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1. 发明授权

US08173650B2 Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use 有权
标题翻译：双环嘧啶PI3K抑制剂化合物选择性为P110δ，以及使用方法
公开(公告)号：US08173650B2
公开(公告)日：2012-05-08
申请号：US12787613
申请日：2010-05-26
申请人： Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
发明人： Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译：式（I）和（Ib）化合物，其中（i）X1为N，X 2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，或（iv）X1为CR7， X 2为O，包括立体异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学和癌症介导的病症。公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

2. 发明申请

US20060288352A1 Data Processing Method and System 审中-公开
标题翻译：数据处理方法与系统
公开(公告)号：US20060288352A1
公开(公告)日：2006-12-21
申请号：US11419775
申请日：2006-05-23
申请人： Matthew Lucas
发明人： Matthew Lucas
IPC分类号： G06F9/46
CPC分类号： G06F8/73
摘要： A data processing method for operating a sample program and a related application programming interface comprises executing instructions of the sample program, and, for each specific instruction consisting of a call to the related application programming interface, accessing information embedded in the application programming interface relating to the specific instruction and presenting the information relating to the specific instruction.
摘要翻译：用于操作示例程序和相关应用程序编程接口的数据处理方法包括执行示例程序的指令，并且对于由对相关应用编程接口的调用组成的每个特定指令，访问嵌入在应用编程接口中的信息具体说明并提供与具体说明有关的信息。

3. 发明申请

US20210077079A1 Reusable specimen imaging device holder system with replaceable membranes 有权
公开(公告)号：US20210077079A1
公开(公告)日：2021-03-18
申请号：US16575372
申请日：2019-09-18
申请人： Janice Ann Cureton , Matthew Lucas Chatman
发明人： Janice Ann Cureton , Matthew Lucas Chatman
IPC分类号： A61B10/00 , B01L9/00 , G01N33/483
摘要： The present invention is for the retention of surgically removed tissue for radiographic imaging. In breast conservation surgery specimen radiographic imaging is used to evaluate the success of removed diseased tissue with a negative margin. Accurate positioning of tissue orientation with minimal compression of the removed pathologic neoplasm is employed. The radiolucent device holder's purpose is to secure the tissue in proper orientation for radiographic imaging and margin evaluation. The present invention is a reusable system. It features a snap together component that allows for the replacing of the radiolucent membranes. Components are properly disinfected and membranes replaced making the device holder ready for reuse. This reusability is innovative, more cost effective and reduces medical waste. While this present invention, reusable specimen imaging holder device system with replaceable membranes has particular use in breast conservation surgery specimen imaging for optimal margin evaluation it is not exclusive to that purpose.

4. 发明授权

US08299077B2 Inhibitors of Bruton's tyrosine kinase 有权
标题翻译： Bruton酪氨酸激酶抑制剂
公开(公告)号：US08299077B2
公开(公告)日：2012-10-30
申请号：US12711312
申请日：2010-02-24
申请人： Steven Berthel , Fariborz Firooznia , Daniel Fishlock , Jun-Bae Hong , Yan Lou , Matthew Lucas , Timothy D. Owens , Keshab Sarma , Zachary Kevin Sweeney , Joshua Paul Gergely Taygerly
发明人： Steven Berthel , Fariborz Firooznia , Daniel Fishlock , Jun-Bae Hong , Yan Lou , Matthew Lucas , Timothy D. Owens , Keshab Sarma , Zachary Kevin Sweeney , Joshua Paul Gergely Taygerly
IPC分类号： A61K31/502 , C07D237/32
CPC分类号： C07D401/10 , C07D401/14 , C07D403/14 , C07D413/14
摘要： This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formula I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I-III and at least one carrier, diluent or excipient.
摘要翻译：该申请公开了根据通式I-III的5-苯基-1H-吡啶-2-酮，6-苯基-2H-哒嗪-3-酮和5-苯基-1H-吡嗪-2-酮衍生物：其中，变量Q，R，X，X'，Y1，Y2，Y2'，Y3，Y4，Y5，m和n如本文所述限定Btk。本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。还公开了含有式I-III化合物和至少一种载体，稀释剂或赋形剂的组合物。

5. 发明申请

US20120178736A1 BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE 失效
标题翻译：用于P110 DELTA的双相PYRIMIDIN PI3K抑制剂化合物选择及使用方法
公开(公告)号：US20120178736A1
公开(公告)日：2012-07-12
申请号：US13427081
申请日：2012-03-22
申请人： Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
发明人： Georgette Castanedo , Bryan Chan , David Goldstein , Rama Kondru , Matthew Lucas , Wylie Palmer , Stephen Price , Brian Safina , Pascal Pierre Alexandre Savy , Eileen Mary Seward , Daniel P. Sutherlin , Zachary K. Sweeney
IPC分类号： A61K31/5377 , C07D487/04 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P1/04 , A61P1/00 , A61P17/00 , A61P11/06 , A61P19/04 , A61P25/00 , A61P7/02 , A61P7/00 , A61P11/00 , A61P17/06 , A61P19/02 , C07D495/04
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is 0, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译：式（I）和（Ib）化合物，其中（i）X1为N，X 2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，或（iv）X1为CR7， X 2为0，包括立体异构体，互变异构体，代谢物和药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学和癌症介导的病症。公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

6. 发明申请

US20080053072A1 Spark plug having separate housing-mounted electrode 有权
标题翻译：火花塞具有独立的外壳安装电极
公开(公告)号：US20080053072A1
公开(公告)日：2008-03-06
申请号：US11513285
申请日：2006-08-31
申请人： Robert L. Miller , Thomas Randall McClure , Kevin James Karkkainen , Robert Matthew Lucas
发明人： Robert L. Miller , Thomas Randall McClure , Kevin James Karkkainen , Robert Matthew Lucas
IPC分类号： F01N3/00
CPC分类号： H01T13/08 , H01T13/32
摘要： A spark plug arrangement for an exhaust treatment device is disclosed. The spark plug arrangement may have a body, and a center electrode extending from an end of the body. The spark plug arrangement may further have a mounting member with a bore configured to receive the body, and a grounded electrode extending proximal the center electrode.
摘要翻译：公开了一种用于废气处理装置的火花塞装置。火花塞装置可以具有主体和从主体的端部延伸的中心电极。火花塞装置还可以具有安装构件，其具有构造成容纳主体的孔，以及在中心电极附近延伸的接地电极。

7. 发明申请

US20070123527A1 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof 失效
标题翻译： 3-氨基-1-芳基丙基吲哚和氮杂取代的吲哚及其用途
公开(公告)号：US20070123527A1
公开(公告)日：2007-05-31
申请号：US11605528
申请日：2006-11-29
申请人： Pravin Iyer , Matthew Lucas , Ryan Schoenfeld , Marzia Villa , Robert Weikert
发明人： Pravin Iyer , Matthew Lucas , Ryan Schoenfeld , Marzia Villa , Robert Weikert
IPC分类号： A61K31/538 , A61K31/498 , A61K31/506 , A61K31/501 , A61K31/4745 , A61K31/428 , A61K31/423 , C07D413/02 , C07D417/02 , C07D403/02
CPC分类号： C07D209/12 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/32 , C07D209/40 , C07D209/42 , C07D231/56 , C07D235/06 , C07D235/24 , C07D235/26 , C07D307/79 , C07D311/04 , C07D333/52 , C07D333/58 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/06 , C07D413/06 , C07D417/10 , C07D471/04
摘要： The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
摘要翻译：本发明提供下式的化合物或其药学上可接受的盐，溶剂合物或前药，其中p，Ar，R 1，R 2，R 3， R SUP，R，B，R，C，R，D， / SUP>。还提供药物组合物，使用方法和制备化合物的方法。

8. 发明授权

US07183765B2 Micro-position sensor using faraday effect 失效
标题翻译：微位置传感器采用法拉第效应
公开(公告)号：US07183765B2
公开(公告)日：2007-02-27
申请号：US10879222
申请日：2004-06-28
申请人： Michael McElfresh , Matthew Lucas , Joseph P. Silveira , Scott E. Groves
发明人： Michael McElfresh , Matthew Lucas , Joseph P. Silveira , Scott E. Groves
IPC分类号： G01R33/032 , G01B7/14
CPC分类号： G01D5/145 , G01D5/266 , G01D5/35303
摘要： A micro-position sensor and sensing system using the Faraday Effect. The sensor uses a permanent magnet to provide a magnetic field, and a magneto-optic material positioned in the magnetic field for rotating the plane of polarization of polarized light transmitted through the magneto-optic material. The magnet is independently movable relative to the magneto-optic material so as to rotate the plane of polarization of the polarized light as a function of the relative position of the magnet. In this manner, the position of the magnet relative to the magneto-optic material may be determined from the rotated polarized light. The sensing system also includes a light source, such as a laser or LED, for producing polarized light, and an optical fiber which is connected to the light source and to the magneto-optic material at a sensing end of the optical fiber. Processing electronics, such as a polarimeter, are also provided for determining the Faraday rotation of the plane of polarization of the back-reflected polarized light to determine the position of the magnet relative to the sensing end of the optical fiber.
摘要翻译：使用法拉第效应的微位置传感器和感测系统。传感器使用永久磁铁提供磁场，以及位于磁场中的磁光材料，用于旋转透过磁光材料的偏振光的偏振平面。磁体可相对于磁光材料独立地移动，以便作为磁体的相对位置的函数旋转偏振光的偏振平面。以这种方式，可以从旋转的偏振光确定磁体相对于磁光材料的位置。感测系统还包括用于产生偏振光的光源，例如激光器或LED，以及在光纤的感测端连接到光源和磁光材料的光纤。还提供诸如旋光仪的处理电子设备，用于确定背反射偏振光的偏振平面的法拉第旋转，以确定磁体相对于光纤的感测端的位置。

9. 发明申请

US20060117022A1 Communication method and system using notification availability indicators 审中-公开
标题翻译：通信方式和系统使用通知可用性指标
公开(公告)号：US20060117022A1
公开(公告)日：2006-06-01
申请号：US11260794
申请日：2005-10-27
申请人： Matthew Lucas
发明人： Matthew Lucas
IPC分类号： G06F17/30
CPC分类号： G06F16/2358
摘要： A communication method comprises generating a notification that includes a content portion and a notification availability indicator; transmitting the notification from a server to a client; and receiving the notification at the client. In one embodiment, the notification availability indicator includes a time value, indicating the likely time before another notification will be transmitted.
摘要翻译：通信方法包括生成包括内容部分和通知可用性指示符的通知; 将所述通知从服务器发送到客户端; 并在客户端收到通知。在一个实施例中，通知可用性指示符包括指示在另一通知被发送之前的可能时间的时间值。

10. 发明申请

US20110296413A1 METHODS AND SYSTEMS FOR GENERATING A DYNAMIC WORKFLOW IN A MULTI-TENANT DATABASE ENVIRONMENT 有权
标题翻译：在多重数据库环境中生成动态工作流的方法和系统
公开(公告)号：US20110296413A1
公开(公告)日：2011-12-01
申请号：US13116657
申请日：2011-05-26
申请人： Stephen Wood , Samuel William Bailey , Matthew Lucas
发明人： Stephen Wood , Samuel William Bailey , Matthew Lucas
IPC分类号： G06F9/455 , G06F17/30
CPC分类号： G06F9/45533 , G06F8/656 , G06F9/45504 , G06F9/45508 , G06F9/45558 , G06F17/30073 , G06F17/30528 , G06F2009/45575 , G06F2009/45583 , H04L63/102 , H04L63/104
摘要： Techniques and systems for modifying a virtual machine functionality. Archive files each including at least a class files are received. The archive files are stored within the virtual machine. The virtual machine runs on a host system and neither the virtual machine nor the host system are restarted in response to the receiving or storing of the archive files. Files of the host system are scanned to find class files that are not included in a class path for the virtual machine. The class files are copied to a class path for the virtual machine. Neither the virtual machine nor the host system are restarted in response to the copying of the class files. The classes corresponding to the class files are registered in the virtual machine in response to the copying of the class files to the class path. Neither the virtual machine nor the host system are restarted in response to the registration of the classes.
摘要翻译：用于修改虚拟机功能的技术和系统。接收至少包含类文件的归档文件。归档文件存储在虚拟机中。虚拟机在主机系统上运行，并且虚拟机和主机系统都不会重新启动，以响应接收或存储归档文件。扫描主机系统的文件以查找不包含在虚拟机的类路径中的类文件。类文件被复制到虚拟机的类路径。响应于类文件的复制，虚拟机和主机系统都不重新启动。响应于将类文件复制到类路径，对应于类文件的类被注册在虚拟机中。响应于类的注册，虚拟机和主机系统都不重新启动。

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