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1. 发明授权

US5484710A Method of down-regulating a gene linked to a P-53 responsive element 失效
标题翻译：降低与P-53反应元件连锁的基因的方法
公开(公告)号：US5484710A
公开(公告)日：1996-01-16
申请号：US182619
申请日：1994-01-14
申请人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
发明人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
IPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12P21/00 , C12N15/09
CPC分类号： C12Q1/6897 , C07K14/4746 , C07K14/4747 , C07K14/82
摘要： The present invention provides regulatory elements that are linked to genes involved in cell death and are regulated by p53 tumor suppressor protein. Examples of such p53 responsive elements (p53-RE) include p53-RE.sup.D, which is involved in p53-mediated down-regulation of the Bcl-2 gene, and p53-RE.sup.U, which is involved in p53-mediated up-regulation of the Bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death and contains a p53-RE.
摘要翻译：本发明提供与参与细胞死亡的基因相关的调节元件，并且由p53肿瘤抑制蛋白调节。这种p53反应元件（p53-RE）的实例包括p53-RED，其参与p53介导的Bcl-2基因的下调和p53-REU，其参与p53介导的上调调节 Bax基因。本发明还提供用于鉴定试剂的筛选试验，例如有效调节参与细胞死亡并含有p53-RE的基因的表达的药物。

2. 发明授权

US5908750A Screening assays for identifying agents that regulate the expression of genes involved in cell death 失效
标题翻译：用于鉴定调节参与细胞死亡的基因表达的试剂的筛选试验
公开(公告)号：US5908750A
公开(公告)日：1999-06-01
申请号：US838844
申请日：1997-04-11
申请人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
发明人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
IPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/02
CPC分类号： C07K14/4747 , C07K14/4746 , C07K14/82 , C12Q1/6897
摘要： The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
摘要翻译：本发明提供与涉及细胞死亡的基因相关的调节元件。例如，本发明提供参与p53介导的bcl-2基因下调的p53-RED和包含参与p53介导的上调的p53-REU的bax启动子的bax基因。本发明还提供用于鉴定试剂例如有效调节参与细胞死亡的基因的表达的药物的筛选测定。此外，本发明提供了调节细胞凋亡水平的方法。

3. 发明申请

US20060172296A1 Novel gene associated with rheumatoid arthritis 审中-公开
标题翻译：与类风湿关节炎有关的新基因
公开(公告)号：US20060172296A1
公开(公告)日：2006-08-03
申请号：US10521940
申请日：2003-07-18
申请人： Masahiro Takeuchi , Noboru Yamaji , Jun Takasaki , Masahiko Akamatsu , Kazuhisa Tsunoyama , Masayoshi Harigai
发明人： Masahiro Takeuchi , Noboru Yamaji , Jun Takasaki , Masahiko Akamatsu , Kazuhisa Tsunoyama , Masayoshi Harigai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/54
CPC分类号： C07K14/4713 , C12Q1/6883 , C12Q2600/158
摘要： It is disclosed that novel polypeptides which has enhanced expression levels in the synovial tissues of human chronic rheumatoid arthritis (RA) patients compared with the synovial tissues of human osteoarthritis (OA) patients, polynucleotides encoding the polypeptides, vectors comprising the polynucleotides, transformant cells comprising the vectors and an antibody against the polypeptide. It is also disclosed that polynucleotides specifically hybridizing with the polynucleotides and having at least 15 nucleotides, a detection method which is useful for RA diagnosis, and a detection kit which is useful for RA diagnosis.
摘要翻译：公开了与人类骨关节炎（OA）患者的滑膜组织相比，在人类慢性类风湿性关节炎（RA）患者的滑膜组织中具有增强的表达水平的新型多肽，编码多肽的多核苷酸，包含多核苷酸的载体，转化体细胞包含载体和针对多肽的抗体。还公开了与多核苷酸特异性杂交并具有至少15个核苷酸的多核苷酸，可用于RA诊断的检测方法以及可用于RA诊断的检测试剂盒。

4. 发明授权

US5659024A Promotors that regulate the expression of genes involved in cell death 失效
标题翻译：调节细胞死亡基因表达的启动子
公开(公告)号：US5659024A
公开(公告)日：1997-08-19
申请号：US330535
申请日：1994-10-27
申请人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
发明人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
IPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/4747 , C07K14/4746 , C07K14/82 , C12Q1/6897
摘要： The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
摘要翻译：本发明提供与涉及细胞死亡的基因相关的调节元件。例如，本发明提供参与p53介导的bcl-2基因下调的p53-RED和包含参与p53介导的上调的p53-REU的bax启动子的bax基因。本发明还提供用于鉴定试剂例如有效调节参与细胞死亡的基因的表达的药物的筛选测定。此外，本发明提供了调节细胞凋亡水平的方法。

5. 发明授权

US5643727A BCL-2 gene inhibitory element binding factor 失效
标题翻译： BCL-2基因抑制因子结合因子
公开(公告)号：US5643727A
公开(公告)日：1997-07-01
申请号：US390858
申请日：1995-02-16
申请人： John C. Reed , Masayoshi Harigai
发明人： John C. Reed , Masayoshi Harigai
IPC分类号： A61K38/00 , C07K14/47 , C12N15/85 , C12Q1/68 , A61K38/16 , C07H21/04
CPC分类号： C12N15/85 , C07K14/4702 , A61K38/00
摘要： The present invention provides a bcl-2 gene inhibitory element (BIE), which can inhibit expression of a gene in position-dependent and orientation-dependent manner. The invention provides, for example, BIE-1, having the nucleotide sequence 5'-CAAGAATGCAA-3' (SEQ ID NO: 1), which acts in an orientation-dependent and position-dependent manner to down-regulate the expression of the bcl-2 gene. The invention also provides a BIE binding factor (BBF), which is a cellular factor that can bind to a BIE. The invention provides, for example, BBF-A, which binds to BIE-1, including a nucleic acid sequence (SEQ ID NO: 8) encoding a portion of the amino acid sequence (SEQ ID NO: 9) of BBF-A. The invention further provides an antibody that specifically binds BBF-A. The invention also provides screening assays for identifying agents that can increase or decrease the binding of a BBF to a BIE, modulate the expression of a nucleic acid molecule linked to a BIE or modulate apoptosis in a cell.
摘要翻译：本发明提供了能够以位置依赖性和取向依赖性抑制基因表达的bcl-2基因抑制元件（BIE）。本发明提供了具有核苷酸序列5'-CAAGAATGCAA-3'（SEQ ID NO：1）的BIE-1，其以取向依赖性和位置依赖性方式起作用以下调 bcl-2基因。本发明还提供了BIE结合因子（BBF），其是可以结合BIE的细胞因子。本发明提供了例如与BIE-1结合的BBF-A，其包括编码BBF-A的氨基酸序列（SEQ ID NO：9）的一部分的核酸序列（SEQ ID NO：8）。本发明还提供了特异性结合BBF-A的抗体。本发明还提供用于鉴定可以增加或减少BBF与BIE的结合，调节与BIE连接的核酸分子的表达或调节细胞凋亡的试剂的筛选测定。

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