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1. 发明授权

US5902585A Methods of inducing T cell unresponsiveness to donor tissue or organ in a recipient with GP39 antagonists 失效
标题翻译：在GP39拮抗剂的受体中诱导T细胞对供体组织或器官的反应性的方法
公开(公告)号：US5902585A
公开(公告)日：1999-05-11
申请号：US906332
申请日：1997-08-05
申请人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
发明人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
IPC分类号： C12N15/02 , A61K31/00 , A61K35/14 , A61K35/38 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/10 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C12P21/08 , C12R1/91 , A61K35/26 , C07K14/435
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , C07K14/705 , C07K16/2875 , A61K2039/505 , A61K38/00 , C07K2317/73 , Y10S514/885
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, sklin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植食谱中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，肌肉，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

2. 发明授权

US5683693A Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 失效
标题翻译：用抗CD40配体抗体或可溶性CD40诱导T细胞对组织或器官移植物无反应的方法
公开(公告)号：US5683693A
公开(公告)日：1997-11-04
申请号：US234987
申请日：1994-04-25
申请人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
发明人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
IPC分类号： C12N15/02 , A61K31/00 , A61K35/14 , A61K35/38 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/10 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C12P21/08 , C12R1/91
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , C07K14/705 , C07K16/2875 , A61K2039/505 , A61K38/00 , C07K2317/73 , Y10S514/885
摘要： Methods for inducing T cell unresponsiveness to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell unresponsiveness to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植食谱中诱导T细胞对组织或器官移植物无反应的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导T细胞对肝脏，肾脏，心脏，肺，皮肤，肌肉，神经元组织，胃和肠等移植物的反应。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

3. 发明授权

US07501124B2 Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies 失效
标题翻译：用抗gp39 24-31抗体诱导T细胞非反应性的方法
公开(公告)号：US07501124B2
公开(公告)日：2009-03-10
申请号：US10962033
申请日：2004-10-07
申请人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
发明人： Randolph J. Noelle , Fiona H. Durie , David C. Parker , Michael C. Appel , Nancy E. Phillips , John P. Mordes , Dale L. Grenier , Aldo A. Rossini
IPC分类号： A61K39/395 , A61K35/26 , A61K35/28 , C07K16/28
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植食谱中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

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