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1. 发明申请

US20060121550A1 Modulation of PDE11A activity 审中-公开
标题翻译：调节PDE11A活性
公开(公告)号：US20060121550A1
公开(公告)日：2006-06-08
申请号：US10137498
申请日：2002-04-29
申请人： Martyn Burslem , Ian Harrow , Jeremy Lanfear , Stephen Phillips , Christopher Wayman
发明人： Martyn Burslem , Ian Harrow , Jeremy Lanfear , Stephen Phillips , Christopher Wayman
IPC分类号： C12Q1/42 , A61K31/519
CPC分类号： A61K31/519 , C12Q1/42
摘要： The invention provides genetically modified non-human mammals and genetically modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A. The invention also provides agents and methods relating to the effect of PDE11A modulation (i.e. PDE11A inhibition or stimulation) on ex vivo spermatozoa capacitation and PDE11A stimulation on in vivo spermatozoa capacitation. The invention also relates to the effect of PDE11A modulation on male pro-fertility and female sexual dysfunction (FSD), specifically female sexual arousal disorder (FSAD), female orgasmic disorder (FOD), hypoactive sexual desire disorder (HSDD) or sexual pain disorders.
摘要翻译：本发明提供了遗传修饰的非人哺乳动物和含有功能性破坏的PDE11A基因的遗传修饰的动物细胞。本发明还提供筛选调节PDE11A以调节精子发生的药剂的方法，治疗哺乳动物以调节精子发生的方法，以及在表达PDE11A的细胞中调节cAMP和cGMP信号转导的方法。本发明还提供了与PDE11A调节（即PDE11A抑制或刺激）对离体精子获能和PDE11A刺激对体内精子获能的影响有关的药剂和方法。本发明还涉及PDE11A调节对男性生殖能力和女性性功能障碍（FSD），特别是女性性唤起障碍（FSAD），女性高潮症（FOD），低反应性欲欲障碍（HSDD）或性疼痛障碍。

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