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    • 2. 发明授权
    • Biomedical devices
    • 生物医学装置
    • US4284506A
    • 1981-08-18
    • US106571
    • 1979-12-26
    • Marvin T. TetenbaumBarton C. Case
    • Marvin T. TetenbaumBarton C. Case
    • A61M1/18A61L27/18B01D63/02B01D65/00C08G18/12C08G18/18C08G18/42B01D31/00B29C27/14
    • C08G18/4269A61L27/18B01D63/023B01D65/003C08G18/12C08G18/1825C08G18/1841C08G18/1866
    • The present invention is directed to improved separatory devices employing polyurethane forming compositions, such as hollow fiber separatory devices intended to be used in biomedical applications. The separatory device employs at least one separatory membrane, suitable for the intended end use application, which is secured, potted or sealed in a housing using a cured polyurethane composition. The improvement comprises utilizing as the potting agent a polyurethane composition comprising the reaction product of an NCO-terminated prepolymer and a hydroxy terminated lactone derived polyester. The lactone polyester comprises the reaction product of a lactone such as caprolactone, and a polyol such as 1,6-hexane diol. The lactone derived polyester imparts to the polyurethane-forming composition a desirable balance of properties, including low mix viscosity, high reactivity, i.e., low gel and demold times, and acceptable hardness values, when used as a potting agent in biomedical separatory devices.
    • 本发明涉及使用聚氨酯形成组合物的改进的分离装置,例如旨在用于生物医学应用的中空纤维分离装置。 分离装置使用至少一个适用于预期最终用途的分离膜,其使用固化的聚氨酯组合物固定,盆或密封在壳体中。 该改进包括使用包含NCO-封端的预聚物和羟基封端的内酯衍生聚酯的反应产物的聚氨酯组合物作为灌封剂。 内酯聚酯包括内酯如己内酯的反应产物和诸如1,6-己二醇的多元醇。 当在生物医学分离装置中用作灌封剂时,内酯衍生的聚酯赋予形成聚氨酯的组合物所需的性能平衡,包括低混合粘度,高反应性,即低凝胶和脱模时间以及可接受的硬度值。