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1. 发明授权

US08071815B2 CTIP2 expression in squamous cell carcinoma 有权
标题翻译： CTIP2在鳞状细胞癌中的表达
公开(公告)号：US08071815B2
公开(公告)日：2011-12-06
申请号：US12505437
申请日：2009-07-17
申请人： Arup Kumar Indra , Gitali Indra , Joseph Abecassis , Mark Leid
发明人： Arup Kumar Indra , Gitali Indra , Joseph Abecassis , Mark Leid
IPC分类号： C12Q1/68
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57411 , G01N33/57415 , G01N33/57423 , G01N33/57434
摘要： The present disclosure provides methods of diagnosing and staging squamous cell carcinomas, for instance head and neck (HNSCC), by detecting chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) expression. For example, it is demonstrated herein that expression of CTIP2 is increased in SCC relative to a corresponding normal sample. Also included are kits for detecting SCC, as well as methods for identifying CTIP2 inhibitors.
摘要翻译：本公开提供了通过检测鸡卵白蛋白上游启动子 - 转录因子相互作用蛋白2（CTIP2）表达来诊断和分期鳞状细胞癌，例如头颈部（HNSCC）的方法。例如，本文证明了SCC中CTIP2的表达相对于相应的正常样品增加。还包括用于检测SCC的试剂盒，以及鉴定CTIP2抑制剂的方法。

2. 发明授权

US06635429B1 Heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof 失效
标题翻译：异二聚体核受体蛋白，编码相同的基因及其用途
公开(公告)号：US06635429B1
公开(公告)日：2003-10-21
申请号：US08216592
申请日：1994-03-23
申请人： Mark Leid , Philippe Kastner , Pierre Chambon
发明人： Mark Leid , Philippe Kastner , Pierre Chambon
IPC分类号： G01N3353
CPC分类号： C07K14/70567 , C07K2319/715 , C07K2319/80
摘要： The present invention is based in part on the novel observation that two different types of nuclear receptors, retinoic acid receptors (RAR) and thyroid receptors (TR) dimerize with a RX receptor (RXR) to form a heterodimer which is capable of binding to retinoic acid response elements (RARE) or thyroid receptor response elements (TRE) at physiological conditions. In addition, the present invention discloses that RXR homodimers are capable of binding to RARE's. Based on this observation, the present invention provides novel dimeric proteins, methods of identifying agents capable of binding the dimers of the present invention, methods of identifying DNA sequences capable of being bound by the dimers and methods to identify RA metabolic enzymes and proteins which are required for the activation function of nuclear receptors.
摘要翻译：本发明部分基于两种不同类型的核受体，视黄酸受体（RAR）和甲状腺受体（TR）与RX受体（RXR）二聚化以形成能够结合视黄酸的异源二聚体的新观察酸反应元素（RARE）或甲状腺受体反应元件（TRE）。另外，本发明公开了RXR同型二聚体能够与RARE结合。基于该观察，本发明提供了新颖的二聚蛋白，鉴定能够结合本发明的二聚体的试剂的方法，鉴定能够被二聚体结合的DNA序列的方法以及鉴定RA代谢酶和蛋白质的方法核受体激活功能所需。

3. 再颁专利

USRE42700E1 Induction of apoptosis in cancer cells 有权
标题翻译：诱导癌细胞凋亡
公开(公告)号：USRE42700E1
公开(公告)日：2011-09-13
申请号：US12179865
申请日：2008-07-25
申请人： Marcia Dawson , Joseph A. Fontana , Xiao-Kun Zhang , Mark Leid , Ling Jong , Peter D. Hobbs
发明人： Marcia Dawson , Joseph A. Fontana , Xiao-Kun Zhang , Mark Leid , Ling Jong , Peter D. Hobbs
IPC分类号： A61K31/54
CPC分类号： C07D311/82 , C07C59/54 , C07C59/56 , C07C59/72 , C07C59/76 , C07C235/08 , C07C235/52 , C07C255/57 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D311/66 , C07D311/74
摘要： The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.
摘要翻译：本发明提供作为细胞周期停滞前的细胞凋亡的诱导剂或抑制剂的化合物。此外，本发明提供了用于治疗白血病或其他形式的癌症的哺乳动物或用于治疗由细胞凋亡引起的疾病状况的药物组合物和方法。

4. 发明申请

US20100015625A1 CTIP2 EXPRESSION IN SQUAMOUS CELL CARCINOMA 有权
标题翻译： CTIP2在细胞癌中的表达
公开(公告)号：US20100015625A1
公开(公告)日：2010-01-21
申请号：US12505437
申请日：2009-07-17
申请人： Arup Kumar Indra , Gitali Indra , Joseph Abecassis , Mark Leid
发明人： Arup Kumar Indra , Gitali Indra , Joseph Abecassis , Mark Leid
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57411 , G01N33/57415 , G01N33/57423 , G01N33/57434
摘要： The present disclosure provides methods of diagnosing and staging squamous cell carcinomas, for instance head and neck (HNSCC), by detecting chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) expression. For example, it is demonstrated herein that expression of CTIP2 is increased in SCC relative to a corresponding normal sample. Also included are kits for detecting SCC, as well as methods for identifying CTIP2 inhibitors.
摘要翻译：本公开提供了通过检测鸡卵白蛋白上游启动子 - 转录因子相互作用蛋白2（CTIP2）表达来诊断和分期鳞状细胞癌，例如头颈部（HNSCC）的方法。例如，本文证明了SCC中CTIP2的表达相对于相应的正常样品增加。还包括用于检测SCC的试剂盒，以及鉴定CTIP2抑制剂的方法。

5. 发明授权

US07053071B2 Induction of apoptosis in cancer cells 有权
公开(公告)号：US07053071B2
公开(公告)日：2006-05-30
申请号：US10308241
申请日：2002-12-02
申请人： Marcia Dawson , Joseph A. Fontana , Xiao-kun Zhang , Mark Leid , Ling Jong , Peter D. Hobbs
发明人： Marcia Dawson , Joseph A. Fontana , Xiao-kun Zhang , Mark Leid , Ling Jong , Peter D. Hobbs
IPC分类号： A01N57/00 , A01N57/10 , A01N43/40 , A01N43/78 , A01N43/80 , A01N41/02 , A01N53/00 , A61K31/675 , A61K31/66 , A61K31/54 , A61K31/535 , A61K31/445 , A61K31/425 , A61K31/42 , A61K31/255
CPC分类号： C07D311/82 , C07C59/54 , C07C59/56 , C07C59/72 , C07C59/76 , C07C235/08 , C07C235/52 , C07C255/57 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D311/66 , C07D311/74
摘要： The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

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