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1. 发明授权

US09155505B2 Wearable sensor device 有权
标题翻译：耐磨传感器装置
公开(公告)号：US09155505B2
公开(公告)日：2015-10-13
申请号：US13577025
申请日：2010-02-05
申请人： Andreas Caduff , Hans-Joachim Krebs , Gianlucca Stalder , Mark Stuart Talary
发明人： Andreas Caduff , Hans-Joachim Krebs , Gianlucca Stalder , Mark Stuart Talary
IPC分类号： A44C5/00 , A45F5/00 , A45F3/14 , A61B5/00 , A61B5/01 , A61B5/053 , A61B5/145 , A61B8/06 , A61B5/024 , A61B5/0205 , A61B5/026 , A61B5/0265 , A61B5/1455
CPC分类号： A61B5/6831 , A44C5/00 , A45F3/14 , A45F5/00 , A61B5/0059 , A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/0261 , A61B5/0265 , A61B5/053 , A61B5/14532 , A61B5/1455 , A61B5/6824 , A61B5/6843 , A61B5/7207 , A61B8/06
摘要： A sensor device comprises a sensor (1) to be held against the wearer's skin. The sensor (1) is arranged on one side of a housing (2), and the housing is connected to a band (5) for mounting it to a body part, such as an arm or leg. Various stopper devices (10, 14, 20) are arranged on the side of the housing (2) and the band (5) that face the skin. The stopper devices improve static friction, thereby holding the housing (2) in place.
摘要翻译：传感器装置包括被保持抵靠穿着者皮肤的传感器（1）。传感器（1）设置在壳体（2）的一侧，并且壳体连接到带（5），用于将其安装到诸如臂或腿的主体部分。各种止动装置（10,14,20）设置在壳体（2）的侧面和与皮肤相对的带（5）上。止动装置改善静摩擦力，从而将壳体（2）保持在适当的位置。

2. 发明申请

US20100298680A1 METHOD AND DEVICE FOR DETERMINING A PROPERTY OF LIVING TISSUE 审中-公开
标题翻译：用于确定生活组织属性的方法和装置
公开(公告)号：US20100298680A1
公开(公告)日：2010-11-25
申请号：US12809099
申请日：2008-01-11
申请人： Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Lisa Falco
发明人： Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Lisa Falco
IPC分类号： A61B5/1477 , A61B5/053
CPC分类号： A61B5/0531 , A61B5/14532
摘要： The invention relates to a measurement of tissue properties, in particular glucose, by measuring the response of the tissue to an applied electric field. The tissue is modeled by a System of homogeneous layers. In one approach, a plurality of electrical fields are generated in the tissue at different frequencies. For each of the fields, a signal depending on the dielectric permittivity as seen by the electrode arrangement at the frequency is measured, thereby generating a measured dataset. In another approach the different electrode configurations can be used to achieve different penetration depths in the desired layers. A function is then fitted to the dataset by varying at least some parameters of the function. These parameters describe the dispersion of the dielectric permittivity of a plurality of layers in the tissue. At least part of the parameters obtained in this fitting procedure are then used for determining the desired tissue property. Furthermore a combination of these two approaches can be used to optimize the uniqueness of the Solution of the fitting procedure for changes at a specific depth.
摘要翻译：本发明涉及通过测量组织对所施加的电场的响应来测量组织特性，特别是葡萄糖。组织由均匀层系统建模。在一种方法中，在组织中以不同的频率产生多个电场。对于每个场，测量取决于由频率处的电极布置看到的介电常数的信号，从而生成测量的数据集。在另一种方法中，可以使用不同的电极配置来实现所需层中的不同穿透深度。然后通过改变功能的至少一些参数将功能拟合到数据集。这些参数描述了组织中多个层的介电常数的分散。然后使用在该拟合程序中获得的参数的至少一部分来确定期望的组织性质。此外，可以使用这两种方法的组合来优化用于特定深度上的变化的拟合过程的解的唯一性。

3. 发明授权

US09713447B2 Device for determining the glucose level in body tissue 有权
公开(公告)号：US09713447B2
公开(公告)日：2017-07-25
申请号：US12084392
申请日：2005-11-10
申请人： Andreas Caduff , Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Gianluca Stalder
发明人： Andreas Caduff , Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Gianluca Stalder
IPC分类号： A61B5/00 , A61B5/053 , A61B5/145 , A61B5/026 , A61B5/11
CPC分类号： A61B5/6843 , A61B5/0261 , A61B5/0531 , A61B5/11 , A61B5/14532 , A61B5/721 , A61B2560/0242 , A61B2562/0219 , A61B2562/0247
摘要： The apparatus for the non-invasive glucose detection comprises an electrical detection device (2) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (4, 5), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor (6) or alternative perfusion sensor (7), improve the accuracy of the measured result.

4. 发明申请

US20130053654A1 OPTICAL DETERMINATION OF BLOOD PERFUSION AND SIMILAR PARAMETERS 有权
标题翻译：血液透析和类似参数的光学测定
公开(公告)号：US20130053654A1
公开(公告)日：2013-02-28
申请号：US13581191
申请日：2010-02-26
申请人： Andreas Caduff , Hans-Joachim Krebs , Mark Stuart Talary , Pavel Zakharov
发明人： Andreas Caduff , Hans-Joachim Krebs , Mark Stuart Talary , Pavel Zakharov
IPC分类号： A61B5/1455 , A61B5/01
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14552 , A61B5/1491 , A61B5/441
摘要： A parameter affecting the absorptivity or the concentration of blood in tissue is measured using a semiconductor light source (7) and a light detector (8). The semiconductor light source (7) is operated at several operating conditions, at which it has different temperatures and therefore different emission spectra. In particular, the operating conditions correspond to different time intervals after switching the light source (7) on, while the light source (7) has not yet reached thermal equilibrium. This allows to perform a spectroscopic measurement using one light source only, which increases accuracy and reduces device cost.
摘要翻译：使用半导体光源（7）和光检测器（8）测量影响组织中血液的吸收性或浓度的参数。半导体光源（7）在几种工作条件下工作，在这些工作条件下，它具有不同的温度，因此具有不同的发射光谱。特别地，在光源（7）尚未达到热平衡的同时，操作条件对应于切换光源（7）之后的不同时间间隔。这允许仅使用一个光源执行光谱测量，这增加了精度并降低了设备成本。

5. 发明授权

US07063777B2 Dielectrophoretic particle profiling system and method 失效
标题翻译：介电泳粒子分布系统及方法
公开(公告)号：US07063777B2
公开(公告)日：2006-06-20
申请号：US10319860
申请日：2002-12-12
申请人： Richard Stanley Lee , Ronald Pethig , Mark Stuart Talary
发明人： Richard Stanley Lee , Ronald Pethig , Mark Stuart Talary
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N15/1031 , B03C5/026 , G01N15/1463 , G01N33/487 , G01N2015/1075
摘要： An apparatus and methods for determining the dielectrophoretic response of particles under various chemical and physical conditions are disclosed.
摘要翻译：公开了用于在各种化学和物理条件下测定颗粒的介电电泳响应的装置和方法。

6. 发明申请

US20130211204A1 WEARABLE SENSOR DEVICE 有权
标题翻译：耐磨传感器装置
公开(公告)号：US20130211204A1
公开(公告)日：2013-08-15
申请号：US13577025
申请日：2010-02-05
申请人： Andreas Caduff , Hans-Joachim Krebs , Gianlucca Stalder , Mark Stuart Talary
发明人： Andreas Caduff , Hans-Joachim Krebs , Gianlucca Stalder , Mark Stuart Talary
IPC分类号： A61B5/00 , A61B5/1455 , A61B8/06 , A61B5/026 , A61B5/0265 , A61B5/0205 , A61B5/145 , A61B5/01
CPC分类号： A61B5/6831 , A44C5/00 , A45F3/14 , A45F5/00 , A61B5/0059 , A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/0261 , A61B5/0265 , A61B5/053 , A61B5/14532 , A61B5/1455 , A61B5/6824 , A61B5/6843 , A61B5/7207 , A61B8/06
摘要： A sensor device comprises a sensor (1) to be held against the wearer's skin. The sensor (1) is arranged on one side of a housing (2), and the housing is connected to a band (5) for mounting it to a body part, such as an arm or leg. Various stopper devices (10, 14, 20) are arranged on the side of the housing (2) and the band (5) that face the skin. The stopper devices improve static friction, thereby holding the housing (2) in place.
摘要翻译：传感器装置包括被保持抵靠穿着者皮肤的传感器（1）。传感器（1）设置在壳体（2）的一侧，并且壳体连接到带（5），用于将其安装到诸如臂或腿的主体部分。各种止动装置（10,14,20）设置在壳体（2）的侧面和与皮肤相对的带（5）上。止动装置改善静摩擦力，从而将壳体（2）保持在适当的位置。

7. 发明申请

US20120101351A1 WIDE BAND FIELD RESPONSE MEASUREMENT FOR GLUCOSE DETERMINATION 有权
标题翻译：用于葡萄糖测定的宽带场响应测量
公开(公告)号：US20120101351A1
公开(公告)日：2012-04-26
申请号：US13264788
申请日：2009-04-17
申请人： Andreas Caduff , Mark Stuart Talary , Martin Müller , Oscar De Feo
发明人： Andreas Caduff , Mark Stuart Talary , Martin Müller , Oscar De Feo
IPC分类号： A61B5/145
CPC分类号： A61B5/4869 , A61B5/01 , A61B5/0507 , A61B5/0531 , A61B5/0537 , A61B5/14532 , A61B5/1455 , A61B2560/0252 , A61B2562/0209 , A61B2562/043 , A61B2562/046
摘要： A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.
摘要翻译：用于测定活组织中葡萄糖水平的方法和装置是基于测量组织的电场响应以及温度测量。为了提高精度，已经发现，应该组合1kHz至200kHz，0.2MHz，100MHz以及1GHz以上的至少三个频率范围内的测量，因为在这些不同频率范围内组织的响应由不同的机制统治。

8. 发明申请

US20120095307A1 SENSING DEVICE FOR BODY TISSUE PROPERTIES 有权
标题翻译：用于身体组织特性的传感装置
公开(公告)号：US20120095307A1
公开(公告)日：2012-04-19
申请号：US13264774
申请日：2009-04-17
申请人： Andreas Caduff , Mark Stuart Talary , Hans-Joachim Krebs , Alexander Megej , Francois Dewarrat
发明人： Andreas Caduff , Mark Stuart Talary , Hans-Joachim Krebs , Alexander Megej , Francois Dewarrat
IPC分类号： A61B5/1468
CPC分类号： A61B5/0531 , A61B5/0261 , A61B5/14532 , A61B5/6824 , A61B5/6828
摘要： A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (2), which carries a ground electrode (10) as well as a plurality of signal electrodes (12a, 12b, 13a-13c, 14). The gaps (15) between the ground electrode and the signal electrodes are filled with a solid filler material (16) in order to provide an even surface. Optical reflection detectors (23a, 23b, 23c) can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate (2) carries electronic high-frequency components for improving signal quality.
摘要翻译：描述了用于测量活组织参数，特别是葡萄糖水平的装置，该参数影响所述组织对电场的响应。该装置包括承载接地电极（10）以及多个信号电极（12a，12b，13a-13c，14）的基板（2）。为了提供均匀的表面，用固体填充材料（16）填充接地电极和信号电极之间的间隙（15）。光反射检测器（23a，23b，23c）也可以位于这些间隙中，以避免场失真并获得紧凑的设计。基板（2）的背面承载电子高频部件，以提高信号质量。

9. 发明申请

US20120035858A1 DEVICE FOR ELECTRICALLY MEASURING AT LEAST ONE PARAMETER OF A MAMMAL'S TISSUE 审中-公开
标题翻译：用于电动测量至少一个母体组织的参数的装置
公开(公告)号：US20120035858A1
公开(公告)日：2012-02-09
申请号：US13257788
申请日：2009-03-20
申请人： Andreas Caduff , Alexander Megej , Mark Stuart Talary
发明人： Andreas Caduff , Alexander Megej , Mark Stuart Talary
IPC分类号： G06F19/00
CPC分类号： A61B5/0537 , A61B5/0507
摘要： The device measuring a parameter p that depends on the real and/or imaginary parts of the permittivity of body tissue operates at a frequency f where a temperature change affects the permittivity of free water only weakly. If the parameter p depends on the real part of the permittivity only, the frequency f should be between 6.2 and 10.1 GHz. If the parameter p depends on the imaginary part of the permittivity only, the frequency f should be between 25.5 and 36 GHz. If parameter p depends on the real and imaginary parts of the permittivity, the derivative of the parameter in respect to the real and imaginary parts of permittivity can be used to calculate an optimum frequency range.
摘要翻译：测量取决于身体组织的介电常数的实部和/或虚部的参数p的装置以频率f操作，其中温度变化仅影响游离水的介电常数弱。如果参数p仅取决于介电常数的实部，频率f应在6.2到10.1 GHz之间。如果参数p仅取决于介电常数的虚部，则频率f应在25.5和36 GHz之间。如果参数p取决于介电常数的实部和虚部，则可以使用相对于介电常数的实部和虚部的参数的导数来计算最佳频率范围。

10. 发明申请

US20090312615A1 Device for Determining the Glucose Level in Body Tissue 有权
标题翻译：用于确定身体组织中葡萄糖水平的装置
公开(公告)号：US20090312615A1
公开(公告)日：2009-12-17
申请号：US12084392
申请日：2005-11-10
申请人： Andreas Caduff , Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Gianluca Stalder
发明人： Andreas Caduff , Mark Stuart Talary , Francois Dewarrat , Daniel Huber , Gianluca Stalder
IPC分类号： A61B5/1455 , A61B5/1477
CPC分类号： A61B5/6843 , A61B5/0261 , A61B5/0531 , A61B5/11 , A61B5/14532 , A61B5/721 , A61B2560/0242 , A61B2562/0219 , A61B2562/0247
摘要： The apparatus for the non-invasive glucose detection comprises an electrical detection device (2) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (4, 5), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor (6) or alternative perfusion sensor (7), improve the accuracy of the measured result.
摘要翻译：用于非侵入性葡萄糖检测的装置包括用于测量组织或血液对低于1MHz的低频和高于10MHz的高频的电场的响应的电检测装置（2）。前者主要由皮肤水合和汗液占主导地位，后者则含有目前葡萄糖水平的贡献。结合这两个信号可以提高准确度。该装置还包括力或加速度传感器（4,5），其允许检测装置对皮肤的压力和/或快速移动。诸如温度传感器（6）或替代灌注传感器（7）的其它传感器模块提高了测量结果的准确性。

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