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1. 发明授权

US5393466A Fatty acid esters of polyalkoxylated isethionic acid 失效
标题翻译：聚烷氧基化羟乙磺酸的脂肪酸酯
公开(公告)号：US5393466A
公开(公告)日：1995-02-28
申请号：US45951
申请日：1993-04-12
申请人： Leonora Ilardi , Mark Rerek , Michael Massaro , Christine Wenzel
发明人： Leonora Ilardi , Mark Rerek , Michael Massaro , Christine Wenzel
IPC分类号： A61K8/00 , A61K8/46 , A61Q5/02 , A61Q19/10 , C07C309/10 , C07C309/68 , C11D1/12 , C11D1/14
CPC分类号： A61K8/466 , A61Q19/10 , C07C309/10 , C11D1/126 , A61K2800/75
摘要： The present invention provides novel fatty acid esters of alkoxylated isethionic acid and compositions comprising these compounds.
摘要翻译：本发明提供了烷氧基化羟乙磺酸的新型脂肪酸酯和包含这些化合物的组合物。

2. 发明申请

US20070196303A1 STABLE BUFFERED ALUMINUM COMPOSITIONS HAVING HIGH HPLC BANDS III AND IV CONTAINING CALCIUM/STRONTIUM 审中-公开
标题翻译：具有包含钙/锶的高效液相色谱三级和四级的稳定的缓冲铝组合物
公开(公告)号：US20070196303A1
公开(公告)日：2007-08-23
申请号：US11307689
申请日：2006-02-17
申请人： Zijun Li , Mark Rerek
发明人： Zijun Li , Mark Rerek
IPC分类号： A61K8/26
CPC分类号： A61K8/26 , A61K2800/52 , A61Q15/00
摘要： A novel aluminum antiperspirant active composition of enhanced efficacy is provided. The composition is activated by both heat and acid and characterized by having high HPLC Band III and high HPLC Band IV, prepared by the addition of an acid such as AlCl3 to (1) the aluminum calcium and/or strontium betaine solutions, where the calcium and/or strontium is derived from a soluble salt such as calcium and/or strontium chloride or nitrate and (2) the aluminum calcium and/or strontium glycine and/or betaine solutions, where calcium and/or strontium is from strongly alkaline calcium/strontium oxide or hydroxide. The novel aluminum compositions derived according to the invention have HPLC Band I of less than 2%; a Band III of at least 20%; a Band III/II ratio of at least about 0.7; and a Band IV of at least 20%.
摘要翻译：提供了一种增强功效的新型铝止汗剂活性组合物。该组合物由热和酸两者活化，其特征在于具有高HPLC带III和高HPLC带IV，其通过加入酸（例如AlCl 3）制备，以（1）铝钙和/ 或锶甜菜碱溶液，其中钙和/或锶衍生自可溶性盐如钙和/或氯化锶或硝酸锶，和（2）铝钙和/或锶甘氨酸和/或甜菜碱溶液，其中钙和/ 或锶来自强碱性钙/氧化锶或氢氧化物。根据本发明衍生的新型铝组合物具有小于2％的HPLC带I; 至少20％的乐队III; 至少约0.7的Band III / II比率; 和一个至少20％的乐队IV。

3. 发明申请

US20090016979A1 ALUMINUM AND ALUMINUM-ZIRCONIUM COMPOSITIONS OF ENHANCED EFFICACY CONTAINING REDUCED BUFFER AND/OR REDUCED ZIRCONIUM 审中-公开
标题翻译：含有还原缓冲剂和/或还原锆石的增强效率的铝和铝 - 锆组成
公开(公告)号：US20090016979A1
公开(公告)日：2009-01-15
申请号：US11762455
申请日：2007-07-09
申请人： Zijun Li , Mark Rerek
发明人： Zijun Li , Mark Rerek
IPC分类号： A61K8/28
CPC分类号： A61Q15/00 , A61K8/28
摘要： Basic aluminum chloride (BAC) and aluminum zirconium antiperspirant active of enhanced efficacy are proposed. The acid activated aluminum-zirconium composition having low contents of both glycine and zirconium with Band III/II ration of less than 0.5 is found to provide higher efficacy than the corresponding heat activated aluminum zirconium antiperspirant salt with high HPLC Band III/II ratio and having high contents of both glycine and zirconium at similar M/Cl ratio.According to present invention, the interactions between amino acid such as glycine and aluminum species in BAC and aluminum-zirconium solutions greatly reduce the effective amount of aluminum monomer species, which attributed to the reduced efficacy and stability of the corresponding solutions. The aluminum and aluminum-zirconium antiperspirant salt compositions of enhanced efficacy have low molar ratio of amino acid/or buffer to metal(s) of 0.2 and preferably less than 0.15, with metal(s) to chloride molar ratio of at least 1.1. Preferably the aluminum-zirconium salts have aluminum to zirconium atomic ratio of 6 to 10. The compositions are further activated by acid, such as aluminum chloride.
摘要翻译：提出碱性氯化铝（BAC）和铝锆止汗剂活性提高。发现具有小于0.5的Band III / II比率的甘氨酸和锆的低含量的酸活化铝 - 锆组合物具有比具有高HPLC Band III / II比的相应的热活化铝锆止汗剂盐更高的效力，并且具有甘氨酸和锆的含量相似，M / Cl比高。根据本发明，氨基酸如BAC和铝 - 锆溶液中的甘氨酸和铝物质之间的相互作用大大降低了铝单体种类的有效量，这归因于相应溶液的功效和稳定性降低。具有增强功效的铝和铝 - 锆止汗剂盐组合物的氨基酸/或缓冲剂与金属的摩尔比低于0.2，优选小于0.15，金属与氯化物的摩尔比至少为1.1。铝 - 锆盐的铝与锆的原子比优选为6〜10。该组合物进一步由酸如氯化铝活化。

4. 发明授权

US07166275B2 Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds 有权
标题翻译：含有苯乙基芳基酯作为活性有机化合物增溶剂的组合物
公开(公告)号：US07166275B2
公开(公告)日：2007-01-23
申请号：US10617497
申请日：2003-07-11
申请人： Steven H. Bertz , Samuel T. D'Arcangelis , Ilya Makarovsky , Mark Rerek
发明人： Steven H. Bertz , Samuel T. D'Arcangelis , Ilya Makarovsky , Mark Rerek
IPC分类号： A61K7/42
CPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , C07C69/78 , C07C69/76 , C07C69/80
摘要： An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.
摘要翻译：活性或官能的有机化合物溶解在苯乙酯中，例如 2-苯基乙醇的芳基羧酸酯，作为溶剂，共溶剂或添加剂，以形成其组合物。代表性的活性或功能性有机化合物包括个人护理产品，例如。含有UVA / UVB吸收化合物的防晒剂，如阿伏苯宗和二苯甲酮-3。这些组合物还显示增加的临界波长和UVA / UVB吸光度比性能性能。

5. 发明授权

US5916544A Sunscreen concentrate 失效
标题翻译：防晒浓缩液
公开(公告)号：US5916544A
公开(公告)日：1999-06-29
申请号：US968171
申请日：1997-11-12
申请人： Kou-Chang Liu , Michael Helioff , Mark Rerek , Mary Davis , Lawrence J. Grenner , David E. Graham , Anja Waldorf-Geber , Renate Koppel
发明人： Kou-Chang Liu , Michael Helioff , Mark Rerek , Mary Davis , Lawrence J. Grenner , David E. Graham , Anja Waldorf-Geber , Renate Koppel
IPC分类号： A61K8/00 , A61K8/04 , A61K8/19 , A61K8/27 , A61K8/29 , A61K8/30 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/81 , A61Q17/04 , A61K7/42 , A61K6/00 , A61K7/00 , A61K7/44
CPC分类号： A61K8/361 , A61K8/044 , A61K8/27 , A61K8/29 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/445 , A61K8/466 , A61K8/4946 , A61K8/8182 , A61Q17/04 , B82Y5/00 , A61K2800/413
摘要： A sunscreen concentrate in the form of a stable, uniform dispersion comprising, by weight:(a) about 30-65% of ultrafine titanium dioxide or zinc oxide, or mixtures thereof,(b) about 30-70% of an organic sunscreen agent, and(c) about 0.25-25% of a dispersing aid which is polyvinylpyrrolidone alkylated with a C.sub.4 -C.sub.36 alpha-olefin.
摘要翻译：一种防晒浓缩物，其形式为稳定的均匀分散体，其包含：（a）约30-65％的超细二氧化钛或氧化锌或其混合物，（b）约30-70％的有机防晒剂，和（c）约0.25-25％的分散助剂，其是用C 4 -C 36α-烯烃烷基化的聚乙烯吡咯烷酮。

6. 发明授权

US07691363B2 Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds 有权
标题翻译：含有苯乙基芳基酯作为活性有机化合物增溶剂的组合物
公开(公告)号：US07691363B2
公开(公告)日：2010-04-06
申请号：US10859533
申请日：2004-06-02
申请人： Steven H. Bertz , Samuel T. D'Arcangelis , Ilya Makarovsky , Mark Rerek
发明人： Steven H. Bertz , Samuel T. D'Arcangelis , Ilya Makarovsky , Mark Rerek
IPC分类号： A61K7/42
CPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , C07C69/78 , C07C69/76 , C07C69/80
摘要： An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.
摘要翻译：活性或官能的有机化合物溶解在苯乙酯中，例如 2-苯基乙醇的芳基羧酸酯，作为溶剂，共溶剂或添加剂，以形成其组合物。代表性的活性或功能性有机化合物包括个人护理产品，例如。含有UVA / UVB吸收化合物的防晒剂，如阿伏苯宗和二苯甲酮-3。这些组合物还显示增加的临界波长和UVA / UVB吸光度比性能性能。

7. 发明申请

US20080131354A1 Polyaluminum calcium hydroxychlorides and methods of making the same 审中-公开
标题翻译：聚羟基羟基氯化钙及其制备方法
公开(公告)号：US20080131354A1
公开(公告)日：2008-06-05
申请号：US11633998
申请日：2006-12-05
申请人： Zijun Li , Kevin Janak , Mark Rerek
发明人： Zijun Li , Kevin Janak , Mark Rerek
IPC分类号： C01B9/02
CPC分类号： C01F7/002 , A61K8/26 , A61Q15/00 , C01F7/56 , C01P2002/87 , C01P2006/90 , C02F1/5245
摘要： A process is provided for the preparation of a novel polyaluminum calcium hydroxychloride composition of enhanced efficiency for water treatment, paper sizing, and antiperspirant applications. The polyaluminum calcium hydroxychloride compositions are prepared via the acidification of higher basicity reaction products to form mid-to-high basicity final products. Two methods are provided for the preparation of higher basicity products, contemplated in the first, and an aqueous acid solution, such as hydrochloric acid, aluminum chloride, or a mixture thereof, is mixed with a strong alkaline calcium salt such as calcium oxide or calcium carbonate and aluminum powder at temperatures greater than 60° C. In a second method, bauxite, aluminum hydrate, or aluminum metal, and calcium aluminate are mixed with hydrochloric acid and are reacted at high temperatures and/or elevated pressures for a certain period of time whereby, when the reaction is complete, the mixtures are filtered to obtain clear solutions. The final PAC-Ca solutions may be dried to powder to have a wide range of basicities from about 40% to about 80%. At lower basicities, the polyaluminum calcium hydroxychloride sales are used preferably as antiperspirants, while at higher basicities, the solutions are used preferably as water treatment chemicals.
摘要翻译：提供了一种制备用于水处理，纸张施胶和止汗剂应用的增强效率的新型聚羟基氯化铝羟氯化物组合物的方法。通过酸化较高的碱性反应产物来制备羟基氯化铝铝组合物，以形成中至高碱性的最终产物。提供两种方法用于制备较高碱度的产品，首先考虑，酸性溶液如盐酸，氯化铝或其混合物与强碱性钙盐如氧化钙或钙混合碳酸盐和铝粉末。在第二种方法中，将铝土矿，铝水合物或铝金属和铝酸钙与盐酸混合，并在高温和/或高压下反应一定时间时间，当反应完成时，将混合物过滤以获得澄清溶液。最终的PAC-Ca溶液可以被干燥成粉末以具有约40％至约80％的宽范围碱度。在较低的碱度下，聚羟基氯化钙销售优选用作止汗剂，而在较高碱度下，该溶液优选用作水处理化学品。

8. 发明申请

US20050008586A1 Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds 有权
公开(公告)号：US20050008586A1
公开(公告)日：2005-01-13
申请号：US10617497
申请日：2003-07-11
申请人： Steven Bertz , Samuel D'Arcangelis , Ilya Makarovsky , Mark Rerek
发明人： Steven Bertz , Samuel D'Arcangelis , Ilya Makarovsky , Mark Rerek
IPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , A61K7/42
CPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , C07C69/78 , C07C69/76 , C07C69/80
摘要： An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.

9. 发明授权

US06368607B1 Product-structurant composition for personal care formulations 有权
标题翻译：用于个人护理配方的产品结构剂组合物
公开(公告)号：US06368607B1
公开(公告)日：2002-04-09
申请号：US09395382
申请日：1999-09-14
申请人： Mark Rerek , Chester Wang , Elliott Zucker , David Moore , Ilya Makarovskiy
发明人： Mark Rerek , Chester Wang , Elliott Zucker , David Moore , Ilya Makarovskiy
IPC分类号： A61K700
CPC分类号： A61K8/42 , A61K8/0295 , A61K8/345 , A61K8/361 , A61K8/375 , A61K8/416 , A61Q5/12 , A61Q17/04 , A61Q19/00 , Y10S514/844 , Y10S514/847 , Y10S514/937 , Y10S514/943
摘要： A product-structuring composition which forms a bilayer lamellar gel network in an oil-in-water system comprising (a) a cationic swellant which is a fatty acid adduct of amidopropyldimethyl-2-hydroxyethyl ammonium halide, and (b) a gellant blend of low HLB emulsifiers having a resultant HLB of about 1.5 to 4.5.
摘要翻译：一种在水包油体系中形成双层层状凝胶网络的产品结构组合物，其包含（a）阳离子溶胀剂，其是酰氨基丙基二甲基-2-羟乙基卤化铵的脂肪酸加合物，和（b）胶凝剂混合物具有约1.5至4.5的所得HLB的低HLB乳化剂。

10. 发明申请

US20070286830A1 Aluminum compositions of enhanced efficacy having high HPLC Bands III and IV 审中-公开
标题翻译：具有高效液相色谱三级和四级的增强功效的铝组合物
公开(公告)号：US20070286830A1
公开(公告)日：2007-12-13
申请号：US11452101
申请日：2006-06-13
申请人： Zijun Li , Mark Rerek , Kevin Janak
发明人： Zijun Li , Mark Rerek , Kevin Janak
IPC分类号： A61K8/26
CPC分类号： A61Q15/00 , A61K8/26
摘要： Novel aluminum antiperspirant compositions of enhanced efficacy activated by both heat and acid are produced comprising basic aluminum salts of having the formula: Al2(OH)6-aXa wherein X is Cl−, Br−, l−, or NO3−, a is from abut 1.1 to about 1.7, with basic aluminum chloride being the preferred salt. When analyzed by SEC-HPLC at about 10% concentration (i.e., by 2% Al) in water, these compositions exhibit an SEC-HPLC Band I area of less than 10%, a Band III area of at least 20%, with a Band III/II area ratio of at least 0.7, a Band IV area of at least 20%, and have at least 60% aluminum species contained in Bands III and Band IV.
摘要翻译：产生由热和酸热活化的增强功效的新型铝止汗剂组合物，其包含具有下列通式的碱式铝盐：<？in-line-formula description =“In-line Formulas”end =“lead”？> （OH）6-a X a <βin-line-formula description =“In-line Formulas”end =“tail”？>其中 X是Cl - ， - ， - ， - ， - ， - ， - ，a为约1.1至约1.7，碱性氯化铝为优选的盐。当通过SEC-HPLC在水中以约10％浓度（即，2％Al）分析时，这些组合物显示小于10％的SEC-HPLC带I面积，至少20％的Band III面积，其中a Band III / II面积比至少为0.7，Band IV面积至少为20％，并且在III组和Band IV中含有至少60％的铝种类。

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