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1. 发明申请

US20170290664A1 SYSTEMS AND METHODS FOR IMPROVING CARDIAC FUNCTION 审中-公开
公开(公告)号：US20170290664A1
公开(公告)日：2017-10-12
申请号：US15630601
申请日：2017-06-22
申请人： Miles D. ALEXANDER , Matthew L. PEASE , Barry L. TEMPLIN , Serjan D. NIKOLIC
发明人： Miles D. ALEXANDER , Matthew L. PEASE , Barry L. TEMPLIN , Serjan D. NIKOLIC
IPC分类号： A61F2/24 , A61M1/10 , A61B17/12 , A61M1/12
CPC分类号： A61F2/2487 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095 , A61M1/10 , A61M1/1003 , A61M1/1008 , A61M1/1068 , A61M1/12 , A61M1/122 , A61M2205/32
摘要： A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge. Devices and methods are described herein which are directed to the treatment of a patient's heart having, or one which is susceptible to heart failure, to improve diastolic function.

2. 发明授权

US08632579B2 Bifurcated stent and delivery system 失效
标题翻译：分叉支架和分娩系统
公开(公告)号：US08632579B2
公开(公告)日：2014-01-21
申请号：US12882726
申请日：2010-09-15
申请人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral Maron , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude A. Vidal , Thomas Banks , Russ J. Redmond
发明人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral Maron , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude A. Vidal , Thomas Banks , Russ J. Redmond
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/954 , A61F2/958 , A61F2/966 , A61F2/97 , A61F2002/061 , A61F2002/821 , A61F2002/9583 , A61F2250/006
摘要： Systems for delivering a bifurcated stent to a bifurcation site include catheters and/or bifurcated systems delivered therefrom. A catheter includes a balloon with a bulge region that allows a portion of the stent to be expanded.
摘要翻译：将分叉支架输送到分叉部位的系统包括从其输送的导管和/或分叉系统。导管包括具有允许支架的一部分扩张的凸起区域的气囊。

3. 发明授权

US07947072B2 Two-part expandable heart valve 有权
标题翻译：两部分可扩张心脏瓣膜
公开(公告)号：US07947072B2
公开(公告)日：2011-05-24
申请号：US11749722
申请日：2007-05-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

4. 发明授权

US07758634B2 Bifurcated stent and delivery system 失效
标题翻译：分叉支架和分娩系统
公开(公告)号：US07758634B2
公开(公告)日：2010-07-20
申请号：US11726144
申请日：2007-03-21
申请人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss , Simon Furnish , Michael A. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Thomas Banks , Russ Redmond , Claude Vidal
发明人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss , Simon Furnish , Michael A. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Thomas Banks , Russ Redmond , Claude Vidal
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/954 , A61F2/958 , A61F2/966 , A61F2/97 , A61F2002/061 , A61F2002/821 , A61F2002/9583 , A61F2250/006
摘要： A bifurcated stent includes a first stent section and a second stent section. The first stent section is balloon expandable, has an unexpanded configuration, an expanded configuration, and a tubular wall defining a secondary opening. The secondary stent section is self-expanding and an end of the secondary stent section is engaged to a portion of the tubular wall of the primary stent section defining the secondary opening. The secondary stent section has an unexpanded configuration with a first length and an expanded configuration with a second length where the first length is less than the second length. The secondary stent section is expanded to the expanded configuration after the primary stent section is expanded to the expanded configuration. The secondary stent section forms a portion of the tubular wall of the primary stent section in the unexpanded configuration.
摘要翻译：分支支架包括第一支架部分和第二支架部分。第一支架部分是球囊可膨胀的，具有未膨胀的构造，膨胀的构型和限定次级开口的管状壁。辅助支架部分是自膨胀的，并且次级支架部分的端部接合到限定第二开口的主支架部分的管状壁的一部分。次级支架部分具有第一长度和第二长度的膨胀构造的未膨胀构型，其中第一长度小于第二长度。在将主支架部分扩展到扩张构型之后，将二次支架部分扩大到扩张构型。辅助支架部分以未展开的构型形成主支架部分的管状壁的一部分。

5. 发明授权

US07374571B2 Rolled minimally-invasive heart valves and methods of manufacture 有权
标题翻译：滚动的微创心脏瓣膜和制造方法
公开(公告)号：US07374571B2
公开(公告)日：2008-05-20
申请号：US10286009
申请日：2002-11-01
申请人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
发明人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/848 , A61F2/92 , A61F2220/0016 , A61F2220/0075
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery using a catheter, and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The stents may include an annulus section, a sinus section with the membranes attached over sinus apertures, and an outflow section. Lockout tabs and making slots secure the stents in their expanded shapes. Alignment structure ensures concentric unfurling of the stent. Anchoring elements at the stent edges or in the stent body secure the valve within the annulus. A method of manufacture includes shape setting the sheet-like stent to ensure an outward bias during deployment. The stent may also include dear tracks for engagement with a gear mechanism for deployment. The stent is desirably made of a superelastic material such as Nitinol and may have areas removed or thinned to reduce the bending stresses when rolled into its small spiral for catheter delivery.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。使用导管将瓣膜卷成第一收缩构造用于微创递送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。支架可以包括环形部分，具有附接在窦孔上的膜的窦部分和流出部分。锁定标签和插槽将支架固定在其扩展形状中。对准结构确保支架的同心展开。在支架边缘处或支架主体中的锚定元件将瓣膜固定在环形空间内。一种制造方法包括使片状支架的形状设定，以确保在展开期间向外偏置。支架还可以包括用于与用于展开的齿轮机构接合的亲爱的轨道。支架理想地由诸如镍钛诺的超弹性材料制成，并且可以具有去除或变薄的区域，以便在卷入其用于导管递送的小螺旋时减小弯曲应力。

6. 发明授权

US06733525B2 Rolled minimally-invasive heart valves and methods of use 有权
标题翻译：滚动的微创心脏瓣膜和使用方法
公开(公告)号：US06733525B2
公开(公告)日：2004-05-11
申请号：US09815521
申请日：2001-03-23
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

7. 发明授权

US06695877B2 Bifurcated stent 失效
标题翻译：分叉支架
公开(公告)号：US06695877B2
公开(公告)日：2004-02-24
申请号：US10084766
申请日：2002-02-26
申请人： Gregory G. Brucker , Todd Hall , Enrique Malaret , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude Vidal , Thomas Banks , Russ Redmond
发明人： Gregory G. Brucker , Todd Hall , Enrique Malaret , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude Vidal , Thomas Banks , Russ Redmond
IPC分类号： A61F206
CPC分类号： A61F2/958 , A61F2/064 , A61F2/856 , A61F2/95 , A61F2/954 , A61F2/97 , A61F2002/061 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/9583
摘要： A bifurcated stent comprises a first stent section and a second stent section. Each stent section is expandable from a predeployed state to a deployed state independently from one another. The second stent section having an end engaged to a receiving region of the first stent section. In the deployed state the first stent section defines a primary flow path and the second stent section defines a secondary flow path in fluid communication with the first flow path. At least a portion of one or both the first stent section and second stent section is constructed from a wire member.
摘要翻译：分支支架包括第一支架部分和第二支架部分。每个支架部分可以彼此独立地从预部署状态扩展到展开状态。第二支架部分具有与第一支架部分的接收区域接合的端部。在展开状态下，第一支架部分限定一个主流路，第二支架部分限定与第一流动路径流体连通的二次流动路径。第一支架部分和第二支架部分中的一个或两个的至少一部分由线部件构成。

8. 发明授权

US09241788B2 Method for treating an aortic valve 有权
标题翻译：治疗主动脉瓣的方法
公开(公告)号：US09241788B2
公开(公告)日：2016-01-26
申请号：US13529955
申请日：2012-06-21
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24 , A61F2/848 , A61F2/91 , A61F2/92
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outwardly from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium, for example, porcine pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚固部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包膜，例如猪心包膜。假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

9. 发明授权

US08206438B2 Prosthetic heart valve having flared outflow section 有权
标题翻译：假性心脏瓣膜有扩张流出部分
公开(公告)号：US08206438B2
公开(公告)日：2012-06-26
申请号：US13029033
申请日：2011-02-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outward from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚定部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包。假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

10. 发明申请

US20090312785A1 Implantable Pump System 有权
标题翻译：可植入泵系统
公开(公告)号：US20090312785A1
公开(公告)日：2009-12-17
申请号：US12480911
申请日：2009-06-09
申请人： Robert T. Stone , Gregory S. Mast , Matthew L. Pease , Kevin A. Sawyer
发明人： Robert T. Stone , Gregory S. Mast , Matthew L. Pease , Kevin A. Sawyer
IPC分类号： A61M29/00
CPC分类号： A61F5/0053
摘要： A remotely adjustable gastric band system is provided. The system includes a gastric band, an implantable fluid reservoir, and a fluid handling device including a piezoelectric pump, and a drive or controller assembly. The piezoelectric pump includes a diaphragm having a compressible spring positioned at an actuator side of the diaphragm, and a space occupying layer disposed between the compressible spring and the actuator side.
摘要翻译：提供了可远程调节的胃束带系统。该系统包括胃带，可植入液体储存器和包括压电泵的流体处理装置以及驱动器或控制器组件。压电泵包括具有位于隔膜的致动器侧的可压缩弹簧的隔膜和设置在可压缩弹簧和致动器侧之间的空间占据层。

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