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1. 发明授权

US5393740A Neurotensin Hexapeptides 失效
标题翻译：神经降压肽六肽
公开(公告)号：US5393740A
公开(公告)日：1995-02-28
申请号：US920878
申请日：1992-07-28
申请人： Sakae Amagaya , Tadami Fujiwara , Masaki Aburada , Michio Nagasawa , Tsutomu Oyama
发明人： Sakae Amagaya , Tadami Fujiwara , Masaki Aburada , Michio Nagasawa , Tsutomu Oyama
IPC分类号： A61K38/00 , A61P3/00 , A61P7/02 , A61P9/10 , A61P9/12 , A61P29/00 , A61P37/08 , A61P43/00 , C07K5/10 , C07K7/06 , A61K37/00 , C07K5/00 , C07K7/00 , A61K37/02
CPC分类号： C07K7/06 , A61K38/00
摘要： A hexapeptide represented by formula (II):A-B-Pro-C-D-E (I)where A represents an L- or D- form of arginine or lysine whose N-terminal amino group is alkylated or acylated, B represents an L- or D- form of argine, lysine, or histidine, Pro represents an L- or D- form of proline, C represents an L- or D- form of tyrosine, tryptophan, or phenylalanine, D represents an L- or D- form of valine, isolencine, or leucine, and E represents an L-or D- form of valine, isolencine, or lencine, one of the hydrogen atoms of the amino group of which may be substituted a C.sub.1 to C.sub.4 alkyl group, and C-terminal carboxyl group of which is substituted with --COOR*, --CH.sub.2 OR, or --CONHR wherein R* represents a C.sub.1 to C.sub.4 alkyl group, and R represents a hydrogen atom or an C.sub.1 to C.sub.4 alkyl group. The hexapeptide or a pharmaceutically acceptable salt of the hexapeptide is useful as medical agent such as an anti-edematous agent, an anti-shock agent, an anti-thrombus agent, an anti-arteriosclerotic agent, an anti-allergic agent, a hypotensive agent, a wound healing agent, and an anti-inflammatory agent.
摘要翻译：由式（II）表示的六肽：AB-Pro-CDE（I）其中A表示其N-末端氨基被烷基化或酰化的L-或D-型精氨酸或赖氨酸，B表示L-或D- 氨基酸，赖氨酸或组氨酸的形式，Pro代表L-或D-形式的脯氨酸，C代表L-或D-形式的酪氨酸，色氨酸或苯丙氨酸，D表示L-或D-形式的缬氨酸，异亮氨酸或亮氨酸，E表示缬氨酸，异亮氨酸或氨基酸的L-型或D-型，其氨基的一个氢原子可被C1-C4烷基取代，C-末端羧基被-COOR *，-CH 2 OR或-CONHR取代，其中R *表示C1至C4烷基，R表示氢原子或C1至C4烷基。六肽的六肽或药学上可接受的盐可用作药剂，例如抗水肿剂，抗休克剂，抗血栓剂，抗动脉硬化剂，抗过敏剂，降血压剂，伤口愈合剂和抗炎剂。

2. 发明授权

US4613591A Adminiculum for antitumor agents 失效
标题翻译：抗肿瘤药物用途
公开(公告)号：US4613591A
公开(公告)日：1986-09-23
申请号：US509197
申请日：1983-06-29
申请人： Masaki Aburada , Shigefumi Takeda , Eiko Itoh , Moe Matsushita , Eikichi Hosoya
发明人： Masaki Aburada , Shigefumi Takeda , Eiko Itoh , Moe Matsushita , Eikichi Hosoya
IPC分类号： A61K36/00 , A61K20060101 , A61K31/40 , A61K31/65 , A61K31/70 , A61K36/232 , A61K36/234 , A61K36/258 , A61K36/284 , A61K36/48 , A61K36/54 , A61K36/65 , A61K36/804 , A61K47/00 , A61P35/00 , A61P39/02 , A61P43/00 , C12P20060101 , A61K31/71
CPC分类号： A61K36/258 , A61K36/232 , A61K36/234 , A61K36/284 , A61K36/48 , A61K36/54 , A61K36/65 , A61K36/804
摘要： Adminiculum increasing the antitumor activities of mitomycin C and doxorubicin hydrochloride and decreasing the side effects associated with their use comprising an aqueous or aqueous organic solvent extract of a crude preparation of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing said adminiculum and a method for its use. In addition, compositions and methods for treating tumor-bearing patients are disclosed.
摘要翻译：提高丝裂霉素C和多柔比星盐酸盐的抗肿瘤活性，降低与使用相关的副作用，包括黄芪，肉桂皮，地黄，白芍，ii oma，白术的粗制制剂的水性或水性有机溶剂提取物根瘤菌，当归，人参，Hoelen和甘草，一种制备所述体系的方法及其使用方法。此外，公开了用于治疗肿瘤患者的组合物和方法。

3. 发明申请

US20140348961A1 SIRTUIN ACTIVATOR 有权
公开(公告)号：US20140348961A1
公开(公告)日：2014-11-27
申请号：US14368457
申请日：2012-12-27
申请人： Masaki ABURADA , TOKIWA PHYTOCHEMICAL CO., LTD.
发明人： Tsutomu Shimada , Jinwei Yang , Yuka Koike
IPC分类号： C07D311/32 , A23L2/52 , A23L1/30 , A61K36/9068
CPC分类号： C07D311/32 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K8/97 , A61K31/352 , A61K36/9068 , A61K2236/00 , A61K2800/10 , A61K2800/78 , A61Q19/00 , A23V2200/302 , A23V2200/304 , A23V2200/308 , A23V2200/326 , A23V2200/328 , A23V2250/2112 , A61K2300/00
摘要： The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.
摘要翻译：本发明提供了一种具有由黑姜或黑姜提取物组成的活性成分的沉默调节因子活化剂，其可以容易地获得，非常安全，并且从旧食用。本发明还提供了一种具有由通式（I）表示的聚烷氧基类黄酮化合物的活性成分并且具有白藜芦醇或更高的10倍的沉默调节蛋白激活作用的沉默调节蛋白激活剂：其中，R 1至R 7各自独立地为氢原子，羟基或C1〜C6低级烷氧基。

4. 发明授权

US09745279B2 Sirtuin activator 有权
公开(公告)号：US09745279B2
公开(公告)日：2017-08-29
申请号：US14368457
申请日：2012-12-27
申请人： TOKIWA PHYTOCHEMICAL CO., LTD. , Masaki Aburada
发明人： Tsutomu Shimada , Jinwei Yang , Yuka Koike
IPC分类号： A61K36/00 , C07D311/32 , A61K31/352 , A23L2/52 , A61K36/9068 , A61K8/49 , A61Q19/00 , A61K8/97 , A23L33/105
CPC分类号： C07D311/32 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K8/97 , A61K31/352 , A61K36/9068 , A61K2236/00 , A61K2800/10 , A61K2800/78 , A61Q19/00 , A23V2200/302 , A23V2200/304 , A23V2200/308 , A23V2200/326 , A23V2200/328 , A23V2250/2112 , A61K2300/00
摘要： The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.

5. 发明授权

US4618495A Preparation for reducing cancer symptoms without treating cancer 失效
标题翻译：准备减少癌症症状而不治疗癌症
公开(公告)号：US4618495A
公开(公告)日：1986-10-21
申请号：US701458
申请日：1985-02-14
申请人： Hiromichi Okuda , Hiroshi Masuno , Masaki Aburada , Shigefumi Takeda , Eiko Itoh , Moe Matsushita , Eikichi Hosoya
发明人： Hiromichi Okuda , Hiroshi Masuno , Masaki Aburada , Shigefumi Takeda , Eiko Itoh , Moe Matsushita , Eikichi Hosoya
IPC分类号： A61K36/00 , A61K20060101 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/232 , A61K36/234 , A61K36/25 , A61K36/28 , A61K36/48 , A61K36/54 , A61K36/65 , A61K36/71 , A61K36/804 , A61K38/22 , A61P3/06 , A61P35/00 , C12P20060101 , A61K35/78
CPC分类号： A61K36/234 , A61K36/232 , A61K36/28 , A61K36/48 , A61K36/54 , A61K36/65 , A61K36/804
摘要： A composition for reducing cancer symptoms by improving lipid metabolism and eliminating or reducing anorexia in tumor-bearing patients through inhibition of the lipid degradation-promoting action of toxohormone L which comprises an aqueous or aqueous organic solvent extract of one or more crude preparations selected from the group consisting of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing such a composition, and a method for reducing cancer symptoms using the composition.
摘要翻译：一种用于通过抑制荷尔蒙激素L的脂质降解促进作用来改善脂质代谢并消除或减少荷瘤患者厌食症的组合物，其包含一种或多种粗制品的水性或水性有机溶剂提取物，其选自由黄芪，肉桂皮层，地黄，白芍，ii oma，白术，当归，人参，Hoelen和甘草组成的组合物，制备这种组合物的方法，以及使用组成。

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