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2. 发明申请

WO1996015127A1 PYRIDAZINOQUINOLINE COMPOUNDS 审中-公开
标题翻译：吡啶并喹啉化合物
公开(公告)号：WO1996015127A1
公开(公告)日：1996-05-23
申请号：PCT/GB1995002613
申请日：1995-11-08
申请人： ZENECA LIMITED , BARE, Thomas, Michael , CHAPDELAINE, Marc, Jerome , DAVENPORT, Timothy, Wayne , EMPFIELD, James, Roy , GARCIA-DAVENPORT, Laura, Enid , JACKSON, Paul, Francis , McKINNEY, Jeffrey, Alan , McLAREN, Charles, David , SPARKS, Richard, Bruce
发明人： ZENECA LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to pyridazinoquinoline coumpounds of formulae A and A', wherein: ring A is chosen from an ortho fused aromatic or heteroaromatic five- or six-membered ring; R is selected from the group consisting of halo, (1-4C)alkyl, NO2, CN, (C1-3)perfluoroalkyl, OH, OCF3, (2-4C)alkenyl, (2-4C)alkynyl, O(1-4C)alkyl, NR'R", SO2NR'R", or SOmR'; R is selected from H, (1-6C)alkyl, or -(CH2)nL; R is selected from H or -(CH2)nL; L is a variety of substituents including phenyl, heterocyclic groups and heteroaryl; n is 0-6; m is 0-2, R is selected from H, (1-6C)alkyl or (1-6C)alkylaryl; R is selected from H or -(CO)R wherein R is selected from a variety of substituents including hydrogen, (1-12C)alkyl, pyridyl, phenyl, pyridyl (1-12C)alkyl and phenyl (1-4C)alkyl; and R' and R" are selected from H, (1-4C)alkyl, (3-6C)cycloalkyl, phenyl (0-4)alkyl-, heterocycle (0-4C)alkyl- or heteroaryl (0-4C)alkyl- to pharmaceutical compositions containing them and to methods for the treatment of neurological disorders utilizing them.
摘要翻译：本发明涉及式A和A'的哒嗪喹啉基团，其中：环A选自邻近稠合芳族或杂芳族五元或六元环; R 4选自卤素，（1-4C）烷基，NO 2，CN，（C 1-3）全氟烷基，OH，OCF 3，（2-4C）烯基，（2-4C）炔基，O （1-4C）烷基，NR'R“，SO2NR'R”或SOmR'; R 1选自H，（1-6C）烷基或 - （CH 2）n L; R 2选自H或 - （CH 2）n L; L是各种取代基，包括苯基，杂环基和杂芳基; n为0-6; m为0-2，R 5选自H，（1-6C）烷基或（1-6C）烷基芳基; R 3选自H或 - （CO）R 6，其中R 6选自多种取代基，包括氢，（1-12C）烷基，吡啶基，苯基，吡啶基（1-12C）烷基和苯基（1-4C）烷基; 并且R'和R“选自H，（1-4C）烷基，（3-6C）环烷基，苯基（0-4）烷基 - ，杂环（0-4C）烷基 - 或杂芳基（0-4C）烷基 - 含有它们的药物组合物和用于治疗利用它们的神经障碍的方法。

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