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1. 发明授权

US5051407A Methods for treating viruses in patients by administering 2-hydroxymethylene-3,4,5-trihydroxypiperidines 失效
标题翻译：通过给予2-羟基亚甲基-3,4,5-三羟基哌啶来治疗患者病毒的方法
公开(公告)号：US5051407A
公开(公告)日：1991-09-24
申请号：US259932
申请日：1988-10-19
申请人： Horst Boshagen , Bodo Junge , Gunther Kinast , Matthias Schuller , Jurgen Stoltefuss , Arnold Paessens
发明人： Horst Boshagen , Bodo Junge , Gunther Kinast , Matthias Schuller , Jurgen Stoltefuss , Arnold Paessens
IPC分类号： C07H5/04 , A61K31/445 , A61K31/70 , A61K31/7008 , A61K31/7028 , A61P31/12 , C07D211/36 , C07H7/02 , C07H15/04 , C07H15/26
CPC分类号： A61K31/445 , C07H15/26
摘要： A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a 2-hydroxymethylene-3,4,5-trihydroxypiperidine.
摘要翻译：一种用于治疗人或动物患者的病毒感染的方法，包括向所述患者施用抗病毒有效量的取代羟基哌啶，即2-羟基亚甲基-3,4,5-三羟基哌啶。

2. 发明授权

US4940705A N-substituted derivatives of 1-desoxynojirimycin and 1-desoxymannonojirimycin and pharmaceutical use 失效
标题翻译： 1-脱氧野尻霉素和1-脱氧甘露聚菌霉素的N-取代衍生物和药物用途
公开(公告)号：US4940705A
公开(公告)日：1990-07-10
申请号：US262902
申请日：1988-10-26
申请人： Horst Boshagen , Bodo Junge , Arnold Paessens , Matthias Schuller
发明人： Horst Boshagen , Bodo Junge , Arnold Paessens , Matthias Schuller
IPC分类号： C07D487/08 , A61K31/4427 , A61K31/443 , A61K31/445 , A61P31/12 , C07D211/46 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D453/02
CPC分类号： C07D401/06 , C07D211/46 , C07D401/12 , C07D405/12 , C07D409/12 , C07D453/02
摘要： N-substituted derivatives of 1-desoxynojirimycin and 1-desoxymannojirimycin of the formula ##STR1## in which one of R and R' are hydroxyl and the other is hydrogenn is a number from 1 to 6R.sup.1 is hydrogen, alkyl or benzyl andR.sup.2 is alkyl which is optionally substituted by an optionally substituted aryl or by pyridyl, thienyl, furyl, pyrimidyl, pyrazinyl or quinolyl or R.sub.1 is cycloalkyl or R.sup.2 is optionally substituted by aryl or R.sup.2 is a saturated bridged heterocycle or R.sup.1 and R.sup.2 together can form a heterocyclic ring which is optionally substituted. These compounds are useful in the treatment of and prophylaxis of viral infections.
摘要翻译：其中R和R'之一是羟基，另一个是氢的1-脱氧野尻霉素和1-脱氧神经霉素的1-取代的脱氧神经生物霉素的N-取代的衍生物是1至6个。R1是氢，烷基或苄基，R2是是任选被任选取代的芳基或吡啶基，噻吩基，呋喃基，嘧啶基，吡嗪基或喹啉基取代的烷基，或者R 1是环烷基或R 2任选地被芳基取代，或者R 2是饱和桥连杂环，或者R 1和R 2可一起形成任选被取代的杂环。这些化合物可用于治疗和预防病毒感染。

3. 发明授权

US4871747A 3-Amino-4,5-dihydroxypiperidines, process for their preparation and their use 失效
标题翻译： 3-氨基-4,5-二羟基哌啶，其制备及其用途
公开(公告)号：US4871747A
公开(公告)日：1989-10-03
申请号：US937645
申请日：1986-12-03
申请人： Gunther Kinast , Matthias Schuller , Theo Schroder
发明人： Gunther Kinast , Matthias Schuller , Theo Schroder
IPC分类号： C07D211/46 , C07D211/56 , C07D491/04 , C07D491/056 , C07H13/04 , C07H13/12
CPC分类号： C07D491/04 , C07D211/46 , C07D211/56 , C07H13/04 , C07H13/12
摘要： A 3-amino-4,5-dihydroxy-piperidine compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl having up to 8 carbon atoms, aralkyl having 7 to 14 carbon atoms, or represents a group of the formula ##STR2## R.sup.4 denotes straight-chain or branched alkyl having up to 8 carbon atoms, straight-chain or branched alkoxy having up to 8 carbon atoms, or aralkoxy having up to 10 carbon atoms, andR.sup.2 and R.sup.3 represent hydrogen or represent the group NHR.sup.5,R.sup.5 having the same meaning as R.sup.1 and being identical to or different from the latter,with the proviso that, in every case, one substituent of R.sup.2 or R.sup.3 represents hydrogen and the other substituent of R.sup.2 or R.sup.3 represents NHR.sup.5, and physiologically acceptable salts thereof. Such compound is useful to treat prediabetes, gastritis, constipation, caries, atherosclerosis, obesity, diabetes and hyperlipoproteinaemia.
摘要翻译：式（I）的3-氨基-4,5-二羟基 - 哌啶化合物其中R 1表示氢，具有至多8个碳原子的烷基，具有7-14个碳原子的芳烷基，或表示式的基团R4表示具有至多8个碳原子的直链或支链烷基，具有至多8个碳原子的直链或支链烷氧基或具有至多10个碳原子的芳烷氧基，R2和R3表示氢或代表NHR5基团，R 5具有与R 1相同的含义并且与后者相同或不同，条件是在每种情况下，R 2或R 3的一个取代基表示氢，R 2或R 3的其它取代基表示NHR 5 ，及其生理上可接受的盐。这种化合物可用于治疗糖尿病前期，胃炎，便秘，龋齿，动脉粥样硬化，肥胖，糖尿病和高脂蛋白血症。

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