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1. 发明授权

US3985875A .omega.-(N-acylamino)alkylphosphoryl ethanolamines, pharmaceutical compositions containing them, and their uses 失效
标题翻译： {107-（N-酰基氨基）烷基磷酰基乙醇胺，含有它们的药物组合物及其用途
公开(公告)号：US3985875A
公开(公告)日：1976-10-12
申请号：US537601
申请日：1974-12-30
申请人： Kouji Hayashi , Masahisa Hashimoto , Kiyoshi Nakamura , Masanao Shimizu , Naonobu Hatano , Kunihiko Takeyama
发明人： Kouji Hayashi , Masahisa Hashimoto , Kiyoshi Nakamura , Masanao Shimizu , Naonobu Hatano , Kunihiko Takeyama
IPC分类号： C07F9/09 , A01N9/36
CPC分类号： C07F9/091 , Y02P20/55 , Y10S530/86
摘要： New .omega.-(N-acylamino)alkylphosphoryl ethanolamines and their pharmaceutically acceptable acid addition salts have superior renin-inhibitory activities, antihypertensive activities and cholesterol-lowering activities. The .omega.-(N-acylamino)alkylphosphoryl ethanolamines are prepared by (1) reacting an .omega.-(N-acylamino) alkanol with a 2-(N-substituted amino)ethyl phosphate or its derivative, hydrolyzing the resulting product or splitting off the phosphoric acid-protective group of the resulting product thereby to form an .omega.-(N-acylamino) alkyl 2-(N-substituted amino) ethyl phosphate, and splitting off the amino-protective groups of the resulting phosphate, or (2) reacting an .omega.-(N-acylamino) alkanol with a phosphorus oxyhalide, reacting the resulting .omega.-(N-acylamino)alkyl dichlorophosphate with a 2-(N-substituted amino) ethanol, hydrolyzing the reaction product to form an .omega.-(N-acylamino) alkyl 2-(N-substituted)ethyl phosphate, and splitting off the amino-protective groups of said phosphate.
摘要翻译：新的ω-（N-酰基氨基）烷基磷酰基乙醇胺及其药学上可接受的酸加成盐具有优异的肾素抑制活性，降压活性和降胆固醇活性。 ω-（N-酰氨基）烷基磷酰基乙醇胺通过以下步骤制备：（1）使ω-（N-酰氨基）链烷醇与2-（N-取代氨基）乙基磷酸酯或其衍生物反应，水解得到的产物或将得到产物的磷酸保护基，从而形成2-（N-取代氨基）乙基磷酸的ω-（N-酰基氨基）烷基酯，并分离得到的磷酸酯的氨基保护基，或（2）使将具有卤代磷酸酯的ω-（N-酰基氨基）链烷醇与所得的ω-（N-酰基氨基）烷基二氯磷酸酯与2-（N-取代的氨基）乙醇反应，水解反应产物以形成ω-（N- 酰基氨基）烷基2-（N-取代）乙基磷酸酯，并分离出所述磷酸酯的氨基保护基团。

2. 发明申请

US20050145781A1 Optical transducer system having light emitting elements and light detecting elements both regulable in output characteristics 有权
标题翻译：具有发光元件和光检测元件的光学换能器系统均可调节输出特性
公开(公告)号：US20050145781A1
公开(公告)日：2005-07-07
申请号：US11027944
申请日：2005-01-04
申请人： Tomoyuki Ura , Tsutomu Sasaki , Yasuhiko Ohba , Masahisa Hashimoto
发明人： Tomoyuki Ura , Tsutomu Sasaki , Yasuhiko Ohba , Masahisa Hashimoto
IPC分类号： G10F1/02 , G10H1/34 , H01J40/14
CPC分类号： G10H1/344
摘要： Keys, which are incorporated in an automatic player piano, are monitored with an optical transducer system; the optical transducer system includes sensor heads provided on both sides of the key trajectories, LEDs connected to predetermined sensor heads through optical fibers, LDDs connected to the other sensor heads through optical fibers and a controlling unit; a luminescence controller is connected to the LEDs for optimizing the luminescence, and bias controllers are respectively connected to the LDDs; the luminescence controller and bias controllers optimize the luminescence of emitted light and the bias level of electric signals so that the optical transducer system is free from the individuality of component parts and aged deterioration.
摘要翻译：使用光学传感器系统来监视并入自动演奏器钢琴中的琴键; 光传感器系统包括设置在键轨迹两侧的传感器头，通过光纤连接到预定传感器头的LED，通过光纤连接到其它传感器头的LDD和控制单元; 发光控制器连接到LED以优化发光，偏压控制器分别连接到LDD; 发光控制器和偏置控制器优化发射光的发光和电信号的偏置电平，使得光学传感器系统不受组件的个性化和老化的恶化。

3. 发明授权

US3986930A Lipase activity determining method and reagent 失效
标题翻译：脂肪酶活性测定方法和试剂
公开(公告)号：US3986930A
公开(公告)日：1976-10-19
申请号：US579910
申请日：1975-05-22
申请人： Shigeru Kurooka , Masahisa Hashimoto , Masatsugu Tomita , Akio Maki
发明人： Shigeru Kurooka , Masahisa Hashimoto , Masatsugu Tomita , Akio Maki
IPC分类号： C07C327/22 , C12Q1/34 , C12Q1/44 , C12Q1/60 , G01N33/52 , C12K1/04 , C12K1/10
CPC分类号： C12Q1/44 , C07C327/00
摘要： A reagent for determining lipase activity, which comprises as the active ingredient one of the S-acyl compounds of the formula: ##EQU1## WHEREIN N IS AN INTEGER OF 2 TO 4, INCLUSIVE; N' IS AN INTEGER OF 2 TO 4, INCLUSIVE OR OF 9 TO 13, INCLUSIVE; M IS AN INTEGER OF 3, 7 OR 11; M' IS AN INTEGER OF 4 OR 12; Y IS AN INTEGER OF 1 OR 2; X is sulfur atom or oxygen atom; Y is sulfur atom, oxygen atom or ethylene group; provided that when y is 1, m' is 4 and when y is 2, m' is 12, and a method for determining lipase activity by reacting the S-acyl compound with lipase in a buffer solution containing a chromogenic sulfhydryl reagent and then subjecting the resultant to a colorimetry.

4. 发明授权

US07161137B2 Optical transducer system having light emitting elements and light detecting elements both regulable in output characteristics 有权
标题翻译：具有发光元件和光检测元件的光学换能器系统均可调节输出特性
公开(公告)号：US07161137B2
公开(公告)日：2007-01-09
申请号：US11027944
申请日：2005-01-04
申请人： Tomoyuki Ura , Tsutomu Sasaki , Yasuhiko Ohba , Masahisa Hashimoto
发明人： Tomoyuki Ura , Tsutomu Sasaki , Yasuhiko Ohba , Masahisa Hashimoto
IPC分类号： G01V8/10 , G01J1/34 , G01J1/28
CPC分类号： G10H1/344
摘要： Keys, which are incorporated in an automatic player piano, are monitored with an optical transducer system. The optical transducer system includes sensor heads provided on both sides of the key trajectories, LEDs connected to predetermined sensor heads through optical fibers, LDDs connected to the other sensor heads through optical fibers and a controlling unit. A luminescence controller is connected to the LEDs for optimizing the luminescence, and bias controllers are respectively connected to the LDDs. The luminescence controller and bias controllers optimize the luminescence of emitted light and the bias level of electric signals so that the optical transducer system is free from the individuality of component parts and the deterioration.
摘要翻译：使用光学换能器系统监视并入自动演奏器钢琴的琴键。光学传感器系统包括设置在键轨迹两侧的传感器头，通过光纤连接到预定传感器头的LED，通过光纤连接到其它传感器头的LDD和控制单元。发光控制器连接到LED以优化发光，并且偏置控制器分别连接到LDD。发光控制器和偏置控制器优化发射光的发光和电信号的偏置电平，使得光学传感器系统不受组件的个性化和劣化。

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