/00
CPC分类号： G01N27/44747
摘要： Porous plastic electrophoresis sponges having pore sizes range from 10.sup.-9 to 10.sup.-3 meters. The sponges are made from polyethylene, polypropylene, polytetrafluoroethylene, polyvinylidine difluoride, polynitrile or polystyrene. The porous plastic sponges are commercially available and are supplied in a prefabricated form which eliminates the preparative and pouring steps required for conventional gel electrophoresis support media. The porous sponges are available in a range of pore sizes and densities for use in a variety of electrophoresis systems to separate a variety of different materials including proteins, peptides and DNA. The porous electrophoresis sponges are relatively inert and may be used with organic solvents.
摘要翻译：多孔塑料电泳海绵的孔径范围为10-9至10-3米。海绵由聚乙烯，聚丙烯，聚四氟乙烯，聚偏二氟乙烯，聚腈或聚苯乙烯制成。多孔塑料海绵是市售的，并且以预制形式供应，其消除了常规凝胶电泳支持介质所需的制备和倾倒步骤。多孔海绵可用于一系列孔径和密度，用于各种电泳系统以分离各种不同的材料，包括蛋白质，肽和DNA。多孔电泳海绵是相对惰性的，可以与有机溶剂一起使用。

3. 发明授权

US5338428A Poly(N-Acylalkylenimine) electrophoresis support media 失效
标题翻译：聚（N-酰基亚烷基亚胺）电泳支持介质
公开(公告)号：US5338428A
公开(公告)日：1994-08-16
申请号：US69075
申请日：1993-05-28
申请人： Thomas Zewert , Michael G. Harrington
发明人： Thomas Zewert , Michael G. Harrington
IPC分类号： C08G73/02 , G01N27/447 , C25B9/00
CPC分类号： C08G73/0233 , G01N27/44747 , Y10S524/916
摘要： Electrophoresis support media which include one or more poly(N-Acylalkylenimine) polymers (PAEI). The polymers have the formula ##STR1## wherein m and p are between 1 and 3, n is between about 100 and 10,000, where R is an alkyl, perfluoroalkyl or phenyl group and wherein R' is H or an alkyl group. These polymers can be used in place of polyacrylamide gels, agar gels and agarose gels. PAEI polymers may be cross-linked with various cross-linking agents to provide electrophoresis support media with a wide range of pore sizes and physical strength.
摘要翻译：包含一种或多种聚（N-酰基亚烷基亚胺）聚合物（PAEI）的电泳载体介质。所述聚合物具有式（Ⅰa）其中m和p在1和3之间，n在约100和10,000之间，其中R是烷基，全氟烷基或苯基，其中R'是H或烷基。这些聚合物可用于代替聚丙烯酰胺凝胶，琼脂凝胶和琼脂糖凝胶。 PAEI聚合物可以与各种交联剂交联以提供具有宽范围孔径和物理强度的电泳支持介质。

4. 发明授权

US5290411A Acrylic polymer electrophoresis support media 失效
标题翻译：丙烯酸聚合物电泳支持介质
公开(公告)号：US5290411A
公开(公告)日：1994-03-01
申请号：US074266
申请日：1993-06-09
申请人： Thomas Zewert , Michael G. Harrington
发明人： Thomas Zewert , Michael G. Harrington
IPC分类号： G01N27/447 , C25B1/00 , C08F18/00
CPC分类号： G01N27/44747 , Y10S526/934
摘要： Electrophoresis support media which include one or more polymers made from hydroxy alkyl esters of acrylic or methylacrylic acid or poly (alkylene glycol) esters of acrylic or methacrylic acid. These acrylic or methacrylic monomers are polymerized or copolymerized to form electrophoresis support media which can be used in place of polyacrylamide gels, agar gels and agarose gels. The acrylic or methacrylic ester monomers may be cross-linked with various cross-linking agents to provide electrophoresis support media with a wide range of pore sizes and physical strength. The electrophoresis support media is well-suited for use with organic solvents.
摘要翻译：包括一种或多种由丙烯酸或甲基丙烯酸的羟基烷基酯或丙烯酸或甲基丙烯酸的聚（亚烷基二醇）酯制成的聚合物的电泳载体介质。这些丙烯酸或甲基丙烯酸单体被聚合或共聚以形成可用于代替聚丙烯酰胺凝胶，琼脂凝胶和琼脂糖凝胶的电泳支持介质。丙烯酸酯或甲基丙烯酸酯单体可以与各种交联剂交联以提供具有宽范围的孔径和物理强度的电泳支持介质。电泳支持介质非常适合与有机溶剂一起使用。

5. 发明授权

US5998149A Method of detecting transmissible spongiform encephalopathies 失效
标题翻译：检测传染性海绵状脑病的方法
公开(公告)号：US5998149A
公开(公告)日：1999-12-07
申请号：US630961
申请日：1996-04-05
申请人： Gary Hsich , Kimbra Kenney , Clarence J. Gibbs , Michael G. Harrington
发明人： Gary Hsich , Kimbra Kenney , Clarence J. Gibbs , Michael G. Harrington
IPC分类号： G01N27/447 , G01N33/68 , G01N33/53 , A61K49/04 , G01N1/00
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S436/811
摘要： This invention provides an improved assays for the detection of transmissible spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissible spongiform encephalopathies, in particular Creutzfeldt-Jacob disease in humans or mad cow disease in bovines).
摘要翻译：本发明提供了用于检测人和非人哺乳动物中的传染性海绵状脑病（TSEs）的改进的测定方法。该方法涉及检测来自被测生物体的脑脊液中14-3-3蛋白的存在或不存在。升高的水平14-3-3表示传染性海绵状脑病，特别是人类中的Creutzfeldt-Jacob病或牛的疯牛病。

6. 发明授权

US5397449A Acrylic polymer electrophoresis support media 失效
标题翻译：丙烯酸聚合物电泳支持介质
公开(公告)号：US5397449A
公开(公告)日：1995-03-14
申请号：US223582
申请日：1994-04-06
申请人： Thomas Zewert , Michael G. Harrington
发明人： Thomas Zewert , Michael G. Harrington
IPC分类号： G01N27/447 , C25B1/00 , C08F18/00
CPC分类号： G01N27/44747 , Y10S526/934
摘要： Electrophoresis support media which include one or more polymers made from hydroxy alkyl esters of acrylic or methylacrylic acid or poly (alkylene glycol) esters of acrylic or methacrylic acid. These acrylic or methacrylic monomers are polymerized or copolymerized to form electrophoresis support media which can be used in place of polyacrylamide gels, agar gels and agarose gels. The acrylic or methacrylic ester monomers may be cross-linked with various cross-linking agents to provide electrophoresis support media with a wide range of pore sizes and physical strength. The electrophoresis support media is well-suited for use with organic solvents.
摘要翻译：包括一种或多种由丙烯酸或甲基丙烯酸的羟基烷基酯或丙烯酸或甲基丙烯酸的聚（亚烷基二醇）酯制成的聚合物的电泳载体介质。这些丙烯酸或甲基丙烯酸单体被聚合或共聚以形成可用于代替聚丙烯酰胺凝胶，琼脂凝胶和琼脂糖凝胶的电泳支持介质。丙烯酸酯或甲基丙烯酸酯单体可以与各种交联剂交联以提供具有宽范围的孔径和物理强度的电泳支持介质。电泳支持介质非常适合与有机溶剂一起使用。

7. 发明授权

US4892814A Method for distinguishing Creutzfeldt-Jakob disease from other dementias 失效
标题翻译：将克雅氏病与其他痴呆症区分开来的方法
公开(公告)号：US4892814A
公开(公告)日：1990-01-09
申请号：US67420
申请日：1987-06-22
申请人： Michael G. Harrington , Carl R. Merril , David M. Asher , D. Carleton Gajdusek
发明人： Michael G. Harrington , Carl R. Merril , David M. Asher , D. Carleton Gajdusek
IPC分类号： G01N33/487 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/56983 , G01N2800/2828 , Y10S436/811
摘要： A method for distinguishing Creutzfeldt-Jakob disease from other causes of human dementia by analyzing the cerebrospinal fluid of patients for proteins 130 and 131. The presence of these proteins indicates the presence of Creutzfeldt-Jakob disease.
摘要翻译：通过分析患者的蛋白质130和131的脑脊液来区分克雅氏病和其他原因的人类痴呆的方法。这些蛋白质的存在表明Creutzfeldt-Jakob病的存在。

8. 发明授权

US08670941B2 Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease 有权
标题翻译：测定游离氨基酸和二肽水平并诊断阿尔茨海默病的方法
公开(公告)号：US08670941B2
公开(公告)日：2014-03-11
申请号：US12377765
申请日：2007-08-17
申请人： Alfred N. Fonteh , Michael G. Harrington
发明人： Alfred N. Fonteh , Michael G. Harrington
IPC分类号： A61B5/145 , G01N33/48 , G01N33/49 , B01D15/08
CPC分类号： G01N33/6896 , G01N33/6812 , G01N33/9413 , G01N2410/00 , G01N2800/2821
摘要： Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.
摘要翻译：本文提供了基于个体的体液样品中某些游离氨基酸或二肽（统称为“AD诊断标记”）的水平的特征变化来诊断阿尔茨海默氏病（“AD”）的方法，其中肌肽合成活性血浆和血浆中的多巴胺合成活性。还提供了同时测定个体生物流体样品中至少两种游离氨基酸或二肽水平的方法。

9. 发明授权

US08163270B2 Methods of diagnosing and treating migraine 有权
标题翻译：诊断和治疗偏头痛的方法
公开(公告)号：US08163270B2
公开(公告)日：2012-04-24
申请号：US12298254
申请日：2007-04-24
申请人： Michael G. Harrington , Alfred N. Fonteh
发明人： Michael G. Harrington , Alfred N. Fonteh
IPC分类号： A61B5/055
CPC分类号： G01N33/6896 , A61K31/00 , A61K31/7042 , G01N2800/2807
摘要： The present invention provides methods of diagnosing migraine attacks and determining predisposition of an individual to the development of migraine based on sodium level in the cerebrospinal fluid (CSF) and/or brain extracellular fluid. The invention also provides methods of treating migraine, wherein the individual is selected for treatment based in the individual's sodium level in the CSF and/or brain extracellular fluid. The CSF sodium level may be based on the sodium concentration in the saliva.
摘要翻译：本发明提供诊断偏头痛发作的方法，并且基于脑脊液（CSF）和/或脑细胞外液中的钠含量确定个体对偏头痛发展的倾向。本发明还提供了治疗偏头痛的方法，其中根据个体在CSF和/或脑细胞外液中的钠水平选择个体进行治疗。 CSF钠水平可以基于唾液中的钠浓度。

10. 发明申请

US20110285080A1 SHEET DECELERATION APPARATUS AND METHOD 有权
标题翻译：表格递减装置和方法
公开(公告)号：US20110285080A1
公开(公告)日：2011-11-24
申请号：US13086162
申请日：2011-04-13
申请人： Craig H. Gendreau , Curtis A. Roth , Lynn E. Vershum , Kevin P. Brown , Michael G. Harrington
发明人： Craig H. Gendreau , Curtis A. Roth , Lynn E. Vershum , Kevin P. Brown , Michael G. Harrington
IPC分类号： B65H5/34 , B65H31/00
CPC分类号： B65H29/68 , B65H29/14 , B65H29/6618 , B65H2301/42172 , B65H2301/44322 , B65H2404/141 , B65H2404/1411 , B65H2404/1521 , B65H2701/1313 , B65H2701/1764
摘要： Sheet deceleration apparatus and methods for decelerating a sheet of material for use in a sheet stacking or other application. The deceleration apparatus includes a rotatable cam nip, rotatable about a first axis and provided on one side of the travel path, such that the sheet of material can pass by the cam nip. The cam nip includes a lobe end, such that when the lobe end is away from the travel path, the sheet of material can pass substantially unimpeded past the cam nip, and when the lobe end is near the travel path, the sheet of material is nipped by the cam nip decelerating the sheet of material from the first speed to a second speed.
摘要翻译：片材减速装置和方法，用于使片材堆叠或其他应用中使用的材料片减速。减速装置包括可转动的凸轮夹持部，其能够围绕第一轴线旋转并且设置在行进路径的一侧，使得片材材料可以通过凸轮辊隙。凸轮夹持部包括凸起端，使得当凸起端远离行进路径时，该材料片可以基本上不受阻碍地穿过凸轮辊隙，并且当凸起端靠近行进路径时，该材料片是通过凸轮夹持夹持将材料片从第一速度减速到第二速度。

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