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    • 1. 发明授权
    • MRI contrast media recognizing minor environmental changes
    • MRI造影剂识别轻微的环境变化
    • US06372194B1
    • 2002-04-16
    • US09381176
    • 1999-09-17
    • Toshihiro AkaikeMasahito MikawaAtsushi MaruyamaNaoto Miwa
    • Toshihiro AkaikeMasahito MikawaAtsushi MaruyamaNaoto Miwa
    • A61B5055
    • A61K49/085A61K49/12A61K49/128
    • This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in response to environmental changes, particularly, pH, light or temperature, to develop a different water solubility, and a method for imaging by the use of this contrast medium. By binding a polymer responsive to microenvironmental changes with a Gd type MRI contrast agent, on-off switching of MRI imaging capability is enabled, wherein imaging occurs only on the target sites. Consequently, a highly specific MRI contrast medium can be obtained, whereby a highly specific MRI diagnosis is made possible, wherein only the target sites such as a tumor and a particular site are imaged and otherwise at the site where imaging is not necessary.
    • 这涉及含有钆(Gd)型造影剂和聚合物的复合物的造影剂。 更具体地,其中响应于环境变化,特别是pH,光或温度而相转移的聚合物以形成不同的水溶性的造影剂,以及通过使用该造影剂进行成像的方法。 通过用Gd型MRI造影剂结合响应于微环境变化的聚合物,能够进行MRI成像能力的开 - 关切换,其中成像仅在靶位点上发生。 因此,可以获得高度特异性的MRI造影剂,由此可以进行高度特异性的MRI诊断,其中只有目标部位如肿瘤和特定部位成像,否则在不需要成像的部位进行成像。