专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5134065A Tissue plasminogen activator inhibitor and method of purification 失效
标题翻译：组织纤溶酶原激活物抑制剂和纯化方法
公开(公告)号：US5134065A
公开(公告)日：1992-07-28
申请号：US864070
申请日：1986-05-16
申请人： Michael A. Sanzo , Arthur J. Wittwer , Jayne C. Marasa , Joseph Feder
发明人： Michael A. Sanzo , Arthur J. Wittwer , Jayne C. Marasa , Joseph Feder
IPC分类号： C07K14/81
CPC分类号： C07K14/8132
摘要： A novel and unique plasminogen activator inhibitor fragment is obtained from human umbilical vein endothelial cells which has the following characteristics:A. it is derived from a native t-PA inhibitor that binds to and inhibits the activity of t-PA,B. it is dissociated from a complex formed between said native t-PA inhibitor and t-PA, said complex existing in two distinct interconvertible conformations with molecular weight of about 88 KDa and 105 KDa, respectively, and being partially reversible in the presence of fibrin,C. it has a molecular weight of about 40 KDa when dissociated from the complex, andD. it has a novel partial N-terminal amino acid sequence when dissociated from the complex.
摘要翻译：从人脐静脉内皮细胞获得一种新颖独特的纤溶酶原激活物抑制剂片段，其具有以下特征：A.它衍生自结合并抑制t-PA，B的活性的天然t-PA抑制剂。它是从所述天然t-PA抑制剂和t-PA之间形成的复合物解离，所述复合物分别存在于分子量约88KDa和105KDa的两种不同的可互变构象中，并且在纤维蛋白C存在下部分可逆。当从络合物中解离时，其具有约40KDa的分子量，以及D.当从络合物解离时，其具有新的部分N-末端氨基酸序列。

2. 发明授权

US5039791A Peptide fragments of tissue plasminogen activator 失效
标题翻译：组织纤溶酶原激活物的肽片段
公开(公告)号：US5039791A
公开(公告)日：1991-08-13
申请号：US432256
申请日：1989-11-06
申请人： Arthur J. Wittwer , Michael A. Sanzo
发明人： Arthur J. Wittwer , Michael A. Sanzo
IPC分类号： A61K38/00 , C12N9/72
CPC分类号： C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： Novel peptide fragments of tissue plasminogen activator are described which have activity for inhibiting (a) the binding of tPA to human endothelial cells, and (b) the inactivation of tPA by plasminogen activator inhibitor-1 (PAI-1). Six peptides or peptide amides with these activities have the sequences, numbered according to the native protein:tPA (31-55),tPA (81-105),tPA (181-205),tPA (301-325),tPA (451-475, andtPA (531-555).It is hoped that small, synthesizeable molecules which prevent the inactivation of tPA by PAI-1 may provide a means for improving the efficacy of therapeutically administered tPA or for reducing the tendency of patients with elevated plasma PAI-1 concentrations to form fibrin clots.
摘要翻译：描述了组织纤溶酶原激活物的新型肽片段，其具有抑制（a）tPA与人内皮细胞结合的活性，和（b）通过纤溶酶原激活物抑制剂-1（PAI-1）灭活tPA。具有这些活性的六种肽或肽酰胺具有根据天然蛋白质编号的序列：tPA（31-55），tPA（81-105），tPA（181-205），tPA（301-325），tPA（451 -475和tPA（531-555），希望通过PAI-1阻止tPA失活的小的合成分子可以提供治疗性给药tPA或降低患者倾向的方法血浆PAI-1浓度形成纤维蛋白凝块。

3. 发明授权

US4957863A Method of increasing yield of t-PA in cell culture 失效
标题翻译：增加细胞培养中t-PA的产量的方法
公开(公告)号：US4957863A
公开(公告)日：1990-09-18
申请号：US148409
申请日：1988-01-26
申请人： Michael A. Sanzo , Medora M. Hardy , Joseph Feder
发明人： Michael A. Sanzo , Medora M. Hardy , Joseph Feder
IPC分类号： C12N9/64 , C12N9/72
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： A method is disclosed for increasing the yield of t-PA in culture of mammalian cells comprising introducing antibodies to the t-PA of said cells into the cell culture nutrient medium, allowing the cells to grow, and then recovering t-PA from the t-PA-antibody complex thus found in the conditioned medium by exchanging antibody in the complex for t-PA antibody immobilized on an inert support.

4. 发明公开

US20240357982A1 Hydroponic System for Use in a Desert-Like Environment 审中-公开
公开(公告)号：US20240357982A1
公开(公告)日：2024-10-31
申请号：US18642705
申请日：2024-04-22
申请人： Michael A. Sanzo
发明人： Michael A. Sanzo
IPC分类号： A01G31/02 , A01G9/24 , A01G27/00
CPC分类号： A01G31/02 , A01G9/241 , A01G27/005
摘要： The present invention is directed to hydroponic systems that can be used in an environment with large daily fluctuations in temperature and to the use of those systems for growing plants.

5. 发明授权

US12127515B1 Hydroponic system for use in a desert-like environment 有权
公开(公告)号：US12127515B1
公开(公告)日：2024-10-29
申请号：US18642705
申请日：2024-04-22
申请人： Michael A. Sanzo
发明人： Michael A. Sanzo
IPC分类号： A01G31/02 , A01G9/24 , A01G27/00
CPC分类号： A01G31/02 , A01G9/241 , A01G27/005
摘要： The present invention is directed to hydroponic systems that can be used in an environment with large daily fluctuations in temperature and to the use of those systems for growing plants.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式