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1. 发明申请

US20060094737A1 Novel uracil derivatives and medicinal use thereof 审中-公开
标题翻译：新型尿嘧啶衍生物及其药用
公开(公告)号：US20060094737A1
公开(公告)日：2006-05-04
申请号：US10528373
申请日：2003-09-17
申请人： Yoshiaki Isobe , Masanori Tobe , Yoshifumi Inoue , Masakazu Isobe
发明人： Yoshiaki Isobe , Masanori Tobe , Yoshifumi Inoue , Masakazu Isobe
IPC分类号： A61K31/513 , C07D405/02 , C07D239/54
CPC分类号： C07D239/545 , A61K31/513 , C07D405/06 , C07D405/12 , C07D405/14
摘要： It is intended to provide an uracil derivative represented by the following general formula (I): (I) wherein X represents a group selected from among NHCO, NHCH2, CO, CONH and CH2NH; R1 represents hydrogen or optionally substituted C1-6 alkyl; R2 represents a group of the following general formula (II) or (III): (II) (III) (wherein m is 0 or 1; n is an integer of from 1 to 3; Y represents OH or NH2; and a dotted line shows a binding position), provided that when R2 is a group of the general formula (III), X represents NHCO or NHCH2; R3 and R4 independently represent each hydrogen or C1-6 alkyl; and Ar represents phenyl substituted by C1-6 alkyl at the o- and m-positions, optionally substituted heteroaryl or a bicyclic aromatic group; its pharmaceutically acceptable salt, and a remedy containing the above uracil derivative or its pharmaceutically acceptable salt as the active ingredient for, in particular, allergic diseases relating to a type IV allergic reaction, i.e., a novel compound useful in treating diseases in which a type IV allergic reaction participates and a remedy for allergic diseases containing the same as the active ingredient.
摘要翻译：旨在提供由以下通式（I）表示的尿嘧啶衍生物：（I）其中X表示选自NHCO，NHCH 2，CO，CONH和CH 2的基团 NH; R 1表示氢或任选取代的C 1-6烷基; R 2表示下述通式（II）或（III）的基团：（II）（III）（其中m为0或1; n为1至3的整数; Y 表示OH或NH 2，虚线表示结合位置），条件是当R 2为通式（III）的基团时，X表示NHCO或 NHCH 2

2. 发明授权

US4760709A Five-way valve having simultaneous defrosting and heating functions 失效
标题翻译：五通阀具有同时除霜和加热功能
公开(公告)号：US4760709A
公开(公告)日：1988-08-02
申请号：US95391
申请日：1987-09-10
申请人： Tadashi Aoki , Tadatoshi Ashikaga , Hiroshi Kuno , Masakazu Isobe , Hideaki Ohhira
发明人： Tadashi Aoki , Tadatoshi Ashikaga , Hiroshi Kuno , Masakazu Isobe , Hideaki Ohhira
IPC分类号： F25B41/04 , F25B47/02 , F25B13/00
CPC分类号： F25B47/022 , F25B41/046 , Y10T137/86839
摘要： A five-way valve includes a cylindrical valve body. A piston member is employed in one end of the cylindrical valve body to define a high pressure chamber and a first pressure chamber. A defrosting valve is employed in the other end of the cylindrical valve body to define a second pressure chamber. A slider valve member coupled to the piston member is slidably employed within said high pressure chamber into which the high temperature and high pressure refrigerant from the compressor is induced. An electromagnetic valve is connected between both the first and second pressure converting chambers, and the inlet of the compressor. When the electromagnetic valve is energized to communicate the second pressure converting chamber with the inlet of the compressor, resulting in the generation of a pressure difference in the defrosting valve member, the defrosting valve member is actuated to pass the high temperature and high pressure refrigerant in the high pressure chamber to the inlet of the outdoor heat exchanger for the defrosting purpose, while the indoor heat exchanger is operated to heat ambient atmosphere.
摘要翻译：五通阀包括圆柱形阀体。在圆柱形阀体的一端采用活塞构件，以限定高压室和第一压力室。在所述圆筒形阀体的另一端采用除霜阀来限定第二压力室。联接到活塞构件的滑动阀构件可滑动地用于来自压缩机的高温高压制冷剂被引入的高压室内。电磁阀连接在第一和第二压力转换室和压缩机的入口之间。当电磁阀被通电以使第二压力转换室与压缩机的入口连通时，导致除霜阀构件中的压力差产生，使除霜阀构件通过高温高压制冷剂高压室到室外热交换器的入口，用于除霜目的，同时室内热交换器被操作以加热环境大气。

3. 发明授权

US4644760A Reversible four-way valve for reversible refrigerating cycle 失效
标题翻译：用于可逆制冷循环的可逆四通阀
公开(公告)号：US4644760A
公开(公告)日：1987-02-24
申请号：US794851
申请日：1985-11-04
申请人： Tadashi Aoki , Masakazu Isobe , Hiroshi Kuno
发明人： Tadashi Aoki , Masakazu Isobe , Hiroshi Kuno
IPC分类号： F25B41/04 , F25B13/00
CPC分类号： F25B41/046 , Y10T137/86839
摘要： Reversible four-way valve for the refrigerating system. It has a cylindrical valve body through which a single piston is adapted to reciprocate slidably. This single piston divides the cylindrical valve body into two chambers. One of the two chambers is used for admitting high pressure gas thereinto whereas the other is assigned for controlling the piston in counteracting the high pressure gas. For this purpose, the piston is formed with a pressure equalizing hole therein to communicate the two chambers with each other while the piston is urged toward the chamber into which the high pressure is admitted. This is done by a compression spring having a force stronger than required to overcome all resistance when both chambers are under the equal pressure. Since the reversible valve has only two chambers, compact design is possible and the operation is stable.
摘要翻译：用于制冷系统的可逆四通阀。它具有圆柱形阀体，单个活塞通过该圆柱形阀体可滑动地往复运动。该单个活塞将圆柱形阀体分成两个腔室。两个室中的一个用于承认高压气体，而另一个用于控制活塞以抵抗高压气体。为此，活塞在其中形成有压力平衡孔，以在活塞被推向朝向容纳高压的室中时将两个室彼此连通。这通过具有比两个室处于相等压力下克服所有电阻所需的力更强的力的压缩弹簧来完成。由于可逆阀只有两个腔室，所以紧凑的设计是可行的，并且操作是稳定的。

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