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1. 发明授权

US08591531B2 Mesh pouches for implantable medical devices 有权
标题翻译：用于可植入医疗器械的网袋
公开(公告)号：US08591531B2
公开(公告)日：2013-11-26
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
发明人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

2. 发明申请

US20080128315A1 Resorbable Pouches for Implantable Medical Devices 有权
标题翻译：可植入医疗器械的可再吸收袋
公开(公告)号：US20080128315A1
公开(公告)日：2008-06-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： A61B19/02 , B65D69/00 , A61K31/445 , A61K31/496 , A61K31/195 , A61P23/00 , A61P31/00
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

3. 发明申请

US20070198040A1 Temporarily Stiffened Mesh Prostheses 有权
标题翻译：临时加强网状假肢
公开(公告)号：US20070198040A1
公开(公告)日：2007-08-23
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

4. 发明授权

US06756060B1 Anti-inflammatory and antimicrobial uses for bioactive glass compositions 有权
标题翻译：用于生物活性玻璃组合物的抗炎和抗微生物用途
公开(公告)号：US06756060B1
公开(公告)日：2004-06-29
申请号：US09560046
申请日：2000-04-27
申请人： David C. Greenspan , Jon K. West , Sean Lee , James L. Meyers , Mason Diamond
发明人： David C. Greenspan , Jon K. West , Sean Lee , James L. Meyers , Mason Diamond
IPC分类号： A61K914
CPC分类号： A61Q1/02 , A61K8/25 , A61K45/06 , A61L15/18 , A61L15/44 , A61L15/46 , A61Q5/00 , A61Q17/005 , A61Q19/00 , C03C4/0007 , Y10S424/13 , Y10S514/829 , Y10S514/83 , Y10S514/831 , Y10S514/859 , Y10S514/861 , Y10S514/862 , Y10S514/863 , Y10S514/864 , Y10S514/886 , Y10S514/887 , Y10S514/951 , Y10S514/965
摘要： Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.
摘要翻译：用于治疗创伤以显着减少愈合时间的组合物和方法，减少瘢痕形成的发生率，改善皮肤移植物的成功，减少炎症反应并向有需要的患者提供抗菌治疗，包括小的非相互连接公开了生物活性玻璃或高度多孔生物活性玻璃的颗粒。还公开了衍生自生物活性玻璃的抗菌溶液及其制备和使用方法。组合物包括单独的或与抗细菌剂和/或抗炎剂组合的生物活性玻璃的非互连颗粒。组合物可以包括用于局部给药的合适的载体。通过将小生物活性玻璃颗粒或多孔生物活性玻璃并入到植入的材料中，可将植物材料（例如假体植入物，缝合线，支架，螺钉，板，管等）赋予抗菌性能。通过将非生物活性玻璃的非互连颗粒结合到装置中，也可以将抗细菌性质赋予用于体外和离体细胞培养的装置。还公开了衍生自生物活性玻璃的水提取物的抗菌组合物。这些组合物可用于例如食品制备，用于细胞培养的溶液和缓冲溶液，例如静脉内。解决方案

5. 发明申请

US20090018559A1 Temporarily Stiffened Mesh Prostheses 审中-公开
标题翻译：临时加强网状假肢
公开(公告)号：US20090018559A1
公开(公告)日：2009-01-15
申请号：US11936049
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , A61F2/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

6. 发明授权

US09023114B2 Resorbable pouches for implantable medical devices 有权
标题翻译：可植入医疗器械的可吸收袋
公开(公告)号：US09023114B2
公开(公告)日：2015-05-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： B65D83/10 , A61F2/02 , A61B19/02 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/14 , A61L31/16 , A61B17/00 , A61B19/00 , A61N1/375
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

7. 发明授权

US08636753B2 Temporarily stiffened mesh prostheses 有权
标题翻译：临时硬化网眼假体
公开(公告)号：US08636753B2
公开(公告)日：2014-01-28
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

8. 发明申请

US20080132922A1 Mesh Pouches for Implantable Medical Devices 有权
标题翻译：用于植入式医疗器械的网袋
公开(公告)号：US20080132922A1
公开(公告)日：2008-06-05
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

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