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1. 发明专利

JP2011100039A Chord composing sound display panel 审中-公开
标题翻译： CHORD组合声音显示面板
公开(公告)号：JP2011100039A
公开(公告)日：2011-05-19
申请号：JP2009255675
申请日：2009-11-09
申请人： Masazumi Nagai , 正純永井
发明人： NAGAI MASAZUMI
IPC分类号： G10G1/02 , G09B15/02
摘要： PROBLEM TO BE SOLVED: To provide a chord composing sound display panel which eliminates complicated operations of referring to a chord chart and turning over a musical score frequently, and specifies composing sound of a chord easily and inexpensively so as not to cause an obstruction.
SOLUTION: The chord composing sound display panel includes: a display panel body 2 in which the first keyboard display area 21, the second keyboard display area 22 and the second scale name display area 24 are provided collaterally in a vertical direction; and a slide panel 3 in which a composing sound display area 31, a chord name display area 32 and a fundamental note-specifying hole 34 are provided. In the chord composing sound display panel, a plurality of composing sound display holes 35a which expose white key display corresponding to the fundamental note of the chord having the fundamental note of a specified character out of respective white key display in the area 22 when any character is specified by the specifying hole 34, and a plurality of composing sound display holes 35b which expose display corresponding to respective composing sound excluding the fundamental note of the chord having the fundamental note of a specified character out of the respective white key display and respective black key display in the area 22 are formed in the composing sound display area 31 collaterally in the vertical direction for each chord made to correspond in the vertical direction.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种弦构成声音显示面板，其消除了参考和弦图的复杂操作并经常转动乐谱，并且容易且廉价地指定和弦的构成声音，以便不引起梗阻。＆lt; P＆gt;解决方案：构成声音显示面板的和弦包括：显示面板主体2，其中第一键盘显示区域21，第二键盘显示区域22和第二比例名称显示区域24在垂直方向上相互提供; 以及其中提供组成声音显示区域31，和弦名称显示区域32和基本音符指定孔34的滑动面板3。在和弦构成声音显示面板中，多个构成声音显示孔35a，当任何字符在区域22中时，在区域22中的相应白键显示中，具有对应于具有指定字符的基本音符的和弦的基本音符相对应的白键显示由指定孔34指定的多个构成声音显示孔35b，其显示对应于除了具有指定字符的基本音符的和弦的基本音符之外的各个构成声音的显示，并且各自的黑色对于在垂直方向上对应的每个弦，在构成声音显示区域31中沿纵向方向形成区域22中的按键显示。版权所有（C）2011，JPO＆INPIT

2. 发明申请

US20060094908A1 Method for producing fluoroalkyl ether 有权
标题翻译：氟烷基醚的制备方法
公开(公告)号：US20060094908A1
公开(公告)日：2006-05-04
申请号：US11293200
申请日：2005-12-05
申请人： Hidekazu Okamoto , Masazumi Nagai , Kazuya Oharu
发明人： Hidekazu Okamoto , Masazumi Nagai , Kazuya Oharu
IPC分类号： C07C41/06
CPC分类号： C07C41/06 , C07C43/123
摘要： A method for producing a fluoroalkyl ether, which comprises reacting a fluoroalkyl alcohol with a fluorinated olefin in the presence of a solvent and a catalyst, wherein the fluoroalkyl alcohol and the fluorinated olefin are continuously supplied into a reactor, a reaction product containing the fluoroalkyl ether is continuously withdrawn from the reactor, and the reaction is carried out while the concentration of the fluoroalkyl alcohol present in the reactor is maintained to be at most 7 mass % based on the total organic component present in the reactor. According to the present invention, a fluoroalkyl ether having a high purity can be produced in an industrial scale and at a high reaction rate.
摘要翻译：一种制备氟烷基醚的方法，其包括在溶剂和催化剂存在下使氟代烷基醇与氟化烯烃反应，其中将氟代烷基醇和氟化烯烃连续地供入反应器中，将含有氟代烷基醚从反应器中连续取出，反应进行，同时反应器中存在的氟代烷基醇的浓度维持在反应器中存在的总有机成分的7质量％以下。根据本发明，可以以工业规模和高反应速度制备高纯度的氟烷基醚。

3. 发明申请

US20060128915A1 Process for producing fluorinated alkyl ether 有权
标题翻译：制备氟化烷基醚的方法
公开(公告)号：US20060128915A1
公开(公告)日：2006-06-15
申请号：US11348490
申请日：2006-02-07
申请人： Masazumi Nagai , Hidekazu Okamoto , Kazuya Oharu
发明人： Masazumi Nagai , Hidekazu Okamoto , Kazuya Oharu
IPC分类号： C08F16/24
CPC分类号： C07C41/06 , C07C43/123
摘要： To provide a process for producing a fluorinated alkyl ether, whereby a sufficient reaction rate can be attained even under mild reaction conditions, and a post-process such as distillation after the reaction can be efficiently carried out. A process for producing a fluorinated alkyl ether, which comprises introducing an aprotic polar solvent, a fluorinated ether, a catalyst, a fluorinated alkyl alcohol and a fluorinated olefin into a reactor, and then, reacting the fluorinated alkyl alcohol with the fluorinated olefin, characterized in that the ratio of the two components of the aprotic polar solvent and the fluorinated ether introduced into the reactor is the aprotic polar solvent/the fluorinated ether=5/95 to 80/20 by mass ratio.
摘要翻译：为了提供氟化烷基醚的制造方法，即使在温和的反应条件下也能够得到充分的反应速度，能够有效地进行反应后的蒸馏等后处理。一种制备氟化烷基醚的方法，包括将非质子极性溶剂，氟化醚，催化剂，氟化烷基醇和氟化烯烃引入反应器中，然后使氟化烷基醇与氟化烯烃反应，其特征在于引入到反应器中的非质子极性溶剂和氟化醚的两种组分的比例是非质子极性溶剂/氟化醚= 5/95〜80/20质量比。

4. 发明授权

US08815807B2 Peptides and peptide compositions having osteoinductive activity 有权
标题翻译：具有骨诱导活性的肽和肽组合物
公开(公告)号：US08815807B2
公开(公告)日：2014-08-26
申请号：US13309734
申请日：2011-12-02
申请人： Shigemi Nagai , Masazumi Nagai , Mindy Sungmin Gil
发明人： Shigemi Nagai , Masazumi Nagai , Mindy Sungmin Gil
IPC分类号： A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K17/02 , C40B60/12
CPC分类号： C40B60/12
摘要： Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold compositions containing at least one peptide or combinations of peptides are therapeutic agents for stimulating and promoting osteogenic activity and osteoinduction activity for cells. The scaffold is for example apatite, natural cancellous bone, demineralized natural cancellous bone, collagen, calcium phosphate, or hydroxyapatite.
摘要翻译：提供组合物和试剂盒，其具有具有结合真核细胞并实现分化并支持细胞生长的氨基酸序列的肽。含有至少一种肽或肽组合的肽 - 支架组合物是用于刺激和促进细胞的成骨活性和骨诱导活性的治疗剂。脚手架是例如磷灰石，天然松质骨，软化天然松质骨，胶原蛋白，磷酸钙或羟基磷灰石。

5. 发明申请

US20140011864A1 TRANSITION METAL COMPLEXES OF A BIS[THIOHYDRAZIDE AMIDE] COMPOUND 有权
标题翻译： BIS [THOHOHDRAZIDE AMIDE]化合物的过渡金属络合物
公开(公告)号：US20140011864A1
公开(公告)日：2014-01-09
申请号：US13902270
申请日：2013-05-24
申请人： Masazumi Nagai , Jianhua Shen
发明人： Masazumi Nagai , Jianhua Shen
IPC分类号： C07F15/04 , C07F1/08 , A61K31/28 , A61K31/30 , A61K31/337
CPC分类号： C07F15/045 , A61K31/28 , A61K31/30 , A61K31/337 , A61K31/555 , C07B2200/01 , C07C327/56 , C07F1/08 , A61K2300/00
摘要： The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
摘要翻译：本发明涉及包含与过渡金属阳离子络合的双[硫代酰肼酰胺]或其去质子化形式的化合物，其中双[硫代酰肼]由结构式（I）表示：或前药，异构体，酯，盐，水合物，溶剂合物，多晶型物或去质子化形式。本发明还提供了包含本发明化合物及其使用方法的药物组合物。

6. 发明申请

US20130150440A1 USE OF BIS [THIOHYDRAZIDE AMIDE] COMPOUNDS SUCH AS ELESCLOMOL FOR TREATING CANCERS 有权
标题翻译：使用BIS [硫羟酰胺酰胺]化合物作为ELESCLOMOL治疗癌症
公开(公告)号：US20130150440A1
公开(公告)日：2013-06-13
申请号：US13642275
申请日：2011-04-20
申请人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
发明人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
IPC分类号： A61K31/30 , A61K31/337 , A61K45/06 , A61K31/19 , A61K31/16 , A61K31/28
CPC分类号： A61K31/30 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/28 , A61K31/337 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments.
摘要翻译：改进的双[硫代酰肼]化合物如elesclomol的癌症治疗，特别是用于鉴定将受益于这种治疗的患者群体。

7. 发明申请

US20130035386A1 BIS[THIOHYDRAZIDE AMIDE] COMPOUNDS FOR TREATING LEUKEMIA 有权
标题翻译： BIS [THIOHYDRAZIDE AMIDE]用于处理低密度脂蛋白的化合物
公开(公告)号：US20130035386A1
公开(公告)日：2013-02-07
申请号：US13513449
申请日：2010-12-06
申请人： Masazumi Nagai , Jianhua Shen
发明人： Masazumi Nagai , Jianhua Shen
IPC分类号： A61K31/28 , A61P35/02 , A61K31/315 , A61K31/282 , A61K31/30 , A61K31/295
CPC分类号： A61K31/15 , A61K31/282
摘要： Certain bis[thio-hydrazide amide]-related compounds are found to be surprisingly effective at treating with leukemia, e.g., acute myeloid leukemia (AML). Methods of treating a subject with AML including administering bis[thio-hydrazide amide]-related compounds described herein, are disclosed.
摘要翻译：发现某些双[硫代 - 酰肼酰胺]相关化合物在用白血病例如急性骨髓性白血病（AML）治疗方面令人惊奇地有效。公开了用AML治疗受试者的方法，包括施用本文所述的双[硫代 - 酰肼酰胺]相关化合物。

8. 发明申请

US20050014754A1 Fused pyrrole compounds 审中-公开
标题翻译：熔融吡咯化合物
公开(公告)号：US20050014754A1
公开(公告)日：2005-01-20
申请号：US10799389
申请日：2004-03-12
申请人： Mitsunori Ono , Lijun Sun , ZhiQiang Xia , Elena Kostik , Keizo Koya , Masazumi Nagai , Yaming Wu
发明人： Mitsunori Ono , Lijun Sun , ZhiQiang Xia , Elena Kostik , Keizo Koya , Masazumi Nagai , Yaming Wu
IPC分类号： A61K20060101 , A61K31/429 , A61K31/5025 , A61K31/519 , A61K31/53 , C07D455/02 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： This invention relates to fused pyrrole compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, wherein V1, V2, V3, V4, R1, R2, R3, W1 and W2 are as defined herein. The compounds of this invention may be used to prevent or treat cancer, inflammatory disorders, autoimmune diseasesand other conditions involving PDE4 or elevated levels of cytokines. The invention also provides methods of using the compounds to treat or prevent such disorders and pharmaceutical compositions containing the compounds.
摘要翻译：本发明涉及式（I）的稠合吡咯化合物及其药学上可接受的盐和前体药物，其中V1，V2，V3，V4，R1，R2，R3，W1和W2如本文所定义。本发明的化合物可用于预防或治疗癌症，炎症性疾病，自身免疫性疾病和涉及PDE4的其他病症或升高的细胞因子水平。本发明还提供了使用该化合物治疗或预防这些病症的方法和含有这些化合物的药物组合物。

9. 发明授权

US07193119B2 Process for producing fluorinated alkyl ether 有权
标题翻译：制备氟化烷基醚的方法
公开(公告)号：US07193119B2
公开(公告)日：2007-03-20
申请号：US11348490
申请日：2006-02-07
申请人： Masazumi Nagai , Hidekazu Okamoto , Kazuya Oharu
发明人： Masazumi Nagai , Hidekazu Okamoto , Kazuya Oharu
IPC分类号： C07C41/00
CPC分类号： C07C41/06 , C07C43/123
摘要： To provide a process for producing a fluorinated alkyl ether, whereby a sufficient reaction rate can be attained even under mild reaction conditions, and a post-process such as distillation after the reaction can be efficiently carried out.A process for producing a fluorinated alkyl ether, which comprises introducing an aprotic polar solvent, a fluorinated ether, a catalyst, a fluorinated alkyl alcohol and a fluorinated olefin into a reactor, and then, reacting the fluorinated alkyl alcohol with the fluorinated olefin, characterized in that the ratio of the two components of the aprotic polar solvent and the fluorinated ether introduced into the reactor is the aprotic polar solvent/the fluorinated ether=5/95 to 80/20 by mass ratio.
摘要翻译：为了提供氟化烷基醚的制造方法，即使在温和的反应条件下也能够得到充分的反应速度，能够有效地进行反应后的蒸馏等后处理。一种制备氟化烷基醚的方法，包括将非质子极性溶剂，氟化醚，催化剂，氟化烷基醇和氟化烯烃引入反应器中，然后使氟化烷基醇与氟化烯烃反应，其特征在于引入到反应器中的非质子极性溶剂和氟化醚的两种组分的比例是非质子极性溶剂/氟化醚= 5/95〜80/20质量比。

10. 发明授权

US07193118B2 Method for producing fluoroalkyl ether 有权
标题翻译：氟烷基醚的制备方法
公开(公告)号：US07193118B2
公开(公告)日：2007-03-20
申请号：US11293200
申请日：2005-12-05
申请人： Hidekazu Okamoto , Masazumi Nagai , Kazuya Oharu
发明人： Hidekazu Okamoto , Masazumi Nagai , Kazuya Oharu
IPC分类号： C07C41/06
CPC分类号： C07C41/06 , C07C43/123
摘要： A method for producing a fluoroalkyl ether, which comprises reacting a fluoroalkyl alcohol with a fluorinated olefin in the presence of a solvent and a catalyst, wherein the fluoroalkyl alcohol and the fluorinated olefin are continuously supplied into a reactor, a reaction product containing the fluoroalkyl ether is continuously withdrawn from the reactor, and the reaction is carried out while the concentration of the fluoroalkyl alcohol present in the reactor is maintained to be at most 7 mass % based on the total organic component present in the reactor. According to the present invention, a fluoroalkyl ether having a high purity can be produced in an industrial scale and at a high reaction rate.
摘要翻译：一种制备氟烷基醚的方法，其包括在溶剂和催化剂存在下使氟代烷基醇与氟化烯烃反应，其中将氟代烷基醇和氟化烯烃连续地供入反应器中，将含有氟代烷基醚从反应器中连续取出，反应进行，同时反应器中存在的氟代烷基醇的浓度维持在反应器中存在的总有机成分的7质量％以下。根据本发明，可以以工业规模和高反应速度制备高纯度的氟烷基醚。

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